Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPL153C
Length:
821
Number of sequences:
5887
Description:
YPL153C RAD53 SGDID:S000006074, Chr XVI from 264192-261727, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
871P48963    298   CDK2_MESAU Cyclin-dependent kinase 2 OS=Mesoc...3002e-26     115     30     48GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.
872P54666    311   CC2H3_TRYBB Cell division control protein 2 h...2993e-26     115     29     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
873Q96C45    1275   ULK4_HUMAN Serine/threonine-protein kinase UL...3213e-26     119     30     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
874Q8WU08    396   ST32A_HUMAN Serine/threonine-protein kinase 3...2323e-26     115     31     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
875Q9QY78    757   IKKB_RAT Inhibitor of nuclear factor kappa-B ...2194e-26     118     32     51GO:0008385; C:IkappaB kinase complex; IDA:RGD.::GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IDA:RGD.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IDA:RGD.::GO:0008384; F:IkappaB kinase activity; IEA:EC.::GO:0046982; F:protein heterodimerization activity; IPI:RGD.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:RGD.::GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB cascade; IMP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0009636; P:response to toxin; IEP:RGD.::GO:0003009; P:skeletal muscle contraction; IEP:RGD.
876P53349    1493   M3K1_MOUSE Mitogen-activated protein kinase k...2724e-26     119     28     48GO:0005829; C:cytosol; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007257; P:activation of JUN kinase activity; IDA:BHF-UCL.
877Q9NY57    414   ST32B_HUMAN Serine/threonine-protein kinase 3...2184e-26     115     34     52
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
878Q05006    294   CDC22_MEDSA Cell division control protein 2 h...2984e-26     114     30     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.
879Q8VZD5    410   KSG5_ARATH Shaggy-related protein kinase epsi...3044e-26     115     31     47GO:0005829; C:cytosol; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:TAIR.
GO:0006972; P:hyperosmotic response; IEP:TAIR.::GO:0046777; P:protein autophosphorylation; IDA:TAIR.::GO:0009651; P:response to salt stress; IEP:TAIR.
880Q64303    524   PAK2_RAT Serine/threonine-protein kinase PAK ...2764e-26     117     30     52GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
881Q4WPF2    973   ATG1_ASPFU Serine/threonine-protein kinase at...3084e-26     119     27     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
882Q95KV0    756   IKKB_BOVIN Inhibitor of nuclear factor kappa-...3024e-26     118     28     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008384; F:IkappaB kinase activity; IEA:EC.
883Q9N272    365   MK13_PANTR Mitogen-activated protein kinase 1...3264e-26     115     30     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
884Q2VWQ3    642   STE20_PENMA Serine/threonine-protein kinase p...2744e-26     117     31     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
885O15264    365   MK13_HUMAN Mitogen-activated protein kinase 1...3305e-26     115     30     47GO:0005829; C:cytosol; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.::GO:0050729; P:positive regulation of inflammatory response; IC:BHF-UCL.::GO:0032755; P:positive regulation of interleukin-6 production; IMP:BHF-UCL.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006970; P:response to osmotic stress; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
886P33886    605   WIS1_SCHPO Protein kinase wis1 OS=Schizosacch...3065e-26     117     30     46GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; NAS:PomBase.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0051519; P:activation of bipolar cell growth; IMP:PomBase.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0070301; P:cellular response to hydrogen peroxide; IMP:PomBase.::GO:0071470; P:cellular response to osmotic stress; TAS:PomBase.::GO:0070314; P:G1 to G0 transition; IMP:PomBase.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007346; P:regulation of mitotic cell cycle; IMP:PomBase.::GO:0043555; P:regulation of translation in response to stress; IMP:PomBase.::GO:0046685; P:response to arsenic-containing substance; IMP:PomBase.::GO:0051403; P:stress-activated MAPK cascade; TAS:PomBase.
887Q9USX7    526   PPK22_SCHPO Serine/threonine-protein kinase p...3085e-26     116     28     45GO:0005829; C:cytosol; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:PomBase.
GO:0019236; P:response to pheromone; ISS:PomBase.::GO:0007165; P:signal transduction; NAS:PomBase.
888Q29502    524   PAK2_RABIT Serine/threonine-protein kinase PA...2765e-26     116     30     52GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0097194; P:execution phase of apoptosis; IMP:UniProtKB.::GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
889Q8CIN4    524   PAK2_MOUSE Serine/threonine-protein kinase PA...2765e-26     116     30     52GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
890Q8BLF2    595   CDKL3_MOUSE Cyclin-dependent kinase-like 3 OS...2925e-26     117     29     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
891A2AAJ9    8891   OBSCN_MOUSE Obscurin OS=Mus musculus (Mouse)....2743e-17     90.9     26     47GO:0005622; C:intracellular; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
892Q6BRY2    330   PHO85_DEBHA Negative regulator of the PHO sys...2966e-26     114     29     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
893Q09013    629   DMPK_HUMAN Myotonin-protein kinase OS=Homo sa...2806e-26     117     30     49GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031307; C:integral to mitochondrial outer membrane; IDA:UniProtKB.::GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0033017; C:sarcoplasmic reticulum membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0017020; F:myosin phosphatase regulator activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB.::GO:0010657; P:muscle cell apoptotic process; IDA:UniProtKB.::GO:0006998; P:nuclear envelope organization; IMP:UniProtKB.::GO:0008016; P:regulation of heart contraction; IDA:UniProtKB.::GO:0010830; P:regulation of myotube differentiation; ISS:UniProtKB.
894P34117    292   CDK5_DICDI Cyclin-dependent kinase 5 homolog ...2986e-26     113     30     48GO:0005737; C:cytoplasm; IDA:dictyBase.::GO:0072686; C:mitotic spindle; IDA:dictyBase.::GO:0005654; C:nucleoplasm; IDA:dictyBase.::GO:0005625; C:soluble fraction; IDA:dictyBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IDA:dictyBase.::GO:0005515; F:protein binding; IPI:dictyBase.
GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0008283; P:cell proliferation; IMP:dictyBase.::GO:0006909; P:phagocytosis; IMP:dictyBase.::GO:0031157; P:regulation of aggregate size involved in sorocarp development; IMP:dictyBase.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:dictyBase.
895Q4R8T9    590   CDKL3_MACFA Cyclin-dependent kinase-like 3 OS...2926e-26     117     29     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
896Q99759    626   M3K3_HUMAN Mitogen-activated protein kinase k...2776e-26     117     30     50GO:0005829; C:cytosol; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:MGI.
897O08911    367   MK12_MOUSE Mitogen-activated protein kinase 1...3076e-26     114     31     48GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
898A1CX69    950   ATG1_NEOFI Serine/threonine-protein kinase at...3086e-26     118     27     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
899Q94A06    354   M2K1_ARATH Mitogen-activated protein kinase k...2827e-26     114     28     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; IDA:TAIR.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0042742; P:defense response to bacterium; IDA:TAIR.::GO:0009814; P:defense response, incompatible interaction; IGI:TAIR.::GO:0042542; P:response to hydrogen peroxide; IDA:TAIR.::GO:0002237; P:response to molecule of bacterial origin; IDA:TAIR.::GO:0009414; P:response to water deprivation; IMP:TAIR.::GO:0009611; P:response to wounding; IEP:TAIR.
900Q13177    524   PAK2_HUMAN Serine/threonine-protein kinase PA...2767e-26     116     30     52GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0004674; F:protein serine/threonine kinase activity; IDA:BHF-UCL.::GO:0030296; F:protein tyrosine kinase activator activity; IDA:BHF-UCL.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0006921; P:cellular component disassembly involved in apoptotic process; TAS:Reactome.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:2001271; P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; IDA:UniProtKB.::GO:0006469; P:negative regulation of protein kinase activity; TAS:ProtInc.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.::GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.::GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL.::GO:0046777; P:protein autophosphorylation; IDA:MGI.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.::GO:0016032; P:viral reproduction; TAS:Reactome.
901O08648    1597   M3K4_MOUSE Mitogen-activated protein kinase k...2768e-26     118     31     50GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0019100; P:male germ-line sex determination; IMP:MGI.::GO:0043507; P:positive regulation of JUN kinase activity; IDA:UniProtKB.
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