Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YPL015C
Length:
357
Number of sequences:
5887
Description:
YPL015C HST2 SGDID:S000005936, Chr XVI from 526883-525810, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
121Q9FE17    473   SIR1_ARATH NAD-dependent protein deacetylase ...2830.0000000000001     75.5     27     43
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
122Q885X7    248   NPD2_PSESM NAD-dependent protein deacylase 2 ...2450.0000000000001     73.2     28     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
123Q8PQK3    293   NPD_XANAC NAD-dependent protein deacetylase O...2310.0000000000001     73.6     28     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
124F7EZ75    310   SIR5_MACMU NAD-dependent protein deacylase si...2540.0000000000003     73.2     30     43
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
125P59941    334   SIR6_MOUSE NAD-dependent protein deacetylase ...2690.0000000000003     73.6     28     41GO:0005724; C:nuclear telomeric heterochromatin; ISS:UniProtKB.::GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO:0003956; F:NAD(P)+-protein-arginine ADP-ribosyltransferase activity; IDA:UniProtKB.::GO:0070403; F:NAD+ binding; ISS:UniProtKB.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); ISS:UniProtKB.::GO:0005515; F:protein binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0006471; P:protein ADP-ribosylation; IDA:UniProtKB.::GO:0010569; P:regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
126Q8FUC8    281   NPD1_COREF NAD-dependent protein deacetylase ...1990.0000000000003     72.8     28     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
127Q8N6T7    355   SIR6_HUMAN NAD-dependent protein deacetylase ...2690.0000000000003     73.6     27     42GO:0005724; C:nuclear telomeric heterochromatin; IDA:UniProtKB.::GO:0005654; C:nucleoplasm; IDA:UniProtKB.
GO:0003956; F:NAD(P)+-protein-arginine ADP-ribosyltransferase activity; ISS:UniProtKB.::GO:0003950; F:NAD+ ADP-ribosyltransferase activity; TAS:BHF-UCL.::GO:0070403; F:NAD+ binding; ISS:UniProtKB.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0006471; P:protein ADP-ribosylation; ISS:UniProtKB.::GO:0010569; P:regulation of double-strand break repair via homologous recombination; IDA:UniProtKB.
128Q3ZBQ0    310   SIR5_BOVIN NAD-dependent protein deacylase si...2810.0000000000004     72.8     29     43GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0070403; F:NAD+ binding; ISS:UniProtKB.::GO:0036054; F:protein-malonyllysine demalonylase activity; ISS:UniProtKB.::GO:0036055; F:protein-succinyllysine desuccinylase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0006476; P:protein deacetylation; ISS:UniProtKB.
129Q88ZA0    234   NPD_LACPL NAD-dependent protein deacetylase O...2270.0000000000004     71.2     29     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
130Q5WKC8    237   NPD_BACSK NAD-dependent protein deacetylase O...2460.0000000000004     71.2     27     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
131Q9NXA8    310   SIR5_HUMAN NAD-dependent protein deacylase si...2540.0000000000005     72.4     30     43GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.::GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0003950; F:NAD+ ADP-ribosyltransferase activity; TAS:ProtInc.::GO:0070403; F:NAD+ binding; IDA:UniProtKB.::GO:0036054; F:protein-malonyllysine demalonylase activity; IDA:UniProtKB.::GO:0036055; F:protein-succinyllysine desuccinylase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006342; P:chromatin silencing; TAS:ProtInc.::GO:0006471; P:protein ADP-ribosylation; TAS:ProtInc.::GO:0006476; P:protein deacetylation; IDA:UniProtKB.
132Q607X6    255   NPD_METCA NAD-dependent protein deacylase OS=...2240.000000000002     70.1     28     40GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
133Q6DHI5    305   SIR5_DANRE NAD-dependent protein deacylase si...2520.000000000003     70.1     29     41GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0070403; F:NAD+ binding; ISS:UniProtKB.::GO:0036054; F:protein-malonyllysine demalonylase activity; ISS:UniProtKB.::GO:0036055; F:protein-succinyllysine desuccinylase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
134F4P804    305   SIR4_BATDJ NAD-dependent protein deacetylase ...2450.000000000003     70.1     26     44
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
135Q5V4Q5    260   NPD_HALMA NAD-dependent protein deacetylase O...2160.000000000004     69.3     30     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
136Q20481    287   SIR42_CAEEL NAD-dependent protein deacetylase...2820.000000000005     69.3     26     41
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0040011; P:locomotion; IMP:WormBase.::GO:0006476; P:protein deacetylation; IEA:InterPro.
137E1BRE2    309   SIR5_CHICK NAD-dependent protein deacylase si...2530.000000000007     68.9     28     42
GO:0070403; F:NAD+ binding; ISS:UniProtKB.::GO:0036054; F:protein-malonyllysine demalonylase activity; ISS:UniProtKB.::GO:0036055; F:protein-succinyllysine desuccinylase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
138Q584D5    244   SIR5_TRYB2 NAD-dependent protein deacetylase ...2630.000000000007     68.2     30     41
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
139F7DKV7    309   SIR5_XENTR NAD-dependent protein deacylase si...2520.000000000007     68.9     29     42GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0070403; F:NAD+ binding; ISS:UniProtKB.::GO:0036054; F:protein-malonyllysine demalonylase activity; ISS:UniProtKB.::GO:0036055; F:protein-succinyllysine desuccinylase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
140P53687    447   HST3_YEAST NAD-dependent histone deacetylase ...2770.000000000008     69.7     23     40GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IC:SGD.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006348; P:chromatin silencing at telomere; IGI:SGD.::GO:0016575; P:histone deacetylation; IMP:SGD.::GO:0046459; P:short-chain fatty acid metabolic process; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
141Q9CM50    234   NPD_PASMU NAD-dependent protein deacylase OS=...2210.00000000001     67.4     30     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
142Q5HZN8    309   SIR5A_XENLA NAD-dependent protein deacylase s...2520.00000000001     68.6     29     43GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0070403; F:NAD+ binding; ISS:UniProtKB.::GO:0036054; F:protein-malonyllysine demalonylase activity; ISS:UniProtKB.::GO:0036055; F:protein-succinyllysine desuccinylase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
143Q9RYD4    246   NPD_DEIRA NAD-dependent protein deacylase OS=...2270.00000000001     67.4     30     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
144Q8F3Z6    246   NPD_LEPIN NAD-dependent protein deacylase OS=...1680.00000000002     66.6     30     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
145Q9I4L0    250   NPD1_PSEAE NAD-dependent protein deacylase 1 ...2130.00000000002     66.6     27     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
146A9UVV1    308   SIR4_MONBE NAD-dependent protein deacetylase ...2360.00000000003     67.4     27     39
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
147Q72RR0    246   NPD_LEPIC NAD-dependent protein deacylase OS=...1680.00000000003     66.2     30     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
148Q87W79    256   NPD4_PSESM NAD-dependent protein deacylase 4 ...2530.00000000006     65.5     26     40GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
149Q5BE04    595   HST4_EMENI NAD-dependent protein deacetylase ...3870.00000000007     67     26     42
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
150Q8A3H9    234   NPD_BACTN NAD-dependent protein deacylase OS=...2260.0000000001     63.9     28     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006476; P:protein deacetylation; IEA:InterPro.
151Q9UR39    415   HST4_SCHPO NAD-dependent protein deacetylase ...1960.0000000002     65.5     30     45GO:0016585; C:chromatin remodeling complex; ISS:PomBase.::GO:0000790; C:nuclear chromatin; IC:PomBase.::GO:0005730; C:nucleolus; IDA:PomBase.
GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; TAS:PomBase.::GO:0003714; F:transcription corepressor activity; IMP:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006338; P:chromatin remodeling; ISS:PomBase.::GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0006348; P:chromatin silencing at telomere; IMP:PomBase.::GO:0071572; P:histone H3-K56 deacetylation; IMP:PomBase.::GO:0000070; P:mitotic sister chromatid segregation; IMP:PomBase.::GO:2000283; P:negative regulation of cellular amino acid biosynthetic process; IMP:PomBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEP:PomBase.::GO:0006282; P:regulation of DNA repair; IMP:PomBase.::GO:0060303; P:regulation of nucleosome density; IEP:PomBase.::GO:0006974; P:response to DNA damage stimulus; IMP:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
records
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