Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPL154C
Length:
405
Number of sequences:
5887
Description:
YPL154C PEP4 SGDID:S000006075, Chr XVI from 260931-259714, Genome Release 64-1-1, reverse complement, Verified ORF, "Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
121P0CY29    398   CARP3_CANAL Candidapepsin-3 OS=Candida albica...3376e-25     108     28     45GO:0005576; C:extracellular region; IDA:CGD.
GO:0004190; F:aspartic-type endopeptidase activity; IDA:CGD.
GO:0044406; P:adhesion to host; IMP:CGD.::GO:0052391; P:induction by symbiont of defense-related host calcium ion flux; IDA:CGD.::GO:0006807; P:nitrogen compound metabolic process; IMP:CGD.::GO:0009405; P:pathogenesis; IMP:CGD.::GO:0030163; P:protein catabolic process; IMP:CGD.::GO:0006508; P:proteolysis; IDA:CGD.::GO:0006465; P:signal peptide processing; IDA:CGD.
122C4YNQ5    398   CARP3_CANAW Candidapepsin-3 OS=Candida albica...3378e-25     108     28     45GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
123P09177    427   CARP_RHIPU Mucorpepsin OS=Rhizomucor pusillus...3578e-25     108     27     44
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
124Q8NKB6    487   OPSB_ASPOR Probable aspartic-type endopeptida...3523e-24     107     28     48GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
125P0CY27    391   CARP1_CANAL Candidapepsin-1 OS=Candida albica...3505e-24     105     31     46GO:0005576; C:extracellular region; IDA:CGD.
GO:0004190; F:aspartic-type endopeptidase activity; IDA:CGD.
GO:0044406; P:adhesion to host; IMP:CGD.::GO:0052391; P:induction by symbiont of defense-related host calcium ion flux; IDA:CGD.::GO:0052559; P:induction by symbiont of host immune response; IDA:CGD.::GO:0006807; P:nitrogen compound metabolic process; IMP:CGD.::GO:0009405; P:pathogenesis; IMP:CGD.::GO:0030163; P:protein catabolic process; IMP:CGD.::GO:0006508; P:proteolysis; IDA:CGD.::GO:0006465; P:signal peptide processing; IDA:CGD.
126C4YSF6    391   CARP1_CANAW Candidapepsin-1 OS=Candida albica...3466e-24     105     30     47GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
127P0CY26    391   CARP1_CANAX Candidapepsin-1 OS=Candida albica...3452e-23     103     30     46GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
128D4DFT3    495   OPSB_TRIVH Probable aspartic-type endopeptida...3554e-23     104     27     45GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
129D4AIS3    495   OPSB_ARTBC Probable aspartic-type endopeptida...3554e-23     104     27     45GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
130Q4WDN4    485   OPSB_ASPFU Probable aspartic-type endopeptida...3464e-23     103     27     47GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
131O13340    425   CARP_PODAS Podosporapepsin OS=Podospora anser...3392e-22     101     29     46
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
132P85136    224   CARDE_CYNCA Cardosin-E OS=Cynara cardunculus ...410.000004     50.8     56     73GO:0005618; C:cell wall; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.::GO:0000326; C:protein storage vacuole; IEA:UniProtKB-SubCell.::GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
133Q9Y5Z0    518   BACE2_HUMAN Beta-secretase 2 OS=Homo sapiens ...3514e-22     101     25     45GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0016021; C:integral to membrane; NAS:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IDA:UniProtKB.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:UniProtKB.::GO:0042985; P:negative regulation of amyloid precursor protein biosynthetic process; IMP:UniProtKB.::GO:0016486; P:peptide hormone processing; NAS:UniProtKB.
134P43093    417   CARP4_CANAW Candidapepsin-4 OS=Candida albica...3605e-22     100     25     44GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
135P43095    418   CARP6_CANAX Candidapepsin-6 OS=Candida albica...3339e-22     99.8     26     44GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
136P53379    596   MKC7_YEAST Aspartic proteinase MKC7 OS=Saccha...4131e-21     100     27     43GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.::GO:0009277; C:fungal-type cell wall; IDA:SGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IDA:SGD.
GO:0006508; P:proteolysis; IMP:SGD.
137P56819    501   BACE1_RAT Beta-secretase 1 OS=Rattus norvegic...3478e-21     97.8     26     40GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; ISS:UniProtKB.
GO:0050435; P:beta-amyloid metabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; ISS:UniProtKB.
138P32329    569   YPS1_YEAST Aspartic proteinase 3 OS=Saccharom...3298e-21     97.8     26     45GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.::GO:0009277; C:fungal-type cell wall; IDA:SGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IDA:SGD.
GO:0016485; P:protein processing; IDA:SGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
139P32950    412   CARP2_CANPA Candidapepsin-2 OS=Candida paraps...3141e-20     96.3     28     46GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
140Q6IE75    514   BACE2_RAT Beta-secretase 2 OS=Rattus norvegic...3582e-20     96.7     25     44GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004190; F:aspartic-type endopeptidase activity; ISS:UniProtKB.
GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB.::GO:0042985; P:negative regulation of amyloid precursor protein biosynthetic process; ISS:UniProtKB.
141P56818    501   BACE1_MOUSE Beta-secretase 1 OS=Mus musculus ...3472e-20     96.7     26     40GO:0030424; C:axon; IDA:MGI.::GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005624; C:membrane fraction; IDA:MGI.
GO:0004190; F:aspartic-type endopeptidase activity; ISS:UniProtKB.
GO:0050435; P:beta-amyloid metabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; ISS:UniProtKB.
142Q2HJ40    501   BACE1_BOVIN Beta-secretase 1 OS=Bos taurus (B...3472e-20     96.7     26     40GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; ISS:UniProtKB.
GO:0050435; P:beta-amyloid metabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; ISS:UniProtKB.
143P56817    501   BACE1_HUMAN Beta-secretase 1 OS=Homo sapiens ...3477e-20     95.1     25     40GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.::GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IDA:UniProtKB.::GO:0008798; F:beta-aspartyl-peptidase activity; TAS:ProtInc.::GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0050435; P:beta-amyloid metabolic process; IDA:UniProtKB.::GO:0006509; P:membrane protein ectodomain proteolysis; TAS:UniProtKB.
144Q9JL18    514   BACE2_MOUSE Beta-secretase 2 OS=Mus musculus ...3581e-19     94.4     24     44GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004190; F:aspartic-type endopeptidase activity; ISS:UniProtKB.
GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB.::GO:0042985; P:negative regulation of amyloid precursor protein biosynthetic process; ISS:UniProtKB.
145Q9HEZ3    394   PEPB_PENJA Aspartic protease pepB OS=Penicill...3312e-19     92.4     29     43GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
146Q00663    394   CARP_CANTR Candidapepsin OS=Candida tropicali...3463e-19     92.4     28     45GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
147Q06902    404   PEPA_ASPOR Aspartic protease pep1 OS=Aspergil...3243e-19     92.4     30     45GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
148B8NLY9    404   PEPA_ASPFN Aspartic protease pep1 OS=12722 / ...3243e-19     92.4     30     45GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
149P43094    418   CARP5_CANAL Candidapepsin-5 OS=Candida albica...3326e-19     91.3     24     42GO:0005576; C:extracellular region; IDA:CGD.::GO:0005622; C:intracellular; IDA:CGD.
GO:0004190; F:aspartic-type endopeptidase activity; IDA:CGD.
GO:0009405; P:pathogenesis; IMP:CGD.::GO:0006508; P:proteolysis; IDA:CGD.
150P41748    395   PEPA_ASPFU Aspartic protease pep1 OS=A1100) (...3279e-19     90.9     31     47GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
151B0Y1V8    395   PEPA_ASPFC Aspartic protease pep1 OS=(Aspergi...3279e-19     90.9     31     47GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
records
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