rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | P53973 | 706 | HDA1_YEAST Histone deacetylase HDA1 OS=Saccha... | 183 | 0.0000000000005 | 75.1 | 27 | 50 | GO:0070823; C:HDA1 complex; IDA:SGD. | | | | | | | | | | GO:0003682; F:chromatin binding; IDA:SGD.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0031047; P:gene silencing by RNA; IMP:SGD.::GO:0010978; P:gene silencing involved in chronological cell aging; IMP:SGD.::GO:0001308; P:negative regulation of chromatin silencing involved in replicative cell aging; IMP:SGD.::GO:0010621; P:negative regulation of transcription by transcription factor localization; IGI:SGD.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:SGD.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.::GO:0031938; P:regulation of chromatin silencing at telomere; IMP:SGD.::GO:0034401; P:regulation of transcription by chromatin organization; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 62 | Q91WA3 | 347 | HDA11_MOUSE Histone deacetylase 11 OS=Mus mus... | 208 | 0.000000000003 | 71.2 | 29 | 47 | GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008134; F:transcription factor binding; TAS:UniProtKB. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 63 | Q96DB2 | 347 | HDA11_HUMAN Histone deacetylase 11 OS=Homo sa... | 205 | 0.000000000003 | 71.2 | 29 | 47 | GO:0000118; C:histone deacetylase complex; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:LIFEdb. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008134; F:transcription factor binding; TAS:UniProtKB. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 64 | O27262 | 331 | Y1194_METTH Uncharacterized protein MTH_1194 ... | 128 | 0.000000000005 | 70.5 | 28 | 50 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 65 | Q9Z2V6 | 1113 | HDAC5_MOUSE Histone deacetylase 5 OS=Mus musc... | 175 | 0.000000000006 | 71.6 | 29 | 47 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB. | | | | | | | | | | GO:0001046; F:core promoter sequence-specific DNA binding; IDA:UniProtKB.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IMP:UniProtKB.::GO:0001085; F:RNA polymerase II transcription factor binding; IPI:BHF-UCL. | | | | | | | | | | GO:0030183; P:B cell differentiation; TAS:UniProtKB.::GO:0071498; P:cellular response to fluid shear stress; IDA:UniProtKB.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0045843; P:negative regulation of striated muscle tissue development; TAS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; TAS:UniProtKB.::GO:0007399; P:nervous system development; TAS:UniProtKB.::GO:2000179; P:positive regulation of neural precursor cell proliferation; IMP:BHF-UCL.::GO:2000648; P:positive regulation of stem cell proliferation; IMP:BHF-UCL.::GO:0010830; P:regulation of myotube differentiation; IDA:UniProtKB.::GO:0061333; P:renal tubule morphogenesis; IMP:UniProtKB. | 66 | Q20296 | 955 | HDA6_CAEEL Histone deacetylase 6 OS=Caenorhab... | 174 | 0.000000000007 | 71.6 | 25 | 48 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 67 | Q80ZH1 | 1111 | HDAC5_CRIGR Histone deacetylase 5 OS=Cricetul... | 175 | 0.00000000001 | 70.9 | 28 | 47 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0000118; C:histone deacetylase complex; IEA:InterPro. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0010830; P:regulation of myotube differentiation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 68 | Q8LRK8 | 682 | HDA18_ARATH Histone deacetylase 18 OS=Arabido... | 177 | 0.00000000001 | 70.5 | 28 | 47 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0045604; P:regulation of epidermal cell differentiation; IMP:TAIR.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 69 | Q57955 | 343 | Y535_METJA Uncharacterized protein MJ0535 OS=... | 148 | 0.00000000001 | 69.3 | 28 | 47 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 70 | Q9UQL6 | 1122 | HDAC5_HUMAN Histone deacetylase 5 OS=Homo sap... | 175 | 0.00000000002 | 70.1 | 29 | 47 | GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0005080; F:protein kinase C binding; IPI:UniProtKB.::GO:0070491; F:repressing transcription factor binding; IPI:BHF-UCL. | | | | | | | | | | GO:0030183; P:B cell differentiation; TAS:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; NAS:BHF-UCL.::GO:0006338; P:chromatin remodeling; TAS:ProtInc.::GO:0006342; P:chromatin silencing; TAS:ProtInc.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.::GO:0010832; P:negative regulation of myotube differentiation; IMP:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0043393; P:regulation of protein binding; IMP:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 71 | P56524 | 1084 | HDAC4_HUMAN Histone deacetylase 4 OS=Homo sap... | 140 | 0.00000000002 | 70.1 | 34 | 51 | GO:0000118; C:histone deacetylase complex; IDA:BHF-UCL.::GO:0017053; C:transcriptional repressor complex; IDA:BHF-UCL. | | | | | | | | | | GO:0033613; F:activating transcription factor binding; IPI:BHF-UCL.::GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0030955; F:potassium ion binding; IDA:BHF-UCL.::GO:0070491; F:repressing transcription factor binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; IDA:BHF-UCL. | | | | | | | | | | GO:0030183; P:B cell differentiation; TAS:UniProtKB.::GO:0014898; P:cardiac muscle hypertrophy in response to stress; TAS:BHF-UCL.::GO:0006338; P:chromatin remodeling; IDA:BHF-UCL.::GO:0070932; P:histone H3 deacetylation; IDA:BHF-UCL.::GO:0070933; P:histone H4 deacetylation; IDA:BHF-UCL.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0045820; P:negative regulation of glycolysis; ISS:BHF-UCL.::GO:0010832; P:negative regulation of myotube differentiation; IMP:BHF-UCL.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0007399; P:nervous system development; TAS:UniProtKB.::GO:0034983; P:peptidyl-lysine deacetylation; IDA:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.::GO:0033235; P:positive regulation of protein sumoylation; IDA:UniProtKB.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0043393; P:regulation of protein binding; IMP:BHF-UCL.::GO:0014894; P:response to denervation involved in regulation of muscle adaptation; ISS:BHF-UCL.::GO:0070555; P:response to interleukin-1; IMP:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 72 | P83038 | 1080 | HDAC4_CHICK Histone deacetylase 4 OS=Gallus g... | 141 | 0.00000000002 | 70.1 | 34 | 50 | GO:0000118; C:histone deacetylase complex; TAS:UniProtKB. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008134; F:transcription factor binding; TAS:UniProtKB. | | | | | | | | | | GO:0030183; P:B cell differentiation; TAS:UniProtKB.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0045843; P:negative regulation of striated muscle tissue development; TAS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; TAS:UniProtKB.::GO:0007399; P:nervous system development; TAS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 73 | Q9GKU5 | 347 | HDA11_MACFA Histone deacetylase 11 OS=Macaca ... | 205 | 0.00000000003 | 68.2 | 29 | 46 | GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008134; F:transcription factor binding; TAS:UniProtKB. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 74 | Q5R902 | 1122 | HDAC5_PONAB Histone deacetylase 5 OS=Pongo ab... | 175 | 0.00000000004 | 69.3 | 29 | 47 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0000118; C:histone deacetylase complex; IEA:InterPro. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0010830; P:regulation of myotube differentiation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 75 | Q99P99 | 1077 | HDAC4_RAT Histone deacetylase 4 OS=Rattus nor... | 140 | 0.00000000005 | 68.9 | 34 | 51 | GO:0031672; C:A band; IDA:MGI.::GO:0030018; C:Z disc; IDA:MGI. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0042493; P:response to drug; IDA:RGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 76 | Q8RX28 | 660 | HDA5_ARATH Histone deacetylase 5 OS=Arabidops... | 177 | 0.00000000005 | 68.6 | 28 | 45 | GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 77 | Q6NZM9 | 1076 | HDAC4_MOUSE Histone deacetylase 4 OS=Mus musc... | 141 | 0.00000000009 | 68.2 | 33 | 50 | GO:0042641; C:actomyosin; IDA:MGI.::GO:0005829; C:cytosol; IDA:MGI.::GO:0031594; C:neuromuscular junction; IDA:MGI. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0003714; F:transcription corepressor activity; IGI:MGI. | | | | | | | | | | GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.::GO:0045820; P:negative regulation of glycolysis; IMP:BHF-UCL.::GO:0045668; P:negative regulation of osteoblast differentiation; IMP:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0002076; P:osteoblast development; IMP:MGI.::GO:0033235; P:positive regulation of protein sumoylation; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IMP:MGI.::GO:0014894; P:response to denervation involved in regulation of muscle adaptation; IMP:BHF-UCL.::GO:0001501; P:skeletal system development; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 78 | Q8WUI4 | 952 | HDAC7_HUMAN Histone deacetylase 7 OS=Homo sap... | 137 | 0.0000000002 | 66.6 | 31 | 53 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0000118; C:histone deacetylase complex; IEA:InterPro. | | | | | | | | | | GO:0071889; F:14-3-3 protein binding; IDA:UniProtKB.::GO:0033613; F:activating transcription factor binding; IPI:UniProtKB.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0005080; F:protein kinase C binding; IPI:UniProtKB.::GO:0070491; F:repressing transcription factor binding; IPI:BHF-UCL. | | | | | | | | | | GO:0032703; P:negative regulation of interleukin-2 production; IDA:BHF-UCL.::GO:0045668; P:negative regulation of osteoblast differentiation; IMP:UniProtKB.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 79 | Q8C2B3 | 938 | HDAC7_MOUSE Histone deacetylase 7 OS=Mus musc... | 137 | 0.0000000004 | 65.9 | 31 | 52 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB. | | | | | | | | | | GO:0071889; F:14-3-3 protein binding; ISS:UniProtKB.::GO:0003682; F:chromatin binding; IDA:MGI.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0003714; F:transcription corepressor activity; IDA:MGI. | | | | | | | | | | GO:0030183; P:B cell differentiation; TAS:UniProtKB.::GO:0007043; P:cell-cell junction assembly; IMP:MGI.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0045843; P:negative regulation of striated muscle tissue development; TAS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0007399; P:nervous system development; TAS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0001570; P:vasculogenesis; IMP:MGI. | 80 | Q3JUN4 | 341 | APHA_BURP1 Acetylpolyamine aminohydrolase OS=... | 149 | 0.000000001 | 63.2 | 28 | 48 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | | 81 | Q54VQ7 | 1704 | HDA22_DICDI Type-2 histone deacetylase 2 OS=D... | 184 | 0.000000002 | 63.5 | 28 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 82 | Q9Z2V5 | 1149 | HDAC6_MOUSE Histone deacetylase 6 OS=Mus musc... | 243 | 0.000000008 | 62 | 26 | 43 | GO:0005881; C:cytoplasmic microtubule; IDA:MGI.::GO:0005829; C:cytosol; IDA:UniProtKB. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0048487; F:beta-tubulin binding; IDA:MGI.::GO:0008017; F:microtubule binding; IDA:UniProtKB.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0042903; F:tubulin deacetylase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0070842; P:aggresome assembly; IGI:MGI.::GO:0071218; P:cellular response to misfolded protein; IMP:MGI.::GO:0070846; P:Hsp90 deacetylation; IMP:MGI.::GO:0007026; P:negative regulation of microtubule depolymerization; IDA:MGI.::GO:0000209; P:protein polyubiquitination; IDA:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0090042; P:tubulin deacetylation; IDA:UniProtKB.::GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:MGI. | 83 | Q569C4 | 588 | HDA10_RAT Histone deacetylase 10 OS=Rattus no... | 173 | 0.000000008 | 61.2 | 28 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0014003; P:oligodendrocyte development; IEP:RGD.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 84 | Q6P3E7 | 666 | HDA10_MOUSE Histone deacetylase 10 OS=Mus mus... | 267 | 0.00000001 | 61.2 | 25 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 85 | Q9UBN7 | 1215 | HDAC6_HUMAN Histone deacetylase 6 OS=Homo sap... | 243 | 0.0000001 | 57.8 | 25 | 43 | GO:0016235; C:aggresome; IDA:BHF-UCL.::GO:0005901; C:caveola; IDA:BHF-UCL.::GO:0031252; C:cell leading edge; IDA:BHF-UCL.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0000118; C:histone deacetylase complex; IDA:UniProtKB.::GO:0005875; C:microtubule associated complex; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0043014; F:alpha-tubulin binding; IDA:BHF-UCL.::GO:0008013; F:beta-catenin binding; IPI:BHF-UCL.::GO:0070840; F:dynein complex binding; IDA:BHF-UCL.::GO:0042826; F:histone deacetylase binding; IPI:UniProtKB.::GO:0051879; F:Hsp90 protein binding; IDA:BHF-UCL.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0031593; F:polyubiquitin binding; IDA:BHF-UCL.::GO:0048156; F:tau protein binding; IDA:BHF-UCL.::GO:0042903; F:tubulin deacetylase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0070842; P:aggresome assembly; IMP:BHF-UCL.::GO:0070301; P:cellular response to hydrogen peroxide; IMP:BHF-UCL.::GO:0070846; P:Hsp90 deacetylation; IMP:BHF-UCL.::GO:0032418; P:lysosome localization; IMP:BHF-UCL.::GO:0016236; P:macroautophagy; IMP:BHF-UCL.::GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; IMP:BHF-UCL.::GO:0010727; P:negative regulation of hydrogen peroxide metabolic process; IC:BHF-UCL.::GO:0051354; P:negative regulation of oxidoreductase activity; IC:BHF-UCL.::GO:0045861; P:negative regulation of proteolysis; IMP:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0034983; P:peptidyl-lysine deacetylation; IMP:BHF-UCL.::GO:0070845; P:polyubiquitinated misfolded protein transport; IMP:BHF-UCL.::GO:0043065; P:positive regulation of apoptotic process; IMP:BHF-UCL.::GO:0090035; P:positive regulation of chaperone-mediated protein complex assembly; IMP:BHF-UCL.::GO:0010634; P:positive regulation of epithelial cell migration; IMP:BHF-UCL.::GO:0010870; P:positive regulation of receptor biosynthetic process; IMP:BHF-UCL.::GO:0009967; P:positive regulation of signal transduction; IMP:BHF-UCL.::GO:0060765; P:regulation of androgen receptor signaling pathway; TAS:BHF-UCL.::GO:0060632; P:regulation of microtubule-based movement; IC:BHF-UCL.::GO:0010469; P:regulation of receptor activity; IMP:BHF-UCL.::GO:0070848; P:response to growth factor stimulus; IMP:BHF-UCL.::GO:0009636; P:response to toxin; IMP:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0090042; P:tubulin deacetylation; ISS:UniProtKB. | 86 | Q969S8 | 669 | HDA10_HUMAN Histone deacetylase 10 OS=Homo sa... | 178 | 0.0000002 | 57.4 | 29 | 44 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0000118; C:histone deacetylase complex; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0004407; F:histone deacetylase activity; IDA:UniProtKB.::GO:0042826; F:histone deacetylase binding; IDA:UniProtKB.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 87 | Q70I53 | 369 | HDAH_ALCSD Histone deacetylase-like amidohydr... | 200 | 0.0000004 | 55.5 | 24 | 42 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 88 | Q54X15 | 1489 | HDA21_DICDI Type-2 histone deacetylase 1 OS=D... | 105 | 0.0000007 | 55.5 | 30 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 89 | Q944K3 | 387 | HDA2_ARATH Histone deacetylase 2 OS=Arabidops... | 158 | 0.00003 | 49.7 | 25 | 44 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 90 | Q48935 | 341 | APHA_MYCRA Acetylpolyamine aminohydrolase OS=... | 61 | 0.0003 | 46.6 | 34 | 49 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | | 91 | O22446 | 501 | HDA19_ARATH Histone deacetylase 19 OS=Arabido... | 45 | 0.23 | 37.7 | 38 | 60 | GO:0005634; C:nucleus; IDA:TAIR. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0009294; P:DNA mediated transformation; IMP:TAIR.::GO:0016573; P:histone acetylation; IDA:TAIR.::GO:0009861; P:jasmonic acid and ethylene-dependent systemic resistance; IMP:TAIR.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:TAIR.::GO:0009405; P:pathogenesis; IMP:TAIR.::GO:2000026; P:regulation of multicellular organismal development; IMP:TAIR.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |