UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YPR019W

Length:

933

Number of sequences:

5887

Description:

YPR019W MCM4 SGDID:S000006223, Chr XVI from 596750-599551, Genome Release 64-1-1, Verified ORF, "Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
61	P25206	812	MCM3_MOUSE DNA replication licensing factor M...	673	4e-84	293	32	51	GO:0042555; C:MCM complex; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.
62	Q7ZXZ0	806	MCM3Z_XENLA Zygotic DNA replication licensing...	502	7e-84	293	37	55	GO:0042555; C:MCM complex; IDA:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.::GO:0030174; P:regulation of DNA-dependent DNA replication initiation; IC:UniProtKB.
63	Q9XYU1	819	MCM3_DROME DNA replication licensing factor M...	486	6e-83	290	35	52	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.::GO:0007095; P:mitotic cell cycle G2/M transition DNA damage checkpoint; IMP:FlyBase.
64	Q28BS0	809	MCM3Z_XENTR Zygotic DNA replication licensing...	501	9e-83	290	36	55	GO:0042555; C:MCM complex; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.
65	Q9CWV1	833	MCM8_MOUSE DNA replication licensing factor M...	599	7e-82	288	31	51	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
66	Q24849	597	MCM3_ENTHI DNA replication licensing factor M...	601	7e-82	282	32	52	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.
67	Q62724	507	MCM6_RAT DNA replication licensing factor MCM...	336	2e-80	276	43	67
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
68	P24279	971	MCM3_YEAST DNA replication licensing factor M...	588	2e-79	283	34	52	GO:0005737; C:cytoplasm; IDA:SGD.::GO:0031261; C:DNA replication preinitiation complex; IPI:SGD.::GO:0042555; C:MCM complex; IDA:SGD.::GO:0005656; C:pre-replicative complex; IDA:SGD.::GO:0031298; C:replication fork protection complex; IDA:SGD.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; IDA:SGD.::GO:0003688; F:DNA replication origin binding; IDA:SGD.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0006200; P:ATP catabolic process; IDA:GOC.::GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:SGD.::GO:0006348; P:chromatin silencing at telomere; IMP:SGD.::GO:0032508; P:DNA duplex unwinding; IDA:GOC.::GO:0006271; P:DNA strand elongation involved in DNA replication; IMP:SGD.::GO:0006270; P:DNA-dependent DNA replication initiation; IMP:SGD.::GO:0000727; P:double-strand break repair via break-induced replication; IMP:SGD.::GO:0006267; P:pre-replicative complex assembly; IDA:SGD.::GO:0000084; P:S phase of mitotic cell cycle; IMP:SGD.
69	Q2KHI9	1134	MCM9_MOUSE DNA replication licensing factor M...	655	1e-78	282	32	51
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
									GO:0006260; P:DNA replication; IEA:InterPro.
70	Q9UJA3	840	MCM8_HUMAN DNA replication licensing factor M...	626	2e-78	278	31	50	GO:0005654; C:nucleoplasm; TAS:Reactome.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
									GO:0000075; P:cell cycle checkpoint; TAS:Reactome.::GO:0006271; P:DNA strand elongation involved in DNA replication; TAS:Reactome.::GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.::GO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
71	Q6NRM6	1143	MCM9_XENLA DNA replication licensing factor M...	639	2e-73	267	32	50
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
									GO:0006260; P:DNA replication; IEA:InterPro.
72	Q9NXL9	1143	MCM9_HUMAN DNA replication licensing factor M...	596	4e-72	263	32	52
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
									GO:0006260; P:DNA replication; IEA:InterPro.
73	Q58884	682	Y1489_METJA Uncharacterized MCM-type protein ...	673	8e-70	250	31	51
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
74	Q58371	762	Y961_METJA Uncharacterized MCM-type protein M...	672	2e-54	206	27	46
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
75	Q57809	759	Y363_METJA Uncharacterized MCM-type protein M...	694	4e-45	178	28	47
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
76	Q9VF30	885	MCMR_DROME DNA replication licensing factor R...	640	4e-41	167	24	45	GO:0005634; C:nucleus; TAS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004003; F:ATP-dependent DNA helicase activity; TAS:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006270; P:DNA-dependent DNA replication initiation; TAS:UniProtKB.::GO:0007131; P:reciprocal meiotic recombination; IMP:UniProtKB.
77	Q60275	602	Y3513_METJA Uncharacterized MCM-type protein ...	562	1e-21	104	24	42
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
78	Q1GWB6	338	RUVB_SPHAL Holliday junction ATP-dependent DN...	111	0.66	37	27	42
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0009378; F:four-way junction helicase activity; IEA:InterPro.
									GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0009432; P:SOS response; IEA:UniProtKB-KW.
79	P25205	808	MCM3_HUMAN DNA replication licensing factor M...	55	0.82	37.4	33	65	GO:0005658; C:alpha DNA polymerase:primase complex; TAS:ProtInc.::GO:0005813; C:centrosome; IDA:HPA.::GO:0042555; C:MCM complex; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; TAS:ProtInc.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0000075; P:cell cycle checkpoint; TAS:Reactome.::GO:0006271; P:DNA strand elongation involved in DNA replication; TAS:Reactome.::GO:0006270; P:DNA-dependent DNA replication initiation; TAS:ProtInc.::GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.::GO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome.::GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome.
80	Q5R8G6	808	MCM3_PONAB DNA replication licensing factor M...	55	0.83	37.4	33	65	GO:0042555; C:MCM complex; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.
81	A4FUD9	808	MCM3_BOVIN DNA replication licensing factor M...	55	0.95	37	31	65	GO:0042555; C:MCM complex; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.
82	A5V881	342	RUVB_SPHWW Holliday junction ATP-dependent DN...	111	1.2	36.2	27	41
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0009378; F:four-way junction helicase activity; IEA:InterPro.
									GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0009432; P:SOS response; IEA:UniProtKB-KW.
83	P37930	314	HRPR_PSESY Pathogenicity locus probable regul...	100	2.6	35	24	45	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0008134; F:transcription factor binding; IEA:InterPro.
									GO:0034053; P:modulation by symbiont of host defense-related programmed cell death; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0000160; P:two-component signal transduction system (phosphorelay); IEA:UniProtKB-KW.
84	P26316	302	HRPS_PSESH Pathogenicity locus probable regul...	125	2.6	35	26	44	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0008134; F:transcription factor binding; IEA:InterPro.
									GO:0034053; P:modulation by symbiont of host defense-related programmed cell death; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0000160; P:two-component signal transduction system (phosphorelay); IEA:UniProtKB-KW.
85	Q3ZBK1	386	WDR89_BOVIN WD repeat-containing protein 89 O...	66	4.4	34.7	36	45
86	Q96Q15	3661	SMG1_HUMAN Serine/threonine-protein kinase SM...	60	4.6	35	35	47	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0010467; P:gene expression; TAS:Reactome.::GO:0006406; P:mRNA export from nucleus; TAS:UniProtKB.::GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IDA:UniProtKB.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
87	B7LW25	504	NORR_ESCF3 Anaerobic nitric oxide reductase t...	163	6.1	34.3	25	44	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0008134; F:transcription factor binding; IEA:InterPro.
									GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
88	Q1WVA9	1061	CARB_LACS1 Carbamoyl-phosphate synthase large...	95	7	34.3	29	47
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
89	P06695	988	TNP5_PSEAI Transposase for transposon Tn501 O...	128	7.2	34.3	26	44
									GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004803; F:transposase activity; IEA:InterPro.
									GO:0006313; P:transposition, DNA-mediated; IEA:InterPro.
90	B1LQ27	504	NORR_ECOSM Anaerobic nitric oxide reductase t...	123	9	33.5	24	45	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0008134; F:transcription factor binding; IEA:InterPro.
									GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
91	B7LEC0	504	NORR_ECO55 Anaerobic nitric oxide reductase t...	123	9.4	33.5	24	45	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0008134; F:transcription factor binding; IEA:InterPro.
									GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.

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