UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YOR236W

Length:

211

Number of sequences:

5887

Description:

YOR236W DFR1 SGDID:S000005762, Chr XV from 780906-781541, Genome Release 64-1-1, Verified ORF, "Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P07807	211	DYR_YEAST Dihydrofolate reductase OS=Saccharo...	211	6e-157	440	100	100	GO:0005829; C:cytosol; TAS:SGD.
									GO:0004146; F:dihydrofolate reductase activity; IMP:SGD.::GO:0003729; F:mRNA binding; IDA:SGD.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006760; P:folic acid-containing compound metabolic process; IMP:SGD.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
2	P22906	192	DYR_CANAX Dihydrofolate reductase OS=Candida ...	203	2e-43	150	39	65
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
3	Q2QRX6	494	DRTS_ORYSJ Putative bifunctional dihydrofolat...	113	7e-29	116	50	70
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
4	P45350	528	DRTS_DAUCA Bifunctional dihydrofolate reducta...	121	4e-28	114	47	67
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
5	Q07801	229	DYR_CRYNJ Dihydrofolate reductase OS=ATCC MYA...	132	2e-27	109	45	61
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
6	O81395	521	DRTS_MAIZE Bifunctional dihydrofolate reducta...	118	3e-27	112	48	69
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
7	P51820	530	DRTS_SOYBN Bifunctional dihydrofolate reducta...	187	6e-27	111	32	56
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
8	Q05762	519	DRTS1_ARATH Bifunctional dihydrofolate reduct...	118	5e-26	108	44	69	GO:0005829; C:cytosol; IDA:TAIR.
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
9	Q05763	565	DRTS2_ARATH Bifunctional dihydrofolate reduct...	118	5e-26	108	45	69
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
10	Q9U8B8	185	DYR_HELVI Dihydrofolate reductase OS=Heliothi...	169	8e-24	98.6	34	53
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
11	P17719	182	DYR_DROME Dihydrofolate reductase OS=Drosophi...	123	3e-23	97.1	37	62
									GO:0004146; F:dihydrofolate reductase activity; IDA:FlyBase.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.
									GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
12	Q27793	521	DRTS_TRYCR Bifunctional dihydrofolate reducta...	138	4e-23	100	37	58
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
13	Q27783	527	DRTS_TRYBB Bifunctional dihydrofolate reducta...	138	1e-22	99.4	37	58
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
14	Q93341	189	DYR_CAEEL Putative dihydrofolate reductase OS...	124	4e-22	94	39	59
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0000003; P:reproduction; IMP:WormBase.
15	P28019	186	DYR_AEDAL Dihydrofolate reductase OS=Aedes al...	112	2e-20	89.4	38	61
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
16	Q07422	610	DRTS_TOXGO Bifunctional dihydrofolate reducta...	170	8e-20	91.7	32	52
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
17	P16184	206	DYR_PNECA Dihydrofolate reductase OS=Pneumocy...	211	9e-20	87.8	31	48
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
18	P00378	189	DYR_CHICK Dihydrofolate reductase OS=Gallus g...	138	2e-19	86.3	39	59
									GO:0004146; F:dihydrofolate reductase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0003729; F:mRNA binding; ISS:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; ISS:UniProtKB.
19	P09503	187	DYR_SHV21 Viral dihydrofolate reductase OS=Sa...	125	3e-19	85.9	39	63
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
20	Q920D2	187	DYR_RAT Dihydrofolate reductase OS=Rattus nor...	207	1e-18	84.3	32	50	GO:0005625; C:soluble fraction; IDA:RGD.
									GO:0004146; F:dihydrofolate reductase activity; ISS:UniProtKB.::GO:0051871; F:dihydrofolic acid binding; IDA:RGD.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0003729; F:mRNA binding; ISS:UniProtKB.::GO:0050661; F:NADP binding; IDA:RGD.
									GO:0046452; P:dihydrofolate metabolic process; IDA:RGD.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.::GO:0035094; P:response to nicotine; IEP:RGD.::GO:0046654; P:tetrahydrofolate biosynthetic process; IDA:RGD.
21	P00377	186	DYR_PIG Dihydrofolate reductase OS=Sus scrofa...	133	1e-18	84.3	37	60
									GO:0004146; F:dihydrofolate reductase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0003729; F:mRNA binding; ISS:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; ISS:UniProtKB.
22	P00375	187	DYR_MOUSE Dihydrofolate reductase OS=Mus musc...	207	2e-18	84	32	50	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0004146; F:dihydrofolate reductase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0003729; F:mRNA binding; ISS:UniProtKB.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.
23	P04753	187	DYR_MESAU Dihydrofolate reductase OS=Mesocric...	207	2e-18	84	31	50
									GO:0004146; F:dihydrofolate reductase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0003729; F:mRNA binding; ISS:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; ISS:UniProtKB.
24	P00376	187	DYR_BOVIN Dihydrofolate reductase OS=Bos taur...	208	1e-17	81.6	32	52
									GO:0004146; F:dihydrofolate reductase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0003729; F:mRNA binding; ISS:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; ISS:UniProtKB.
25	P27421	186	DYR_SHV24 Viral dihydrofolate reductase OS=sa...	207	1e-17	81.6	29	51
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
26	P16126	520	DRTS_LEIAM Bifunctional dihydrofolate reducta...	135	2e-17	84.3	35	59
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
27	P0A546	159	DYR_MYCTU Dihydrofolate reductase OS=Mycobact...	153	3e-17	80.1	32	52
									GO:0004146; F:dihydrofolate reductase activity; IDA:MTBBASE.::GO:0070401; F:NADP+ binding; IDA:MTBBASE.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IDA:MTBBASE.::GO:0046654; P:tetrahydrofolate biosynthetic process; IDA:MTBBASE.
28	P0A547	159	DYR_MYCBO Dihydrofolate reductase OS=Mycobact...	153	3e-17	80.1	32	52
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
29	P22573	213	DYR_SHV2C Viral dihydrofolate reductase OS=Sa...	207	5e-17	80.1	29	50
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
30	P00374	187	DYR_HUMAN Dihydrofolate reductase OS=Homo sap...	208	6e-17	79.3	31	50	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
									GO:0004146; F:dihydrofolate reductase activity; IDA:UniProtKB.::GO:0008144; F:drug binding; IDA:UniProtKB.::GO:0003729; F:mRNA binding; IDA:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0046655; P:folic acid metabolic process; TAS:Reactome.::GO:0006545; P:glycine biosynthetic process; NAS:UniProtKB.::GO:0046209; P:nitric oxide metabolic process; TAS:Reactome.::GO:0009165; P:nucleotide biosynthetic process; NAS:UniProtKB.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0050999; P:regulation of nitric-oxide synthase activity; TAS:Reactome.::GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; TAS:Reactome.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; IDA:UniProtKB.
31	P57243	161	DYR_BUCAI Dihydrofolate reductase OS=(Acyrtho...	136	2e-16	77.4	32	58
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.

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