rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | P51911 | 297 | CNN1_HUMAN Calponin-1 OS=Homo sapiens (Human)... | 189 | 0.00000005 | 55.1 | 26 | 44 | GO:0005856; C:cytoskeleton; IDA:MGI. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0031032; P:actomyosin structure organization; IEA:InterPro.::GO:0006940; P:regulation of smooth muscle contraction; TAS:UniProtKB. | 32 | P37397 | 330 | CNN3_RAT Calponin-3 OS=Rattus norvegicus (Rat... | 199 | 0.00000008 | 54.7 | 26 | 44 | GO:0005884; C:actin filament; TAS:RGD.::GO:0005874; C:microtubule; TAS:RGD.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0014069; C:postsynaptic density; IDA:RGD. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; IDA:RGD.::GO:0030674; F:protein binding, bridging; NAS:RGD. | | | | | | | | | | GO:0031032; P:actomyosin structure organization; IEA:InterPro.::GO:0032780; P:negative regulation of ATPase activity; IDA:RGD. | 33 | Q9DAW9 | 330 | CNN3_MOUSE Calponin-3 OS=Mus musculus (Mouse)... | 199 | 0.0000001 | 54.3 | 26 | 44 | | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0031032; P:actomyosin structure organization; IEA:InterPro. | 34 | Q5RFN6 | 309 | CNN2_PONAB Calponin-2 OS=Pongo abelii (Sumatr... | 147 | 0.0000003 | 52.8 | 27 | 45 | | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0031032; P:actomyosin structure organization; IEA:InterPro. | 35 | Q99439 | 309 | CNN2_HUMAN Calponin-2 OS=Homo sapiens (Human)... | 147 | 0.0000003 | 52.8 | 27 | 45 | GO:0005911; C:cell-cell junction; TAS:ProtInc.::GO:0001725; C:stress fiber; IDA:MGI. | | | | | | | | | | GO:0003779; F:actin binding; TAS:ProtInc.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0031032; P:actomyosin structure organization; IEA:InterPro.::GO:0071260; P:cellular response to mechanical stimulus; IDA:MGI.::GO:0032970; P:regulation of actin filament-based process; IDA:MGI. | 36 | Q3SYU6 | 309 | CNN2_BOVIN Calponin-2 OS=Bos taurus (Bovine).... | 147 | 0.000002 | 50.8 | 26 | 45 | | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0031032; P:actomyosin structure organization; IEA:InterPro. | 37 | Q9UKW4 | 847 | VAV3_HUMAN Guanine nucleotide exchange factor... | 87 | 0.000002 | 50.8 | 34 | 54 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005096; F:GTPase activator activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0050853; P:B cell receptor signaling pathway; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0030890; P:positive regulation of B cell proliferation; IMP:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0006974; P:response to DNA damage stimulus; IMP:UniProtKB.::GO:0042493; P:response to drug; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 38 | Q08093 | 305 | CNN2_MOUSE Calponin-2 OS=Mus musculus (Mouse)... | 147 | 0.000002 | 50.4 | 27 | 44 | | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0031032; P:actomyosin structure organization; IEA:InterPro.::GO:0030097; P:hemopoiesis; IMP:MGI.::GO:0030336; P:negative regulation of cell migration; IMP:MGI.::GO:0050765; P:negative regulation of phagocytosis; IMP:MGI.::GO:0010628; P:positive regulation of gene expression; IMP:MGI.::GO:0042127; P:regulation of cell proliferation; IMP:MGI.::GO:0042060; P:wound healing; IMP:MGI. | 39 | Q08094 | 296 | CNN2_PIG Calponin-2 OS=Sus scrofa (Pig). GN=C... | 147 | 0.000006 | 49.3 | 27 | 44 | | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0031032; P:actomyosin structure organization; IEA:InterPro. | 40 | Q9R0C8 | 847 | VAV3_MOUSE Guanine nucleotide exchange factor... | 87 | 0.00002 | 47.8 | 33 | 53 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005154; F:epidermal growth factor receptor binding; IPI:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IGI:MGI. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; IGI:MGI.::GO:0007229; P:integrin-mediated signaling pathway; IGI:MGI.::GO:0030032; P:lamellipodium assembly; IGI:MGI.::GO:0045785; P:positive regulation of cell adhesion; IGI:MGI.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IGI:MGI.::GO:0043087; P:regulation of GTPase activity; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI.::GO:0006906; P:vesicle fusion; IGI:MGI. | 41 | Q12280 | 1495 | IQG1_YEAST Ras GTPase-activating-like protein... | 123 | 0.0002 | 45.1 | 29 | 46 | GO:0000142; C:cellular bud neck contractile ring; TAS:SGD. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | GO:0007015; P:actin filament organization; IPI:SGD.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0000910; P:cytokinesis; IMP:SGD.::GO:0006970; P:response to osmotic stress; TAS:SGD.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 42 | Q3UWW6 | 683 | GA2L3_MOUSE GAS2-like protein 3 OS=Mus muscul... | 145 | 0.0003 | 44.3 | 28 | 44 | | | | | | | | | | | | | | | | | | | | | GO:0007050; P:cell cycle arrest; IEA:InterPro. | 43 | O43903 | 313 | GAS2_HUMAN Growth arrest-specific protein 2 O... | 122 | 0.001 | 42.4 | 30 | 46 | GO:0005884; C:actin filament; TAS:ProtInc.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.::GO:0006921; P:cellular component disassembly involved in apoptotic process; TAS:Reactome.::GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. | 44 | P11862 | 314 | GAS2_MOUSE Growth arrest-specific protein 2 O... | 122 | 0.002 | 42 | 30 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.::GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. | 45 | P52735 | 878 | VAV2_HUMAN Guanine nucleotide exchange factor... | 100 | 0.002 | 42.4 | 30 | 47 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 46 | Q60992 | 868 | VAV2_MOUSE Guanine nucleotide exchange factor... | 100 | 0.002 | 42 | 30 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005154; F:epidermal growth factor receptor binding; IPI:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; IGI:MGI.::GO:0030032; P:lamellipodium assembly; IGI:MGI.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI. | 47 | Q13576 | 1575 | IQGA2_HUMAN Ras GTPase-activating-like protei... | 137 | 0.003 | 41.6 | 23 | 47 | GO:0015629; C:actin cytoskeleton; TAS:ProtInc. | | | | | | | | | | GO:0003779; F:actin binding; TAS:ProtInc.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 48 | Q3UQ44 | 1575 | IQGA2_MOUSE Ras GTPase-activating-like protei... | 137 | 0.003 | 41.6 | 23 | 47 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005902; C:microvillus; IDA:MGI. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 49 | Q86XJ1 | 694 | GA2L3_HUMAN GAS2-like protein 3 OS=Homo sapie... | 102 | 0.007 | 40.4 | 28 | 47 | | | | | | | | | | | | | | | | | | | | | GO:0007050; P:cell cycle arrest; IEA:InterPro. | 50 | Q8NHY3 | 880 | GA2L2_HUMAN GAS2-like protein 2 OS=Homo sapie... | 120 | 0.008 | 40.4 | 28 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:UniProtKB.::GO:0008093; F:cytoskeletal adaptor activity; IDA:UniProtKB.::GO:0008017; F:microtubule binding; IDA:UniProtKB. | | | | | | | | | | GO:0007050; P:cell cycle arrest; IEA:InterPro.::GO:0001578; P:microtubule bundle formation; IMP:UniProtKB.::GO:0007026; P:negative regulation of microtubule depolymerization; IMP:UniProtKB. | 51 | Q86VI3 | 1631 | IQGA3_HUMAN Ras GTPase-activating-like protei... | 112 | 0.008 | 40.4 | 22 | 49 | | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | | 52 | Q96II8 | 777 | LRCH3_HUMAN Leucine-rich repeat and calponin ... | 102 | 0.01 | 40 | 30 | 47 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 53 | Q5ZLR6 | 764 | ARHG6_CHICK Rho guanine nucleotide exchange f... | 119 | 0.017 | 39.3 | 33 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 54 | Q5SSG4 | 860 | GA2L2_MOUSE GAS2-like protein 2 OS=Mus muscul... | 120 | 0.018 | 39.3 | 30 | 42 | GO:0005737; C:cytoplasm; ISS:UniProtKB. | | | | | | | | | | GO:0051015; F:actin filament binding; ISS:UniProtKB.::GO:0008093; F:cytoskeletal adaptor activity; ISS:UniProtKB.::GO:0008017; F:microtubule binding; ISS:UniProtKB. | | | | | | | | | | GO:0007050; P:cell cycle arrest; IEA:InterPro.::GO:0001578; P:microtubule bundle formation; ISS:UniProtKB.::GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB. | 55 | Q55GV9 | 686 | LIMCH_DICDI Calponin homology and LIM domain-... | 125 | 0.02 | 38.9 | 28 | 45 | GO:0030863; C:cortical cytoskeleton; IDA:dictyBase.::GO:0005829; C:cytosol; IDA:dictyBase.::GO:0001891; C:phagocytic cup; IDA:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; ISS:dictyBase. | | | | | | | | | | GO:0046847; P:filopodium assembly; IMP:dictyBase.::GO:0050765; P:negative regulation of phagocytosis; IMP:dictyBase.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW. | 56 | O14188 | 1489 | RNG2_SCHPO Ras GTPase-activating-like protein... | 112 | 0.021 | 38.9 | 25 | 44 | GO:0005826; C:actomyosin contractile ring; IDA:PomBase.::GO:0030428; C:cell septum; IDA:UniProtKB.::GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.::GO:0005816; C:spindle pole body; IDA:UniProtKB. | | | | | | | | | | GO:0003779; F:actin binding; IDA:PomBase.::GO:0005516; F:calmodulin binding; IPI:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | GO:0071519; P:actin filament bundle assembly involved in actomyosin contractile ring formation; IDA:PomBase.::GO:0071520; P:actin filament bundle convergence involved in actomyosin contractile ring formation; IDA:PomBase.::GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 57 | Q45FX5 | 1007 | VAV_CAEEL Protein vav-1 OS=Caenorhabditis ele... | 91 | 0.021 | 38.9 | 33 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0045746; P:negative regulation of Notch signaling pathway; IGI:WormBase.::GO:0040027; P:negative regulation of vulval development; IMP:WormBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 58 | Q8BVU0 | 778 | LRCH3_MOUSE Leucine-rich repeat and calponin ... | 98 | 0.021 | 38.9 | 31 | 47 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 59 | P41737 | 251 | LRCH1_FELCA Leucine-rich repeat and calponin ... | 121 | 0.029 | 38.1 | 30 | 43 | | | | | | | | | | | | | | | | | | | | | | 60 | Q9JKF1 | 1657 | IQGA1_MOUSE Ras GTPase-activating-like protei... | 112 | 0.042 | 38.1 | 21 | 49 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0036057; C:slit diaphragm; ISS:UniProtKB. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 61 | P46940 | 1657 | IQGA1_HUMAN Ras GTPase-activating-like protei... | 112 | 0.052 | 37.7 | 21 | 49 | GO:0005884; C:actin filament; TAS:ProtInc.::GO:0005737; C:cytoplasm; IDA:HPA.::GO:0030496; C:midbody; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0036057; C:slit diaphragm; ISS:UniProtKB. | | | | | | | | | | GO:0005516; F:calmodulin binding; TAS:ProtInc.::GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.::GO:0019903; F:protein phosphatase binding; IPI:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.::GO:0050796; P:regulation of insulin secretion; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. |