Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPR122W
Length:
1208
Number of sequences:
5887
Description:
YPR122W AXL1 SGDID:S000006326, Chr XVI from 782045-785671, Genome Release 64-1-1, Verified ORF, "Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P40851    1208   AXL1_YEAST Putative protease AXL1 OS=Saccharo...12080     2479     100     100GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.::GO:0000300; C:peripheral to membrane of membrane fraction; IDA:SGD.
GO:0004222; F:metalloendopeptidase activity; IMP:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007120; P:axial cellular bud site selection; IMP:SGD.::GO:0007323; P:peptide pheromone maturation; IMP:SGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
2P14735    1019   IDE_HUMAN Insulin-degrading enzyme OS=Homo sa...10764e-49     194     22     41GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0050435; P:beta-amyloid metabolic process; IDA:UniProtKB.::GO:0010815; P:bradykinin catabolic process; IDA:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.
3P35559    1019   IDE_RAT Insulin-degrading enzyme OS=Rattus no...10912e-45     182     21     41GO:0009986; C:cell surface; IDA:RGD.::GO:0031597; C:cytosolic proteasome complex; IDA:RGD.::GO:0005615; C:extracellular space; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.::GO:0005782; C:peroxisomal matrix; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0016887; F:ATPase activity; IDA:RGD.::GO:0001540; F:beta-amyloid binding; IPI:RGD.::GO:0031626; F:beta-endorphin binding; IMP:RGD.::GO:0043559; F:insulin binding; IMP:RGD.::GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:RGD.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0050435; P:beta-amyloid metabolic process; ISS:UniProtKB.::GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.::GO:0042447; P:hormone catabolic process; IDA:RGD.::GO:0045861; P:negative regulation of proteolysis; IDA:RGD.::GO:0051291; P:protein heterooligomerization; IDA:RGD.::GO:0051289; P:protein homotetramerization; IDA:RGD.::GO:0051603; P:proteolysis involved in cellular protein catabolic process; IMP:RGD.
4O14077    969   MU138_SCHPO Putative zinc protease mug138 OS=...10183e-44     178     22     41GO:0005829; C:cytosol; IDA:PomBase.
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0071432; P:peptide mating pheromone maturation involved in conjugation with cellular fusion; ISS:PomBase.::GO:0006508; P:proteolysis; ISS:PomBase.
5Q9JHR7    1019   IDE_MOUSE Insulin-degrading enzyme OS=Mus mus...10913e-44     178     21     40GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0050435; P:beta-amyloid metabolic process; ISS:UniProtKB.::GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
6Q10040    856   YQA4_CAEEL Putative zinc protease C28F5.4 OS=...4072e-29     130     27     43
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
7P42789    596   SDP_EIMBO Sporozoite developmental protein OS...2299e-28     123     33     53
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
8Q54JQ2    962   IDE_DICDI Insulin-degrading enzyme homolog OS...2524e-25     117     32     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
9P05458    962   PTRA_ECOLI Protease 3 OS=Escherichia coli (st...3968e-25     115     26     42GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IDA:EcoCyc.
10Q8X6M8    962   PTRA_ECO57 Protease 3 OS=Escherichia coli O15...3958e-25     115     25     42GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
11Q8CVS2    962   PTRA_ECOL6 Protease 3 OS=Escherichia coli O6:...3951e-24     115     25     42GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
12Q83QC3    962   PTRA_SHIFL Protease 3 OS=Shigella flexneri. G...3951e-24     115     25     43GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
13P47245    1161   NRDC_RAT Nardilysin OS=Rattus norvegicus (Rat...2223e-21     104     31     47
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
14Q8BHG1    1161   NRDC_MOUSE Nardilysin OS=Mus musculus (Mouse)...2223e-21     104     31     47GO:0005739; C:mitochondrion; IDA:MGI.
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
15O43847    1150   NRDC_HUMAN Nardilysin OS=Homo sapiens (Human)...2044e-21     103     32     47GO:0009986; C:cell surface; TAS:UniProtKB.::GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0048408; F:epidermal growth factor binding; TAS:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; NAS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016477; P:cell migration; TAS:UniProtKB.::GO:0008283; P:cell proliferation; TAS:UniProtKB.::GO:0007528; P:neuromuscular junction development; TAS:ProtInc.::GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IDA:BHF-UCL.::GO:0006508; P:proteolysis; NAS:UniProtKB.::GO:0052548; P:regulation of endopeptidase activity; IDA:BHF-UCL.
16Q5R4H6    1152   NRDC_PONAB Nardilysin OS=Pongo abelii (Sumatr...2044e-21     103     32     47
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
17Q8ZMB5    962   PTRA_SALTY Protease 3 OS=Salmonella typhimuri...3945e-21     103     24     41GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
18Q8Z418    962   PTRA_SALTI Protease 3 OS=Salmonella typhi. GN...3947e-20     99.8     24     40GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
19Q9I2D2    775   PQQF_PSEAE Coenzyme PQQ synthesis protein F O...2322e-16     89     26     46
GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-KW.
20Q88A79    779   PQQF_PSESM Coenzyme PQQ synthesis protein F O...2150.00000000000001     82.8     28     44
GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-KW.
21P27508    761   PQQF_KLEPN Coenzyme PQQ synthesis protein F O...2200.0000000003     68.2     26     44
GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-KW.
22Q24K02    1019   IDE_BOVIN Insulin-degrading enzyme OS=Bos tau...7830.000000002     65.5     19     39GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0050435; P:beta-amyloid metabolic process; ISS:UniProtKB.::GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
23Q88QV3    766   PQQF_PSEPK Coenzyme PQQ synthesis protein F O...2110.000000009     63.5     27     41
GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-KW.
24Q00302    465   MPPB_BLAEM Mitochondrial-processing peptidase...2330.00000004     60.8     24     42GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
25Q4W6B5    469   MPPB_DICDI Mitochondrial-processing peptidase...2550.00000005     60.8     24     40GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.::GO:0017087; C:mitochondrial processing peptidase complex; ISS:dictyBase.::GO:0031982; C:vesicle; IDA:dictyBase.
GO:0004222; F:metalloendopeptidase activity; ISS:dictyBase.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0031930; P:mitochondria-nucleus signaling pathway; IMP:dictyBase.::GO:0006627; P:protein processing involved in protein targeting to mitochondrion; ISS:dictyBase.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
26P55174    829   PQQF_PSEFL Coenzyme PQQ synthesis protein F O...2080.0000002     59.7     25     39
GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-KW.
27O22941    970   PXM16_ARATH Zinc-metallopeptidase, peroxisoma...4420.000003     55.8     20     39GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
28Q6PF24    1027   PREP_XENLA Presequence protease, mitochondria...2380.00002     52.8     27     44GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; ISS:UniProtKB.
29Q5JRX3    1037   PREP_HUMAN Presequence protease, mitochondria...2310.00003     52.4     28     45GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.
GO:0008047; F:enzyme activator activity; TAS:ProtInc.::GO:0004222; F:metalloendopeptidase activity; IMP:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IMP:UniProtKB.
30Q28BR5    1027   PREP_XENTR Presequence protease, mitochondria...2380.00004     52     28     44GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; ISS:UniProtKB.
31P10507    462   MPPB_YEAST Mitochondrial-processing peptidase...2260.00005     50.8     24     41GO:0017087; C:mitochondrial processing peptidase complex; IDA:SGD.
GO:0004222; F:metalloendopeptidase activity; TAS:Reactome.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006627; P:protein processing involved in protein targeting to mitochondrion; IDA:SGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
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