Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPR068C
Length:
470
Number of sequences:
5887
Description:
YPR068C HOS1 SGDID:S000006272, Chr XVI from 684353-682941, Genome Release 64-1-1, reverse complement, Verified ORF, "Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q12214    470   HOS1_YEAST Histone deacetylase HOS1 OS=Saccha...4700     980     100     100GO:0000118; C:histone deacetylase complex; TAS:SGD.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0034983; P:peptidyl-lysine deacetylation; IMP:SGD.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
2B1H369    369   HDAC8_XENTR Histone deacetylase 8 OS=Xenopus ...2661e-50     182     38     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
3Q6GPA7    325   HDAC8_XENLA Histone deacetylase 8 OS=Xenopus ...2662e-50     179     37     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
4Q94517    521   HDAC1_DROME Histone deacetylase Rpd3 OS=Droso...2418e-49     180     39     59GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0035098; C:ESC/E(Z) complex; IDA:FlyBase.::GO:0031523; C:Myb complex; IDA:FlyBase.::GO:0016581; C:NuRD complex; IPI:FlyBase.::GO:0005705; C:polytene chromosome interband; IDA:FlyBase.::GO:0016580; C:Sin3 complex; NAS:FlyBase.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0003714; F:transcription corepressor activity; IPI:FlyBase.::GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO:0007350; P:blastoderm segmentation; IMP:FlyBase.::GO:0006342; P:chromatin silencing; IMP:FlyBase.::GO:0070983; P:dendrite guidance; IMP:FlyBase.::GO:0008340; P:determination of adult lifespan; IMP:FlyBase.::GO:0007517; P:muscle organ development; IMP:FlyBase.::GO:0050771; P:negative regulation of axonogenesis; IMP:FlyBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:FlyBase.::GO:0048477; P:oogenesis; TAS:FlyBase.::GO:0022904; P:respiratory electron transport chain; IDA:FlyBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IDA:FlyBase.
5O09106    482   HDAC1_MOUSE Histone deacetylase 1 OS=Mus musc...2411e-48     179     39     60GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0000792; C:heterochromatin; IDA:MGI.::GO:0043025; C:neuronal cell body; IDA:MGI.::GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.::GO:0016581; C:NuRD complex; IDA:MGI.::GO:0005667; C:transcription factor complex; IDA:UniProtKB.
GO:0003682; F:chromatin binding; IDA:MGI.::GO:0003677; F:DNA binding; IDA:MGI.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0001103; F:RNA polymerase II repressing transcription factor binding; IPI:MGI.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.::GO:0003714; F:transcription corepressor activity; IDA:MGI.
GO:0042733; P:embryonic digit morphogenesis; IGI:BHF-UCL.::GO:0007492; P:endoderm development; IDA:MGI.::GO:0009913; P:epidermal cell differentiation; IGI:BHF-UCL.::GO:0061029; P:eyelid development in camera-type eye; IGI:BHF-UCL.::GO:0061198; P:fungiform papilla formation; IGI:BHF-UCL.::GO:0060789; P:hair follicle placode formation; IGI:BHF-UCL.::GO:0021766; P:hippocampus development; IGI:MGI.::GO:0043066; P:negative regulation of apoptotic process; IGI:BHF-UCL.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IGI:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:BHF-UCL.::GO:0030182; P:neuron differentiation; IGI:MGI.::GO:0042475; P:odontogenesis of dentin-containing tooth; IGI:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; IGI:BHF-UCL.::GO:0048714; P:positive regulation of oligodendrocyte differentiation; IGI:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
6Q5RAG0    482   HDAC1_PONAB Histone deacetylase 1 OS=Pongo ab...2412e-48     179     39     60GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
7Q13547    482   HDAC1_HUMAN Histone deacetylase 1 OS=Homo sap...2412e-48     179     39     60GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0016581; C:NuRD complex; IDA:UniProtKB.::GO:0016580; C:Sin3 complex; IDA:BHF-UCL.
GO:0033613; F:activating transcription factor binding; IPI:UniProtKB.::GO:0001047; F:core promoter binding; IDA:UniProtKB.::GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0001106; F:RNA polymerase II transcription corepressor activity; IDA:BHF-UCL.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
GO:0006916; P:anti-apoptosis; TAS:ProtInc.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006338; P:chromatin remodeling; IC:BHF-UCL.::GO:0042733; P:embryonic digit morphogenesis; ISS:BHF-UCL.::GO:0009913; P:epidermal cell differentiation; ISS:BHF-UCL.::GO:0061029; P:eyelid development in camera-type eye; ISS:BHF-UCL.::GO:0061198; P:fungiform papilla formation; ISS:BHF-UCL.::GO:0060789; P:hair follicle placode formation; ISS:BHF-UCL.::GO:0070932; P:histone H3 deacetylation; IDA:BHF-UCL.::GO:0070933; P:histone H4 deacetylation; IDA:BHF-UCL.::GO:0000278; P:mitotic cell cycle; TAS:Reactome.::GO:0043922; P:negative regulation by host of viral transcription; IMP:UniProtKB.::GO:0060766; P:negative regulation of androgen receptor signaling pathway; IDA:BHF-UCL.::GO:0045786; P:negative regulation of cell cycle; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0042475; P:odontogenesis of dentin-containing tooth; ISS:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.::GO:0010870; P:positive regulation of receptor biosynthetic process; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
8Q4QQW4    482   HDAC1_RAT Histone deacetylase 1 OS=Rattus nor...2412e-48     178     39     60GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
9Q32PJ8    482   HDAC1_BOVIN Histone deacetylase 1 OS=Bos taur...2412e-48     178     39     60
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
10P56517    480   HDAC1_CHICK Histone deacetylase 1 OS=Gallus g...2413e-48     178     38     59
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
11O42227    480   HDA1B_XENLA Probable histone deacetylase 1-B ...2413e-48     177     38     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
12Q55FN5    495   HDA11_DICDI Type-1 histone deacetylase 1 OS=D...2405e-48     177     38     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
13Q9BY41    377   HDAC8_HUMAN Histone deacetylase 8 OS=Homo sap...2362e-47     173     39     57GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.::GO:0000228; C:nuclear chromosome; TAS:ProtInc.
GO:0004407; F:histone deacetylase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO:0006333; P:chromatin assembly or disassembly; TAS:ProtInc.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
14Q8VH37    377   HDAC8_MOUSE Histone deacetylase 8 OS=Mus musc...2363e-47     172     38     57GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
15B1WC68    377   HDAC8_RAT Histone deacetylase 8 OS=Rattus nor...2513e-47     172     36     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
16O17695    461   HDA1_CAEEL Histone deacetylase 1 OS=Caenorhab...2507e-47     174     39     56GO:0005737; C:cytoplasm; IDA:WormBase.::GO:0043073; C:germ cell nucleus; IDA:WormBase.::GO:0000118; C:histone deacetylase complex; IPI:WormBase.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0048557; P:embryonic digestive tract morphogenesis; IGI:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0045746; P:negative regulation of Notch signaling pathway; IMP:WormBase.::GO:0046580; P:negative regulation of Ras protein signal transduction; IGI:WormBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:WormBase.::GO:0040027; P:negative regulation of vulval development; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.::GO:0045595; P:regulation of cell differentiation; IGI:WormBase.::GO:0006974; P:response to DNA damage stimulus; IMP:WormBase.::GO:0045138; P:tail tip morphogenesis; IMP:WormBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
17Q8H0W2    426   HDA9_ARATH Histone deacetylase 9 OS=Arabidops...2401e-45     169     38     58GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
18Q0VCB2    377   HDAC8_BOVIN Histone deacetylase 8 OS=Bos taur...2363e-45     167     38     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
19Q9FML2    471   HDA6_ARATH Histone deacetylase 6 OS=Arabidops...2298e-45     168     37     59GO:0009941; C:chloroplast envelope; IDA:TAIR.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.::GO:0016441; P:posttranscriptional gene silencing; IMP:TAIR.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0009737; P:response to abscisic acid stimulus; IMP:TAIR.::GO:0009651; P:response to salt stress; IMP:TAIR.::GO:0010431; P:seed maturation; IMP:TAIR.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
20P53096    452   HOS2_YEAST Probable histone deacetylase HOS2 ...2303e-44     166     41     59GO:0070210; C:Rpd3L-Expanded complex; IDA:SGD.::GO:0034967; C:Set3 complex; IDA:SGD.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0045129; F:NAD-independent histone deacetylase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0045835; P:negative regulation of meiosis; IMP:SGD.::GO:0032874; P:positive regulation of stress-activated MAPK cascade; IMP:SGD.::GO:0006355; P:regulation of transcription, DNA-dependent; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
21P32561    433   RPD3_YEAST Histone deacetylase RPD3 OS=Saccha...2435e-44     165     37     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0033698; C:Rpd3L complex; IDA:SGD.::GO:0070210; C:Rpd3L-Expanded complex; IDA:SGD.::GO:0032221; C:Rpd3S complex; IDA:SGD.::GO:0070211; C:Snt2C complex; IDA:SGD.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003713; F:transcription coactivator activity; IMP:SGD.::GO:0003714; F:transcription corepressor activity; IMP:SGD.
GO:0070932; P:histone H3 deacetylation; IMP:SGD.::GO:0070933; P:histone H4 deacetylation; IMP:SGD.::GO:0061188; P:negative regulation of chromatin silencing at rDNA; IMP:SGD.::GO:0061186; P:negative regulation of chromatin silencing at silent mating-type cassette; IMP:SGD.::GO:0031939; P:negative regulation of chromatin silencing at telomere; IDA:SGD.::GO:0045128; P:negative regulation of reciprocal meiotic recombination; IMP:SGD.::GO:0051038; P:negative regulation of transcription during meiosis; IMP:SGD.::GO:0016479; P:negative regulation of transcription from RNA polymerase I promoter; IMP:SGD.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:SGD.::GO:0061408; P:positive regulation of transcription from RNA polymerase II promoter in response to heat stress; IMP:SGD.::GO:0034503; P:protein localization to nucleolar rDNA repeats; IMP:SGD.::GO:0030174; P:regulation of DNA-dependent DNA replication initiation; IMP:SGD.::GO:0034401; P:regulation of transcription by chromatin organization; IMP:SGD.::GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; IPI:SGD.::GO:0000117; P:regulation of transcription involved in G2/M-phase of mitotic cell cycle; IGI:SGD.::GO:0000115; P:regulation of transcription involved in S phase of mitotic cell cycle; IMP:SGD.::GO:0001302; P:replicative cell aging; IMP:SGD.::GO:0006368; P:transcription elongation from RNA polymerase II promoter; IGI:SGD.
22O59702    405   CLR6_SCHPO Histone deacetylase clr6 OS=Schizo...2286e-44     164     38     59GO:0005829; C:cytosol; IDA:PomBase.::GO:0033698; C:Rpd3L complex; IDA:PomBase.::GO:0070210; C:Rpd3L-Expanded complex; IDA:PomBase.::GO:0032221; C:Rpd3S complex; IDA:PomBase.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006338; P:chromatin remodeling; NAS:PomBase.::GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0030466; P:chromatin silencing at silent mating-type cassette; IGI:PomBase.::GO:0030261; P:chromosome condensation; IMP:PomBase.::GO:0000070; P:mitotic sister chromatid segregation; TAS:PomBase.::GO:0051570; P:regulation of histone H3-K9 methylation; NAS:PomBase.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEP:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
23O15379    428   HDAC3_HUMAN Histone deacetylase 3 OS=Homo sap...2478e-44     164     35     56GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.::GO:0005876; C:spindle microtubule; IDA:UniProtKB.::GO:0017053; C:transcriptional repressor complex; IDA:UniProtKB.
GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0003714; F:transcription corepressor activity; IMP:UniProtKB.::GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO:0006916; P:anti-apoptosis; TAS:ProtInc.::GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0045786; P:negative regulation of cell cycle; TAS:Reactome.::GO:0046329; P:negative regulation of JNK cascade; IMP:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0051225; P:spindle assembly; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
24Q5RB76    428   HDAC3_PONAB Histone deacetylase 3 OS=Pongo ab...2479e-44     164     35     56GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
25O88895    424   HDAC3_MOUSE Histone deacetylase 3 OS=Mus musc...2473e-43     162     35     56GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
26Q55BW2    422   HDA12_DICDI Histone deacetylase B OS=Dictyost...2423e-43     162     37     57GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:dictyBase.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
27Q6P6W3    428   HDAC3_RAT Histone deacetylase 3 OS=Rattus nor...2473e-43     162     35     56GO:0000785; C:chromatin; IDA:RGD.::GO:0005737; C:cytoplasm; IDA:RGD.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0070932; P:histone H3 deacetylation; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
28P56520    428   HDAC3_CHICK Histone deacetylase 3 OS=Gallus g...2413e-43     162     36     56GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
29Q803C3    428   HDAC3_DANRE Histone deacetylase 3 OS=Danio re...2464e-43     162     34     56GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0001525; P:angiogenesis; IMP:ZFIN.::GO:0001889; P:liver development; IMP:ZFIN.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
30Q92769    488   HDAC2_HUMAN Histone deacetylase 2 OS=Homo sap...2156e-43     163     37     60GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0035098; C:ESC/E(Z) complex; IDA:UniProtKB.::GO:0016581; C:NuRD complex; IDA:UniProtKB.::GO:0016580; C:Sin3 complex; IDA:UniProtKB.
GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IDA:BHF-UCL.::GO:0008134; F:transcription factor binding; IPI:BHF-UCL.
GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006338; P:chromatin remodeling; IC:BHF-UCL.::GO:0016358; P:dendrite development; ISS:UniProtKB.::GO:0042733; P:embryonic digit morphogenesis; ISS:BHF-UCL.::GO:0009913; P:epidermal cell differentiation; ISS:BHF-UCL.::GO:0061029; P:eyelid development in camera-type eye; ISS:BHF-UCL.::GO:0061198; P:fungiform papilla formation; ISS:BHF-UCL.::GO:0060789; P:hair follicle placode formation; ISS:BHF-UCL.::GO:0006344; P:maintenance of chromatin silencing; IMP:BHF-UCL.::GO:0043066; P:negative regulation of apoptotic process; ISS:BHF-UCL.::GO:0045786; P:negative regulation of cell cycle; TAS:Reactome.::GO:0045347; P:negative regulation of MHC class II biosynthetic process; IC:BHF-UCL.::GO:0010977; P:negative regulation of neuron projection development; ISS:BHF-UCL.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0042475; P:odontogenesis of dentin-containing tooth; ISS:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.::GO:0032967; P:positive regulation of collagen biosynthetic process; IC:BHF-UCL.::GO:0045862; P:positive regulation of proteolysis; IMP:BHF-UCL.::GO:0010870; P:positive regulation of receptor biosynthetic process; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
31Q91695    480   HDA1A_XENLA Probable histone deacetylase 1-A ...2089e-43     162     38     59GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
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