Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPL015C
Length:
357
Number of sequences:
5887
Description:
YPL015C HST2 SGDID:S000005936, Chr XVI from 526883-525810, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31P06700    562   SIR2_YEAST NAD-dependent histone deacetylase ...2921e-33     134     32     45GO:0000783; C:nuclear telomere cap complex; IDA:SGD.::GO:0005724; C:nuclear telomeric heterochromatin; IDA:SGD.::GO:0030869; C:RENT complex; IDA:SGD.
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IDA:SGD.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IDA:SGD.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006333; P:chromatin assembly or disassembly; IDA:SGD.::GO:0000183; P:chromatin silencing at rDNA; IMP:SGD.::GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:SGD.::GO:0006348; P:chromatin silencing at telomere; IMP:SGD.::GO:0001300; P:chronological cell aging; IMP:SGD.::GO:0006303; P:double-strand break repair via nonhomologous end joining; IDA:SGD.::GO:0001308; P:negative regulation of chromatin silencing involved in replicative cell aging; TAS:SGD.::GO:0045910; P:negative regulation of DNA recombination; IGI:SGD.::GO:0008156; P:negative regulation of DNA replication; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
32O94640    475   SIR2_SCHPO NAD-dependent histone deacetylase ...3014e-33     132     32     45GO:0016585; C:chromatin remodeling complex; ISS:PomBase.::GO:0000775; C:chromosome, centromeric region; IDA:PomBase.::GO:0000781; C:chromosome, telomeric region; IDA:PomBase.::GO:0031934; C:mating-type region heterochromatin; IDA:PomBase.::GO:0000790; C:nuclear chromatin; IC:PomBase.
GO:0070403; F:NAD+ binding; IDA:PomBase.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IDA:PomBase.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IDA:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006338; P:chromatin remodeling; ISS:PomBase.::GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:PomBase.::GO:0006348; P:chromatin silencing at telomere; IMP:PomBase.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0000070; P:mitotic sister chromatid segregation; IMP:PomBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEP:PomBase.::GO:0070198; P:protein localization to chromosome, telomeric region; IGI:PomBase.::GO:0051570; P:regulation of histone H3-K9 methylation; IMP:PomBase.::GO:0060303; P:regulation of nucleosome density; IEP:PomBase.::GO:0001302; P:replicative cell aging; ISS:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
33P53685    503   HST1_YEAST NAD-dependent protein deacetylase ...2857e-33     132     31     47GO:0034967; C:Set3 complex; IDA:SGD.
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:SGD.::GO:0045129; F:NAD-independent histone deacetylase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006342; P:chromatin silencing; IMP:SGD.::GO:0045950; P:negative regulation of mitotic recombination; IMP:SGD.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
34Q6FWI7    509   SIR2_CANGA NAD-dependent histone deacetylase ...2651e-31     128     33     45GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006342; P:chromatin silencing; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
35Q73KE1    251   NPD_TREDE NAD-dependent protein deacetylase O...2691e-30     121     34     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
36Q8R984    250   NPD2_THETN NAD-dependent protein deacetylase ...2485e-30     120     32     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
37B5YJW3    256   NPD_THEYD NAD-dependent protein deacetylase O...2067e-27     111     36     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
38Q8ZT00    249   NPD2_PYRAE NAD-dependent protein deacylase 2 ...2591e-25     107     32     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
39Q8ZU41    254   NPD1_PYRAE NAD-dependent protein deacetylase ...2591e-25     107     33     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
40Q97MB4    245   NPD_CLOAB NAD-dependent protein deacetylase O...2253e-25     106     35     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
41O07595    247   NPD_BACSU NAD-dependent protein deacetylase O...2667e-25     105     31     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
42Q97VX5    247   NPD_SULSO NAD-dependent protein deacetylase O...2472e-24     103     30     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
43Q8ELR0    236   NPD_OCEIH NAD-dependent protein deacetylase O...2143e-24     103     31     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
44Q8XNS6    244   NPD_CLOPE NAD-dependent protein deacetylase O...2404e-24     103     33     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
45Q54LF0    778   SIR2B_DICDI NAD-dependent deacetylase sir2B O...2656e-24     107     30     43
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
46A8MBU4    257   NPD_CALMQ NAD-dependent protein deacetylase O...2446e-24     102     32     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
47Q5L014    242   NPD1_GEOKA NAD-dependent protein deacetylase ...2601e-23     102     29     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
48Q974M6    250   NPD_SULTO NAD-dependent protein deacetylase O...2632e-23     101     29     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
49Q67KQ0    251   NPD_SYMTH NAD-dependent protein deacetylase O...2107e-23     99.8     30     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
50Q899G3    247   NPD_CLOTE NAD-dependent protein deacetylase O...2778e-23     99.4     30     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
51Q9UZE7    250   NPD_PYRAB NAD-dependent protein deacylase OS=...2325e-22     97.1     33     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:HAMAP.::GO:0008270; F:zinc ion binding; IEA:HAMAP.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
52Q8REC3    252   NPD_FUSNN NAD-dependent protein deacetylase O...2706e-22     97.1     31     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
53Q4JBN2    252   NPD_SULAC NAD-dependent protein deacetylase O...2367e-22     96.7     30     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
54Q89LY4    254   NPD1_BRAJA NAD-dependent protein deacetylase ...2251e-21     96.3     31     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
55Q6A5T5    244   NPD_PROAC NAD-dependent protein deacetylase O...2462e-21     95.5     32     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
56Q8Y3U2    229   NPD_LISMO NAD-dependent protein deacetylase O...2323e-21     94.4     30     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
57Q5JG47    257   NPD_PYRKO NAD-dependent protein deacylase OS=...2404e-21     94.7     32     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
58Q9YB13    245   NPD_AERPE NAD-dependent protein deacylase OS=...2734e-21     94.4     30     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
59Q71W25    229   NPD_LISMF NAD-dependent protein deacetylase O...2315e-21     94     30     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
60C6A243    255   NPD_THESM NAD-dependent protein deacylase OS=...2148e-21     93.6     32     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
61Q8NSM4    258   NPD_CORGL NAD-dependent protein deacylase OS=...2121e-20     93.6     28     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
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