Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPR106W
Length:
443
Number of sequences:
5887
Description:
YPR106W ISR1 SGDID:S000006310, Chr XVI from 740061-741392, Genome Release 64-1-1, Verified ORF, "Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
391Q6K5F8    693   CDKG1_ORYSJ Cyclin-dependent kinase G-1 OS=Or...1080.004     43.1     30     53
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
392Q8S8Y9    568   WNK2_ARATH Serine/threonine-protein kinase WN...1260.004     43.1     30     44
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0048573; P:photoperiodism, flowering; IMP:TAIR.
393P16092    822   FGFR1_MOUSE Fibroblast growth factor receptor...2730.004     43.1     22     40GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; IPI:UniProtKB.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IDA:MGI.::GO:0008201; F:heparin binding; ISS:UniProtKB.
GO:0001525; P:angiogenesis; IGI:MGI.::GO:0060117; P:auditory receptor cell development; IMP:MGI.::GO:0060445; P:branching involved in salivary gland morphogenesis; IMP:MGI.::GO:0048469; P:cell maturation; IMP:MGI.::GO:0002062; P:chondrocyte differentiation; IGI:MGI.::GO:0030326; P:embryonic limb morphogenesis; IMP:MGI.::GO:0035607; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; IMP:UniProtKB.::GO:0001701; P:in utero embryonic development; IGI:MGI.::GO:0042472; P:inner ear morphogenesis; IMP:MGI.::GO:0060484; P:lung-associated mesenchyme development; IGI:MGI.::GO:0048762; P:mesenchymal cell differentiation; IGI:MGI.::GO:0030901; P:midbrain development; IMP:MGI.::GO:0042474; P:middle ear morphogenesis; IMP:MGI.::GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0001759; P:organ induction; IMP:MGI.::GO:0042473; P:outer ear morphogenesis; IMP:MGI.::GO:0048339; P:paraxial mesoderm development; IGI:MGI.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IGI:MGI.::GO:0045787; P:positive regulation of cell cycle; IMP:UniProtKB.::GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.::GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI.::GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; IGI:MGI.::GO:0010863; P:positive regulation of phospholipase C activity; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IDA:MGI.::GO:0048378; P:regulation of lateral mesodermal cell fate specification; IGI:MGI.::GO:0007605; P:sensory perception of sound; IMP:MGI.::GO:0001657; P:ureteric bud development; IGI:MGI.::GO:0060979; P:vasculogenesis involved in coronary vascular morphogenesis; TAS:DFLAT.::GO:0021847; P:ventricular zone neuroblast division; IMP:UniProtKB.
394O22834    664   LRK53_ARATH Probable L-type lectin-domain con...1300.004     43.1     32     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
395Q9FG33    652   LRKS5_ARATH Probable L-type lectin-domain con...2400.004     43.1     24     38GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
396Q55CA6    635   Y0146_DICDI Probable serine/threonine-protein...1140.004     43.1     30     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
397Q58D94    420   MKNK1_BOVIN MAP kinase-interacting serine/thr...1170.004     42.7     26     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
398P54737    380   PKN5_MYXXA Serine/threonine-protein kinase pk...1060.004     42.7     27     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
399Q5BBL3    848   STE20_EMENI Serine/threonine-protein kinase s...1090.005     43.1     27     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
400Q68UT7    714   HUNK_PANTR Hormonally up-regulated neu tumor-...1660.005     43.1     23     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
401P11362    822   FGFR1_HUMAN Fibroblast growth factor receptor...2730.005     43.1     22     40GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; NAS:UniProtKB.::GO:0005887; C:integral to plasma membrane; TAS:ProtInc.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; IDA:UniProtKB.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IDA:UniProtKB.::GO:0008201; F:heparin binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0000165; P:MAPK cascade; TAS:ProtInc.::GO:0001764; P:neuron migration; TAS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:UniProtKB.::GO:0043406; P:positive regulation of MAP kinase activity; IDA:UniProtKB.::GO:0043410; P:positive regulation of MAPK cascade; IMP:UniProtKB.::GO:0045666; P:positive regulation of neuron differentiation; IMP:UniProtKB.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; TAS:UniProtKB.::GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0048705; P:skeletal system morphogenesis; TAS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
402P57058    714   HUNK_HUMAN Hormonally up-regulated neu tumor-...1660.005     43.1     23     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0007275; P:multicellular organismal development; TAS:ProtInc.::GO:0007165; P:signal transduction; TAS:ProtInc.
403P33981    857   TTK_HUMAN Dual specificity protein kinase TTK...2350.005     43.1     26     45GO:0005819; C:spindle; TAS:ProtInc.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; TAS:ProtInc.
GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; TAS:ProtInc.::GO:0007052; P:mitotic spindle organization; TAS:ProtInc.::GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc.::GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; TAS:BHF-UCL.
404O61122    478   SVKA_DICDI Serine/threonine-protein kinase sv...1150.005     42.7     25     47GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005813; C:centrosome; IDA:dictyBase.::GO:0032154; C:cleavage furrow; IDA:dictyBase.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IMP:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006972; P:hyperosmotic response; IEP:dictyBase.::GO:0051781; P:positive regulation of cell division; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:dictyBase.::GO:0032956; P:regulation of actin cytoskeleton organization; IMP:UniProtKB.::GO:0010590; P:regulation of cytokinetic cell separation; IMP:dictyBase.::GO:0031156; P:regulation of sorocarp development; IMP:dictyBase.::GO:0007165; P:signal transduction; ISS:dictyBase.
405P70032    598   PLK1_XENLA Serine/threonine-protein kinase PL...1070.005     43.1     28     47GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0000776; C:kinetochore; ISS:UniProtKB.::GO:0030496; C:midbody; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0051233; C:spindle midzone; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0007092; P:activation of mitotic anaphase-promoting complex activity; ISS:UniProtKB.::GO:0051297; P:centrosome organization; ISS:UniProtKB.::GO:0000910; P:cytokinesis; ISS:UniProtKB.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.::GO:0001578; P:microtubule bundle formation; ISS:UniProtKB.::GO:0007067; P:mitosis; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0001556; P:oocyte maturation; IDA:UniProtKB.::GO:0071168; P:protein localization to chromatin; ISS:UniProtKB.
406Q9WTR2    1291   M3K6_MOUSE Mitogen-activated protein kinase k...1100.005     43.1     28     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.
407Q54Y06    636   Y8487_DICDI Probable cyclin-dependent serine/...1180.005     43.1     26     51
GO:0005524; F:ATP binding; ISS:dictyBase.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
408Q8AYC9    476   CHK1_CHICK Serine/threonine-protein kinase Ch...1150.005     42.7     30     48GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0000785; C:chromatin; ISS:UniProtKB.::GO:0000794; C:condensed nuclear chromosome; ISS:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0035402; F:histone kinase activity (H3-T11 specific); ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0048096; P:chromatin-mediated maintenance of transcription; ISS:UniProtKB.::GO:0006975; P:DNA damage induced protein phosphorylation; ISS:UniProtKB.::GO:0000724; P:double-strand break repair via homologous recombination; TAS:Reactome.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0045839; P:negative regulation of mitosis; ISS:UniProtKB.::GO:0010569; P:regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.::GO:2000615; P:regulation of histone H3-K9 acetylation; ISS:UniProtKB.::GO:0046602; P:regulation of mitotic centrosome separation; ISS:UniProtKB.::GO:0010767; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; ISS:UniProtKB.
409O80397    366   M2K4_ARATH Mitogen-activated protein kinase k...1540.005     42.7     22     45GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009814; P:defense response, incompatible interaction; IMP:TAIR.::GO:0010227; P:floral organ abscission; IMP:TAIR.::GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.::GO:2000038; P:regulation of stomatal complex development; IGI:TAIR.::GO:2000037; P:regulation of stomatal complex patterning; IGI:TAIR.
410Q8GVC7    399   PKZ1_PHYIN Serine/threonine-protein kinase PK...1210.005     42.7     29     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
411O94768    372   ST17B_HUMAN Serine/threonine-protein kinase 1...1090.005     42.7     27     51GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; IMP:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.
412Q9SYM9    355   Y1853_ARATH Receptor-like serine/threonine-pr...1450.005     42.4     26     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
413P18652    752   KS6AA_CHICK Ribosomal protein S6 kinase 2 alp...1410.005     42.7     27     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.
414Q9VKN7    329   AURKB_DROME Aurora kinase B OS=Drosophila mel...1060.005     42.4     30     45GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0000776; C:kinetochore; TAS:FlyBase.::GO:0030496; C:midbody; IDA:FlyBase.::GO:0051233; C:spindle midzone; IDA:FlyBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0008608; P:attachment of spindle microtubules to kinetochore; TAS:FlyBase.::GO:0000910; P:cytokinesis; IMP:FlyBase.::GO:0016572; P:histone phosphorylation; IMP:FlyBase.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0007076; P:mitotic chromosome condensation; IMP:FlyBase.::GO:0007052; P:mitotic spindle organization; IMP:FlyBase.
415Q9VP22    1157   CDK12_DROME Cyclin-dependent kinase 12 OS=Dro...1000.005     43.1     31     49GO:0000228; C:nuclear chromosome; IDA:UniProtKB.::GO:0019908; C:nuclear cyclin-dependent protein kinase holoenzyme complex; IDA:UniProtKB.::GO:0005703; C:polytene chromosome puff; IDA:FlyBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0030332; F:cyclin binding; IPI:UniProtKB.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IDA:UniProtKB.
GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.::GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IDA:UniProtKB.
416P35761    856   TTK_MOUSE Dual specificity protein kinase TTK...2170.005     42.7     27     44
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
417A7SNN5    978   PLK4_NEMVE Serine/threonine-protein kinase PL...1500.006     42.7     27     49GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
418O95382    1288   M3K6_HUMAN Mitogen-activated protein kinase k...1100.006     43.1     28     46
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0004709; F:MAP kinase kinase kinase activity; IDA:UniProtKB.
GO:0007257; P:activation of JUN kinase activity; TAS:ProtInc.
419O96017    543   CHK2_HUMAN Serine/threonine-protein kinase Ch...1910.006     42.7     26     40GO:0016605; C:PML body; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0044257; P:cellular protein catabolic process; IMP:UniProtKB.::GO:0006975; P:DNA damage induced protein phosphorylation; IMP:UniProtKB.::GO:0008630; P:DNA damage response, signal transduction resulting in induction of apoptosis; IDA:UniProtKB.::GO:0006302; P:double-strand break repair; IMP:UniProtKB.::GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0042176; P:regulation of protein catabolic process; IMP:UniProtKB.::GO:0090399; P:replicative senescence; NAS:BHF-UCL.::GO:0072428; P:signal transduction involved in intra-S DNA damage checkpoint; IMP:UniProtKB.::GO:0090307; P:spindle assembly involved in mitosis; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
420Q54JQ1    891   MKCC_DICDI Probable serine/threonine-protein ...1090.006     42.7     27     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
421Q9M3D7    667   LRK14_ARATH Putative L-type lectin-domain con...1090.006     42.7     29     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005739; C:mitochondrion; IDA:TAIR.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
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