rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | P57243 | 161 | DYR_BUCAI Dihydrofolate reductase OS=(Acyrtho... | 136 | 2e-16 | 77.4 | 32 | 58 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 32 | P07382 | 520 | DRTS_LEIMA Bifunctional dihydrofolate reducta... | 135 | 0.000000000000001 | 79 | 34 | 58 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 33 | P13922 | 608 | DRTS_PLAFK Bifunctional dihydrofolate reducta... | 168 | 0.000000000000002 | 78.6 | 33 | 48 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 34 | Q9CBW1 | 165 | DYR_MYCLE Dihydrofolate reductase OS=Mycobact... | 139 | 0.000000000000002 | 74.7 | 30 | 53 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 35 | Q86XF0 | 187 | DYRL1_HUMAN Dihydrofolate reductase, mitochon... | 141 | 0.000000000000003 | 74.7 | 32 | 53 | GO:0005743; C:mitochondrial inner membrane; IMP:UniProtKB.::GO:0005759; C:mitochondrial matrix; IMP:UniProtKB. | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IMP:UniProtKB.::GO:0003729; F:mRNA binding; IDA:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; IDA:UniProtKB.::GO:0046105; P:thymidine biosynthetic process; IDA:UniProtKB. | 36 | O62583 | 205 | DYR_ENCCU Dihydrofolate reductase OS=Encephal... | 133 | 0.00000000000003 | 71.6 | 33 | 50 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 37 | P36591 | 461 | DYR_SCHPO Dihydrofolate reductase OS=Schizosa... | 152 | 0.00000000000004 | 74.3 | 30 | 51 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004146; F:dihydrofolate reductase activity; IGI:PomBase.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006760; P:folic acid-containing compound metabolic process; ISS:PomBase.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 38 | P11045 | 168 | DYR_BACSU Dihydrofolate reductase OS=Bacillus... | 137 | 0.00000000000005 | 70.9 | 31 | 55 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 39 | Q23695 | 515 | DRTS_CRIFA Bifunctional dihydrofolate reducta... | 135 | 0.0000000000001 | 73.2 | 33 | 56 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 40 | P20712 | 583 | DRTS_PLACH Bifunctional dihydrofolate reducta... | 154 | 0.0000000000001 | 72.8 | 31 | 49 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 41 | P43791 | 160 | DYR_HAEIN Dihydrofolate reductase OS=Haemophi... | 123 | 0.0000000000001 | 69.3 | 35 | 54 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. | 42 | P46103 | 182 | DRTS_PLAVN Bifunctional dihydrofolate reducta... | 154 | 0.0000000000002 | 69.3 | 30 | 49 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 43 | Q8K9Z8 | 161 | DYR_BUCAP Dihydrofolate reductase OS=Buchnera... | 124 | 0.000000000002 | 66.2 | 31 | 56 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 44 | P31074 | 159 | DYR_ENTAE Dihydrofolate reductase OS=Enteroba... | 162 | 0.000000000004 | 65.1 | 31 | 47 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 45 | Q89AV2 | 164 | DYR_BUCBP Dihydrofolate reductase OS=Buchnera... | 135 | 0.000000000005 | 64.7 | 29 | 53 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 46 | P04174 | 162 | DYR_NEIGO Dihydrofolate reductase OS=Neisseri... | 136 | 0.00000000001 | 63.9 | 29 | 49 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. | 47 | P31073 | 159 | DYR_CITFR Dihydrofolate reductase OS=Citrobac... | 163 | 0.00000000002 | 63.2 | 33 | 47 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 48 | P0ABQ6 | 159 | DYR_SHIFL Dihydrofolate reductase OS=Shigella... | 162 | 0.00000000003 | 62.8 | 31 | 45 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 49 | P0ABQ4 | 159 | DYR_ECOLI Dihydrofolate reductase OS=Escheric... | 162 | 0.00000000003 | 62.8 | 31 | 45 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; IDA:EcoliWiki.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0042493; P:response to drug; IDA:EcoliWiki.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW. | 50 | P0ABQ5 | 159 | DYR_ECOL6 Dihydrofolate reductase OS=Escheric... | 162 | 0.00000000003 | 62.8 | 31 | 45 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 51 | Q27713 | 587 | DRTS_PLABA Bifunctional dihydrofolate reducta... | 159 | 0.00000000009 | 64.3 | 30 | 47 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 52 | Q59397 | 177 | DYR9_ECOLX Dihydrofolate reductase type 9 OS=... | 135 | 0.0000000001 | 61.2 | 28 | 52 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW. | 53 | P0C0P1 | 161 | DYR_STAES Dihydrofolate reductase OS=Staphylo... | 136 | 0.0000000001 | 60.8 | 30 | 50 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 54 | Q5HPB1 | 161 | DYR_STAEQ Dihydrofolate reductase OS=Staphylo... | 136 | 0.0000000001 | 60.8 | 30 | 50 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 55 | P0C0P0 | 161 | DYR_STAEP Dihydrofolate reductase OS=Staphylo... | 136 | 0.0000000001 | 60.8 | 30 | 50 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 56 | P13955 | 161 | DYRA_STAAU Dihydrofolate reductase type 1 fro... | 136 | 0.0000000001 | 60.8 | 30 | 49 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW. | 57 | P12833 | 162 | DYR3_SALTM Dihydrofolate reductase type 3 OS=... | 137 | 0.0000000002 | 60.1 | 28 | 53 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW. | 58 | Q5UQG3 | 563 | DRTS_MIMIV Bifunctional dihydrofolate reducta... | 210 | 0.0000000004 | 62.4 | 25 | 46 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 59 | Q59408 | 165 | DYR13_ECOLX Dihydrofolate reductase type A13 ... | 162 | 0.0000000004 | 59.3 | 27 | 48 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW. | 60 | Q5V600 | 167 | DYR2_HALMA Dihydrofolate reductase 2 OS=B-180... | 136 | 0.0000000005 | 59.3 | 26 | 47 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 61 | Q9JSQ9 | 162 | DYR_NEIMA Dihydrofolate reductase OS=Neisseri... | 139 | 0.0000000006 | 58.9 | 29 | 47 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. |