UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YAL012W

Length:

394

Number of sequences:

5887

Description:

YAL012W CYS3 SGDID:S000000010, Chr I from 130799-131983, Genome Release 64-1-1, Verified ORF, "Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P31373	394	CYS3_YEAST Cystathionine gamma-lyase OS=Sacch...	394	0	806	100	100	GO:0005737; C:cytoplasm; IDA:SGD.
									GO:0004123; F:cystathionine gamma-lyase activity; IDA:SGD.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019343; P:cysteine biosynthetic process via cystathionine; IMP:SGD.::GO:0019346; P:transsulfuration; IMP:SGD.
2	Q55DV9	387	CGL_DICDI Cystathionine gamma-lyase OS=Dictyo...	394	5e-136	401	53	66	GO:0005737; C:cytoplasm; ISS:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.
									GO:0004123; F:cystathionine gamma-lyase activity; ISS:dictyBase.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.
3	Q60HG7	405	CGL_MACFA Cystathionine gamma-lyase OS=Macaca...	387	2e-128	382	51	68	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
4	Q19QT7	405	CGL_PIG Cystathionine gamma-lyase OS=Sus scro...	387	7e-128	381	51	68	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
5	P18757	398	CGL_RAT Cystathionine gamma-lyase OS=Rattus n...	387	8e-124	370	50	67	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004121; F:cystathionine beta-lyase activity; IDA:RGD.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0006749; P:glutathione metabolic process; IMP:RGD.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; IMP:RGD.::GO:0008285; P:negative regulation of cell proliferation; IMP:RGD.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.::GO:0019346; P:transsulfuration; TAS:RGD.
6	Q8VCN5	398	CGL_MOUSE Cystathionine gamma-lyase OS=Mus mu...	387	8e-124	370	50	67	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IDA:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; IMP:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.::GO:0044524; P:protein sulfhydration; IDA:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
7	P32929	405	CGL_HUMAN Cystathionine gamma-lyase OS=Homo s...	387	4e-121	363	52	69	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:HPA.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; IDA:UniProtKB.::GO:0047982; F:homocysteine desulfhydrase activity; TAS:Reactome.::GO:0080146; F:L-cysteine desulfhydrase activity; TAS:Reactome.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IMP:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; IDA:UniProtKB.
									GO:0019344; P:cysteine biosynthetic process; IDA:UniProtKB.::GO:0030968; P:endoplasmic reticulum unfolded protein response; TAS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; IDA:UniProtKB.::GO:0051289; P:protein homotetramerization; IPI:UniProtKB.::GO:0044524; P:protein sulfhydration; IMP:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; IDA:UniProtKB.::GO:0000098; P:sulfur amino acid catabolic process; TAS:Reactome.::GO:0019346; P:transsulfuration; TAS:Reactome.
8	Q58DW2	405	CGL_BOVIN Cystathionine gamma-lyase OS=Bos ta...	372	2e-119	359	50	68	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
9	P55216	392	CGL2_CAEEL Putative cystathionine gamma-lyase...	390	1e-114	347	49	68	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004123; F:cystathionine gamma-lyase activity; IEA:EC.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
10	A2RM21	380	METC_LACLM Cystathionine beta-lyase OS=Lactoc...	384	4e-110	335	48	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
11	P0A4K2	380	METC_LACLA Cystathionine beta-lyase OS=lactis...	384	4e-110	335	48	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
12	Q83A83	387	METC_COXBU Cystathionine beta-lyase OS=Coxiel...	383	8e-109	332	46	65	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
13	Q1M0P5	380	METB_HELPX Cystathionine gamma-synthase OS=He...	384	1e-107	328	48	63	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
14	O05394	379	MCCB_BACSU Cystathionine gamma-lyase OS=Bacil...	385	3e-106	324	48	62
									GO:0004123; F:cystathionine gamma-lyase activity; IEA:EC.::GO:0047982; F:homocysteine desulfhydrase activity; IEA:EC.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
15	P56069	380	METB_HELPY Cystathionine gamma-synthase OS=py...	387	5e-106	324	47	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
16	P46807	388	METB_MYCLE Cystathionine gamma-synthase OS=My...	386	2e-105	323	48	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
17	P0C2T9	380	METC_LACLC Cystathionine beta-lyase OS=Lactoc...	384	7e-105	321	48	61	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
18	P66875	388	METB_MYCTU Cystathionine gamma-synthase OS=My...	385	1e-104	320	48	62	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:MTBBASE.
									GO:0004123; F:cystathionine gamma-lyase activity; IDA:MTBBASE.::GO:0003962; F:cystathionine gamma-synthase activity; IDA:MTBBASE.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019343; P:cysteine biosynthetic process via cystathionine; IMP:MTBBASE.::GO:0019279; P:L-methionine biosynthetic process from L-homoserine via cystathionine; IMP:MTBBASE.
19	P66876	388	METB_MYCBO Cystathionine gamma-synthase OS=My...	385	1e-104	320	48	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
20	Q9ZMW7	380	METB_HELPJ Cystathionine gamma-synthase OS=He...	387	3e-102	314	45	61	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
21	O31632	390	METC_BACSU Cystathionine beta-lyase metC OS=B...	369	2e-93	292	44	61	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
22	P24601	319	METB_HERAU Probable cystathionine gamma-synth...	324	2e-90	282	46	64	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
23	O31631	373	METI_BACSU Cystathionine gamma-synthase/O-ace...	390	1e-89	282	42	58	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
24	P53780	464	METC_ARATH Cystathionine beta-lyase, chloropl...	391	3e-88	281	39	59	GO:0009570; C:chloroplast stroma; IDA:TAIR.
									GO:0004121; F:cystathionine beta-lyase activity; IMP:TAIR.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019279; P:L-methionine biosynthetic process from L-homoserine via cystathionine; TAS:TAIR.
25	P44502	369	METB_HAEIN Cystathionine gamma-synthase OS=Ha...	378	1e-82	263	39	57	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
26	O94350	390	CBL_SCHPO Cystathionine beta-lyase OS=Schizos...	384	3e-77	250	38	59	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005777; C:peroxisome; ISS:PomBase.
									GO:0004121; F:cystathionine beta-lyase activity; ISS:PomBase.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019279; P:L-methionine biosynthetic process from L-homoserine via cystathionine; IC:PomBase.
27	P13254	398	MEGL_PSEPU Methionine gamma-lyase OS=Pseudomo...	396	5e-77	250	39	57
									GO:0018826; F:methionine gamma-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
28	P00935	386	METB_ECOLI Cystathionine gamma-synthase OS=Es...	390	2e-73	240	38	56	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IDA:EcoCyc.::GO:0042802; F:identical protein binding; IPI:EcoCyc.::GO:0030170; F:pyridoxal phosphate binding; IDA:EcoCyc.
									GO:0009086; P:methionine biosynthetic process; IMP:EcoCyc.
29	P55218	403	METZ_PSEAE O-succinylhomoserine sulfhydrylase...	344	7e-63	213	37	58
									GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
									GO:0071268; P:homocysteine biosynthetic process; IEA:InterPro.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
30	P55217	563	METB_ARATH Cystathionine gamma-synthase, chlo...	347	1e-62	216	37	56	GO:0009570; C:chloroplast stroma; IDA:TAIR.
									GO:0003962; F:cystathionine gamma-synthase activity; IDA:TAIR.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IMP:TAIR.::GO:0001887; P:selenium compound metabolic process; IDA:TAIR.
31	P95199	406	METZ_MYCTU O-succinylhomoserine sulfhydrylase...	363	2e-52	186	35	52
									GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
									GO:0071268; P:homocysteine biosynthetic process; IEA:InterPro.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.

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