Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPL140C
Length:
506
Number of sequences:
5887
Description:
YPL140C MKK2 SGDID:S000006061, Chr XVI from 289034-287514, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
631Q00771    414   KCC1_EMENI Calcium/calmodulin-dependent prote...2922e-21     99.8     27     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
632Q12263    1142   GIN4_YEAST Serine/threonine-protein kinase GI...2832e-21     102     31     45GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007117; P:budding cell bud growth; IGI:SGD.::GO:0046777; P:protein autophosphorylation; IDA:SGD.::GO:0000135; P:septin checkpoint; IMP:SGD.::GO:0000921; P:septin ring assembly; IGI:SGD.
633Q9KIG4    641   PK1_STRTO Serine/threonine-protein kinase PK-...1842e-21     101     30     53
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008658; F:penicillin binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
634A1CPG7    365   HOG1_ASPCL Mitogen-activated protein kinase h...2202e-21     99     32     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
635B0WAU8    761   PLK4_CULQU Serine/threonine-protein kinase PL...2902e-21     101     25     45GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
636P42818    465   KPK1_ARATH Serine/threonine-protein kinase At...2212e-21     100     29     50GO:0005737; C:cytoplasm; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:TAIR.::GO:0004674; F:protein serine/threonine kinase activity; IDA:TAIR.
GO:0045727; P:positive regulation of translation; TAS:TAIR.::GO:0009409; P:response to cold; IEP:TAIR.::GO:0009651; P:response to salt stress; IEP:TAIR.
637Q9UIK4    370   DAPK2_HUMAN Death-associated protein kinase 2...3012e-21     99     26     47GO:0034423; C:autophagic vacuole lumen; IEA:UniProtKB-SubCell.::GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0005516; F:calmodulin binding; IDA:UniProtKB.::GO:0004683; F:calmodulin-dependent protein kinase activity; TAS:ProtInc.::GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0043276; P:anoikis; IMP:UniProtKB.::GO:0006917; P:induction of apoptosis; IMP:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; TAS:UniProtKB.::GO:0010506; P:regulation of autophagy; TAS:UniProtKB.
638Q05512    776   MARK2_MOUSE Serine/threonine-protein kinase M...2402e-21     101     29     50GO:0045180; C:basal cortex; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0008289; F:lipid binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0030010; P:establishment of cell polarity; ISS:UniProtKB.::GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; ISS:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; ISS:UniProtKB.::GO:0001764; P:neuron migration; ISS:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0050770; P:regulation of axonogenesis; ISS:UniProtKB.::GO:0051493; P:regulation of cytoskeleton organization; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
639Q8TDC3    778   BRSK1_HUMAN Serine/threonine-protein kinase B...2692e-21     101     27     49GO:0030054; C:cell junction; IDA:HPA.::GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:HPA.::GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
GO:0005524; F:ATP binding; IC:UniProtKB.::GO:0043015; F:gamma-tubulin binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0007409; P:axonogenesis; ISS:UniProtKB.::GO:0051298; P:centrosome duplication; ISS:UniProtKB.::GO:0030010; P:establishment of cell polarity; ISS:UniProtKB.::GO:0031572; P:G2/M transition DNA damage checkpoint; IDA:UniProtKB.::GO:0007269; P:neurotransmitter secretion; ISS:UniProtKB.::GO:0009411; P:response to UV; IDA:UniProtKB.
640P21137    404   KAPC_CAEEL cAMP-dependent protein kinase cata...2402e-21     99.4     28     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004691; F:cAMP-dependent protein kinase activity; IDA:WormBase.
GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0018991; P:oviposition; IMP:WormBase.
641P17157    305   PHO85_YEAST Cyclin-dependent protein kinase P...2922e-21     98.2     27     48GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IPI:SGD.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0050849; P:negative regulation of calcium-mediated signaling; IGI:SGD.::GO:0045719; P:negative regulation of glycogen biosynthetic process; IMP:SGD.::GO:0016242; P:negative regulation of macroautophagy; IMP:SGD.::GO:0045936; P:negative regulation of phosphate metabolic process; IGI:SGD.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:SGD.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:SGD.::GO:0016239; P:positive regulation of macroautophagy; IMP:SGD.::GO:0032878; P:regulation of establishment or maintenance of cell polarity; IGI:SGD.::GO:0032880; P:regulation of protein localization; IDA:SGD.::GO:0031647; P:regulation of protein stability; IMP:SGD.::GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; IMP:SGD.::GO:0006974; P:response to DNA damage stimulus; IMP:SGD.
642P47811    360   MK14_MOUSE Mitogen-activated protein kinase 1...2132e-21     99     31     53GO:0005739; C:mitochondrion; IDA:MGI.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0000922; C:spindle pole; IDA:MGI.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IDA:UniProtKB.::GO:0051525; F:NFAT protein binding; IPI:BHF-UCL.
GO:0001525; P:angiogenesis; IMP:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0000902; P:cell morphogenesis; IGI:MGI.::GO:0002062; P:chondrocyte differentiation; IDA:MGI.::GO:0000077; P:DNA damage checkpoint; IMP:MGI.::GO:0019395; P:fatty acid oxidation; IMP:MGI.::GO:0006006; P:glucose metabolic process; IMP:MGI.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IDA:MGI.::GO:0030316; P:osteoclast differentiation; IMP:BHF-UCL.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.::GO:0045648; P:positive regulation of erythrocyte differentiation; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0032495; P:response to muramyl dipeptide; IDA:MGI.::GO:0007519; P:skeletal muscle tissue development; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
643P70618    360   MK14_RAT Mitogen-activated protein kinase 14 ...2132e-21     99     31     53GO:0044445; C:cytosolic part; IDA:RGD.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0005524; F:ATP binding; IDA:RGD.::GO:0004707; F:MAP kinase activity; ISS:UniProtKB.::GO:0008022; F:protein C-terminus binding; IDA:RGD.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0046777; P:protein autophosphorylation; IDA:RGD.::GO:0009749; P:response to glucose stimulus; IEP:RGD.::GO:0051403; P:stress-activated MAPK cascade; IDA:RGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
644Q4WSF6    366   HOG1_ASPFU Mitogen-activated protein kinase h...2203e-21     99     32     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
645A1D2C9    366   HOG1_NEOFI Mitogen-activated protein kinase h...2203e-21     99     32     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
646Q8NJT7    359   HOG1_HORWE Mitogen-activated protein kinase H...2203e-21     98.6     31     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
647Q9H0K1    926   SIK2_HUMAN Serine/threonine-protein kinase SI...2053e-21     101     32     49GO:0005794; C:Golgi apparatus; IDA:HPA.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0046626; P:regulation of insulin receptor signaling pathway; ISS:UniProtKB.
648O74456    288   PEF1_SCHPO Serine/threonine-protein kinase pe...1973e-21     97.8     32     53GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; TAS:PomBase.::GO:0005515; F:protein binding; IPI:PomBase.
GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; IGI:PomBase.::GO:0007165; P:signal transduction; IC:PomBase.::GO:0007089; P:traversing start control point of mitotic cell cycle; IGI:PomBase.
649Q9QY01    1037   ULK2_MOUSE Serine/threonine-protein kinase UL...2113e-21     101     32     50GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0034045; C:pre-autophagosomal structure membrane; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0048675; P:axon extension; IMP:MGI.::GO:0048671; P:negative regulation of collateral sprouting; IMP:MGI.::GO:0010506; P:regulation of autophagy; IMP:UniProtKB.::GO:0042594; P:response to starvation; IDA:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
650Q95NE7    360   MK14_PANTR Mitogen-activated protein kinase 1...2133e-21     98.6     31     53GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
651Q5VT25    1732   MRCKA_HUMAN Serine/threonine-protein kinase M...2493e-21     101     30     47GO:0042641; C:actomyosin; IDA:UniProtKB.::GO:0031252; C:cell leading edge; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
GO:0031532; P:actin cytoskeleton reorganization; IDA:UniProtKB.::GO:0031032; P:actomyosin structure organization; IMP:UniProtKB.::GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
652Q60DG4    943   NEK4_ORYSJ Serine/threonine-protein kinase Ne...2713e-21     101     26     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
653Q17446    377   PMK1_CAEEL Mitogen-activated protein kinase p...2113e-21     99     33     53GO:0005829; C:cytosol; IDA:WormBase.::GO:0005634; C:nucleus; IDA:WormBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IDA:UniProtKB.::GO:0008134; F:transcription factor binding; IPI:WormBase.
GO:0050829; P:defense response to Gram-negative bacterium; IMP:WormBase.::GO:0045087; P:innate immune response; IMP:WormBase.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:WormBase.::GO:0012501; P:programmed cell death; IMP:WormBase.
654Q08942    431   NRKA_TRYBB Putative serine/threonine-protein ...1583e-21     99.8     36     56
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
655Q8VDF3    370   DAPK2_MOUSE Death-associated protein kinase 2...3013e-21     98.6     26     47GO:0034423; C:autophagic vacuole lumen; IEA:UniProtKB-SubCell.::GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0005516; F:calmodulin binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; ISS:UniProtKB.
656P10666    629   KS6AB_XENLA Ribosomal protein S6 kinase 2 bet...2105e-21     100     32     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
657O34507    648   PRKC_BACSU Serine/threonine-protein kinase Pr...1723e-21     100     32     55GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008658; F:penicillin binding; IEA:InterPro.::GO:0042834; F:peptidoglycan binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0071224; P:cellular response to peptidoglycan; IMP:UniProtKB.::GO:0007165; P:signal transduction; IMP:UniProtKB.::GO:0009847; P:spore germination; IMP:UniProtKB.
658Q7SY24    670   KPCB_DANRE Protein kinase C beta type OS=Dani...2193e-21     100     29     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0050681; F:androgen receptor binding; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035403; F:histone kinase activity (H3-T6 specific); ISS:UniProtKB.::GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; ISS:UniProtKB.::GO:0004697; F:protein kinase C activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042113; P:B cell activation; ISS:UniProtKB.::GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.::GO:0035162; P:embryonic hemopoiesis; IMP:ZFIN.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
659P49071    359   MAPK2_DROME MAP kinase-activated protein kina...2163e-21     98.6     31     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; NAS:FlyBase.
GO:0007155; P:cell adhesion; IMP:FlyBase.::GO:0045793; P:positive regulation of cell size; IGI:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.
660Q69ZA1    1511   CDK13_MOUSE Cyclin-dependent kinase 13 OS=Mus...2353e-21     101     30     49GO:0019908; C:nuclear cyclin-dependent protein kinase holoenzyme complex; IDA:UniProtKB.::GO:0016607; C:nuclear speck; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0030332; F:cyclin binding; IPI:UniProtKB.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; ISS:UniProtKB.
GO:0000380; P:alternative nuclear mRNA splicing, via spliceosome; IDA:UniProtKB.::GO:0030097; P:hemopoiesis; ISS:UniProtKB.::GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; ISS:UniProtKB.
661B5DE93    1239   CDK12_XENTR Cyclin-dependent kinase 12 OS=Xen...2353e-21     101     30     50GO:0019908; C:nuclear cyclin-dependent protein kinase holoenzyme complex; ISS:UniProtKB.::GO:0016607; C:nuclear speck; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; ISS:UniProtKB.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; ISS:UniProtKB.::GO:0043405; P:regulation of MAP kinase activity; ISS:UniProtKB.::GO:0008380; P:RNA splicing; ISS:UniProtKB.
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