Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPR068C
Length:
470
Number of sequences:
5887
Description:
YPR068C HOS1 SGDID:S000006272, Chr XVI from 684353-682941, Genome Release 64-1-1, reverse complement, Verified ORF, "Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q91695    480   HDA1A_XENLA Probable histone deacetylase 1-A ...2089e-43     162     38     59GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
32P70288    488   HDAC2_MOUSE Histone deacetylase 2 OS=Mus musc...2081e-42     162     38     60GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.::GO:0000792; C:heterochromatin; IDA:MGI.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.::GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.::GO:0005657; C:replication fork; IDA:MGI.::GO:0005667; C:transcription factor complex; IPI:MGI.::GO:0017053; C:transcriptional repressor complex; IPI:MGI.
GO:0031490; F:chromatin DNA binding; IDA:MGI.::GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.::GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO:0016358; P:dendrite development; IMP:UniProtKB.::GO:0042733; P:embryonic digit morphogenesis; IGI:BHF-UCL.::GO:0009913; P:epidermal cell differentiation; IGI:BHF-UCL.::GO:0061029; P:eyelid development in camera-type eye; IGI:BHF-UCL.::GO:0061198; P:fungiform papilla formation; IGI:BHF-UCL.::GO:0060789; P:hair follicle placode formation; IGI:BHF-UCL.::GO:0021766; P:hippocampus development; IGI:MGI.::GO:0043066; P:negative regulation of apoptotic process; IGI:BHF-UCL.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IGI:MGI.::GO:0010977; P:negative regulation of neuron projection development; IDA:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:BHF-UCL.::GO:0042475; P:odontogenesis of dentin-containing tooth; IGI:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; IGI:BHF-UCL.::GO:0048714; P:positive regulation of oligodendrocyte differentiation; IGI:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
33Q4SFA0    428   HDAC3_TETNG Histone deacetylase 3 OS=nigrovir...2401e-42     161     35     56GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
34Q28DV3    428   HDAC3_XENTR Histone deacetylase 3 OS=Xenopus ...2411e-42     161     36     55GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
35Q6IRL9    428   HDAC3_XENLA Histone deacetylase 3 OS=Xenopus ...2414e-42     160     36     55GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
36P56518    576   HDAC1_STRPU Histone deacetylase 1 OS=Strongyl...2158e-42     160     39     59GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
37Q7SXM0    378   HDAC8_DANRE Histone deacetylase 8 OS=Danio re...2411e-41     157     37     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
38P56519    488   HDAC2_CHICK Histone deacetylase 2 OS=Gallus g...2155e-40     155     36     60GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
39O13298    434   PHD1_SCHPO Histone deacetylase phd1 OS=Schizo...2391e-39     153     34     54GO:0005829; C:cytosol; IDA:PomBase.::GO:0070210; C:Rpd3L-Expanded complex; IDA:PomBase.::GO:0034967; C:Set3 complex; IDA:PomBase.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006338; P:chromatin remodeling; NAS:PomBase.::GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:PomBase.::GO:0006348; P:chromatin silencing at telomere; IMP:PomBase.::GO:0060303; P:regulation of nucleosome density; IEP:PomBase.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEP:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
40Q09440    507   HDA2_CAEEL Putative histone deacetylase 2 OS=...2335e-39     152     37     58GO:0000118; C:histone deacetylase complex; ISS:WormBase.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0003714; F:transcription corepressor activity; ISS:WormBase.
GO:0042262; P:DNA protection; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0040017; P:positive regulation of locomotion; IMP:WormBase.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0006974; P:response to DNA damage stimulus; IMP:WormBase.::GO:0045138; P:tail tip morphogenesis; IMP:WormBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
41P56521    513   HDA19_MAIZE Probable histone deacetylase 19 O...2031e-36     145     38     58GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
42Q9FH09    409   HDA7_ARATH Histone deacetylase 7 OS=Arabidops...2697e-35     139     34     55GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
43P39067    387   ACUC_BACSU Acetoin utilization protein AcuC O...2141e-24     108     31     47
GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-KW.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
44Q56195    385   ACUC_STAXY Acetoin utilization protein AcuC O...2237e-24     106     29     47
GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-KW.
45Q8NW34    389   ACUC_STAAW Acetoin utilization protein AcuC O...2271e-23     105     30     46
GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-KW.
46Q6G8J2    389   ACUC_STAAS Acetoin utilization protein AcuC O...2271e-23     105     30     46
GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-KW.
47Q5HF39    389   ACUC_STAAC Acetoin utilization protein AcuC O...2272e-23     104     30     46
GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-KW.
48Q6GFX3    389   ACUC_STAAR Acetoin utilization protein AcuC O...2093e-23     104     30     47
GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-KW.
49P64376    389   ACUC_STAAN Acetoin utilization protein AcuC O...2275e-23     103     29     46
GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-KW.
50P64375    389   ACUC_STAAM Acetoin utilization protein AcuC O...2275e-23     103     29     46
GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-KW.
51O30107    359   Y130_ARCFU Uncharacterized protein AF_0130 OS...1483e-17     86.7     30     51
GO:0004407; F:histone deacetylase activity; IEA:InterPro.
52Q941D6    423   HDA14_ARATH Histone deacetylase 14 OS=Arabido...2273e-16     84.3     28     44GO:0009507; C:chloroplast; IDA:TAIR.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
53P72702    304   Y245_SYNY3 Uncharacterized protein slr0245 OS...2345e-16     82     26     45
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
54P28606    300   Y1628_SYNP2 Uncharacterized protein SYNPCC700...1840.000000000000002     80.1     31     52
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
55P56523    687   CLR3_SCHPO Histone deacetylase clr3 OS=Schizo...2830.000000000000003     82     25     43GO:0005721; C:centromeric heterochromatin; IDA:PomBase.::GO:0031934; C:mating-type region heterochromatin; IDA:PomBase.::GO:0030874; C:nucleolar chromatin; IDA:PomBase.::GO:0016581; C:NuRD complex; IDA:PomBase.::GO:0033553; C:rDNA heterochromatin; IDA:PomBase.::GO:0031933; C:telomeric heterochromatin; IDA:PomBase.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0000183; P:chromatin silencing at rDNA; IMP:PomBase.::GO:0006348; P:chromatin silencing at telomere; IMP:PomBase.::GO:0035391; P:maintenance of chromatin silencing at silent mating-type cassette; NAS:PomBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:PomBase.::GO:0016584; P:nucleosome positioning; IMP:PomBase.::GO:0031060; P:regulation of histone methylation; IMP:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
56Q94EJ2    377   HDA8_ARATH Histone deacetylase 8 OS=Arabidops...1980.00000000000002     78.6     23     48GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
57Q8GXJ1    552   HDA15_ARATH Histone deacetylase 15 OS=Arabido...1720.00000000000006     77.4     30     50GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009294; P:DNA mediated transformation; IMP:TAIR.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
58O17323    816   HDA4_CAEEL Histone deacetylase 4 OS=Caenorhab...1770.00000000000007     77.8     28     53GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
59Q613L4    892   HDA4_CAEBR Histone deacetylase 4 OS=Caenorhab...1770.00000000000009     77.4     29     51GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
60Q9UKV0    1011   HDAC9_HUMAN Histone deacetylase 9 OS=Homo sap...1750.0000000000002     76.6     30     49GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.::GO:0035097; C:histone methyltransferase complex; ISS:UniProtKB.::GO:0005667; C:transcription factor complex; IDA:BHF-UCL.
GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0005080; F:protein kinase C binding; IPI:UniProtKB.::GO:0070491; F:repressing transcription factor binding; IDA:BHF-UCL.::GO:0003714; F:transcription corepressor activity; ISS:BHF-UCL.
GO:0030183; P:B cell differentiation; TAS:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; IDA:BHF-UCL.::GO:0007507; P:heart development; ISS:BHF-UCL.::GO:0070932; P:histone H3 deacetylation; IDA:BHF-UCL.::GO:0070933; P:histone H4 deacetylation; IDA:BHF-UCL.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0034983; P:peptidyl-lysine deacetylation; IDA:BHF-UCL.::GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.::GO:0048742; P:regulation of skeletal muscle fiber development; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
61P53973    706   HDA1_YEAST Histone deacetylase HDA1 OS=Saccha...1830.0000000000005     75.1     27     50GO:0070823; C:HDA1 complex; IDA:SGD.
GO:0003682; F:chromatin binding; IDA:SGD.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
GO:0031047; P:gene silencing by RNA; IMP:SGD.::GO:0010978; P:gene silencing involved in chronological cell aging; IMP:SGD.::GO:0001308; P:negative regulation of chromatin silencing involved in replicative cell aging; IMP:SGD.::GO:0010621; P:negative regulation of transcription by transcription factor localization; IGI:SGD.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:SGD.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.::GO:0031938; P:regulation of chromatin silencing at telomere; IMP:SGD.::GO:0034401; P:regulation of transcription by chromatin organization; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
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