Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YAL015C
Length:
399
Number of sequences:
5887
Description:
YAL015C NTG1 SGDID:S000000013, Chr I from 128102-126903, Genome Release 64-1-1, reverse complement, Verified ORF, "DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P31378    399   NTG1_YEAST Mitochondrial DNA base excision re...3990     818     100     100GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0008534; F:oxidized purine base lesion DNA N-glycosylase activity; IDA:SGD.::GO:0000703; F:oxidized pyrimidine base lesion DNA N-glycosylase activity; IDA:SGD.
GO:0006285; P:base-excision repair, AP site formation; IDA:SGD.::GO:0034599; P:cellular response to oxidative stress; IMP:SGD.::GO:0090297; P:positive regulation of mitochondrial DNA replication; IMP:SGD.
2Q08214    380   NTG2_YEAST DNA base excision repair N-glycosy...2852e-98     305     51     67GO:0005634; C:nucleus; IDA:SGD.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0000703; F:oxidized pyrimidine base lesion DNA N-glycosylase activity; IDA:SGD.
GO:0006285; P:base-excision repair, AP site formation; IDA:SGD.
3O35980    300   NTHL1_MOUSE Endonuclease III-like protein 1 O...2211e-54     188     46     61GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0019104; F:DNA N-glycosylase activity; IDA:UniProtKB.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IDA:UniProtKB.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.::GO:0006296; P:nucleotide-excision repair, DNA incision, 5'-to lesion; IDA:UniProtKB.
4Q2KID2    305   NTHL1_BOVIN Endonuclease III-like protein 1 O...2192e-51     180     44     61GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
5P78549    312   NTHL1_HUMAN Endonuclease III-like protein 1 O...2195e-51     179     44     60GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0019104; F:DNA N-glycosylase activity; IDA:UniProtKB.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IDA:UniProtKB.::GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.::GO:0004519; F:endonuclease activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0045008; P:depyrimidination; TAS:Reactome.::GO:0006296; P:nucleotide-excision repair, DNA incision, 5'-to lesion; IDA:UniProtKB.
6Q09907    355   NTH1_SCHPO Endonuclease III homolog OS=Schizo...2261e-49     177     42     57GO:0005759; C:mitochondrial matrix; ISS:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0034042; F:5-formyluracil DNA N-glycosylase activity; IDA:PomBase.::GO:0034043; F:5-hydroxymethyluracil DNA N-glycosylase activity; IDA:PomBase.::GO:0034039; F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; IDA:PomBase.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006285; P:base-excision repair, AP site formation; IDA:PomBase.
7P54137    298   NTH1_CAEEL Probable endonuclease III homolog ...2106e-43     157     40     59GO:0005634; C:nucleus; ISS:WormBase.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0034042; F:5-formyluracil DNA N-glycosylase activity; IDA:WormBase.::GO:0034043; F:5-hydroxymethyluracil DNA N-glycosylase activity; IDA:WormBase.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0045008; P:depyrimidination; IDA:WormBase.
8Q8SRB8    238   NTH1_ENCCU Endonuclease III homolog OS=Enceph...2193e-29     118     33     53
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
9Q58030    344   Y613_METJA Putative endonuclease MJ0613 OS=JC...1782e-22     100     39     58GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
10Q9WYK0    213   END3_THEMA Endonuclease III OS=Thermotoga mar...1846e-21     94     33     53GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
11P63540    245   END3_MYCTU Endonuclease III OS=Mycobacterium ...1954e-16     80.9     28     49GO:0005618; C:cell wall; IDA:MTBBASE.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IDA:MTBBASE.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0019104; F:DNA N-glycosylase activity; IDA:MTBBASE.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0003690; F:double-stranded DNA binding; IDA:MTBBASE.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
12P63541    245   END3_MYCBO Endonuclease III OS=Mycobacterium ...1954e-16     80.9     28     49GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
13P73715    219   END3_SYNY3 Endonuclease III OS=Synechocystis ...1805e-16     80.5     30     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
14Q4UK93    213   END3_RICFE Endonuclease III OS=Rickettsia fel...1830.00000000000001     75.9     31     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
15P46303    279   UVEN_MICLC Ultraviolet N-glycosylase/AP lyase...1770.00000000000002     76.3     30     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
16Q9CB92    245   END3_MYCLE Endonuclease III OS=Mycobacterium ...1950.00000000000008     74.3     26     47GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
17Q92GH4    210   END3_RICCN Endonuclease III OS=Rickettsia con...1830.000000000009     67.4     30     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
18O05956    212   END3_RICPR Endonuclease III OS=Rickettsia pro...1880.0000000002     63.9     28     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
19P39788    219   END3_BACSU Probable endonuclease III OS=Bacil...1780.0000000008     62     27     51GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
20Q68W04    212   END3_RICTY Endonuclease III OS=Rickettsia typ...1810.000000001     61.2     28     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
21Q89AW4    215   END3_BUCBP Endonuclease III OS=Buchnera aphid...1770.000000002     60.5     28     44GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
22P0AB83    211   END3_ECOLI Endonuclease III OS=Escherichia co...1740.00000001     58.2     26     45GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006284; P:base-excision repair; IEA:InterPro.
23P0AB84    211   END3_ECOL6 Endonuclease III OS=Escherichia co...1740.00000001     58.2     26     45GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
24Q8KA16    209   END3_BUCAP Endonuclease III OS=Buchnera aphid...1340.00000009     55.8     29     54GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
25P44319    211   END3_HAEIN Endonuclease III OS=Haemophilus in...1600.0000003     54.3     26     44GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
26O83754    211   END3_TREPA Endonuclease III OS=Treponema pall...1240.0000006     53.1     29     49GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
27P57219    210   END3_BUCAI Endonuclease III OS=(Acyrthosiphon...1420.000004     50.8     27     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:EC.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
28Q58829    220   Y1434_METJA Putative endonuclease MJ1434 OS=J...1940.00002     48.9     26     45
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:InterPro.
29Q10159    461   MYH1_SCHPO A/G-specific adenine DNA glycosyla...770.01     41.6     38     55GO:0005634; C:nucleus; IDA:PomBase.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IDA:PomBase.::GO:0004519; F:endonuclease activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0000702; F:oxidized base lesion DNA N-glycosylase activity; TAS:PomBase.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0000701; F:purine-specific mismatch base pair DNA N-glycosylase activity; IMP:PomBase.
GO:0006284; P:base-excision repair; IC:PomBase.::GO:0034644; P:cellular response to UV; IMP:PomBase.::GO:0000077; P:DNA damage checkpoint; IGI:PomBase.
30Q7VGC0    208   RS4_HELHP 30S ribosomal protein S4 OS=Helicob...1100.012     40.4     25     49GO:0015935; C:small ribosomal subunit; IEA:InterPro.
GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.::GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
GO:0006412; P:translation; IEA:InterPro.
31Q1IS94    209   RS4_KORVE 30S ribosomal protein S4 OS=Koribac...1140.014     40.4     24     48GO:0015935; C:small ribosomal subunit; IEA:InterPro.
GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.::GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
GO:0006412; P:translation; IEA:InterPro.
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