Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOR360C
Length:
526
Number of sequences:
5887
Description:
YOR360C PDE2 SGDID:S000005887, Chr XV from 1014821-1013241, Genome Release 64-1-1, reverse complement, Verified ORF, "High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31P27664    859   PDE6A_MOUSE Rod cGMP-specific 3',5'-cyclic ph...2500.0000000000009     74.7     25     48GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0060041; P:retina development in camera-type eye; IMP:MGI.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0007601; P:visual perception; IEA:UniProtKB-KW.
32Q08493    712   PDE4C_HUMAN cAMP-specific 3',5'-cyclic phosph...2040.0000000000009     74.3     31     49GO:0005829; C:cytosol; TAS:Reactome.::GO:0072372; C:primary cilium; ISS:UniProtKB.
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
33Q28263    861   PDE6A_CANFA Rod cGMP-specific 3',5'-cyclic ph...2500.000000000001     74.7     25     48GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.::GO:0007601; P:visual perception; IEA:UniProtKB-KW.
34P16499    860   PDE6A_HUMAN Rod cGMP-specific 3',5'-cyclic ph...2500.000000000001     73.9     25     48GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IMP:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0051480; P:cytosolic calcium ion homeostasis; IMP:BHF-UCL.::GO:0046037; P:GMP metabolic process; IMP:BHF-UCL.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0007601; P:visual perception; TAS:ProtInc.
35O54735    833   PDE5A_RAT cGMP-specific 3',5'-cyclic phosphod...3310.000000000002     73.9     23     42GO:0005829; C:cytosol; IDA:RGD.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IDA:RGD.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007399; P:nervous system development; IEP:RGD.::GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.::GO:0002678; P:positive regulation of chronic inflammatory response; IMP:RGD.::GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.::GO:0002026; P:regulation of the force of heart contraction; IMP:RGD.::GO:0001666; P:response to hypoxia; IEP:RGD.::GO:0032496; P:response to lipopolysaccharide; IEP:RGD.::GO:0033574; P:response to testosterone stimulus; IEP:RGD.::GO:0007614; P:short-term memory; IMP:RGD.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0042311; P:vasodilation; IEP:RGD.
36O08593    426   PDE7A_RAT High affinity cAMP-specific 3',5'-c...1970.000000000002     72.8     31     45
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0019933; P:cAMP-mediated signaling; IEP:RGD.
37P27815    886   PDE4A_HUMAN cAMP-specific 3',5'-cyclic phosph...2850.000000000002     73.6     27     46GO:0005829; C:cytosol; TAS:Reactome.::GO:0005624; C:membrane fraction; TAS:ProtInc.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; TAS:ProtInc.
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0006198; P:cAMP catabolic process; IMP:UniProtKB.::GO:0007165; P:signal transduction; TAS:ProtInc.
38P11541    859   PDE6A_BOVIN Rod cGMP-specific 3',5'-cyclic ph...2500.000000000002     73.2     25     48GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.::GO:0007601; P:visual perception; IEA:UniProtKB-KW.
39P23440    856   PDE6B_MOUSE Rod cGMP-specific 3',5'-cyclic ph...2450.000000000003     73.2     27     48GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0009583; P:detection of light stimulus; IMP:MGI.::GO:0060041; P:retina development in camera-type eye; IMP:MGI.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0007601; P:visual perception; IEA:UniProtKB-KW.
40P70453    456   PDE7A_MOUSE High affinity cAMP-specific 3',5'...1970.000000000003     72.4     31     45
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
41Q91ZQ1    861   PDE6C_MOUSE Cone cGMP-specific 3',5'-cyclic p...2500.000000000003     73.2     26     47GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007603; P:phototransduction, visible light; IMP:MGI.::GO:0046549; P:retinal cone cell development; IMP:MGI.::GO:0007601; P:visual perception; IEA:UniProtKB-KW.
42Q01065    535   PDE1B_MOUSE Calcium/calmodulin-dependent 3',5...2110.000000000003     72.4     29     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007626; P:locomotory behavior; IMP:MGI.::GO:0042053; P:regulation of dopamine metabolic process; IMP:MGI.::GO:0001505; P:regulation of neurotransmitter levels; IMP:MGI.::GO:0001975; P:response to amphetamine; IMP:MGI.::GO:0042428; P:serotonin metabolic process; IMP:MGI.::GO:0007165; P:signal transduction; IMP:MGI.::GO:0008542; P:visual learning; IMP:MGI.
43Q01066    535   PDE1B_RAT Calcium/calmodulin-dependent 3',5'-...2110.000000000004     72.4     29     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0043025; C:neuronal cell body; IDA:RGD.
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:RGD.::GO:0048101; F:calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; IDA:RGD.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; IDA:RGD.::GO:0046069; P:cGMP catabolic process; IDA:RGD.
44P16586    855   PDE6C_BOVIN Cone cGMP-specific 3',5'-cyclic p...2510.000000000004     72.8     26     47GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.::GO:0007601; P:visual perception; IEA:UniProtKB-KW.
45O76074    875   PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosph...3310.000000000004     72.4     23     42GO:0005829; C:cytosol; TAS:Reactome.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; TAS:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0046069; P:cGMP catabolic process; IDA:UniProtKB.::GO:0007165; P:signal transduction; NAS:UniProtKB.
46O77746    865   PDE5A_CANFA cGMP-specific 3',5'-cyclic phosph...3310.000000000004     72.4     23     42GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
47Q01061    534   PDE1B_BOVIN Calcium/calmodulin-dependent 3',5...1920.000000000005     72     30     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0048101; F:calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; IDA:MGI.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
48Q28156    865   PDE5A_BOVIN cGMP-specific 3',5'-cyclic phosph...3310.000000000009     71.6     22     42
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:AgBase.::GO:0030553; F:cGMP binding; ISS:AgBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0046069; P:cGMP catabolic process; ISS:AgBase.::GO:0007165; P:signal transduction; IEA:InterPro.
49P35913    854   PDE6B_HUMAN Rod cGMP-specific 3',5'-cyclic ph...2450.000000000009     71.2     26     48GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IMP:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0051480; P:cytosolic calcium ion homeostasis; IMP:BHF-UCL.::GO:0046037; P:GMP metabolic process; IMP:BHF-UCL.::GO:0007603; P:phototransduction, visible light; TAS:ProtInc.::GO:0007601; P:visual perception; TAS:ProtInc.
50P51160    858   PDE6C_HUMAN Cone cGMP-specific 3',5'-cyclic p...2510.00000000001     70.9     25     46GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007601; P:visual perception; TAS:ProtInc.
51Q64395    199   PDE1B_CRIGR Calcium/calmodulin-dependent 3',5...1860.00000000006     65.5     30     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
52P52731    862   PDE6C_CHICK Cone cGMP-specific 3',5'-cyclic p...2510.00000000006     68.9     24     46GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.::GO:0007601; P:visual perception; IEA:UniProtKB-KW.
53Q61481    565   PDE1A_MOUSE Calcium/calmodulin-dependent 3',5...1930.0000000001     67.8     30     46
GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
54Q01064    536   PDE1B_HUMAN Calcium/calmodulin-dependent 3',5...1920.0000000001     67.4     29     49GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.::GO:0006915; P:apoptotic process; TAS:ProtInc.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IDA:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; IDA:UniProtKB.::GO:0046069; P:cGMP catabolic process; IDA:UniProtKB.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0030224; P:monocyte differentiation; IEP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.
55P14100    530   PDE1A_BOVIN Calcium/calmodulin-dependent 3',5...1930.0000000005     65.5     28     46
GO:0048101; F:calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; IDA:MGI.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
56P54750    535   PDE1A_HUMAN Calcium/calmodulin-dependent 3',5...1930.000000001     64.3     28     46GO:0005829; C:cytosol; TAS:Reactome.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.
57Q22000    674   PDE4_CAEEL Probable 3',5'-cyclic phosphodiest...2250.000000001     64.7     28     46GO:0045202; C:synapse; IDA:WormBase.
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; ISS:WormBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; ISS:WormBase.::GO:0043951; P:negative regulation of cAMP-mediated signaling; IGI:WormBase.::GO:0040013; P:negative regulation of locomotion; IMP:WormBase.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0030431; P:sleep; IMP:WormBase.
58Q64338    706   PDE1C_MOUSE Calcium/calmodulin-dependent 3',5...3150.000000002     63.5     25     42
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
59Q63421    768   PDE1C_RAT Calcium/calmodulin-dependent 3',5'-...3150.000000002     63.5     25     42GO:0043025; C:neuronal cell body; IDA:RGD.
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:RGD.::GO:0048101; F:calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; IDA:MGI.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; IDA:MGI.::GO:0030552; F:cAMP binding; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; IDA:RGD.::GO:0046069; P:cGMP catabolic process; IDA:RGD.::GO:0046676; P:negative regulation of insulin secretion; IMP:RGD.::GO:0051592; P:response to calcium ion; IDA:MGI.::GO:0007608; P:sensory perception of smell; IEP:RGD.::GO:0007165; P:signal transduction; IEA:InterPro.
60P0C1Q2    933   PDE11_MOUSE Dual 3',5'-cyclic-AMP and -GMP ph...3280.000000003     63.5     23     42GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; ISS:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
61Q8VID6    935   PDE11_RAT Dual 3',5'-cyclic-AMP and -GMP phos...3280.000000003     63.5     24     42GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0043204; C:perikaryon; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030552; F:cAMP binding; IDA:RGD.::GO:0030553; F:cGMP binding; IDA:RGD.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; IDA:RGD.::GO:0046069; P:cGMP catabolic process; IDA:RGD.::GO:0007165; P:signal transduction; IEA:InterPro.
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