Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPR065W
Length:
368
Number of sequences:
5887
Description:
YPR065W ROX1 SGDID:S000006269, Chr XVI from 679693-680799, Genome Release 64-1-1, Verified ORF, "Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P25042    368   ROX1_YEAST Repressor ROX1 OS=Saccharomyces ce...3680     734     100     100GO:0000790; C:nuclear chromatin; IC:SGD.
GO:0008301; F:DNA binding, bending; IDA:SGD.::GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IMP:SGD.::GO:0001135; F:RNA polymerase II transcription factor recruiting transcription factor activity; IMP:SGD.::GO:0043565; F:sequence-specific DNA binding; IDA:SGD.
GO:0097201; P:negative regulation of transcription from RNA polymerase II promoter in response to stress; IMP:SGD.
2O15370    315   SOX12_HUMAN Transcription factor SOX-12 OS=Ho...820.000000000009     68.9     41     63GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ISS:UniProtKB.::GO:0001105; F:RNA polymerase II transcription coactivator activity; ISS:UniProtKB.::GO:0000976; F:transcription regulatory region sequence-specific DNA binding; ISS:UniProtKB.
GO:0045165; P:cell fate commitment; IEP:UniProtKB.::GO:0021510; P:spinal cord development; ISS:UniProtKB.
3Q04890    314   SOX12_MOUSE Transcription factor SOX-12 OS=Mu...820.00000000001     68.6     41     63GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0032993; C:protein-DNA complex; IDA:UniProtKB.
GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:UniProtKB.::GO:0001105; F:RNA polymerase II transcription coactivator activity; IDA:UniProtKB.::GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:UniProtKB.
GO:0065004; P:protein-DNA complex assembly; IDA:UniProtKB.::GO:0021510; P:spinal cord development; IDA:UniProtKB.
4B1H349    777   SOX6_XENTR Transcription factor Sox-6 OS=Xeno...1140.0000000005     64.7     37     57GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
5Q28GD5    362   SOX7_XENTR Transcription factor Sox-7 OS=Xeno...950.0000000006     63.9     36     57GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
GO:0001706; P:endoderm formation; ISS:UniProtKB.::GO:0007507; P:heart development; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0048793; P:pronephros development; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
6O42342    362   SOX7_XENLA Transcription factor Sox-7 OS=Xeno...950.0000000006     63.9     36     57GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0001706; P:endoderm formation; IMP:UniProtKB.::GO:0007507; P:heart development; IMP:UniProtKB.::GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0048793; P:pronephros development; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
7P40646    380   SOX7_MOUSE Transcription factor SOX-7 OS=Mus ...950.0000000006     63.9     38     58GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.
GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:MGI.::GO:0043565; F:sequence-specific DNA binding; IDA:MGI.::GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.
8Q5RCU4    787   SOX6_PONAB Transcription factor SOX-6 OS=Pong...1140.0000000007     64.3     37     57GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
9P40645    827   SOX6_MOUSE Transcription factor SOX-6 OS=Mus ...1140.0000000008     63.9     37     57GO:0005667; C:transcription factor complex; IC:MGI.
GO:0046982; F:protein heterodimerization activity; IPI:MGI.::GO:0043565; F:sequence-specific DNA binding; IDA:MGI.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.::GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI.
GO:0035051; P:cardiac cell differentiation; IDA:MGI.::GO:0051216; P:cartilage development; IGI:MGI.::GO:0000902; P:cell morphogenesis; IMP:MGI.::GO:0048821; P:erythrocyte development; IMP:MGI.::GO:0016458; P:gene silencing; IMP:MGI.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0042692; P:muscle cell differentiation; IDA:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0021778; P:oligodendrocyte cell fate specification; IMP:MGI.::GO:0032332; P:positive regulation of chondrocyte differentiation; IDA:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.::GO:0009791; P:post-embryonic development; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
10P35712    828   SOX6_HUMAN Transcription factor SOX-6 OS=Homo...1140.0000000009     63.9     37     57GO:0005634; C:nucleus; NAS:UniProtKB.
GO:0003677; F:DNA binding; NAS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:UniProtKB.::GO:0007517; P:muscle organ development; NAS:UniProtKB.::GO:0061036; P:positive regulation of cartilage development; IDA:UniProtKB.::GO:0032332; P:positive regulation of chondrocyte differentiation; IDA:UniProtKB.::GO:2000741; P:positive regulation of mesenchymal stem cell differentiation; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
11Q8AXQ4    244   SOX12_XENLA Transcription factor Sox-12 OS=Xe...930.000000001     61.6     38     58GO:0005634; C:nucleus; IC:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
12P40634    72   ADW2_ALLMI SRY-related protein ADW2 OS=Alliga...770.000000001     58.5     38     61GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
13Q9BT81    388   SOX7_HUMAN Transcription factor SOX-7 OS=Homo...950.000000002     62.4     37     57GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; ISS:BHF-UCL.
GO:0001706; P:endoderm formation; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.::GO:0060828; P:regulation of canonical Wnt receptor signaling pathway; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
14P40636    72   ADW5_ALLMI SRY-related protein ADW5 OS=Alliga...770.000000003     57.4     38     60GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
15P0CY17    181   MTMC3_SCHPO Silenced mating-type M-specific p...900.000000005     58.9     37     60
GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; NAS:PomBase.
GO:0000747; P:conjugation with cellular fusion; NAS:PomBase.::GO:0007531; P:mating type determination; NAS:PomBase.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; NAS:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
16P0CY16    181   MATMC_SCHPO Mating-type M-specific polypeptid...900.000000005     58.9     37     60GO:0005634; C:nucleus; IDA:PomBase.::GO:0005816; C:spindle pole body; IDA:PomBase.
GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; NAS:PomBase.
GO:0000747; P:conjugation with cellular fusion; NAS:PomBase.::GO:0007531; P:mating type determination; NAS:PomBase.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; NAS:PomBase.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
17C7U331    181   MATMC_SCHPM Mating-type M-specific polypeptid...900.000000005     58.9     37     60GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
18P40657    784   SOX15_DROME Putative transcription factor SOX...980.000000006     61.6     31     59GO:0005634; C:nucleus; IDA:FlyBase.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0022416; P:chaeta development; IMP:FlyBase.::GO:0043066; P:negative regulation of apoptotic process; IMP:FlyBase.::GO:0008285; P:negative regulation of cell proliferation; IMP:FlyBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:FlyBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0035220; P:wing disc development; IMP:FlyBase.
19P43267    231   SOX15_MOUSE Protein SOX-15 OS=Mus musculus (M...830.000000007     59.3     41     58GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.
GO:0003682; F:chromatin binding; IDA:MGI.::GO:0003677; F:DNA binding; IDA:MGI.::GO:0005515; F:protein binding; IPI:MGI.
GO:0048627; P:myoblast development; IMP:MGI.::GO:0045843; P:negative regulation of striated muscle tissue development; IDA:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0043403; P:skeletal muscle tissue regeneration; IMP:MGI.
20Q6WRX6    181   MATMC_SCHKA Mating-type M-specific polypeptid...890.000000008     58.2     37     60GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
21P36393    208   SRY_PIG Sex-determining region Y protein OS=S...960.000000009     58.5     36     54GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0030238; P:male sex determination; IEA:InterPro.::GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
22Q9BG90    204   SRY_MACMU Sex-determining region Y protein OS...870.00000001     58.2     41     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0030238; P:male sex determination; IEA:InterPro.::GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
23P40635    72   ADW4_ALLMI SRY-related protein ADW4 OS=Alliga...770.00000001     55.8     38     58GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
24Q9W757    461   SOX10_CHICK Transcription factor SOX-10 OS=Ga...880.00000001     59.7     34     58GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0060959; P:cardiac neuron development; IEP:UniProtKB.
25Q8AXX8    446   SOX10_XENLA Transcription factor Sox-10 OS=Xe...880.00000001     59.7     34     58GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0032183; F:SUMO binding; IPI:UniProtKB.
GO:0030318; P:melanocyte differentiation; IMP:UniProtKB.::GO:0014029; P:neural crest formation; IMP:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
26P40647    757   SOX5_XENLA Transcription factor Sox-5 OS=Xeno...1150.00000002     59.7     36     56GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IDA:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
27P35710    763   SOX5_MOUSE Transcription factor SOX-5 OS=Mus ...1400.00000002     59.7     31     52GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046982; F:protein heterodimerization activity; IPI:MGI.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.::GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI.
GO:0051216; P:cartilage development; IGI:MGI.::GO:0045165; P:cell fate commitment; IGI:MGI.::GO:0021953; P:central nervous system neuron differentiation; IGI:MGI.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.::GO:0048709; P:oligodendrocyte differentiation; IMP:MGI.::GO:0032332; P:positive regulation of chondrocyte differentiation; IDA:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0060164; P:regulation of timing of neuron differentiation; IMP:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
28P35711    763   SOX5_HUMAN Transcription factor SOX-5 OS=Homo...1400.00000002     59.7     31     52GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:UniProtKB.::GO:0061036; P:positive regulation of cartilage development; IDA:UniProtKB.::GO:0032332; P:positive regulation of chondrocyte differentiation; IDA:UniProtKB.::GO:2000741; P:positive regulation of mesenchymal stem cell differentiation; IDA:UniProtKB.::GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc.
29O55170    466   SOX10_RAT Transcription factor SOX-10 OS=Ratt...880.00000002     59.3     34     58GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0048863; P:stem cell differentiation; IEP:RGD.
30A4IIJ8    436   SOX10_XENTR Transcription factor Sox-10 OS=Xe...880.00000002     59.3     34     58GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0019899; F:enzyme binding; ISS:UniProtKB.::GO:0032183; F:SUMO binding; ISS:UniProtKB.
GO:0030318; P:melanocyte differentiation; ISS:UniProtKB.::GO:0014029; P:neural crest formation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
31A5A763    469   SOX10_PIG Transcription factor SOX-10 OS=Sus ...880.00000002     59.3     34     58GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
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