Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPL023C
Length:
657
Number of sequences:
5887
Description:
YPL023C MET12 SGDID:S000005944, Chr XVI from 506312-504339, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P46151    657   MTHR1_YEAST Methylenetetrahydrofolate reducta...6570     1361     100     100
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006555; P:methionine metabolic process; IEA:InterPro.
2O74927    641   MTHR2_SCHPO Methylenetetrahydrofolate reducta...6732e-172     513     42     60GO:0005737; C:cytoplasm; ISS:PomBase.
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IDA:PomBase.
GO:0009086; P:methionine biosynthetic process; IDA:PomBase.
3Q10258    603   MTHR1_SCHPO Methylenetetrahydrofolate reducta...6425e-135     416     37     55GO:0005829; C:cytosol; IDA:PomBase.::GO:0005739; C:mitochondrion; ISS:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IDA:PomBase.
GO:0009086; P:methionine biosynthetic process; IDA:PomBase.
4Q9SE60    592   MTHR1_ARATH Methylenetetrahydrofolate reducta...6448e-110     350     36     52GO:0005829; C:cytosol; IDA:TAIR.
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
5P53128    600   MTHR2_YEAST Methylenetetrahydrofolate reducta...2605e-49     185     39     58GO:0005739; C:mitochondrion; IDA:SGD.
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0009086; P:methionine biosynthetic process; IMP:SGD.
6Q75HE6    594   MTHR_ORYSJ Probable methylenetetrahydrofolate...2505e-47     179     36     59
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0006555; P:methionine metabolic process; IEA:InterPro.
7O80585    594   MTHR2_ARATH Methylenetetrahydrofolate reducta...2502e-43     168     36     57GO:0005829; C:cytosol; IDA:TAIR.
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0006555; P:methionine metabolic process; IEA:InterPro.
8Q9SE94    593   MTHR1_MAIZE Methylenetetrahydrofolate reducta...2504e-47     179     36     59
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0006555; P:methionine metabolic process; IEA:InterPro.
9Q5I598    655   MTHR_BOVIN Methylenetetrahydrofolate reductas...2786e-49     186     37     59
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0006555; P:methionine metabolic process; IEA:InterPro.
10Q9WU20    654   MTHR_MOUSE Methylenetetrahydrofolate reductas...2782e-48     184     37     59
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IMP:MGI.
GO:0009086; P:methionine biosynthetic process; IMP:MGI.
11P42898    656   MTHR_HUMAN Methylenetetrahydrofolate reductas...2722e-49     187     38     60GO:0005829; C:cytosol; TAS:Reactome.
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; TAS:Reactome.::GO:0072341; F:modified amino acid binding; IDA:UniProtKB.
GO:0008015; P:blood circulation; TAS:ProtInc.::GO:0046655; P:folic acid metabolic process; TAS:Reactome.::GO:0050667; P:homocysteine metabolic process; IDA:UniProtKB.
12O67422    296   METF_AQUAE 5,10-methylenetetrahydrofolate red...2841e-51     185     39     56
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
13Q60HE5    656   MTHR_MACFA Methylenetetrahydrofolate reductas...2726e-49     186     38     60
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0006555; P:methionine metabolic process; IEA:InterPro.
14Q17693    663   MTHR_CAEEL Probable methylenetetrahydrofolate...2713e-43     168     35     59
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0006555; P:methionine metabolic process; IEA:InterPro.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.
15O54235    307   METF_STRLI 5,10-methylenetetrahydrofolate red...3016e-41     155     36     53
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
16Q9JZQ3    292   METF_NEIMB 5,10-methylenetetrahydrofolate red...2944e-38     147     33     53
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
17P71319    298   METF_PECCC 5,10-methylenetetrahydrofolate red...2944e-38     147     32     53
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
18P11003    296   METF_SALTY 5,10-methylenetetrahydrofolate red...2966e-36     141     32     53
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
19P0AEZ2    296   METF_SHIFL 5,10-methylenetetrahydrofolate red...2962e-35     139     32     52
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
20P0AEZ1    296   METF_ECOLI 5,10-methylenetetrahydrofolate red...2962e-35     139     32     52
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IDA:EcoCyc.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
21Q89B13    295   METF_BUCBP 5,10-methylenetetrahydrofolate red...2897e-35     138     34     52
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
22P45208    292   METF_HAEIN 5,10-methylenetetrahydrofolate red...2941e-34     137     32     51
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
23P57154    292   METF_BUCAI 5,10-methylenetetrahydrofolate red...2895e-32     130     31     52
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
24Q8KA62    292   METF_BUCAP 5,10-methylenetetrahydrofolate red...2822e-27     117     30     49
GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
25O06745    612   YITJ_BACSU Bifunctional homocysteine S-methyl...1980.0004     47.4     25     42
GO:0008898; F:homocysteine S-methyltransferase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
26P01846    105   LAC_PIG Ig lambda chain C region OS=Sus scrof...640.57     34.7     36     58
GO:0003823; F:antigen binding; IEA:UniProtKB-KW.
27Q9FLQ7    1649   FH20_ARATH Formin-like protein 20 OS=Arabidop...1451.3     36.2     27     47
GO:0003779; F:actin binding; IEA:InterPro.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
28Q5JVS0    413   HABP4_HUMAN Intracellular hyaluronan-binding ...573.3     34.3     30     49GO:0005829; C:cytosol; TAS:Reactome.::GO:0005576; C:extracellular region; TAS:Reactome.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0030017; C:sarcomere; ISS:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.::GO:0043392; P:negative regulation of DNA binding; IDA:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0002576; P:platelet degranulation; TAS:Reactome.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
29Q9ZN34    218   BIOD_HELPJ ATP-dependent dethiobiotin synthet...1185.1     33.1     25     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004141; F:dethiobiotin synthase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO:0009102; P:biotin biosynthetic process; IEA:UniProtKB-KW.
30Q2NVS2    264   SPED_SODGM S-adenosylmethionine decarboxylase...1906.5     33.1     23     43
GO:0004014; F:adenosylmethionine decarboxylase activity; IEA:EC.
GO:0008295; P:spermidine biosynthetic process; IEA:UniProtKB-KW.
records
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