UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YOR256C

Length:

809

Number of sequences:

5887

Description:

YOR256C TRE2 SGDID:S000005782, Chr XV from 810683-808254, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	Q08693	809	TRE2_YEAST Putative zinc metalloprotease TRE2...	809	0	1658	100	100	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
									GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
2	Q08919	783	TRE1_YEAST Uncharacterized protein TRE1 OS=Sa...	770	0	675	45	64	GO:0000324; C:fungal-type vacuole; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
3	O43023	794	YGV9_SCHPO Uncharacterized zinc metalloprotea...	830	5e-33	140	24	41	GO:0005783; C:endoplasmic reticulum; IDA:PomBase.::GO:0071627; C:integral to fungal-type vacuolar membrane; IC:PomBase.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
									GO:0043328; P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISS:PomBase.
4	Q9M1S8	705	GCP2_ARATH Probable glutamate carboxypeptidas...	695	6e-23	108	23	42	GO:0016021; C:integral to membrane; NAS:UniProtKB.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004181; F:metallocarboxypeptidase activity; IMP:UniProtKB.
									GO:0009790; P:embryo development; IMP:TAIR.::GO:0009908; P:flower development; IGI:TAIR.::GO:0010305; P:leaf vascular tissue pattern formation; IGI:TAIR.::GO:0009640; P:photomorphogenesis; IMP:TAIR.::GO:0006508; P:proteolysis; IMP:UniProtKB.::GO:0010080; P:regulation of floral meristem growth; IMP:UniProtKB.::GO:0010081; P:regulation of inflorescence meristem growth; IMP:UniProtKB.::GO:0010082; P:regulation of root meristem growth; IMP:UniProtKB.
5	Q9Y3Q0	740	NALD2_HUMAN N-acetylated-alpha-linked acidic ...	706	2e-22	106	23	40	GO:0016021; C:integral to membrane; NAS:UniProtKB.
									GO:0004180; F:carboxypeptidase activity; NAS:UniProtKB.::GO:0016805; F:dipeptidase activity; NAS:UniProtKB.::GO:0008239; F:dipeptidyl-peptidase activity; NAS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008236; F:serine-type peptidase activity; NAS:UniProtKB.
									GO:0006508; P:proteolysis; NAS:UniProtKB.
6	P70627	752	FOLH1_RAT Glutamate carboxypeptidase 2 OS=Rat...	728	5e-19	95.9	22	38
									GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.::GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
									GO:0006508; P:proteolysis; IDA:RGD.
7	Q04609	750	FOLH1_HUMAN Glutamate carboxypeptidase 2 OS=H...	729	3e-18	93.6	22	39	GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005887; C:integral to plasma membrane; TAS:ProtInc.::GO:0005624; C:membrane fraction; TAS:ProtInc.::GO:0005634; C:nucleus; IDA:HPA.
									GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.::GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
									GO:0006508; P:proteolysis; NAS:UniProtKB.
8	Q9CZR2	740	NALD2_MOUSE N-acetylated-alpha-linked acidic ...	699	3e-18	93.2	21	38	GO:0016021; C:integral to membrane; IDA:MGI.
									GO:0004180; F:carboxypeptidase activity; IDA:MGI.::GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0050129; F:N-formylglutamate deformylase activity; IDA:MGI.
									GO:0042135; P:neurotransmitter catabolic process; IDA:MGI.::GO:0006508; P:proteolysis; IDA:MGI.
9	O77564	751	FOLH1_PIG Glutamate carboxypeptidase 2 OS=Sus...	703	5e-18	92.8	22	39	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.::GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
									GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
10	Q7M758	745	NALDL_MOUSE N-acetylated-alpha-linked acidic ...	484	4e-16	86.3	24	40	GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.::GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
									GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
11	Q9UQQ1	740	NALDL_HUMAN N-acetylated-alpha-linked acidic ...	475	9e-16	85.5	25	40	GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; NAS:UniProtKB.
									GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.::GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
									GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
12	Q5WN23	770	GCP2_CAEBR Glutamate carboxypeptidase 2 homol...	395	0.000000000000009	82	24	43	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004181; F:metallocarboxypeptidase activity; ISS:UniProtKB.
									GO:0006508; P:proteolysis; ISS:UniProtKB.
13	P91406	770	GCP2_CAEEL Glutamate carboxypeptidase 2 homol...	387	0.00000000000004	80.1	24	42	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004181; F:metallocarboxypeptidase activity; ISS:UniProtKB.
									GO:0006508; P:proteolysis; ISS:UniProtKB.
14	Q9JKX3	798	TFR2_MOUSE Transferrin receptor protein 2 OS=...	344	0.00000000000004	80.1	28	42	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004998; F:transferrin receptor activity; TAS:MGI.
									GO:0006879; P:cellular iron ion homeostasis; TAS:MGI.::GO:0006508; P:proteolysis; IEA:InterPro.
15	O54697	745	NALDL_RAT N-acetylated-alpha-linked acidic di...	698	0.00000000000006	79.3	22	38	GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.::GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
									GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
16	B2GUY2	798	TFR2_RAT Transferrin receptor protein 2 OS=Ra...	342	0.0000000000002	77.8	28	42	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
									GO:0006508; P:proteolysis; IEA:InterPro.
17	O35409	752	FOLH1_MOUSE Glutamate carboxypeptidase 2 OS=M...	726	0.0000000000005	76.6	21	38	GO:0005887; C:integral to plasma membrane; IDA:MGI.
									GO:0004180; F:carboxypeptidase activity; IDA:MGI.::GO:0016805; F:dipeptidase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
									GO:0006760; P:folic acid-containing compound metabolic process; IDA:MGI.::GO:0006508; P:proteolysis; IDA:MGI.
18	Q9UP52	801	TFR2_HUMAN Transferrin receptor protein 2 OS=...	357	0.000000000002	74.7	27	42	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
									GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004998; F:transferrin receptor activity; NAS:UniProtKB.
									GO:0006879; P:cellular iron ion homeostasis; TAS:UniProtKB.::GO:0006826; P:iron ion transport; NAS:UniProtKB.::GO:0006508; P:proteolysis; IEA:InterPro.
19	Q9HBA9	442	FOH1B_HUMAN Putative N-acetylated-alpha-linke...	431	0.000000000007	72	23	40	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
									GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
20	Q07891	757	TFR1_CRIGR Transferrin receptor protein 1 OS=...	518	0.00000000002	71.2	23	44	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:InterPro.
21	Q90997	776	TFR1_CHICK Transferrin receptor protein 1 OS=...	349	0.00000000007	69.7	23	44	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:InterPro.
22	P02786	760	TFR1_HUMAN Transferrin receptor protein 1 OS=...	332	0.00000000007	69.7	25	46	GO:0005905; C:coated pit; IDA:UniProtKB.::GO:0005887; C:integral to plasma membrane; TAS:ProtInc.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
									GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004998; F:transferrin receptor activity; NAS:UniProtKB.
									GO:0006879; P:cellular iron ion homeostasis; NAS:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:InterPro.::GO:0033572; P:transferrin transport; TAS:Reactome.::GO:0055085; P:transmembrane transport; TAS:Reactome.
23	Q2V905	767	TFR1_HORSE Transferrin receptor protein 1 OS=...	336	0.0000000002	67.8	24	46	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:InterPro.
24	Q99376	622	TFR1_RAT Transferrin receptor protein 1 OS=Ra...	318	0.0000000002	67.8	25	47	GO:0009986; C:cell surface; IDA:MGI.::GO:0070062; C:extracellular vesicular exosome; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005739; C:mitochondrion; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:RGD.::GO:0055038; C:recycling endosome membrane; IDA:RGD.
									GO:0051087; F:chaperone binding; IPI:RGD.::GO:0030544; F:Hsp70 protein binding; IPI:RGD.::GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004998; F:transferrin receptor activity; IDA:RGD.
									GO:0006953; P:acute-phase response; IEP:RGD.::GO:0007568; P:aging; IEP:RGD.::GO:0006508; P:proteolysis; IEA:InterPro.::GO:0046688; P:response to copper ion; IEP:RGD.::GO:0001666; P:response to hypoxia; IEP:RGD.::GO:0010039; P:response to iron ion; IEP:RGD.::GO:0010042; P:response to manganese ion; IEP:RGD.::GO:0010033; P:response to organic substance; IEP:RGD.::GO:0032526; P:response to retinoic acid; IEP:RGD.
25	Q9GLD3	770	TFR1_CANFA Transferrin receptor protein 1 OS=...	330	0.0000000004	67	25	46	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:InterPro.
26	Q9MYZ3	769	TFR1_FELCA Transferrin receptor protein 1 OS=...	329	0.0000000005	67	23	47	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:InterPro.
27	Q62351	763	TFR1_MOUSE Transferrin receptor protein 1 OS=...	258	0.000000001	65.5	24	49	GO:0009897; C:external side of plasma membrane; IDA:MGI.::GO:0070062; C:extracellular vesicular exosome; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
									GO:0005381; F:iron ion transmembrane transporter activity; TAS:MGI.::GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004998; F:transferrin receptor activity; TAS:MGI.
									GO:0006879; P:cellular iron ion homeostasis; IMP:MGI.::GO:0030316; P:osteoclast differentiation; IMP:DFLAT.::GO:0045780; P:positive regulation of bone resorption; IDA:DFLAT.::GO:0006508; P:proteolysis; IEA:InterPro.
28	Q5RDH6	760	TFR1_PONAB Transferrin receptor protein 1 OS=...	339	0.000000003	64.7	24	41	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:InterPro.
29	Q8HZV3	768	TFR1_PIG Transferrin receptor protein 1 OS=Su...	108	0.00000005	60.5	31	58	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0008233; F:peptidase activity; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:InterPro.
30	P47161	811	VPS70_YEAST Vacuolar protein sorting-associat...	297	0.0000002	58.2	25	44	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
									GO:0006623; P:protein targeting to vacuole; IMP:SGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
31	Q58DX5	795	NADL2_HUMAN Inactive N-acetylated-alpha-linke...	265	0.00003	51.2	21	44	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0008233; F:peptidase activity; IEA:InterPro.
									GO:0006508; P:proteolysis; IEA:InterPro.

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