Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPR106W
Length:
443
Number of sequences:
5887
Description:
YPR106W ISR1 SGDID:S000006310, Chr XVI from 740061-741392, Genome Release 64-1-1, Verified ORF, "Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
91A8X0C4    649   PAR4_CAEBR Serine/threonine-protein kinase pa...1920.00007     48.9     25     48GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
92Q9Y6R4    1608   M3K4_HUMAN Mitogen-activated protein kinase k...1520.00007     48.9     25     46GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007254; P:JNK cascade; TAS:ProtInc.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.
93P15735    406   PHKG2_HUMAN Phosphorylase b kinase gamma cata...1110.00007     48.5     28     50GO:0005829; C:cytosol; TAS:Reactome.::GO:0005964; C:phosphorylase kinase complex; TAS:UniProtKB.
GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004689; F:phosphorylase kinase activity; TAS:UniProtKB.::GO:0050321; F:tau-protein kinase activity; TAS:UniProtKB.
GO:0006006; P:glucose metabolic process; TAS:Reactome.::GO:0005978; P:glycogen biosynthetic process; IEA:InterPro.::GO:0005980; P:glycogen catabolic process; TAS:Reactome.::GO:0045819; P:positive regulation of glycogen catabolic process; TAS:UniProtKB.
94Q99JT2    416   MST4_MOUSE Serine/threonine-protein kinase MS...1490.00007     48.5     26     46GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
95P50527    658   STE20_SCHPO Serine/threonine-protein kinase s...1180.00008     48.9     30     48GO:0071521; C:Cdc42 GTPase complex; TAS:PomBase.::GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; TAS:PomBase.
GO:0032488; P:Cdc42 protein signal transduction; IGI:PomBase.::GO:0034613; P:cellular protein localization; IGI:PomBase.::GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; TAS:PomBase.::GO:0061161; P:positive regulation of establishment of bipolar cell polarity regulating cell shape; IGI:PomBase.::GO:0071775; P:regulation of cell cycle cytokinesis; IMP:PomBase.::GO:0070507; P:regulation of microtubule cytoskeleton organization; IGI:PomBase.
96Q9DB30    406   PHKG2_MOUSE Phosphorylase b kinase gamma cata...1110.00008     48.5     28     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004689; F:phosphorylase kinase activity; IEA:EC.::GO:0050321; F:tau-protein kinase activity; IEA:EC.
GO:0005978; P:glycogen biosynthetic process; IEA:InterPro.
97A1A5Q6    654   SMK_RAT Sperm motility kinase OS=Rattus norve...770.00008     48.5     40     55
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
98Q8NU97    469   PKN2_CORGL Serine/threonine-protein kinases p...1460.00008     48.5     27     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
99O08815    1206   SLK_RAT STE20-like serine/threonine-protein k...1140.00008     48.9     31     53GO:0005737; C:cytoplasm; IDA:RGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004518; F:nuclease activity; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006289; P:nucleotide-excision repair; IEA:InterPro.::GO:0046777; P:protein autophosphorylation; IDA:RGD.
100Q13546    671   RIPK1_HUMAN Receptor-interacting serine/threo...1660.00009     48.5     27     45GO:0005829; C:cytosol; TAS:Reactome.::GO:0031264; C:death-inducing signaling complex; IDA:BHF-UCL.::GO:0010008; C:endosome membrane; TAS:Reactome.::GO:0005739; C:mitochondrion; IDA:BHF-UCL.::GO:0043235; C:receptor complex; IDA:BHF-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0070513; F:death domain binding; IPI:BHF-UCL.::GO:0005123; F:death receptor binding; IPI:BHF-UCL.::GO:0004674; F:protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome.::GO:0007257; P:activation of JUN kinase activity; TAS:BHF-UCL.::GO:0008633; P:activation of pro-apoptotic gene products; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0060555; P:induction of necroptosis by extracellular signals; IMP:BHF-UCL.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.::GO:0045768; P:positive regulation of anti-apoptosis; TAS:BHF-UCL.::GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB.::GO:0032757; P:positive regulation of interleukin-8 production; IDA:BHF-UCL.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:2000379; P:positive regulation of reactive oxygen species metabolic process; TAS:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:BHF-UCL.::GO:0032481; P:positive regulation of type I interferon production; TAS:Reactome.::GO:0046777; P:protein autophosphorylation; IDA:BHF-UCL.::GO:0070926; P:regulation of ATP:ADP antiporter activity; IMP:BHF-UCL.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IC:BHF-UCL.
101Q5B4Z3    1346   SEPH_EMENI Cytokinesis protein sepH OS=194 / ...1110.00009     48.9     32     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.
102Q9JIH7    2126   WNK1_RAT Serine/threonine-protein kinase WNK1...1210.00009     48.9     31     45GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005626; C:insoluble fraction; IDA:RGD.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IMP:RGD.::GO:0019902; F:phosphatase binding; ISS:UniProtKB.::GO:0019870; F:potassium channel inhibitor activity; IDA:RGD.::GO:0019901; F:protein kinase binding; IPI:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0030291; F:protein serine/threonine kinase inhibitor activity; IDA:RGD.
GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0006811; P:ion transport; ISS:UniProtKB.::GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:RGD.
103Q0D847    601   WNK3_ORYSJ Probable serine/threonine-protein ...1110.00009     48.5     32     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
104Q54R82    942   MKKA_DICDI Mitogen-activated protein kinase k...1490.00009     48.5     30     48GO:0005938; C:cell cortex; IDA:dictyBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; ISS:dictyBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0030587; P:sorocarp development; IMP:dictyBase.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
105A2QHV0    1336   SEPH_ASPNC Cytokinesis protein sepH OS=Asperg...1110.00009     48.9     32     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.
106Q2KJ16    406   PHKG2_BOVIN Phosphorylase b kinase gamma cata...1570.00009     48.1     27     46GO:0005964; C:phosphorylase kinase complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004689; F:phosphorylase kinase activity; IEA:EC.::GO:0050321; F:tau-protein kinase activity; IEA:EC.
GO:0005978; P:glycogen biosynthetic process; IEA:InterPro.
107O54988    1233   SLK_MOUSE STE20-like serine/threonine-protein...1140.00009     48.5     31     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004518; F:nuclease activity; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
108P10650    346   MOS_CHLAE Proto-oncogene serine/threonine-pro...1310.00009     47.8     29     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
109Q86I06    1123   NEK3_DICDI Probable serine/threonine-protein ...1510.00009     48.5     32     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
110Q91727    319   CDK4_XENLA Cyclin-dependent kinase 4 OS=Xenop...1050.0001     47.8     34     53
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
111F1NBT0    969   STK10_CHICK Serine/threonine-protein kinase 1...1140.0001     48.5     29     53GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0071593; P:lymphocyte aggregation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:2000401; P:regulation of lymphocyte migration; ISS:UniProtKB.
112P00540    346   MOS_HUMAN Proto-oncogene serine/threonine-pro...1310.0001     47.8     28     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
113O55092    1231   SLK_CAVPO STE20-like serine/threonine-protein...1140.0001     48.5     31     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004518; F:nuclease activity; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
114P10741    349   MOS_CHICK Serine/threonine-protein kinase mos...1350.0001     47.8     28     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
115Q8AYG3    982   TTK_DANRE Dual specificity protein kinase Ttk...1300.0001     48.1     29     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0009790; P:embryo development; IMP:UniProtKB.::GO:0007093; P:mitotic cell cycle checkpoint; IMP:UniProtKB.::GO:0042246; P:tissue regeneration; IMP:UniProtKB.
116Q8FUI5    660   PKN1_COREF Probable serine/threonine-protein ...1890.0001     48.1     29     44
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008658; F:penicillin binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
117Q9CAL8    710   PEK13_ARATH Proline-rich receptor-like protei...1250.0001     48.1     31     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
118Q0CL79    1342   SEPH_ASPTN Cytokinesis protein sepH OS=Asperg...1110.0001     48.1     31     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.
119P07331    374   MOS_MSVMH Serine/threonine-protein kinase-tra...1650.0001     47.8     27     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
120P04627    604   ARAF_MOUSE Serine/threonine-protein kinase A-...2330.0001     48.1     24     41GO:0005739; C:mitochondrion; IDA:MGI.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:MGI.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
121Q6FKC6    567   SSN3_CANGA Serine/threonine-protein kinase SS...1020.0001     48.1     31     49GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
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