rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q9Z1B3 | 1216 | PLCB1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 619 | 5e-51 | 198 | 29 | 47 | GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.::GO:0016607; C:nuclear speck; IDA:BHF-UCL.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005516; F:calmodulin binding; ISS:BHF-UCL.::GO:0019899; F:enzyme binding; ISS:BHF-UCL.::GO:0005521; F:lamin binding; IPI:BHF-UCL.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:BHF-UCL.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:BHF-UCL.::GO:0042803; F:protein homodimerization activity; ISS:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0060466; P:activation of meiosis involved in egg activation; IDA:BHF-UCL.::GO:0007155; P:cell adhesion; IC:BHF-UCL.::GO:0021987; P:cerebral cortex development; IMP:BHF-UCL.::GO:0030218; P:erythrocyte differentiation; TAS:BHF-UCL.::GO:0045444; P:fat cell differentiation; IDA:BHF-UCL.::GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; IMP:BHF-UCL.::GO:0051318; P:G1 phase; IDA:BHF-UCL.::GO:0000086; P:G2/M transition of mitotic cell cycle; IDA:BHF-UCL.::GO:0007215; P:glutamate receptor signaling pathway; IMP:BHF-UCL.::GO:0008286; P:insulin receptor signaling pathway; TAS:BHF-UCL.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; IDA:BHF-UCL.::GO:0035722; P:interleukin-12-mediated signaling pathway; ISS:BHF-UCL.::GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0030225; P:macrophage differentiation; NAS:BHF-UCL.::GO:0007613; P:memory; IMP:BHF-UCL.::GO:0006397; P:mRNA processing; TAS:BHF-UCL.::GO:2000438; P:negative regulation of monocyte extravasation; IDA:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0001556; P:oocyte maturation; NAS:BHF-UCL.::GO:0046488; P:phosphatidylinositol metabolic process; ISS:BHF-UCL.::GO:2000344; P:positive regulation of acrosome reaction; IMP:BHF-UCL.::GO:2000560; P:positive regulation of CD24 biosynthetic process; IDA:BHF-UCL.::GO:0048639; P:positive regulation of developmental growth; IMP:BHF-UCL.::GO:0040019; P:positive regulation of embryonic development; IMP:BHF-UCL.::GO:0032735; P:positive regulation of interleukin-12 production; IMP:BHF-UCL.::GO:0046330; P:positive regulation of JNK cascade; ISS:BHF-UCL.::GO:0045663; P:positive regulation of myoblast differentiation; IDA:BHF-UCL.::GO:0032417; P:positive regulation of sodium:hydrogen antiporter activity; NAS:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0080154; P:regulation of fertilization; IMP:BHF-UCL.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IMP:BHF-UCL. | 32 | Q62688 | 1096 | PLCL1_RAT Inactive phospholipase C-like prote... | 528 | 7e-51 | 197 | 28 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006629; P:lipid metabolic process; IEA:InterPro. | 33 | P10687 | 1216 | PLCB1_RAT 1-phosphatidylinositol 4,5-bisphosp... | 619 | 7e-51 | 197 | 29 | 47 | GO:0005829; C:cytosol; IDA:RGD.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0016607; C:nuclear speck; ISS:BHF-UCL. | | | | | | | | | | GO:0005509; F:calcium ion binding; IDA:BHF-UCL.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0060466; P:activation of meiosis involved in egg activation; ISS:BHF-UCL.::GO:0021987; P:cerebral cortex development; ISS:BHF-UCL.::GO:0051318; P:G1 phase; ISS:BHF-UCL.::GO:0007215; P:glutamate receptor signaling pathway; ISS:BHF-UCL.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007612; P:learning; IEP:RGD.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007613; P:memory; IEP:RGD.::GO:2000438; P:negative regulation of monocyte extravasation; ISS:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:BHF-UCL.::GO:0046488; P:phosphatidylinositol metabolic process; IEP:RGD.::GO:2000560; P:positive regulation of CD24 biosynthetic process; ISS:BHF-UCL.::GO:0048639; P:positive regulation of developmental growth; ISS:BHF-UCL.::GO:0032735; P:positive regulation of interleukin-12 production; ISS:BHF-UCL.::GO:0045663; P:positive regulation of myoblast differentiation; ISS:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:BHF-UCL.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:BHF-UCL.::GO:0034284; P:response to monosaccharide stimulus; IDA:BHF-UCL.::GO:0010243; P:response to organic nitrogen; IEP:RGD.::GO:0043434; P:response to peptide hormone stimulus; IDA:BHF-UCL. | 34 | Q8SPR7 | 772 | PLCD4_PIG 1-phosphatidylinositol 4,5-bisphosp... | 292 | 9e-50 | 191 | 40 | 57 | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 35 | Q99JE6 | 1234 | PLCB3_RAT 1-phosphatidylinositol 4,5-bisphosp... | 669 | 8e-48 | 188 | 26 | 43 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005626; C:insoluble fraction; IDA:UniProtKB.::GO:0042383; C:sarcolemma; IDA:RGD. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; NAS:UniProtKB. | | | | | | | | | | GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD.::GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IDA:UniProtKB.::GO:0006892; P:post-Golgi vesicle-mediated transport; IDA:RGD. | 36 | P51432 | 1234 | PLCB3_MOUSE 1-phosphatidylinositol 4,5-bispho... | 668 | 8e-46 | 182 | 25 | 43 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 37 | P13217 | 1095 | PIPA_DROME 1-phosphatidylinositol 4,5-bisphos... | 613 | 2e-41 | 168 | 26 | 43 | GO:0016027; C:inaD signaling complex; IPI:FlyBase.::GO:0005624; C:membrane fraction; IDA:FlyBase. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005096; F:GTPase activator activity; NAS:FlyBase.::GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:FlyBase.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008344; P:adult locomotory behavior; IMP:FlyBase.::GO:0019722; P:calcium-mediated signaling; TAS:FlyBase.::GO:0016059; P:deactivation of rhodopsin mediated signaling; IDA:FlyBase.::GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IMP:FlyBase.::GO:0006651; P:diacylglycerol biosynthetic process; TAS:FlyBase.::GO:0051482; P:elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger; TAS:FlyBase.::GO:0009649; P:entrainment of circadian clock; IMP:FlyBase.::GO:0008377; P:light-induced release of internally sequestered calcium ion; TAS:FlyBase.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0002385; P:mucosal immune response; IMP:FlyBase.::GO:0046673; P:negative regulation of compound eye retinal cell programmed cell death; IMP:FlyBase.::GO:0046488; P:phosphatidylinositol metabolic process; IMP:FlyBase.::GO:0008654; P:phospholipid biosynthetic process; TAS:FlyBase.::GO:0045494; P:photoreceptor cell maintenance; IMP:FlyBase.::GO:0043052; P:thermotaxis; IMP:FlyBase. | 38 | A3KGF7 | 1181 | PLCB2_MOUSE 1-phosphatidylinositol 4,5-bispho... | 521 | 3e-40 | 164 | 29 | 45 | | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 39 | O89040 | 1183 | PLCB2_RAT 1-phosphatidylinositol 4,5-bisphosp... | 525 | 7e-40 | 163 | 29 | 46 | GO:0005829; C:cytosol; IDA:RGD.::GO:0031680; C:G-protein beta/gamma-subunit complex; IDA:RGD.::GO:0005794; C:Golgi apparatus; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:RGD. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0031683; F:G-protein beta/gamma-subunit complex binding; IDA:RGD.::GO:0004435; F:phosphatidylinositol phospholipase C activity; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IDA:RGD.::GO:0004871; F:signal transducer activity; IDA:UniProtKB. | | | | | | | | | | GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.::GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.::GO:0009395; P:phospholipid catabolic process; NAS:UniProtKB. | 40 | Q00722 | 1185 | PLCB2_HUMAN 1-phosphatidylinositol 4,5-bispho... | 634 | 9e-40 | 163 | 27 | 44 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:ProtInc.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007202; P:activation of phospholipase C activity; TAS:ProtInc.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0006644; P:phospholipid metabolic process; TAS:ProtInc.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 41 | Q95JS1 | 641 | PLCZ1_MACFA 1-phosphatidylinositol 4,5-bispho... | 296 | 4e-38 | 155 | 34 | 56 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007338; P:single fertilization; IEA:UniProtKB-KW. | 42 | Q944C2 | 578 | PLCD5_ARATH Phosphoinositide phospholipase C ... | 581 | 2e-37 | 152 | 26 | 45 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 43 | Q8GV43 | 613 | PLCD6_ARATH Phosphoinositide phospholipase C ... | 508 | 2e-35 | 147 | 27 | 43 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 44 | Q39033 | 581 | PLCD2_ARATH Phosphoinositide phospholipase C ... | 619 | 5e-30 | 129 | 24 | 40 | GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 45 | Q944C1 | 597 | PLCD4_ARATH Phosphoinositide phospholipase C ... | 507 | 1e-29 | 128 | 25 | 42 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 46 | Q39032 | 561 | PLCD1_ARATH Phosphoinositide phospholipase C ... | 525 | 2e-29 | 127 | 24 | 43 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009738; P:abscisic acid mediated signaling pathway; TAS:TAIR.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0009409; P:response to cold; IEP:TAIR.::GO:0009651; P:response to salt stress; IEP:TAIR.::GO:0009414; P:response to water deprivation; IEP:TAIR. | 47 | Q9LY51 | 584 | PLCD7_ARATH Phosphoinositide phospholipase C ... | 528 | 3e-28 | 124 | 26 | 43 | GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 48 | Q56W08 | 564 | PLCD3_ARATH Phosphoinositide phospholipase C ... | 494 | 6e-28 | 123 | 25 | 41 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 49 | Q99P84 | 2281 | PLCE1_RAT 1-phosphatidylinositol 4,5-bisphosp... | 265 | 3e-21 | 104 | 30 | 46 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0004435; F:phosphatidylinositol phospholipase C activity; ISS:UniProtKB.::GO:0017016; F:Ras GTPase binding; IDA:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.::GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; ISS:UniProtKB.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007265; P:Ras protein signal transduction; IDA:RGD.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:UniProtKB.::GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB. | 50 | Q8K4S1 | 2282 | PLCE1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 265 | 6e-21 | 102 | 30 | 46 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019899; F:enzyme binding; ISS:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0004435; F:phosphatidylinositol phospholipase C activity; ISS:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.::GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; ISS:UniProtKB.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:UniProtKB.::GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 51 | Q9P212 | 2302 | PLCE1_HUMAN 1-phosphatidylinositol 4,5-bispho... | 265 | 1e-20 | 102 | 29 | 46 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:UniProtKB.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0017016; F:Ras GTPase binding; TAS:UniProtKB.::GO:0005057; F:receptor signaling protein activity; TAS:UniProtKB. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; IDA:UniProtKB.::GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; IDA:UniProtKB.::GO:0007205; P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; NAS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; NAS:UniProtKB.::GO:0008283; P:cell proliferation; NAS:UniProtKB.::GO:0007010; P:cytoskeleton organization; NAS:UniProtKB.::GO:0006651; P:diacylglycerol biosynthetic process; TAS:UniProtKB.::GO:0007204; P:elevation of cytosolic calcium ion concentration; TAS:UniProtKB.::GO:0007173; P:epidermal growth factor receptor signaling pathway; NAS:UniProtKB.::GO:0032835; P:glomerulus development; IMP:HGNC.::GO:0007507; P:heart development; TAS:UniProtKB.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0006644; P:phospholipid metabolic process; IC:UniProtKB.::GO:0007265; P:Ras protein signal transduction; TAS:UniProtKB.::GO:0001558; P:regulation of cell growth; TAS:UniProtKB.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IDA:UniProtKB.::GO:0046578; P:regulation of Ras protein signal transduction; IDA:UniProtKB.::GO:0006940; P:regulation of smooth muscle contraction; TAS:UniProtKB. | 52 | Q4KWH8 | 1693 | PLCH1_HUMAN 1-phosphatidylinositol 4,5-bispho... | 271 | 7e-20 | 99.4 | 26 | 45 | GO:0031965; C:nuclear membrane; IDA:HPA. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0050429; F:calcium-dependent phospholipase C activity; IDA:MGI.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:MGI. | 53 | P19174 | 1290 | PLCG1_HUMAN 1-phosphatidylinositol 4,5-bispho... | 266 | 2e-19 | 97.8 | 28 | 43 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0030027; C:lamellipodium; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0001726; C:ruffle; IDA:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005168; F:neurotrophin TRKA receptor binding; IPI:UniProtKB.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; NAS:UniProtKB. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:UniProtKB.::GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0045766; P:positive regulation of angiogenesis; IDA:DFLAT.::GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:DFLAT.::GO:0010634; P:positive regulation of epithelial cell migration; IMP:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome. | 54 | Q4KWH5 | 1682 | PLCH1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 271 | 2e-19 | 98.2 | 25 | 45 | GO:0005829; C:cytosol; IDA:MGI.::GO:0005624; C:membrane fraction; IDA:MGI. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 55 | Q62077 | 1302 | PLCG1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 266 | 3e-19 | 97.1 | 28 | 43 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0035254; F:glutamate receptor binding; IPI:MGI.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0010634; P:positive regulation of epithelial cell migration; ISS:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; IDA:MGI. | 56 | P10686 | 1290 | PLCG1_RAT 1-phosphatidylinositol 4,5-bisphosp... | 266 | 3e-19 | 97.1 | 28 | 43 | GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0005886; C:plasma membrane; TAS:Reactome.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005158; F:insulin receptor binding; IDA:RGD.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0051219; F:phosphoprotein binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006816; P:calcium ion transport; IMP:RGD.::GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.::GO:0032959; P:inositol trisphosphate biosynthetic process; IMP:RGD.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0032236; P:positive regulation of calcium ion transport via store-operated calcium channel activity; IMP:RGD.::GO:0010634; P:positive regulation of epithelial cell migration; IMP:RGD.::GO:0009306; P:protein secretion; IMP:RGD.::GO:0009629; P:response to gravity; IEP:RGD.::GO:0042542; P:response to hydrogen peroxide; IEP:RGD.::GO:0043278; P:response to morphine; IEP:RGD.::GO:0010243; P:response to organic nitrogen; IEP:RGD. | 57 | P25455 | 1318 | PIP1_DROME 1-phosphatidylinositol 4,5-bisphos... | 279 | 3e-19 | 97.1 | 30 | 48 | | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007629; P:flight behavior; IGI:FlyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 58 | A2AP18 | 1501 | PLCH2_MOUSE 1-phosphatidylinositol 4,5-bispho... | 275 | 5e-19 | 96.7 | 28 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0046488; P:phosphatidylinositol metabolic process; IDA:MGI. | 59 | Q86YW0 | 608 | PLCZ1_HUMAN 1-phosphatidylinositol 4,5-bispho... | 236 | 9e-19 | 94.7 | 31 | 47 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 60 | Q8K3R3 | 807 | PLCD4_MOUSE 1-phosphatidylinositol 4,5-bispho... | 268 | 4e-18 | 93.2 | 28 | 43 | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007340; P:acrosome reaction; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0046488; P:phosphatidylinositol metabolic process; TAS:MGI. | 61 | P08487 | 1291 | PLCG1_BOVIN 1-phosphatidylinositol 4,5-bispho... | 262 | 4e-18 | 93.6 | 27 | 42 | GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.::GO:0001701; P:in utero embryonic development; ISS:AgBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0010634; P:positive regulation of epithelial cell migration; ISS:UniProtKB. |