Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPL015C
Length:
357
Number of sequences:
5887
Description:
YPL015C HST2 SGDID:S000005936, Chr XVI from 526883-525810, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
151Q9UR39    415   HST4_SCHPO NAD-dependent protein deacetylase ...1960.0000000002     65.5     30     45GO:0016585; C:chromatin remodeling complex; ISS:PomBase.::GO:0000790; C:nuclear chromatin; IC:PomBase.::GO:0005730; C:nucleolus; IDA:PomBase.
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; TAS:PomBase.::GO:0003714; F:transcription corepressor activity; IMP:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006338; P:chromatin remodeling; ISS:PomBase.::GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0006348; P:chromatin silencing at telomere; IMP:PomBase.::GO:0071572; P:histone H3-K56 deacetylation; IMP:PomBase.::GO:0000070; P:mitotic sister chromatid segregation; IMP:PomBase.::GO:2000283; P:negative regulation of cellular amino acid biosynthetic process; IMP:PomBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEP:PomBase.::GO:0006282; P:regulation of DNA repair; IMP:PomBase.::GO:0060303; P:regulation of nucleosome density; IEP:PomBase.::GO:0006974; P:response to DNA damage stimulus; IMP:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
152Q57YZ9    306   SIR4_TRYB2 NAD-dependent protein deacetylase ...2660.0000000003     63.9     26     39
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
153Q7UFQ9    239   NPD_RHOBA NAD-dependent protein deacylase OS=...2340.0000000004     62.8     26     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
154Q9VH08    317   SIR6_DROME NAD-dependent protein deacetylase ...2650.0000000004     63.9     27     43
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0008340; P:determination of adult lifespan; IMP:FlyBase.::GO:0006476; P:protein deacetylation; IEA:InterPro.
155A9A0B2    273   NPD_DESOH NAD-dependent protein deacylase OS=...2720.0000000004     63.2     24     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
156Q4Q2Y6    243   SIR5_LEIMA NAD-dependent protein deacetylase ...2170.0000000006     62.4     29     43
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
157P53688    370   HST4_YEAST NAD-dependent histone deacetylase ...2560.0000000007     63.5     27     43GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006348; P:chromatin silencing at telomere; IGI:SGD.::GO:0016575; P:histone deacetylation; IMP:SGD.::GO:0046459; P:short-chain fatty acid metabolic process; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
158Q68F47    309   SIR5B_XENLA NAD-dependent protein deacylase s...2520.000000002     61.6     28     41GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0070403; F:NAD+ binding; ISS:UniProtKB.::GO:0036054; F:protein-malonyllysine demalonylase activity; ISS:UniProtKB.::GO:0036055; F:protein-succinyllysine desuccinylase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
159Q9ZJW8    234   NPD_HELPJ NAD-dependent protein deacylase OS=...2170.000000003     60.1     29     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
160Q9KRX4    246   NPD_VIBCH NAD-dependent protein deacylase OS=...2210.000000005     59.7     29     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
161Q7WLE5    274   NPD_BORBR NAD-dependent protein deacetylase O...2330.000000009     59.3     26     40GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
162Q7VX46    274   NPD_BORPE NAD-dependent protein deacetylase O...2330.00000001     58.9     26     40GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
163Q7MKT7    245   NPD_VIBVY NAD-dependent protein deacylase OS=...2150.00000002     58.2     28     40GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
164Q0P595    400   SIR7_BOVIN NAD-dependent protein deacetylase ...3180.00000002     59.3     25     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005731; C:nucleolus organizer region; ISS:UniProtKB.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007072; P:positive regulation of transcription on exit from mitosis; ISS:UniProtKB.::GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0009303; P:rRNA transcription; ISS:UniProtKB.
165Q88A13    230   NPD1_PSESM NAD-dependent protein deacylase 1 ...2010.00000002     57.8     25     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
166Q8D9J9    245   NPD_VIBVU NAD-dependent protein deacylase OS=...2150.00000002     58.2     28     40GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
167O25849    229   NPD_HELPY NAD-dependent protein deacylase OS=...2170.00000003     57.4     29     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
168Q4QB33    320   SIR4_LEIMA NAD-dependent protein deacetylase ...2500.00000003     58.2     24     38
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
169Q9NRC8    400   SIR7_HUMAN NAD-dependent protein deacetylase ...3150.00000004     58.2     25     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005731; C:nucleolus organizer region; IDA:UniProtKB.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007072; P:positive regulation of transcription on exit from mitosis; IMP:UniProtKB.::GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0009303; P:rRNA transcription; IMP:UniProtKB.
170Q6MJJ2    235   NPD_BDEBA NAD-dependent protein deacylase OS=...2370.00000006     56.2     27     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
171B8ARK7    484   SIR1_ORYSI NAD-dependent protein deacetylase ...2510.00000006     57.8     27     44
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
172Q94AQ6    373   SIR4_ARATH NAD-dependent protein deacetylase ...2110.00000006     57.4     24     40GO:0005634; C:nucleus; IDA:TAIR.
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0042742; P:defense response to bacterium; IMP:TAIR.::GO:0031348; P:negative regulation of defense response; IMP:TAIR.::GO:0006476; P:protein deacetylation; IEA:InterPro.
173Q8BKJ9    402   SIR7_MOUSE NAD-dependent protein deacetylase ...3140.0000002     56.2     25     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005731; C:nucleolus organizer region; ISS:UniProtKB.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007072; P:positive regulation of transcription on exit from mitosis; ISS:UniProtKB.::GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0009303; P:rRNA transcription; ISS:UniProtKB.
174F7D4X9    315   SIR5_MONDO NAD-dependent protein deacylase si...1560.0000002     55.8     31     46
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
175A8NWP2    299   SIR5_COPC7 NAD-dependent protein deacylase OS...2800.0000002     55.5     29     39
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
176Q87PH8    241   NPD_VIBPA NAD-dependent protein deacylase OS=...2190.0000006     53.5     28     39GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
177Q83RR8    236   NPD_SHIFL NAD-dependent protein deacylase OS=...2670.0000006     53.5     28     39GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
178Q9ZAB8    208   NPD_AGGAC NAD-dependent protein deacylase OS=...2200.0000009     52.4     26     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
179P75960    242   NPD_ECOLI NAD-dependent protein deacylase OS=...2670.000002     52.4     28     39GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006935; P:chemotaxis; IMP:EcoCyc.::GO:0006476; P:protein deacetylation; IDA:EcoCyc.
180Q8X8E0    236   NPD_ECO57 NAD-dependent protein deacylase OS=...2670.000002     52     28     39GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
181Q8IE47    273   SIR5_PLAF7 NAD-dependent protein deacylase Si...2210.000002     52.4     23     39
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
records
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