rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
121 | Q63484 | 479 | AKT3_RAT RAC-gamma serine/threonine-protein k... | 338 | 5e-42 | 162 | 31 | 49 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005080; F:protein kinase C binding; IPI:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IDA:RGD. | | | | | | | | | | GO:0032869; P:cellular response to insulin stimulus; IMP:MGI.::GO:0010765; P:positive regulation of sodium ion transport; IMP:MGI. | 122 | Q9Y243 | 479 | AKT3_HUMAN RAC-gamma serine/threonine-protein... | 338 | 5e-42 | 162 | 31 | 49 | GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0000002; P:mitochondrial genome maintenance; IMP:UniProtKB.::GO:0007165; P:signal transduction; IMP:UniProtKB. | 123 | A8XNJ6 | 464 | SGK1_CAEBR Serine/threonine-protein kinase sg... | 337 | 6e-42 | 161 | 30 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007154; P:cell communication; IEA:InterPro.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW. | 124 | P05383 | 351 | KAPCB_PIG cAMP-dependent protein kinase catal... | 347 | 6e-42 | 159 | 30 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004691; F:cAMP-dependent protein kinase activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB. | | | | | | | | | | | 125 | Q9MZD9 | 351 | KAPCA_SHEEP cAMP-dependent protein kinase cat... | 343 | 9e-42 | 158 | 30 | 48 | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004691; F:cAMP-dependent protein kinase activity; IEA:EC. | | | | | | | | | | | 126 | P00517 | 351 | KAPCA_BOVIN cAMP-dependent protein kinase cat... | 343 | 9e-42 | 158 | 29 | 47 | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0031594; C:neuromuscular junction; ISS:AgBase.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004691; F:cAMP-dependent protein kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0001707; P:mesoderm formation; ISS:AgBase. | 127 | P51817 | 358 | PRKX_HUMAN cAMP-dependent protein kinase cata... | 351 | 9e-42 | 158 | 29 | 47 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004691; F:cAMP-dependent protein kinase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0001525; P:angiogenesis; IMP:UniProtKB.::GO:0031589; P:cell-substrate adhesion; IMP:UniProtKB.::GO:0043542; P:endothelial cell migration; IMP:UniProtKB.::GO:0001935; P:endothelial cell proliferation; IMP:UniProtKB.::GO:0060562; P:epithelial tube morphogenesis; IDA:UniProtKB.::GO:0060993; P:kidney morphogenesis; IDA:UniProtKB.::GO:0030099; P:myeloid cell differentiation; IDA:UniProtKB.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0030155; P:regulation of cell adhesion; IDA:UniProtKB.::GO:0030334; P:regulation of cell migration; IDA:UniProtKB.::GO:2000696; P:regulation of epithelial cell differentiation involved in kidney development; IDA:UniProtKB. | 128 | P06245 | 380 | KAPB_YEAST cAMP-dependent protein kinase type... | 345 | 1e-41 | 159 | 29 | 50 | GO:0005952; C:cAMP-dependent protein kinase complex; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004691; F:cAMP-dependent protein kinase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.::GO:0007265; P:Ras protein signal transduction; ISS:SGD. | 129 | Q6IP76 | 485 | AKT2B_XENLA RAC-beta serine/threonine-protein... | 351 | 1e-41 | 160 | 31 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 130 | Q05513 | 592 | KPCZ_HUMAN Protein kinase C zeta type OS=Homo... | 351 | 1e-41 | 162 | 31 | 50 | GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; TAS:ProtInc. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043560; F:insulin receptor substrate binding; IC:BHF-UCL.::GO:0004697; F:protein kinase C activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006916; P:anti-apoptosis; TAS:ProtInc.::GO:0030010; P:establishment of cell polarity; ISS:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0060291; P:long-term synaptic potentiation; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:BHF-UCL.::GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IMP:BHF-UCL.::GO:0031333; P:negative regulation of protein complex assembly; IMP:BHF-UCL.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.::GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; ISS:UniProtKB.::GO:0046628; P:positive regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:2001181; P:positive regulation of interleukin-10 secretion; ISS:UniProtKB.::GO:2000667; P:positive regulation of interleukin-13 secretion; ISS:UniProtKB.::GO:0032753; P:positive regulation of interleukin-4 production; ISS:UniProtKB.::GO:2000664; P:positive regulation of interleukin-5 secretion; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; ISS:UniProtKB.::GO:0045630; P:positive regulation of T-helper 2 cell differentiation; ISS:UniProtKB. | 131 | Q02956 | 592 | KPCZ_MOUSE Protein kinase C zeta type OS=Mus ... | 351 | 1e-41 | 162 | 31 | 50 | GO:0045179; C:apical cortex; IDA:MGI.::GO:0016324; C:apical plasma membrane; IDA:MGI.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0035748; C:myelin sheath abaxonal region; IDA:BHF-UCL.::GO:0005635; C:nuclear envelope; IDA:MGI.::GO:0016363; C:nuclear matrix; IDA:MGI.::GO:0043234; C:protein complex; IDA:MGI.::GO:0005625; C:soluble fraction; IDA:MGI.::GO:0005923; C:tight junction; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004697; F:protein kinase C activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0030010; P:establishment of cell polarity; ISS:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0060291; P:long-term synaptic potentiation; ISS:UniProtKB.::GO:0000226; P:microtubule cytoskeleton organization; IMP:MGI.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; ISS:UniProtKB.::GO:0046628; P:positive regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:2001181; P:positive regulation of interleukin-10 secretion; IMP:UniProtKB.::GO:2000667; P:positive regulation of interleukin-13 secretion; IMP:UniProtKB.::GO:0032753; P:positive regulation of interleukin-4 production; IMP:UniProtKB.::GO:2000664; P:positive regulation of interleukin-5 secretion; IMP:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; IMP:UniProtKB.::GO:0045630; P:positive regulation of T-helper 2 cell differentiation; IMP:UniProtKB.::GO:0072659; P:protein localization in plasma membrane; IMP:MGI. | 132 | P09217 | 592 | KPCZ_RAT Protein kinase C zeta type OS=Rattus... | 351 | 1e-41 | 162 | 31 | 50 | GO:0031252; C:cell leading edge; IDA:RGD.::GO:0005829; C:cytosol; IDA:RGD.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005792; C:microsome; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD. | | | | | | | | | | GO:0071889; F:14-3-3 protein binding; IPI:RGD.::GO:0005524; F:ATP binding; IDA:RGD.::GO:0043274; F:phospholipase binding; IPI:RGD.::GO:0015459; F:potassium channel regulator activity; IMP:RGD.::GO:0019904; F:protein domain specific binding; IPI:RGD.::GO:0019901; F:protein kinase binding; IPI:RGD.::GO:0004697; F:protein kinase C activity; IDA:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; IMP:RGD.::GO:0031584; P:activation of phospholipase D activity; IMP:RGD.::GO:0032148; P:activation of protein kinase B activity; IMP:RGD.::GO:0016477; P:cell migration; IMP:RGD.::GO:0034613; P:cellular protein localization; IMP:RGD.::GO:0030010; P:establishment of cell polarity; IMP:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0008286; P:insulin receptor signaling pathway; IMP:RGD.::GO:0007616; P:long-term memory; IMP:RGD.::GO:0060291; P:long-term synaptic potentiation; IMP:UniProtKB.::GO:0060081; P:membrane hyperpolarization; IMP:RGD.::GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.::GO:0051346; P:negative regulation of hydrolase activity; IDA:RGD.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:RGD.::GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.::GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:RGD.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.::GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; IDA:UniProtKB.::GO:0046326; P:positive regulation of glucose import; IMP:RGD.::GO:0046628; P:positive regulation of insulin receptor signaling pathway; IMP:UniProtKB.::GO:2001181; P:positive regulation of interleukin-10 secretion; ISS:UniProtKB.::GO:2000667; P:positive regulation of interleukin-13 secretion; ISS:UniProtKB.::GO:0032753; P:positive regulation of interleukin-4 production; ISS:UniProtKB.::GO:2000664; P:positive regulation of interleukin-5 secretion; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.::GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; ISS:UniProtKB.::GO:0045630; P:positive regulation of T-helper 2 cell differentiation; ISS:UniProtKB.::GO:0070528; P:protein kinase C signaling cascade; IMP:RGD.::GO:0047496; P:vesicle transport along microtubule; IMP:RGD. | 133 | Q01314 | 480 | AKT1_BOVIN RAC-alpha serine/threonine-protein... | 349 | 2e-41 | 160 | 31 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.::GO:0010975; P:regulation of neuron projection development; ISS:UniProtKB.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. | 134 | P05132 | 351 | KAPCA_MOUSE cAMP-dependent protein kinase cat... | 343 | 2e-41 | 157 | 30 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005739; C:mitochondrion; IDA:MGI.::GO:0031594; C:neuromuscular junction; IDA:MGI.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004691; F:cAMP-dependent protein kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0071374; P:cellular response to parathyroid hormone stimulus; IMP:MGI.::GO:0001707; P:mesoderm formation; IGI:MGI.::GO:0071158; P:positive regulation of cell cycle arrest; IDA:UniProtKB.::GO:0046827; P:positive regulation of protein export from nucleus; IMP:MGI.::GO:0046777; P:protein autophosphorylation; IDA:MGI.::GO:0048240; P:sperm capacitation; IDA:UniProtKB. | 135 | Q54UZ1 | 411 | Y1639_DICDI Probable serine/threonine-protein... | 373 | 2e-41 | 159 | 30 | 50 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 136 | P47197 | 481 | AKT2_RAT RAC-beta serine/threonine-protein ki... | 351 | 3e-41 | 159 | 31 | 47 | GO:0005829; C:cytosol; IDA:RGD.::GO:0032593; C:insulin-responsive compartment; IDA:RGD.::GO:0005792; C:microsome; IDA:RGD.::GO:0005739; C:mitochondrion; IDA:RGD.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005080; F:protein kinase C binding; IPI:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IDA:RGD. | | | | | | | | | | GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:RGD.::GO:0033119; P:negative regulation of RNA splicing; IMP:RGD.::GO:0030335; P:positive regulation of cell migration; IMP:RGD.::GO:0046326; P:positive regulation of glucose import; IMP:RGD.::GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:RGD.::GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:RGD.::GO:0050927; P:positive regulation of positive chemotaxis; IDA:RGD.::GO:0009967; P:positive regulation of signal transduction; IMP:RGD.::GO:0010765; P:positive regulation of sodium ion transport; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:RGD.::GO:0043491; P:protein kinase B signaling cascade; IMP:RGD.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0014850; P:response to muscle activity; IEP:RGD.::GO:0006970; P:response to osmotic stress; IEP:RGD. | 137 | P31750 | 480 | AKT1_MOUSE RAC-alpha serine/threonine-protein... | 349 | 4e-41 | 159 | 31 | 49 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0005819; C:spindle; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0042640; P:anagen; IMP:MGI.::GO:0008637; P:apoptotic mitochondrial changes; IDA:MGI.::GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:UniProtKB.::GO:0007010; P:cytoskeleton organization; TAS:UniProtKB.::GO:0031018; P:endocrine pancreas development; TAS:Reactome.::GO:0007281; P:germ cell development; IDA:MGI.::GO:0042593; P:glucose homeostasis; IMP:MGI.::GO:0006006; P:glucose metabolic process; IMP:MGI.::GO:0015758; P:glucose transport; IMP:UniProtKB.::GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.::GO:0060709; P:glycogen cell development involved in embryonic placenta development; IMP:MGI.::GO:0006954; P:inflammatory response; IDA:MGI.::GO:0008286; P:insulin receptor signaling pathway; IMP:UniProtKB.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0060716; P:labyrinthine layer blood vessel development; IMP:MGI.::GO:0001893; P:maternal placenta development; IMP:MGI.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.::GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IDA:UniProtKB.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.::GO:0032287; P:peripheral nervous system myelin maintenance; IMP:MGI.::GO:0045768; P:positive regulation of anti-apoptosis; IDA:UniProtKB.::GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI.::GO:0010765; P:positive regulation of sodium ion transport; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.::GO:0030163; P:protein catabolic process; IDA:MGI.::GO:0016567; P:protein ubiquitination; IDA:MGI.::GO:0010975; P:regulation of neuron projection development; IDA:UniProtKB.::GO:0045884; P:regulation of survival gene product expression; IDA:MGI.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0032094; P:response to food; IDA:MGI.::GO:0051146; P:striated muscle cell differentiation; IGI:MGI. | 138 | P47196 | 480 | AKT1_RAT RAC-alpha serine/threonine-protein k... | 349 | 4e-41 | 159 | 31 | 49 | GO:0005829; C:cytosol; IDA:RGD.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0005080; F:protein kinase C binding; IPI:RGD.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0007568; P:aging; IDA:RGD.::GO:0030030; P:cell projection organization; IDA:MGI.::GO:0071456; P:cellular response to hypoxia; IDA:RGD.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0005978; P:glycogen biosynthetic process; IMP:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; IMP:UniProtKB.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0045792; P:negative regulation of cell size; IDA:MGI.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0046329; P:negative regulation of JNK cascade; IDA:RGD.::GO:0006469; P:negative regulation of protein kinase activity; IDA:BHF-UCL.::GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:UniProtKB.::GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.::GO:0030307; P:positive regulation of cell growth; IDA:RGD.::GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.::GO:0010975; P:regulation of neuron projection development; ISS:UniProtKB.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0006412; P:translation; IMP:UniProtKB. | 139 | P31748 | 501 | AKT_MLVAT AKT kinase-transforming protein OS=... | 349 | 8e-41 | 158 | 31 | 49 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW. | 140 | Q7ZX15 | 486 | AKT2A_XENLA RAC-beta serine/threonine-protein... | 339 | 9e-41 | 158 | 31 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 141 | P28867 | 674 | KPCD_MOUSE Protein kinase C delta type OS=Mus... | 350 | 9e-41 | 160 | 29 | 48 | GO:0005911; C:cell-cell junction; IDA:MGI.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043560; F:insulin receptor substrate binding; IPI:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004697; F:protein kinase C activity; IEA:EC. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042100; P:B cell proliferation; IMP:MGI.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0016064; P:immunoglobulin mediated immune response; IMP:MGI.::GO:0032613; P:interleukin-10 production; IMP:MGI.::GO:0032615; P:interleukin-12 production; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030837; P:negative regulation of actin filament polymerization; IMP:UniProtKB.::GO:0051490; P:negative regulation of filopodium assembly; IMP:UniProtKB.::GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:BHF-UCL.::GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IMP:BHF-UCL.::GO:0090331; P:negative regulation of platelet aggregation; IMP:UniProtKB.::GO:0032930; P:positive regulation of superoxide anion generation; ISS:UniProtKB. | 142 | P31751 | 481 | AKT2_HUMAN RAC-beta serine/threonine-protein ... | 355 | 1e-40 | 158 | 31 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.::GO:0045444; P:fat cell differentiation; TAS:UniProtKB.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.::GO:0008286; P:insulin receptor signaling pathway; TAS:UniProtKB.::GO:0060644; P:mammary gland epithelial cell differentiation; TAS:UniProtKB.::GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport; IMP:BHF-UCL.::GO:0032000; P:positive regulation of fatty acid beta-oxidation; IMP:BHF-UCL.::GO:0046326; P:positive regulation of glucose import; IMP:BHF-UCL.::GO:0045725; P:positive regulation of glycogen biosynthetic process; IMP:BHF-UCL.::GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. | 143 | P31749 | 480 | AKT1_HUMAN RAC-alpha serine/threonine-protein... | 349 | 1e-40 | 157 | 31 | 49 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0030235; F:nitric-oxide synthase regulator activity; IMP:BHF-UCL.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.::GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0008633; P:activation of pro-apoptotic gene products; TAS:Reactome.::GO:0006924; P:activation-induced cell death of T cells; IMP:MGI.::GO:0008283; P:cell proliferation; TAS:UniProtKB.::GO:0031018; P:endocrine pancreas development; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.::GO:0008629; P:induction of apoptosis by intracellular signals; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; IMP:UniProtKB.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; IMP:UniProtKB.::GO:0060644; P:mammary gland epithelial cell differentiation; TAS:UniProtKB.::GO:0016071; P:mRNA metabolic process; TAS:Reactome.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0031999; P:negative regulation of fatty acid beta-oxidation; IMP:BHF-UCL.::GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport; IMP:BHF-UCL.::GO:0006469; P:negative regulation of protein kinase activity; IMP:BHF-UCL.::GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0006809; P:nitric oxide biosynthetic process; TAS:ProtInc.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:UniProtKB.::GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:DFLAT.::GO:0030307; P:positive regulation of cell growth; IDA:UniProtKB.::GO:0031659; P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S; IDA:BHF-UCL.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IMP:BHF-UCL.::GO:0045600; P:positive regulation of fat cell differentiation; IMP:BHF-UCL.::GO:0046326; P:positive regulation of glucose import; IMP:BHF-UCL.::GO:0045725; P:positive regulation of glycogen biosynthetic process; IMP:BHF-UCL.::GO:0046889; P:positive regulation of lipid biosynthetic process; IMP:BHF-UCL.::GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:BHF-UCL.::GO:0051000; P:positive regulation of nitric-oxide synthase activity; IMP:BHF-UCL.::GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.::GO:0046777; P:protein autophosphorylation; TAS:UniProtKB.::GO:0000060; P:protein import into nucleus, translocation; IMP:UniProtKB.::GO:2001047; P:regulation of G1/S transition checkpoint; TAS:UniProtKB.::GO:0010975; P:regulation of neuron projection development; ISS:UniProtKB.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0034405; P:response to fluid shear stress; IMP:BHF-UCL.::GO:0009408; P:response to heat; TAS:ProtInc.::GO:0070141; P:response to UV-A; IDA:BHF-UCL.::GO:0031295; P:T cell costimulation; TAS:Reactome. | 144 | Q60823 | 481 | AKT2_MOUSE RAC-beta serine/threonine-protein ... | 351 | 1e-40 | 157 | 30 | 46 | GO:0030027; C:lamellipodium; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.::GO:0032287; P:peripheral nervous system myelin maintenance; IMP:MGI.::GO:2001275; P:positive regulation of glucose import in response to insulin stimulus; IGI:MGI.::GO:0072659; P:protein localization in plasma membrane; IGI:MGI.::GO:0046328; P:regulation of JNK cascade; IDA:MGI.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. | 145 | Q6TJY3 | 527 | KS6B1_BOVIN Ribosomal protein S6 kinase beta-... | 380 | 2e-40 | 158 | 29 | 48 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0071363; P:cellular response to growth factor stimulus; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB. | 146 | P0C605 | 671 | KGP1_MOUSE cGMP-dependent protein kinase 1 OS... | 349 | 2e-40 | 159 | 30 | 48 | GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IMP:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005246; F:calcium channel regulator activity; ISS:UniProtKB.::GO:0030553; F:cGMP binding; IDA:UniProtKB.::GO:0004692; F:cGMP-dependent protein kinase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0016358; P:dendrite development; IMP:MGI.::GO:0030900; P:forebrain development; IMP:MGI.::GO:0090331; P:negative regulation of platelet aggregation; ISS:UniProtKB.::GO:0001764; P:neuron migration; IMP:MGI.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0007165; P:signal transduction; IDA:UniProtKB. | 147 | P00516 | 671 | KGP1_BOVIN cGMP-dependent protein kinase 1 OS... | 349 | 2e-40 | 159 | 30 | 48 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005246; F:calcium channel regulator activity; ISS:UniProtKB.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0004692; F:cGMP-dependent protein kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0090331; P:negative regulation of platelet aggregation; ISS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB. | 148 | O77676 | 671 | KGP1_RABIT cGMP-dependent protein kinase 1 OS... | 349 | 2e-40 | 159 | 30 | 48 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005246; F:calcium channel regulator activity; ISS:UniProtKB.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0004692; F:cGMP-dependent protein kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0090331; P:negative regulation of platelet aggregation; ISS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB. | 149 | Q13976 | 671 | KGP1_HUMAN cGMP-dependent protein kinase 1 OS... | 349 | 2e-40 | 159 | 30 | 48 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005246; F:calcium channel regulator activity; IDA:UniProtKB.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0004692; F:cGMP-dependent protein kinase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0090331; P:negative regulation of platelet aggregation; IMP:UniProtKB.::GO:0043087; P:regulation of GTPase activity; IMP:UniProtKB.::GO:0007165; P:signal transduction; TAS:ProtInc. | 150 | Q04759 | 706 | KPCT_HUMAN Protein kinase C theta type OS=Hom... | 356 | 2e-40 | 159 | 29 | 49 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004697; F:protein kinase C activity; IEA:EC. | | | | | | | | | | GO:0007411; P:axon guidance; TAS:Reactome.::GO:0006921; P:cellular component disassembly involved in apoptotic process; TAS:Reactome.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.::GO:0006509; P:membrane protein ectodomain proteolysis; ISS:BHF-UCL.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:UniProtKB.::GO:0070233; P:negative regulation of T cell apoptotic process; IMP:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0032740; P:positive regulation of interleukin-17 production; ISS:UniProtKB.::GO:0032753; P:positive regulation of interleukin-4 production; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:2000318; P:positive regulation of T-helper 17 type immune response; ISS:UniProtKB.::GO:2000570; P:positive regulation of T-helper 2 cell activation; ISS:UniProtKB.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome. | 151 | Q9ST27 | 907 | PHOT2_ORYSJ Phototropin-2 OS=Oryza sativa sub... | 324 | 2e-40 | 160 | 32 | 50 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0009882; F:blue light photoreceptor activity; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0000155; F:two-component sensor activity; IEA:InterPro. | | | | | | | | | | GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. |