Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOR360C
Length:
526
Number of sequences:
5887
Description:
YOR360C PDE2 SGDID:S000005887, Chr XV from 1014821-1013241, Genome Release 64-1-1, reverse complement, Verified ORF, "High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
61Q8VID6    935   PDE11_RAT Dual 3',5'-cyclic-AMP and -GMP phos...3280.000000003     63.5     24     42GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0043204; C:perikaryon; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030552; F:cAMP binding; IDA:RGD.::GO:0030553; F:cGMP binding; IDA:RGD.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; IDA:RGD.::GO:0046069; P:cGMP catabolic process; IDA:RGD.::GO:0007165; P:signal transduction; IEA:InterPro.
62Q86H13    1039   PDE4_DICDI cAMP-specific 3',5'-cAMP phosphodi...1770.00000001     61.6     29     45GO:0005576; C:extracellular region; TAS:dictyBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005624; C:membrane fraction; IDA:dictyBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IMP:dictyBase.::GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; IMP:dictyBase.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase.
63Q14123    709   PDE1C_HUMAN Calcium/calmodulin-dependent 3',5...3180.00000001     61.2     25     42GO:0005829; C:cytosol; TAS:Reactome.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.
64Q9HCR9    933   PDE11_HUMAN Dual 3',5'-cyclic-AMP and -GMP ph...3240.00000002     61.2     23     40GO:0005829; C:cytosol; TAS:Reactome.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; IDA:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007165; P:signal transduction; TAS:ProtInc.
65Q9VJ79    1451   PDE11_DROME Dual 3',5'-cyclic-AMP and -GMP ph...2910.00000003     60.5     23     45
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:UniProtKB.::GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0046058; P:cAMP metabolic process; IDA:UniProtKB.::GO:0046068; P:cGMP metabolic process; IDA:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
66O18696    664   PDE1_CAEEL Probable 3',5'-cyclic phosphodiest...2300.00000003     59.7     25     43
GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0005516; F:calmodulin binding; IPI:WormBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
67B4NAL6    1127   PDE6_DROWI cGMP-specific 3',5'-cyclic phospho...2140.0000003     57     24     43GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
68B4LVU6    893   PDE6_DROVI cGMP-specific 3',5'-cyclic phospho...2140.0000003     57     24     43GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
69B4K9L4    1116   PDE6_DROMO cGMP-specific 3',5'-cyclic phospho...2140.0000004     57     24     43GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
70Q1KKS3    903   PDE11_TAKRU Dual 3',5'-cyclic-AMP and -GMP ph...2420.0000004     56.6     26     42GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
71B4JXX2    1078   PDE6_DROGR cGMP-specific 3',5'-cyclic phospho...2140.0000006     56.2     24     43GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
72B3LVW5    1158   PDE6_DROAN cGMP-specific 3',5'-cyclic phospho...2140.0000008     55.5     23     43GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
73B3P3K2    1131   PDE6_DROER cGMP-specific 3',5'-cyclic phospho...2140.0000009     55.5     23     43GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
74B4PSS5    1149   PDE6_DROYA cGMP-specific 3',5'-cyclic phospho...2140.0000009     55.5     23     43GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
75B4QZU1    1143   PDE6_DROSI cGMP-specific 3',5'-cyclic phospho...2140.0000009     55.5     23     43GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
76Q9VFI9    1118   PDE6_DROME cGMP-specific 3',5'-cyclic phospho...2140.000001     55.5     23     43GO:0016324; C:apical plasma membrane; IDA:FlyBase.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0046068; P:cGMP metabolic process; IDA:UniProtKB.::GO:0032240; P:negative regulation of nucleobase-containing compound transport; IMP:FlyBase.::GO:0007165; P:signal transduction; IEA:InterPro.
77Q8I0P7    625   PDE3_CAEEL Probable 3',5'-cyclic phosphodiest...2170.000001     54.7     26     43
GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
78P30645    831   PDE2_CAEEL Probable 3',5'-cyclic phosphodiest...2160.000004     53.5     28     47
GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
79Q9QYJ6    794   PDE10_RAT cAMP and cAMP-inhibited cGMP 3',5'-...3000.00002     51.2     24     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0043204; C:perikaryon; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030552; F:cAMP binding; IDA:RGD.::GO:0030553; F:cGMP binding; IDA:RGD.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; IDA:RGD.::GO:0046069; P:cGMP catabolic process; IDA:RGD.::GO:0007165; P:signal transduction; IEA:InterPro.
80Q8CA95    790   PDE10_MOUSE cAMP and cAMP-inhibited cGMP 3',5...3000.00002     51.2     24     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030552; F:cAMP binding; ISS:UniProtKB.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
81Q9Y233    779   PDE10_HUMAN cAMP and cAMP-inhibited cGMP 3',5...3020.00002     50.8     24     40GO:0005829; C:cytosol; TAS:Reactome.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030552; F:cAMP binding; IDA:UniProtKB.::GO:0030553; F:cGMP binding; NAS:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007165; P:signal transduction; IEA:InterPro.
82Q01062    928   PDE2A_RAT cGMP-dependent 3',5'-cyclic phospho...2750.0001     48.5     24     41GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0042734; C:presynaptic membrane; ISS:UniProtKB.
GO:0030552; F:cAMP binding; IDA:RGD.::GO:0030553; F:cGMP binding; IDA:RGD.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:RGD.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IDA:RGD.
GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0071321; P:cellular response to cGMP; ISS:UniProtKB.::GO:0035690; P:cellular response to drug; ISS:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.::GO:0046069; P:cGMP catabolic process; IDA:RGD.::GO:0019934; P:cGMP-mediated signaling; ISS:UniProtKB.::GO:0061028; P:establishment of endothelial barrier; IDA:UniProtKB.::GO:0030818; P:negative regulation of cAMP biosynthetic process; IMP:UniProtKB.::GO:0033159; P:negative regulation of protein import into nucleus, translocation; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043116; P:negative regulation of vascular permeability; ISS:UniProtKB.::GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; ISS:UniProtKB.::GO:0006626; P:protein targeting to mitochondrion; IMP:UniProtKB.
83O00408    941   PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosp...2780.0001     48.5     24     42GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0042734; C:presynaptic membrane; ISS:UniProtKB.
GO:0005262; F:calcium channel activity; TAS:UniProtKB.::GO:0030552; F:cAMP binding; IMP:UniProtKB.::GO:0030553; F:cGMP binding; IDA:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.::GO:0008144; F:drug binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0030911; F:TPR domain binding; IPI:UniProtKB.
GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0071321; P:cellular response to cGMP; IDA:UniProtKB.::GO:0035690; P:cellular response to drug; IMP:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IDA:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; IDA:UniProtKB.::GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.::GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:UniProtKB.::GO:0046069; P:cGMP catabolic process; IDA:UniProtKB.::GO:0019934; P:cGMP-mediated signaling; IMP:UniProtKB.::GO:0061028; P:establishment of endothelial barrier; ISS:UniProtKB.::GO:0030224; P:monocyte differentiation; IEP:UniProtKB.::GO:0030818; P:negative regulation of cAMP biosynthetic process; ISS:UniProtKB.::GO:0033159; P:negative regulation of protein import into nucleus, translocation; IDA:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043116; P:negative regulation of vascular permeability; IMP:UniProtKB.::GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; IMP:UniProtKB.::GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
84Q922S4    916   PDE2A_MOUSE cGMP-dependent 3',5'-cyclic phosp...2750.0002     48.1     24     41GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0042734; C:presynaptic membrane; IDA:UniProtKB.
GO:0030552; F:cAMP binding; IMP:UniProtKB.::GO:0030553; F:cGMP binding; IDA:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0036004; F:GAF domain binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0006198; P:cAMP catabolic process; IMP:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0071321; P:cellular response to cGMP; ISS:UniProtKB.::GO:0035690; P:cellular response to drug; ISS:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0071222; P:cellular response to lipopolysaccharide; IEP:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0071260; P:cellular response to mechanical stimulus; IDA:UniProtKB.::GO:0046069; P:cGMP catabolic process; IMP:UniProtKB.::GO:0019934; P:cGMP-mediated signaling; ISS:UniProtKB.::GO:0061028; P:establishment of endothelial barrier; ISS:UniProtKB.::GO:0030818; P:negative regulation of cAMP biosynthetic process; IMP:UniProtKB.::GO:0033159; P:negative regulation of protein import into nucleus, translocation; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043116; P:negative regulation of vascular permeability; ISS:UniProtKB.::GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.::GO:0050729; P:positive regulation of inflammatory response; IMP:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; ISS:UniProtKB.::GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
85P14099    921   PDE2A_BOVIN cGMP-dependent 3',5'-cyclic phosp...2780.0003     47.8     24     41GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0042734; C:presynaptic membrane; ISS:UniProtKB.
GO:0030553; F:cGMP binding; ISS:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; ISS:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; ISS:UniProtKB.::GO:0071321; P:cellular response to cGMP; ISS:UniProtKB.::GO:0035690; P:cellular response to drug; ISS:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.::GO:0046069; P:cGMP catabolic process; ISS:UniProtKB.::GO:0019934; P:cGMP-mediated signaling; ISS:UniProtKB.::GO:0061028; P:establishment of endothelial barrier; ISS:UniProtKB.::GO:0046038; P:GMP catabolic process; TAS:AgBase.::GO:0030818; P:negative regulation of cAMP biosynthetic process; ISS:UniProtKB.::GO:0033159; P:negative regulation of protein import into nucleus, translocation; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043116; P:negative regulation of vascular permeability; ISS:UniProtKB.::GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; ISS:UniProtKB.::GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
86Q9Z0X4    1141   PDE3A_MOUSE cGMP-inhibited 3',5'-cyclic phosp...2860.0006     46.2     23     35GO:0005626; C:insoluble fraction; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005625; C:soluble fraction; IDA:MGI.
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0001556; P:oocyte maturation; IDA:MGI.::GO:0060282; P:positive regulation of oocyte development; IGI:MGI.::GO:0040020; P:regulation of meiosis; IDA:MGI.::GO:0042493; P:response to drug; IDA:MGI.
87Q62865    1141   PDE3A_RAT cGMP-inhibited 3',5'-cyclic phospho...2860.0008     46.2     23     35GO:0005829; C:cytosol; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:RGD.::GO:0030552; F:cAMP binding; IDA:RGD.::GO:0004119; F:cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; IDA:RGD.::GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.::GO:0001556; P:oocyte maturation; IEP:RGD.::GO:0051591; P:response to cAMP; IEP:RGD.
88P91119    728   PDE5_CAEEL Probable 3',5'-cyclic phosphodiest...1750.001     45.1     27     45
GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0000003; P:reproduction; IMP:WormBase.::GO:0007165; P:signal transduction; IEA:InterPro.
89Q13370    1112   PDE3B_HUMAN cGMP-inhibited 3',5'-cyclic phosp...2400.003     44.3     23     35GO:0005829; C:cytosol; TAS:Reactome.::GO:0005783; C:endoplasmic reticulum; ISS:BHF-UCL.::GO:0005794; C:Golgi apparatus; ISS:BHF-UCL.::GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:BHF-UCL.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; ISS:BHF-UCL.
GO:0004119; F:cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0043422; F:protein kinase B binding; ISS:BHF-UCL.
GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006198; P:cAMP catabolic process; IEP:BHF-UCL.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0043951; P:negative regulation of cAMP-mediated signaling; IC:BHF-UCL.::GO:0033629; P:negative regulation of cell adhesion mediated by integrin; IC:BHF-UCL.::GO:0050995; P:negative regulation of lipid catabolic process; IMP:BHF-UCL.
90Q61409    1100   PDE3B_MOUSE cGMP-inhibited 3',5'-cyclic phosp...2400.005     43.5     23     35GO:0005829; C:cytosol; TAS:Reactome.::GO:0005783; C:endoplasmic reticulum; IDA:BHF-UCL.::GO:0005794; C:Golgi apparatus; IDA:BHF-UCL.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:BHF-UCL.
GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0043422; F:protein kinase B binding; IPI:BHF-UCL.
GO:0032869; P:cellular response to insulin stimulus; IEP:BHF-UCL.::GO:0031018; P:endocrine pancreas development; IDA:MGI.::GO:0042593; P:glucose homeostasis; IDA:MGI.::GO:0050796; P:regulation of insulin secretion; IDA:MGI.::GO:0007165; P:signal transduction; IEA:InterPro.
91Q14432    1141   PDE3A_HUMAN cGMP-inhibited 3',5'-cyclic phosp...3300.01     42.4     24     37GO:0005829; C:cytosol; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004119; F:cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0071321; P:cellular response to cGMP; IDA:UniProtKB.::GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:UniProtKB.::GO:0019934; P:cGMP-mediated signaling; IMP:UniProtKB.::GO:0006629; P:lipid metabolic process; TAS:ProtInc.::GO:0043116; P:negative regulation of vascular permeability; IMP:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; IMP:UniProtKB.
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