Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPL015C
Length:
357
Number of sequences:
5887
Description:
YPL015C HST2 SGDID:S000005936, Chr XVI from 526883-525810, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
91Q9CBW6    237   NPD_MYCLE NAD-dependent protein deacylase OS=...2176e-17     82.4     32     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
92Q5KZE8    247   NPD2_GEOKA NAD-dependent protein deacetylase ...1826e-17     82.4     31     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
93P66813    237   NPD_MYCTU NAD-dependent protein deacylase OS=...2151e-16     81.6     32     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0003953; F:NAD+ nucleosidase activity; IDA:MTBBASE.::GO:0034979; F:NAD-dependent protein deacetylase activity; IDA:MTBBASE.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070213; P:protein auto-ADP-ribosylation; IDA:MTBBASE.::GO:0006476; P:protein deacetylation; IDA:MTBBASE.
94P66814    237   NPD_MYCBO NAD-dependent protein deacylase OS=...2151e-16     81.6     32     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
95Q9I4E1    256   NPD2_PSEAE NAD-dependent protein deacylase 2 ...2134e-16     80.5     30     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
96Q9RL35    299   NPD1_STRCO NAD-dependent protein deacetylase ...1904e-16     81.3     31     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
97Q72IV5    254   NPD_THET2 NAD-dependent protein deacylase OS=...2185e-16     80.1     31     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
98Q8TWG0    250   NPD_METKA NAD-dependent protein deacylase OS=...2157e-16     79.3     30     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
99Q8R216    333   SIR4_MOUSE NAD-dependent protein deacetylase ...2339e-16     80.5     27     45GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0003950; F:NAD+ ADP-ribosyltransferase activity; ISS:UniProtKB.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0046676; P:negative regulation of insulin secretion; ISS:UniProtKB.::GO:0006476; P:protein deacetylation; IEA:InterPro.
100Q8IRR5    312   SIR4_DROME NAD-dependent protein deacetylase ...2150.000000000000001     80.1     31     47
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
101Q73WM7    237   NPD_MYCPA NAD-dependent protein deacylase OS=...2130.000000000000002     78.2     31     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
102A0QC96    233   NPD2_MYCA1 NAD-dependent protein deacylase 2 ...2100.000000000000002     78.2     31     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
103Q5SIH7    254   NPD_THET8 NAD-dependent protein deacylase OS=...2180.000000000000002     78.2     31     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
104Q89EA6    273   NPD2_BRAJA NAD-dependent protein deacetylase ...2290.000000000000007     77     27     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
105E2RDZ6    310   SIR5_CANFA NAD-dependent protein deacylase si...2800.000000000000007     77.8     29     45
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
106A9SDL4    323   SIR5_PHYPA NAD-dependent protein deacylase OS...2310.00000000000001     77.4     30     43
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
107Q9Y6E7    314   SIR4_HUMAN NAD-dependent protein deacetylase ...2330.00000000000001     77     27     45GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IDA:UniProtKB.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006342; P:chromatin silencing; TAS:ProtInc.::GO:0046676; P:negative regulation of insulin secretion; IMP:UniProtKB.::GO:0006471; P:protein ADP-ribosylation; TAS:BHF-UCL.::GO:0006476; P:protein deacetylation; IEA:InterPro.
108Q8Y015    246   NPD_RALSO NAD-dependent protein deacylase OS=...2510.00000000000002     75.1     29     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
109Q1JQC6    315   SIR4_BOVIN NAD-dependent protein deacetylase ...2330.00000000000003     76.3     27     45GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0003950; F:NAD+ ADP-ribosyltransferase activity; ISS:UniProtKB.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0046676; P:negative regulation of insulin secretion; ISS:UniProtKB.::GO:0006476; P:protein deacetylation; IEA:InterPro.
110Q5AI90    306   SIR5_CANAL NAD-dependent protein deacylase OS...2770.00000000000003     75.9     28     39
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
111Q8PDM9    293   NPD_XANCP NAD-dependent protein deacetylase O...2310.00000000000003     75.5     29     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
112Q4UZX0    293   NPD_XANC8 NAD-dependent protein deacetylase O...2310.00000000000003     75.5     29     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
113Q20480    287   SIR41_CAEEL NAD-dependent protein deacetylase...2810.00000000000004     75.1     25     43
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006974; P:response to DNA damage stimulus; IMP:WormBase.
114Q5A1W9    487   HST3_CANAL NAD-dependent histone deacetylase ...2590.00000000000004     76.6     27     45
GO:0004407; F:histone deacetylase activity; IMP:CGD.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0048869; P:cellular developmental process; IMP:CGD.::GO:0071572; P:histone H3-K56 deacetylation; IMP:CGD.::GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0045595; P:regulation of cell differentiation; IMP:CGD.
115A0QDH4    282   NPD1_MYCA1 NAD-dependent protein deacetylase ...1910.00000000000005     74.7     27     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0019213; F:deacetylase activity; IEA:HAMAP.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:HAMAP.
GO:0006476; P:protein deacetylation; IEA:InterPro.
116Q5R6G3    310   SIR5_PONAB NAD-dependent protein deacylase si...2750.00000000000005     75.1     30     43GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0070403; F:NAD+ binding; ISS:UniProtKB.::GO:0036054; F:protein-malonyllysine demalonylase activity; ISS:UniProtKB.::GO:0036055; F:protein-succinyllysine desuccinylase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0006476; P:protein deacetylation; ISS:UniProtKB.
117E9GD30    274   SIR5_DAPPU NAD-dependent protein deacylase OS...2540.00000000000006     74.3     29     44
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
118B0RM75    293   NPD_XANCB NAD-dependent protein deacetylase O...2310.0000000000001     74.3     29     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
119Q68FX9    310   SIR5_RAT NAD-dependent protein deacylase sirt...2570.0000000000001     74.3     30     43GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0070403; F:NAD+ binding; ISS:UniProtKB.::GO:0036054; F:protein-malonyllysine demalonylase activity; ISS:UniProtKB.::GO:0036055; F:protein-succinyllysine desuccinylase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0006476; P:protein deacetylation; ISS:UniProtKB.
120Q8K2C6    310   SIR5_MOUSE NAD-dependent protein deacylase si...2580.0000000000001     74.3     30     43GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0036054; F:protein-malonyllysine demalonylase activity; IMP:UniProtKB.::GO:0036055; F:protein-succinyllysine desuccinylase activity; IMP:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; ISS:UniProtKB.
121Q9FE17    473   SIR1_ARATH NAD-dependent protein deacetylase ...2830.0000000000001     75.5     27     43
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
records
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