Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPR106W
Length:
443
Number of sequences:
5887
Description:
YPR106W ISR1 SGDID:S000006310, Chr XVI from 740061-741392, Genome Release 64-1-1, Verified ORF, "Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
421Q9M3D7    667   LRK14_ARATH Putative L-type lectin-domain con...1090.006     42.7     29     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005739; C:mitochondrion; IDA:TAIR.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
422P34100    714   PKD1_DICDI Developmentally-regulated protein ...1060.006     42.7     27     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
423P50488    744   DAF4_CAEEL Cell surface receptor daf-4 OS=Cae...1630.006     42.7     29     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019838; F:growth factor binding; IPI:WormBase.::GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; ISS:WormBase.
GO:0040024; P:dauer larval development; IMP:WormBase.::GO:0050832; P:defense response to fungus; IMP:WormBase.::GO:0045087; P:innate immune response; IMP:WormBase.::GO:0030514; P:negative regulation of BMP signaling pathway; IMP:WormBase.::GO:0018991; P:oviposition; IMP:WormBase.::GO:0030513; P:positive regulation of BMP signaling pathway; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IMP:WormBase.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:WormBase.
424Q4P9T2    654   SSN3_USTMA Serine/threonine-protein kinase SS...1190.006     42.7     27     51GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
425Q2ULU3    848   STE20_ASPOR Serine/threonine-protein kinase s...1090.006     42.7     26     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
426Q3MHJ9    542   KCC2B_BOVIN Calcium/calmodulin-dependent prot...1860.006     42.4     22     43GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
GO:0061003; P:positive regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.::GO:0090129; P:positive regulation of synapse maturation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
427Q9ESL4    802   MLTK_MOUSE Mitogen-activated protein kinase k...980.006     42.7     31     49GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:MGI.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0004709; F:MAP kinase kinase kinase activity; IDA:MGI.
GO:0007010; P:cytoskeleton organization; IDA:MGI.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
428P75524    389   PKNS_MYCPN Putative serine/threonine-protein ...1060.006     42.4     31     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
429Q8R9T6    625   PKN1_THETN Probable serine/threonine-protein ...1160.006     42.7     30     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008658; F:penicillin binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
430O22040    666   ANP1_ARATH Mitogen-activated protein kinase k...1110.006     42.7     27     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.
GO:0009908; P:flower development; IGI:TAIR.::GO:0046777; P:protein autophosphorylation; IDA:TAIR.::GO:0006979; P:response to oxidative stress; IDA:TAIR.
431Q9M021    682   LRK62_ARATH L-type lectin-domain containing r...900.006     42.7     34     54GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0009738; P:abscisic acid mediated signaling pathway; IMP:TAIR.::GO:0009845; P:seed germination; IMP:TAIR.
432O13958    369   SSN3_SCHPO Serine/threonine-protein kinase sr...1130.006     42.4     30     48GO:0016592; C:mediator complex; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; ISS:PomBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
GO:0051519; P:activation of bipolar cell growth; IMP:PomBase.::GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; NAS:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
433Q99KY4    1305   GAK_MOUSE Cyclin-G-associated kinase OS=Mus m...2860.006     42.7     23     41GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031072; F:heat shock protein binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
434P34331    649   PLK1_CAEEL Serine/threonine-protein kinase pl...1430.007     42.4     27     45GO:0005813; C:centrosome; IDA:WormBase.::GO:0000793; C:condensed chromosome; IDA:WormBase.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0051233; C:spindle midzone; IDA:WormBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IMP:WormBase.::GO:0007417; P:central nervous system development; IMP:UniProtKB.::GO:0007098; P:centrosome cycle; IMP:UniProtKB.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0045132; P:meiotic chromosome segregation; IMP:WormBase.::GO:0007067; P:mitosis; IMP:WormBase.::GO:0007077; P:mitotic nuclear envelope disassembly; IMP:UniProtKB.::GO:0007052; P:mitotic spindle organization; IMP:UniProtKB.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0048477; P:oogenesis; IMP:WormBase.::GO:0040038; P:polar body extrusion after meiotic divisions; IMP:WormBase.::GO:0051726; P:regulation of cell cycle; IMP:WormBase.
435Q6PFQ0    740   KS6A6_DANRE Ribosomal protein S6 kinase alpha...1410.007     42.7     26     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.
436O75676    772   KS6A4_HUMAN Ribosomal protein S6 kinase alpha...1490.007     42.7     29     47GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0048273; F:mitogen-activated protein kinase p38 binding; IGI:UniProtKB.::GO:0004711; F:ribosomal protein S6 kinase activity; NAS:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0043987; P:histone H3-S10 phosphorylation; IMP:UniProtKB.::GO:0043988; P:histone H3-S28 phosphorylation; IMP:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0070498; P:interleukin-1-mediated signaling pathway; IMP:BHF-UCL.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0001818; P:negative regulation of cytokine production; TAS:UniProtKB.::GO:0032793; P:positive regulation of CREB transcription factor activity; TAS:UniProtKB.::GO:0035066; P:positive regulation of histone acetylation; IMP:BHF-UCL.::GO:0033129; P:positive regulation of histone phosphorylation; IMP:BHF-UCL.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
437P46549    982   SULU_CAEEL Serine/threonine-protein kinase SU...1090.007     42.7     28     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0007631; P:feeding behavior; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0043051; P:regulation of pharyngeal pumping; IMP:WormBase.::GO:0000003; P:reproduction; IMP:WormBase.
438Q9UQ88    783   CD11A_HUMAN Cyclin-dependent kinase 11A OS=Ho...1020.007     42.4     30     51GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
GO:0006915; P:apoptotic process; NAS:UniProtKB.::GO:0007067; P:mitosis; NAS:UniProtKB.::GO:0001558; P:regulation of cell growth; IEP:UniProtKB.::GO:0050684; P:regulation of mRNA processing; IDA:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.
439Q9NYL2    800   MLTK_HUMAN Mitogen-activated protein kinase k...980.007     42.4     31     49GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0004709; F:MAP kinase kinase kinase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0007257; P:activation of JUN kinase activity; IDA:UniProtKB.::GO:0007050; P:cell cycle arrest; IMP:UniProtKB.::GO:0008219; P:cell death; NAS:UniProtKB.::GO:0030154; P:cell differentiation; NAS:UniProtKB.::GO:0008283; P:cell proliferation; NAS:UniProtKB.::GO:0000077; P:DNA damage checkpoint; IMP:UniProtKB.::GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.::GO:0009314; P:response to radiation; IDA:UniProtKB.
440P32801    640   ELM1_YEAST Serine/threonine-protein kinase EL...1950.007     42.4     27     44GO:0000142; C:cellular bud neck contractile ring; TAS:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:SGD.
GO:0007120; P:axial cellular bud site selection; TAS:SGD.::GO:0007117; P:budding cell bud growth; IMP:SGD.::GO:0000902; P:cell morphogenesis; IMP:SGD.::GO:0006006; P:glucose metabolic process; IMP:SGD.::GO:0031954; P:positive regulation of protein autophosphorylation; IDA:SGD.::GO:0046777; P:protein autophosphorylation; IDA:SGD.::GO:0007124; P:pseudohyphal growth; IMP:SGD.::GO:0042493; P:response to drug; IMP:SGD.::GO:0006970; P:response to osmotic stress; TAS:SGD.::GO:0000135; P:septin checkpoint; TAS:SGD.
441Q55DU7    1620   GDT4_DICDI Probable serine/threonine-protein ...2370.007     42.7     24     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
442Q551H4    1028   FRAY2_DICDI Serine/threonine-protein kinase f...1890.007     42.7     26     43
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
443Q9LP51    520   CIPKI_ARATH CBL-interacting serine/threonine-...1350.007     42.4     24     44
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
444O42376    363   MK12_DANRE Mitogen-activated protein kinase 1...1500.007     42     25     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
445Q9UV50    387   HOG1_DEBHA Mitogen-activated protein kinase H...1020.007     42     32     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
446O88506    553   STK39_RAT STE20/SPS1-related proline-alanine-...1160.007     42.4     26     47GO:0005737; C:cytoplasm; IDA:RGD.::GO:0005856; C:cytoskeleton; IDA:RGD.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; IPI:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IDA:RGD.
GO:0043268; P:positive regulation of potassium ion transport; IMP:RGD.
447Q55GG4    2230   Y9847_DICDI Probable serine/threonine-protein...2660.007     42.7     26     43
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
448Q8CE90    535   MP2K7_MOUSE Dual specificity mitogen-activate...1180.007     42.4     26     47GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0019903; F:protein phosphatase binding; IPI:BHF-UCL.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
449O14733    419   MP2K7_HUMAN Dual specificity mitogen-activate...1150.007     42     27     48GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0004708; F:MAP kinase kinase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0019903; F:protein phosphatase binding; ISS:BHF-UCL.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
GO:0007257; P:activation of JUN kinase activity; ISS:BHF-UCL.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
450Q498D6    800   FGFR4_RAT Fibroblast growth factor receptor 4...2790.008     42.4     23     38GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; ISS:UniProtKB.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IPI:MGI.::GO:0008201; F:heparin binding; ISS:UniProtKB.
GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0055062; P:phosphate ion homeostasis; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0048554; P:positive regulation of metalloenzyme activity; ISS:UniProtKB.::GO:0045862; P:positive regulation of proteolysis; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0070857; P:regulation of bile acid biosynthetic process; ISS:UniProtKB.::GO:2000188; P:regulation of cholesterol homeostasis; ISS:UniProtKB.::GO:0010715; P:regulation of extracellular matrix disassembly; ISS:UniProtKB.
451Q5JJY4    657   P2C04_ORYSJ Protein kinase and PP2C-like doma...1260.008     42.4     30     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
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