Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPL140C
Length:
506
Number of sequences:
5887
Description:
YPL140C MKK2 SGDID:S000006061, Chr XVI from 289034-287514, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
211O22040    666   ANP1_ARATH Mitogen-activated protein kinase k...3061e-30     129     29     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.
GO:0009908; P:flower development; IGI:TAIR.::GO:0046777; P:protein autophosphorylation; IDA:TAIR.::GO:0006979; P:response to oxidative stress; IDA:TAIR.
212Q9FZ36    651   M3K2_ARATH Mitogen-activated protein kinase k...2931e-30     129     30     51GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.
GO:0043622; P:cortical microtubule organization; IMP:UniProtKB.::GO:0000910; P:cytokinesis; IGI:TAIR.
213Q03497    939   STE20_YEAST Serine/threonine-protein kinase S...2822e-30     129     31     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000131; C:incipient cellular bud site; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.::GO:0001950; C:plasma membrane enriched fraction; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0035174; F:histone serine kinase activity; IDA:SGD.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0008349; F:MAP kinase kinase kinase kinase activity; IDA:SGD.
GO:0000282; P:cellular bud site selection; IMP:SGD.::GO:0034605; P:cellular response to heat; IMP:SGD.::GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.::GO:0010629; P:negative regulation of gene expression; IMP:SGD.::GO:0007232; P:osmosensory signaling pathway via Sho1 osmosensor; IMP:SGD.::GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:SGD.::GO:0043065; P:positive regulation of apoptotic process; IMP:SGD.::GO:0007124; P:pseudohyphal growth; IMP:SGD.::GO:0007096; P:regulation of exit from mitosis; IMP:SGD.::GO:0001402; P:signal transduction involved in filamentous growth; IMP:SGD.::GO:0035376; P:sterol import; IMP:SGD.::GO:0034063; P:stress granule assembly; IMP:SGD.::GO:0000011; P:vacuole inheritance; IMP:SGD.
214C4YRB7    1224   STE20_CANAW Serine/threonine-protein kinase C...2682e-30     129     33     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
215P0CY24    1228   STE20_CANAL Serine/threonine-protein kinase C...2682e-30     129     33     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0001410; P:chlamydospore formation; IMP:CGD.::GO:0000747; P:conjugation with cellular fusion; IMP:CGD.::GO:0031505; P:fungal-type cell wall organization; IMP:CGD.::GO:0030448; P:hyphal growth; IMP:CGD.::GO:0000165; P:MAPK cascade; IGI:CGD.::GO:0009405; P:pathogenesis; IMP:CGD.::GO:0001558; P:regulation of cell growth; IGI:CGD.
216Q683C9    282   AUR2_ARATH Serine/threonine-protein kinase Au...2642e-30     123     31     50GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0035175; F:histone kinase activity (H3-S10 specific); IDA:TAIR.
217Q7Z2Y5    1582   NRK_HUMAN Nik-related protein kinase OS=Homo ...3462e-30     129     29     43
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
218Q6ZQ29    1240   TAOK2_MOUSE Serine/threonine-protein kinase T...2822e-30     129     32     53GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0051403; P:stress-activated MAPK cascade; ISS:UniProtKB.
219P0CY23    1230   STE20_CANAX Serine/threonine-protein kinase C...2682e-30     129     33     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
220Q54C77    1186   Y3184_DICDI Probable inactive serine/threonin...2562e-30     129     30     50GO:0005622; C:intracellular; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0004672; F:protein kinase activity; IEA:InterPro.
GO:0007165; P:signal transduction; IEA:InterPro.
221Q9NQU5    681   PAK6_HUMAN Serine/threonine-protein kinase PA...2713e-30     128     30     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; TAS:UniProtKB.::GO:0007010; P:cytoskeleton organization; TAS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; TAS:UniProtKB.
222Q8C015    719   PAK7_MOUSE Serine/threonine-protein kinase PA...2723e-30     128     31     51GO:0005739; C:mitochondrion; IDA:MGI.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI.
GO:0006916; P:anti-apoptosis; IDA:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
223Q6NW76    320   AURKB_DANRE Aurora kinase B OS=Danio rerio (Z...2633e-30     124     31     49GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007059; P:chromosome segregation; IMP:ZFIN.::GO:0000910; P:cytokinesis; IMP:ZFIN.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0071777; P:positive regulation of cell cycle cytokinesis; ISS:UniProtKB.::GO:0034501; P:protein localization to kinetochore; ISS:UniProtKB.::GO:0051256; P:spindle midzone assembly involved in mitosis; ISS:UniProtKB.
224Q5R8Z4    681   PAK6_PONAB Serine/threonine-protein kinase PA...2713e-30     128     30     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
225D4A280    718   PAK7_RAT Serine/threonine-protein kinase PAK ...2723e-30     128     31     51GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
226Q6NU21    1001   TAO1A_XENLA Serine/threonine-protein kinase T...2773e-30     129     33     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; ISS:UniProtKB.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0046330; P:positive regulation of JNK cascade; ISS:UniProtKB.::GO:0051493; P:regulation of cytoskeleton organization; ISS:UniProtKB.
227Q9JLS3    1235   TAOK2_RAT Serine/threonine-protein kinase TAO...2823e-30     129     32     53GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0051403; P:stress-activated MAPK cascade; ISS:UniProtKB.
228O96013    591   PAK4_HUMAN Serine/threonine-protein kinase PA...2734e-30     127     30     52GO:0005794; C:Golgi apparatus; TAS:ProtInc.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; TAS:UniProtKB.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0016049; P:cell growth; TAS:UniProtKB.::GO:0016477; P:cell migration; TAS:UniProtKB.::GO:0008283; P:cell proliferation; TAS:UniProtKB.::GO:0007010; P:cytoskeleton organization; TAS:UniProtKB.::GO:0007165; P:signal transduction; TAS:UniProtKB.
229Q7RZD3    954   STE20_NEUCR Serine/threonine-protein kinase s...2664e-30     128     32     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
230Q9UL54    1235   TAOK2_HUMAN Serine/threonine-protein kinase T...2824e-30     129     32     53GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031434; F:mitogen-activated protein kinase kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; IDA:UniProtKB.::GO:0000186; P:activation of MAPKK activity; IDA:UniProtKB.::GO:0006915; P:apoptotic process; NAS:UniProtKB.::GO:0016477; P:cell migration; NAS:UniProtKB.::GO:0048041; P:focal adhesion assembly; IDA:UniProtKB.::GO:0031572; P:G2/M transition DNA damage checkpoint; IMP:UniProtKB.::GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.::GO:0006612; P:protein targeting to membrane; NAS:UniProtKB.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0008360; P:regulation of cell shape; IDA:UniProtKB.::GO:0051403; P:stress-activated MAPK cascade; IDA:UniProtKB.
231Q9VXE5    639   PAKM_DROME Serine/threonine-protein kinase PA...2844e-30     127     30     49GO:0005913; C:cell-cell adherens junction; IDA:FlyBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IMP:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004702; F:receptor signaling protein serine/threonine kinase activity; NAS:FlyBase.
GO:0000187; P:activation of MAPK activity; TAS:UniProtKB.::GO:0001751; P:compound eye photoreceptor cell differentiation; IMP:UniProtKB.::GO:0007010; P:cytoskeleton organization; TAS:UniProtKB.::GO:0007030; P:Golgi organization; IMP:FlyBase.::GO:0016319; P:mushroom body development; IMP:UniProtKB.::GO:0045792; P:negative regulation of cell size; IMP:FlyBase.::GO:0045315; P:positive regulation of compound eye photoreceptor development; IMP:UniProtKB.
232Q7ZYJ0    1001   TAO1B_XENLA Serine/threonine-protein kinase T...2774e-30     128     33     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; ISS:UniProtKB.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0046330; P:positive regulation of JNK cascade; ISS:UniProtKB.::GO:0051493; P:regulation of cytoskeleton organization; ISS:UniProtKB.
233O14427    971   CLA4_CANAX Serine/threonine-protein kinase CL...2674e-30     128     32     53
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
234Q6GPL3    368   AUKBB_XENLA Aurora kinase B-B OS=Xenopus laev...2635e-30     124     32     49GO:0000785; C:chromatin; ISS:UniProtKB.::GO:0032133; C:chromosome passenger complex; ISS:UniProtKB.::GO:0000775; C:chromosome, centromeric region; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0035175; F:histone kinase activity (H3-S10 specific); ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.::GO:0071777; P:positive regulation of cell cycle cytokinesis; ISS:UniProtKB.::GO:0034501; P:protein localization to kinetochore; ISS:UniProtKB.::GO:0051256; P:spindle midzone assembly involved in mitosis; ISS:UniProtKB.
235Q6DD27    896   TAOK3_XENLA Serine/threonine-protein kinase T...2745e-30     128     32     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
236Q2ULU3    848   STE20_ASPOR Serine/threonine-protein kinase s...2706e-30     127     33     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
237Q4P5N0    746   STE20_USTMA Serine/threonine-protein kinase S...2697e-30     127     32     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
238Q8BTW9    593   PAK4_MOUSE Serine/threonine-protein kinase PA...2727e-30     126     30     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
239Q6GPK9    1025   TAOK2_XENLA Serine/threonine-protein kinase T...2818e-30     127     33     52
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.::GO:0051403; P:stress-activated MAPK cascade; ISS:UniProtKB.
240Q4WHP3    815   STE20_ASPFU Serine/threonine-protein kinase s...2708e-30     127     33     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
241Q13153    545   PAK1_HUMAN Serine/threonine-protein kinase PA...2809e-30     125     30     49GO:0030424; C:axon; ISS:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030425; C:dendrite; ISS:UniProtKB.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0014704; C:intercalated disc; ISS:UniProtKB.::GO:0031965; C:nuclear membrane; ISS:UniProtKB.::GO:0043234; C:protein complex; IDA:UniProtKB.::GO:0001726; C:ruffle; IDA:UniProtKB.::GO:0030018; C:Z disc; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005518; F:collagen binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0031532; P:actin cytoskeleton reorganization; IDA:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0048754; P:branching morphogenesis of a tube; IMP:UniProtKB.::GO:0060244; P:negative regulation of cell proliferation involved in contact inhibition; IMP:UniProtKB.::GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IDA:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; IMP:UniProtKB.::GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0051496; P:positive regulation of stress fiber assembly; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.::GO:0042060; P:wound healing; IMP:UniProtKB.
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