rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | Q8VID6 | 935 | PDE11_RAT Dual 3',5'-cyclic-AMP and -GMP phos... | 328 | 0.000000003 | 63.5 | 24 | 42 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0043204; C:perikaryon; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030552; F:cAMP binding; IDA:RGD.::GO:0030553; F:cGMP binding; IDA:RGD.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IDA:RGD.::GO:0046069; P:cGMP catabolic process; IDA:RGD.::GO:0007165; P:signal transduction; IEA:InterPro. | 62 | Q86H13 | 1039 | PDE4_DICDI cAMP-specific 3',5'-cAMP phosphodi... | 177 | 0.00000001 | 61.6 | 29 | 45 | GO:0005576; C:extracellular region; TAS:dictyBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005624; C:membrane fraction; IDA:dictyBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IMP:dictyBase.::GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IMP:dictyBase.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase. | 63 | Q14123 | 709 | PDE1C_HUMAN Calcium/calmodulin-dependent 3',5... | 318 | 0.00000001 | 61.2 | 25 | 42 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome. | 64 | Q9HCR9 | 933 | PDE11_HUMAN Dual 3',5'-cyclic-AMP and -GMP ph... | 324 | 0.00000002 | 61.2 | 23 | 40 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; IDA:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007165; P:signal transduction; TAS:ProtInc. | 65 | Q9VJ79 | 1451 | PDE11_DROME Dual 3',5'-cyclic-AMP and -GMP ph... | 291 | 0.00000003 | 60.5 | 23 | 45 | | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:UniProtKB.::GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046058; P:cAMP metabolic process; IDA:UniProtKB.::GO:0046068; P:cGMP metabolic process; IDA:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 66 | O18696 | 664 | PDE1_CAEEL Probable 3',5'-cyclic phosphodiest... | 230 | 0.00000003 | 59.7 | 25 | 43 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0005516; F:calmodulin binding; IPI:WormBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 67 | B4NAL6 | 1127 | PDE6_DROWI cGMP-specific 3',5'-cyclic phospho... | 214 | 0.0000003 | 57 | 24 | 43 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 68 | B4LVU6 | 893 | PDE6_DROVI cGMP-specific 3',5'-cyclic phospho... | 214 | 0.0000003 | 57 | 24 | 43 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 69 | B4K9L4 | 1116 | PDE6_DROMO cGMP-specific 3',5'-cyclic phospho... | 214 | 0.0000004 | 57 | 24 | 43 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 70 | Q1KKS3 | 903 | PDE11_TAKRU Dual 3',5'-cyclic-AMP and -GMP ph... | 242 | 0.0000004 | 56.6 | 26 | 42 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 71 | B4JXX2 | 1078 | PDE6_DROGR cGMP-specific 3',5'-cyclic phospho... | 214 | 0.0000006 | 56.2 | 24 | 43 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 72 | B3LVW5 | 1158 | PDE6_DROAN cGMP-specific 3',5'-cyclic phospho... | 214 | 0.0000008 | 55.5 | 23 | 43 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 73 | B3P3K2 | 1131 | PDE6_DROER cGMP-specific 3',5'-cyclic phospho... | 214 | 0.0000009 | 55.5 | 23 | 43 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 74 | B4PSS5 | 1149 | PDE6_DROYA cGMP-specific 3',5'-cyclic phospho... | 214 | 0.0000009 | 55.5 | 23 | 43 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 75 | B4QZU1 | 1143 | PDE6_DROSI cGMP-specific 3',5'-cyclic phospho... | 214 | 0.0000009 | 55.5 | 23 | 43 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 76 | Q9VFI9 | 1118 | PDE6_DROME cGMP-specific 3',5'-cyclic phospho... | 214 | 0.000001 | 55.5 | 23 | 43 | GO:0016324; C:apical plasma membrane; IDA:FlyBase. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0046068; P:cGMP metabolic process; IDA:UniProtKB.::GO:0032240; P:negative regulation of nucleobase-containing compound transport; IMP:FlyBase.::GO:0007165; P:signal transduction; IEA:InterPro. | 77 | Q8I0P7 | 625 | PDE3_CAEEL Probable 3',5'-cyclic phosphodiest... | 217 | 0.000001 | 54.7 | 26 | 43 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 78 | P30645 | 831 | PDE2_CAEEL Probable 3',5'-cyclic phosphodiest... | 216 | 0.000004 | 53.5 | 28 | 47 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 79 | Q9QYJ6 | 794 | PDE10_RAT cAMP and cAMP-inhibited cGMP 3',5'-... | 300 | 0.00002 | 51.2 | 24 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0043204; C:perikaryon; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030552; F:cAMP binding; IDA:RGD.::GO:0030553; F:cGMP binding; IDA:RGD.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IDA:RGD.::GO:0046069; P:cGMP catabolic process; IDA:RGD.::GO:0007165; P:signal transduction; IEA:InterPro. | 80 | Q8CA95 | 790 | PDE10_MOUSE cAMP and cAMP-inhibited cGMP 3',5... | 300 | 0.00002 | 51.2 | 24 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030552; F:cAMP binding; ISS:UniProtKB.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 81 | Q9Y233 | 779 | PDE10_HUMAN cAMP and cAMP-inhibited cGMP 3',5... | 302 | 0.00002 | 50.8 | 24 | 40 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030552; F:cAMP binding; IDA:UniProtKB.::GO:0030553; F:cGMP binding; NAS:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007165; P:signal transduction; IEA:InterPro. | 82 | Q01062 | 928 | PDE2A_RAT cGMP-dependent 3',5'-cyclic phospho... | 275 | 0.0001 | 48.5 | 24 | 41 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0042734; C:presynaptic membrane; ISS:UniProtKB. | | | | | | | | | | GO:0030552; F:cAMP binding; IDA:RGD.::GO:0030553; F:cGMP binding; IDA:RGD.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:RGD.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IDA:RGD. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0071321; P:cellular response to cGMP; ISS:UniProtKB.::GO:0035690; P:cellular response to drug; ISS:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.::GO:0046069; P:cGMP catabolic process; IDA:RGD.::GO:0019934; P:cGMP-mediated signaling; ISS:UniProtKB.::GO:0061028; P:establishment of endothelial barrier; IDA:UniProtKB.::GO:0030818; P:negative regulation of cAMP biosynthetic process; IMP:UniProtKB.::GO:0033159; P:negative regulation of protein import into nucleus, translocation; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043116; P:negative regulation of vascular permeability; ISS:UniProtKB.::GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; ISS:UniProtKB.::GO:0006626; P:protein targeting to mitochondrion; IMP:UniProtKB. | 83 | O00408 | 941 | PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosp... | 278 | 0.0001 | 48.5 | 24 | 42 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0042734; C:presynaptic membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005262; F:calcium channel activity; TAS:UniProtKB.::GO:0030552; F:cAMP binding; IMP:UniProtKB.::GO:0030553; F:cGMP binding; IDA:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.::GO:0008144; F:drug binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0030911; F:TPR domain binding; IPI:UniProtKB. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0071321; P:cellular response to cGMP; IDA:UniProtKB.::GO:0035690; P:cellular response to drug; IMP:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IDA:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; IDA:UniProtKB.::GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.::GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:UniProtKB.::GO:0046069; P:cGMP catabolic process; IDA:UniProtKB.::GO:0019934; P:cGMP-mediated signaling; IMP:UniProtKB.::GO:0061028; P:establishment of endothelial barrier; ISS:UniProtKB.::GO:0030224; P:monocyte differentiation; IEP:UniProtKB.::GO:0030818; P:negative regulation of cAMP biosynthetic process; ISS:UniProtKB.::GO:0033159; P:negative regulation of protein import into nucleus, translocation; IDA:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043116; P:negative regulation of vascular permeability; IMP:UniProtKB.::GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; IMP:UniProtKB.::GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB. | 84 | Q922S4 | 916 | PDE2A_MOUSE cGMP-dependent 3',5'-cyclic phosp... | 275 | 0.0002 | 48.1 | 24 | 41 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0042734; C:presynaptic membrane; IDA:UniProtKB. | | | | | | | | | | GO:0030552; F:cAMP binding; IMP:UniProtKB.::GO:0030553; F:cGMP binding; IDA:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0036004; F:GAF domain binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IMP:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0071321; P:cellular response to cGMP; ISS:UniProtKB.::GO:0035690; P:cellular response to drug; ISS:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0071222; P:cellular response to lipopolysaccharide; IEP:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0071260; P:cellular response to mechanical stimulus; IDA:UniProtKB.::GO:0046069; P:cGMP catabolic process; IMP:UniProtKB.::GO:0019934; P:cGMP-mediated signaling; ISS:UniProtKB.::GO:0061028; P:establishment of endothelial barrier; ISS:UniProtKB.::GO:0030818; P:negative regulation of cAMP biosynthetic process; IMP:UniProtKB.::GO:0033159; P:negative regulation of protein import into nucleus, translocation; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043116; P:negative regulation of vascular permeability; ISS:UniProtKB.::GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.::GO:0050729; P:positive regulation of inflammatory response; IMP:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; ISS:UniProtKB.::GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB. | 85 | P14099 | 921 | PDE2A_BOVIN cGMP-dependent 3',5'-cyclic phosp... | 278 | 0.0003 | 47.8 | 24 | 41 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0042734; C:presynaptic membrane; ISS:UniProtKB. | | | | | | | | | | GO:0030553; F:cGMP binding; ISS:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; ISS:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; ISS:UniProtKB.::GO:0071321; P:cellular response to cGMP; ISS:UniProtKB.::GO:0035690; P:cellular response to drug; ISS:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.::GO:0046069; P:cGMP catabolic process; ISS:UniProtKB.::GO:0019934; P:cGMP-mediated signaling; ISS:UniProtKB.::GO:0061028; P:establishment of endothelial barrier; ISS:UniProtKB.::GO:0046038; P:GMP catabolic process; TAS:AgBase.::GO:0030818; P:negative regulation of cAMP biosynthetic process; ISS:UniProtKB.::GO:0033159; P:negative regulation of protein import into nucleus, translocation; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043116; P:negative regulation of vascular permeability; ISS:UniProtKB.::GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; ISS:UniProtKB.::GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB. | 86 | Q9Z0X4 | 1141 | PDE3A_MOUSE cGMP-inhibited 3',5'-cyclic phosp... | 286 | 0.0006 | 46.2 | 23 | 35 | GO:0005626; C:insoluble fraction; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005625; C:soluble fraction; IDA:MGI. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0001556; P:oocyte maturation; IDA:MGI.::GO:0060282; P:positive regulation of oocyte development; IGI:MGI.::GO:0040020; P:regulation of meiosis; IDA:MGI.::GO:0042493; P:response to drug; IDA:MGI. | 87 | Q62865 | 1141 | PDE3A_RAT cGMP-inhibited 3',5'-cyclic phospho... | 286 | 0.0008 | 46.2 | 23 | 35 | GO:0005829; C:cytosol; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:RGD.::GO:0030552; F:cAMP binding; IDA:RGD.::GO:0004119; F:cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IDA:RGD.::GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.::GO:0001556; P:oocyte maturation; IEP:RGD.::GO:0051591; P:response to cAMP; IEP:RGD. | 88 | P91119 | 728 | PDE5_CAEEL Probable 3',5'-cyclic phosphodiest... | 175 | 0.001 | 45.1 | 27 | 45 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000003; P:reproduction; IMP:WormBase.::GO:0007165; P:signal transduction; IEA:InterPro. | 89 | Q13370 | 1112 | PDE3B_HUMAN cGMP-inhibited 3',5'-cyclic phosp... | 240 | 0.003 | 44.3 | 23 | 35 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005783; C:endoplasmic reticulum; ISS:BHF-UCL.::GO:0005794; C:Golgi apparatus; ISS:BHF-UCL.::GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:BHF-UCL.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; ISS:BHF-UCL. | | | | | | | | | | GO:0004119; F:cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0043422; F:protein kinase B binding; ISS:BHF-UCL. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006198; P:cAMP catabolic process; IEP:BHF-UCL.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0043951; P:negative regulation of cAMP-mediated signaling; IC:BHF-UCL.::GO:0033629; P:negative regulation of cell adhesion mediated by integrin; IC:BHF-UCL.::GO:0050995; P:negative regulation of lipid catabolic process; IMP:BHF-UCL. | 90 | Q61409 | 1100 | PDE3B_MOUSE cGMP-inhibited 3',5'-cyclic phosp... | 240 | 0.005 | 43.5 | 23 | 35 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005783; C:endoplasmic reticulum; IDA:BHF-UCL.::GO:0005794; C:Golgi apparatus; IDA:BHF-UCL.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:BHF-UCL. | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0043422; F:protein kinase B binding; IPI:BHF-UCL. | | | | | | | | | | GO:0032869; P:cellular response to insulin stimulus; IEP:BHF-UCL.::GO:0031018; P:endocrine pancreas development; IDA:MGI.::GO:0042593; P:glucose homeostasis; IDA:MGI.::GO:0050796; P:regulation of insulin secretion; IDA:MGI.::GO:0007165; P:signal transduction; IEA:InterPro. | 91 | Q14432 | 1141 | PDE3A_HUMAN cGMP-inhibited 3',5'-cyclic phosp... | 330 | 0.01 | 42.4 | 24 | 37 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004119; F:cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0071321; P:cellular response to cGMP; IDA:UniProtKB.::GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:UniProtKB.::GO:0019934; P:cGMP-mediated signaling; IMP:UniProtKB.::GO:0006629; P:lipid metabolic process; TAS:ProtInc.::GO:0043116; P:negative regulation of vascular permeability; IMP:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; IMP:UniProtKB. |