UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YPR006C

Length:

575

Number of sequences:

5887

Description:

YPR006C ICL2 SGDID:S000006210, Chr XVI from 568996-567269, Genome Release 64-1-1, reverse complement, Verified ORF, "2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
31	P41555	540	ACEA_YARLI Isocitrate lyase OS=lipolytica). G...	542	2e-132	404	40	58	GO:0009514; C:glyoxysome; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
32	Q9C124	550	ACEA_PICPA Isocitrate lyase OS=Pichia pastori...	535	1e-128	395	39	59	GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
33	Q9P6J1	518	ACEB_SCHPO Mitochondrial 2-methylisocitrate l...	527	1e-79	266	31	52	GO:0005829; C:cytosol; IDA:PomBase.::GO:0005759; C:mitochondrial matrix; ISS:PomBase.
									GO:0004451; F:isocitrate lyase activity; IEA:InterPro.::GO:0046421; F:methylisocitrate lyase activity; ISS:PomBase.
									GO:0019541; P:propionate metabolic process; ISS:PomBase.::GO:0006567; P:threonine catabolic process; ISS:PomBase.
34	P46831	606	ACEA_MYCLE Isocitrate lyase OS=Mycobacterium ...	566	2e-69	241	31	45	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
35	P0A9G6	434	ACEA_ECOLI Isocitrate lyase OS=Escherichia co...	181	2e-38	150	44	61	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
36	P0A9G7	434	ACEA_ECOL6 Isocitrate lyase OS=Escherichia co...	181	2e-38	150	44	61	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
37	P51066	434	ACEA_SALTY Isocitrate lyase OS=Salmonella typ...	181	3e-38	150	45	60	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
38	P0A5H3	428	ACEA_MYCTU Isocitrate lyase OS=Mycobacterium ...	180	1e-32	133	41	56	GO:0005829; C:cytosol; IDA:MTBBASE.::GO:0005886; C:plasma membrane; IDA:MTBBASE.
									GO:0004451; F:isocitrate lyase activity; IDA:MTBBASE.::GO:0046421; F:methylisocitrate lyase activity; IDA:MTBBASE.
									GO:0071456; P:cellular response to hypoxia; IEP:MTBBASE.::GO:0006097; P:glyoxylate cycle; IDA:MTBBASE.::GO:0006102; P:isocitrate metabolic process; IDA:MTBBASE.::GO:0075141; P:maintenance of symbiont tolerance to host environment; IMP:MTBBASE.::GO:0009405; P:pathogenesis; IMP:MTBBASE.::GO:0010034; P:response to acetate; IDA:MTBBASE.::GO:0001101; P:response to acid; IEP:MTBBASE.::GO:0070542; P:response to fatty acid; IDA:MTBBASE.::GO:0052572; P:response to host immune response; IEP:MTBBASE.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
39	P0A5H4	428	ACEA_MYCBO Isocitrate lyase OS=Mycobacterium ...	180	1e-32	133	41	56	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
40	P41554	429	ACEA_RHOFA Isocitrate lyase OS=Rhodococcus fa...	184	4e-32	131	39	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
41	Q8RQN6	431	ACEA_COREF Isocitrate lyase OS=11189 / NBRC 1...	181	5e-31	128	40	55	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
42	P42449	432	ACEA_CORGL Isocitrate lyase OS=LMG 3730 / NCI...	181	2e-30	127	40	55	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
43	Q9K9H0	427	ACEA_BACHD Isocitrate lyase OS=9153 / C-125)....	157	3e-30	126	42	58	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
44	Q10663	968	GCP_CAEEL Bifunctional glyoxylate cycle prote...	202	3e-29	127	35	54
									GO:0004451; F:isocitrate lyase activity; IEA:EC.::GO:0004474; F:malate synthase activity; IEA:EC.
									GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009790; P:embryo development; IPI:WormBase.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
45	Q9I0K4	531	ACEA_PSEAE Isocitrate lyase OS=12228). GN=PA2...	404	0.000000000001	73.9	24	42	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
46	O49290	339	CPPM_ARATH Carboxyvinyl-carboxyphosphonate ph...	149	0.000000001	63.5	34	46	GO:0009570; C:chloroplast stroma; IDA:TAIR.
									GO:0008807; F:carboxyvinyl-carboxyphosphonate phosphorylmutase activity; IEA:EC.
47	O50078	540	ACEA_HYPME Isocitrate lyase OS=Hyphomicrobium...	175	0.000000004	62.8	28	46	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0046914; F:transition metal ion binding; IDA:UniProtKB.
									GO:0006097; P:glyoxylate cycle; IDA:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IDA:UniProtKB.
48	Q56062	295	PRPB_SALTY Methylisocitrate lyase OS=Salmonel...	185	0.00000001	60.1	29	42
									GO:0046421; F:methylisocitrate lyase activity; IEA:EC.
									GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro.
49	Q9KSC2	308	PRPB_VIBCH Methylisocitrate lyase OS=Vibrio c...	179	0.00000004	58.5	27	42
									GO:0046421; F:methylisocitrate lyase activity; IEA:EC.
									GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro.
50	P77541	296	PRPB_ECOLI Methylisocitrate lyase OS=Escheric...	174	0.00000007	57.8	29	42
									GO:0046421; F:methylisocitrate lyase activity; IEA:EC.
									GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro.
51	P20699	58	ACEA_HELAN Isocitrate lyase OS=Helianthus ann...	57	0.00000008	54.3	44	63	GO:0009514; C:glyoxysome; IEA:UniProtKB-SubCell.
									GO:0004451; F:isocitrate lyase activity; IEA:EC.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
52	P11435	295	CPPM_STRHY Carboxyvinyl-carboxyphosphonate ph...	86	0.0000004	55.5	37	53
									GO:0008807; F:carboxyvinyl-carboxyphosphonate phosphorylmutase activity; IEA:EC.
									GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
53	Q8NSL2	307	PRPB2_CORGL Probable methylisocitrate lyase 2...	93	0.0000007	54.7	37	52
									GO:0046421; F:methylisocitrate lyase activity; IEA:EC.
									GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro.
54	Q0QLE4	289	DML_EUBBA 2,3-dimethylmalate lyase OS=Eubacte...	86	0.000001	54.3	36	56
									GO:0047529; F:2,3-dimethylmalate lyase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0051187; P:cofactor catabolic process; IDA:UniProtKB.
55	Q9YFM7	308	PRPB_AERPE Methylisocitrate lyase OS=100138 /...	85	0.000003	53.1	34	54
									GO:0046421; F:methylisocitrate lyase activity; IEA:EC.
									GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro.
56	Q8NSH8	305	PRPB1_CORGL Probable methylisocitrate lyase 1...	87	0.00001	51.2	36	51
									GO:0046421; F:methylisocitrate lyase activity; IEA:EC.
									GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro.
57	P54528	301	PRPB_BACSU Methylisocitrate lyase OS=Bacillus...	83	0.0001	47.8	31	52
									GO:0046421; F:methylisocitrate lyase activity; IEA:EC.
									GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro.
58	Q9Z9T7	300	PRPB_BACHD Methylisocitrate lyase OS=9153 / C...	83	0.0005	45.8	30	52
									GO:0046421; F:methylisocitrate lyase activity; IEA:EC.
									GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro.
59	Q05957	318	PDP_DIACA Petal death protein OS=Dianthus car...	71	0.001	44.7	34	55
									GO:0047776; F:citramalate lyase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0030603; F:oxaloacetase activity; IEA:EC.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
60	Q3KEL1	289	OADC1_PSEPF Oxaloacetate decarboxylase 1 OS=P...	140	0.002	43.9	26	39
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008948; F:oxaloacetate decarboxylase activity; IEA:EC.
61	Q1I5P3	289	OADC_PSEE4 Oxaloacetate decarboxylase OS=Pseu...	134	0.002	43.9	25	40
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008948; F:oxaloacetate decarboxylase activity; IEA:EC.

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