Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPR106W
Length:
443
Number of sequences:
5887
Description:
YPR106W ISR1 SGDID:S000006310, Chr XVI from 740061-741392, Genome Release 64-1-1, Verified ORF, "Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
271O88866    714   HUNK_MOUSE Hormonally up-regulated neu tumor-...1660.001     45.1     23     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
272Q8RX66    568   NEK3_ARATH Serine/threonine-protein kinase Ne...1850.001     45.1     27     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
273O59790    355   ARK1_SCHPO Serine/threonine-protein kinase ar...1090.001     44.7     28     47GO:0032133; C:chromosome passenger complex; NAS:PomBase.::GO:0000778; C:condensed nuclear chromosome kinetochore; IDA:PomBase.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0051233; C:spindle midzone; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0004674; F:protein serine/threonine kinase activity; IDA:PomBase.
GO:0051315; P:attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation; TAS:PomBase.::GO:0033205; P:cell cycle cytokinesis; IMP:PomBase.::GO:2000775; P:histone H3-S10 phosphorylation involved in chromosome condensation; IDA:PomBase.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; IMP:PomBase.::GO:0034501; P:protein localization to kinetochore; IGI:PomBase.::GO:0034503; P:protein localization to nucleolar rDNA repeats; IGI:PomBase.::GO:0031134; P:sister chromatid biorientation; TAS:PomBase.
274Q03407    766   PKH1_YEAST Serine/threonine-protein kinase PK...1190.001     45.1     29     44GO:0005829; C:cytosol; IDA:SGD.::GO:0032126; C:eisosome; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0033962; P:cytoplasmic mRNA processing body assembly; IGI:SGD.::GO:0006897; P:endocytosis; IMP:SGD.::GO:0000196; P:MAPK cascade involved in cell wall biogenesis; IGI:SGD.::GO:0060211; P:regulation of nuclear-transcribed mRNA poly(A) tail shortening; IGI:SGD.
275Q751F5    581   SSN3_ASHGO Serine/threonine-protein kinase SS...1240.001     45.1     31     48GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
276Q9XBQ0    547   PKN3_MYXXA Serine/threonine-protein kinase pk...1120.001     45.1     31     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
277Q9BYP7    1800   WNK3_HUMAN Serine/threonine-protein kinase WN...1240.001     45.4     31     44GO:0005912; C:adherens junction; ISS:BHF-UCL.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005923; C:tight junction; ISS:BHF-UCL.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0035827; F:rubidium ion transmembrane transporter activity; IDA:UniProtKB.::GO:0015081; F:sodium ion transmembrane transporter activity; IDA:UniProtKB.
GO:0006916; P:anti-apoptosis; IMP:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; ISS:UniProtKB.::GO:0051928; P:positive regulation of calcium ion transport; IMP:UniProtKB.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IDA:BHF-UCL.::GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IDA:UniProtKB.::GO:2000688; P:positive regulation of rubidium ion transmembrane transporter activity; IDA:UniProtKB.::GO:2000682; P:positive regulation of rubidium ion transport; IDA:UniProtKB.::GO:2000651; P:positive regulation of sodium ion transmembrane transporter activity; IDA:UniProtKB.::GO:0010765; P:positive regulation of sodium ion transport; IDA:BHF-UCL.::GO:0046777; P:protein autophosphorylation; IDA:BHF-UCL.::GO:2000021; P:regulation of ion homeostasis; IMP:UniProtKB.
278Q6I5Y0    519   CDKC1_ORYSJ Cyclin-dependent kinase C-1 OS=Or...1040.001     44.7     34     52
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
279O97143    769   PLK4_DROME Serine/threonine-protein kinase PL...1480.001     45.1     30     51GO:0005814; C:centriole; IDA:FlyBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
GO:0007099; P:centriole replication; IMP:FlyBase.::GO:0007052; P:mitotic spindle organization; IMP:FlyBase.::GO:0046599; P:regulation of centriole replication; IDA:FlyBase.::GO:0007288; P:sperm axoneme assembly; IMP:FlyBase.
280Q4P5N0    746   STE20_USTMA Serine/threonine-protein kinase S...1180.001     45.1     26     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
281Q0WPH8    956   NEK5_ARATH Serine/threonine-protein kinase Ne...1500.001     45.1     27     49GO:0055028; C:cortical microtubule; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009913; P:epidermal cell differentiation; IMP:TAIR.::GO:0007017; P:microtubule-based process; IMP:TAIR.
282Q63531    735   KS6A1_RAT Ribosomal protein S6 kinase alpha-1...1410.001     45.1     28     45GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004711; F:ribosomal protein S6 kinase activity; TAS:RGD.::GO:0008134; F:transcription factor binding; IDA:RGD.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:2000491; P:positive regulation of hepatic stellate cell activation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:RGD.
283F1SPM8    968   AAK1_PIG AP2-associated protein kinase 1 OS=S...1490.001     45.1     29     44GO:0031252; C:cell leading edge; ISS:UniProtKB.::GO:0030136; C:clathrin-coated vesicle; IDA:UniProtKB.::GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.::GO:0019897; C:extrinsic to plasma membrane; ISS:UniProtKB.::GO:0043195; C:terminal button; ISS:UniProtKB.
GO:0035612; F:AP-2 adaptor complex binding; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005112; F:Notch binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0045747; P:positive regulation of Notch signaling pathway; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0050821; P:protein stabilization; ISS:UniProtKB.::GO:2000369; P:regulation of clathrin-mediated endocytosis; IDA:UniProtKB.::GO:0032880; P:regulation of protein localization; ISS:UniProtKB.
284A1CL96    426   SSN3_ASPCL Serine/threonine-protein kinase ss...1020.001     44.7     31     50GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
285Q9HFF4    1023   PPK1_SCHPO Serine/threonine-protein kinase pp...2530.001     45.1     21     43
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:PomBase.
GO:0007165; P:signal transduction; NAS:PomBase.
286A1D624    426   SSN3_NEOFI Serine/threonine-protein kinase ss...1020.001     44.7     31     50GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
287Q4WYR6    426   SSN3_ASPFU Serine/threonine-protein kinase ss...1020.001     44.3     31     50GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
288P11346    782   KRAF1_DROME Raf homolog serine/threonine-prot...1070.001     44.7     25     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:FlyBase.::GO:0004674; F:protein serine/threonine kinase activity; IDA:FlyBase.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro.
GO:0007298; P:border follicle cell migration; IGI:FlyBase.::GO:0008069; P:dorsal/ventral axis specification, ovarian follicular epithelium; IMP:FlyBase.::GO:0007173; P:epidermal growth factor receptor signaling pathway; IGI:FlyBase.::GO:0007369; P:gastrulation; IMP:FlyBase.::GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.::GO:0002168; P:instar larval development; IMP:FlyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035171; P:lamellocyte differentiation; IMP:FlyBase.::GO:0008284; P:positive regulation of cell proliferation; IMP:FlyBase.::GO:0046534; P:positive regulation of photoreceptor cell differentiation; IMP:FlyBase.::GO:0007428; P:primary branching, open tracheal system; TAS:FlyBase.::GO:0046777; P:protein autophosphorylation; IDA:FlyBase.::GO:0040014; P:regulation of multicellular organism growth; IMP:FlyBase.::GO:0007283; P:spermatogenesis; IMP:FlyBase.::GO:0007362; P:terminal region determination; IMP:FlyBase.::GO:0008293; P:torso signaling pathway; IMP:FlyBase.::GO:0035309; P:wing and notum subfield formation; IGI:FlyBase.
289Q7ZX42    376   CDK9B_XENLA Cyclin-dependent kinase 9-B OS=Xe...1440.001     44.3     28     45GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
290Q2QMI0    454   CIPK4_ORYSJ CBL-interacting protein kinase 4 ...1250.001     44.3     23     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
291Q9LFT8    505   CDKC1_ARATH Cyclin-dependent kinase C-1 OS=Ar...1040.002     44.3     32     51GO:0005829; C:cytosol; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
GO:0048366; P:leaf development; IGI:TAIR.::GO:0009615; P:response to virus; IEP:TAIR.
292Q2M2I8    961   AAK1_HUMAN AP2-associated protein kinase 1 OS...1490.002     44.7     29     44GO:0031252; C:cell leading edge; ISS:UniProtKB.::GO:0030136; C:clathrin-coated vesicle; ISS:UniProtKB.::GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.::GO:0019897; C:extrinsic to plasma membrane; ISS:UniProtKB.::GO:0043195; C:terminal button; ISS:UniProtKB.
GO:0035612; F:AP-2 adaptor complex binding; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005112; F:Notch binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0045747; P:positive regulation of Notch signaling pathway; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0050821; P:protein stabilization; IDA:UniProtKB.::GO:2000369; P:regulation of clathrin-mediated endocytosis; IDA:UniProtKB.::GO:0032880; P:regulation of protein localization; IDA:UniProtKB.
293Q75DK7    971   STE20_ASHGO Serine/threonine-protein kinase S...1160.002     44.7     30     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
294Q8G6P9    690   PKNB_BIFLO Probable serine/threonine-protein ...1070.002     44.7     30     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008658; F:penicillin binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
295Q9ZUE0    720   PEK12_ARATH Proline-rich receptor-like protei...1210.002     44.7     28     46GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0032502; P:developmental process; IMP:TAIR.
296Q9Z265    546   CHK2_MOUSE Serine/threonine-protein kinase Ch...1130.002     44.3     28     50GO:0016605; C:PML body; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IMP:MGI.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006975; P:DNA damage induced protein phosphorylation; ISS:UniProtKB.::GO:0008630; P:DNA damage response, signal transduction resulting in induction of apoptosis; ISS:UniProtKB.::GO:0006302; P:double-strand break repair; ISS:UniProtKB.::GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0042176; P:regulation of protein catabolic process; ISS:UniProtKB.::GO:0010332; P:response to gamma radiation; IDA:MGI.::GO:0072428; P:signal transduction involved in intra-S DNA damage checkpoint; ISS:UniProtKB.::GO:0090307; P:spindle assembly involved in mitosis; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
297Q9WTY9    366   MK13_RAT Mitogen-activated protein kinase 13 ...980.002     44.3     31     50GO:0005625; C:soluble fraction; IDA:RGD.
GO:0005524; F:ATP binding; IDA:RGD.::GO:0004707; F:MAP kinase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
298Q7XUF4    710   CDKG2_ORYSJ Cyclin-dependent kinase G-2 OS=Or...1060.002     44.7     31     55
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
299A2XUW1    710   CDKG2_ORYSI Cyclin-dependent kinase G-2 OS=Or...1060.002     44.7     31     55
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
300Q54WX4    384   AURK_DICDI Aurora kinase OS=Dictyostelium dis...1050.002     44.3     30     49GO:0005813; C:centrosome; IDA:dictyBase.::GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0032154; C:cleavage furrow; IDA:dictyBase.::GO:0051233; C:spindle midzone; IDA:dictyBase.::GO:0000922; C:spindle pole; IDA:dictyBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0000278; P:mitotic cell cycle; ISS:dictyBase.
301Q8BG48    372   ST17B_MOUSE Serine/threonine-protein kinase 1...1280.002     43.9     24     50GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; ISS:UniProtKB.
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