UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YOR236W

Length:

211

Number of sequences:

5887

Description:

YOR236W DFR1 SGDID:S000005762, Chr XV from 780906-781541, Genome Release 64-1-1, Verified ORF, "Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
31	P57243	161	DYR_BUCAI Dihydrofolate reductase OS=(Acyrtho...	136	2e-16	77.4	32	58
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
32	P07382	520	DRTS_LEIMA Bifunctional dihydrofolate reducta...	135	0.000000000000001	79	34	58
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
33	P13922	608	DRTS_PLAFK Bifunctional dihydrofolate reducta...	168	0.000000000000002	78.6	33	48
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
34	Q9CBW1	165	DYR_MYCLE Dihydrofolate reductase OS=Mycobact...	139	0.000000000000002	74.7	30	53
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
35	Q86XF0	187	DYRL1_HUMAN Dihydrofolate reductase, mitochon...	141	0.000000000000003	74.7	32	53	GO:0005743; C:mitochondrial inner membrane; IMP:UniProtKB.::GO:0005759; C:mitochondrial matrix; IMP:UniProtKB.
									GO:0004146; F:dihydrofolate reductase activity; IMP:UniProtKB.::GO:0003729; F:mRNA binding; IDA:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; IDA:UniProtKB.::GO:0046105; P:thymidine biosynthetic process; IDA:UniProtKB.
36	O62583	205	DYR_ENCCU Dihydrofolate reductase OS=Encephal...	133	0.00000000000003	71.6	33	50
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
37	P36591	461	DYR_SCHPO Dihydrofolate reductase OS=Schizosa...	152	0.00000000000004	74.3	30	51	GO:0005829; C:cytosol; IDA:PomBase.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004146; F:dihydrofolate reductase activity; IGI:PomBase.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006760; P:folic acid-containing compound metabolic process; ISS:PomBase.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
38	P11045	168	DYR_BACSU Dihydrofolate reductase OS=Bacillus...	137	0.00000000000005	70.9	31	55
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
39	Q23695	515	DRTS_CRIFA Bifunctional dihydrofolate reducta...	135	0.0000000000001	73.2	33	56
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
40	P20712	583	DRTS_PLACH Bifunctional dihydrofolate reducta...	154	0.0000000000001	72.8	31	49
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
41	P43791	160	DYR_HAEIN Dihydrofolate reductase OS=Haemophi...	123	0.0000000000001	69.3	35	54
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
42	P46103	182	DRTS_PLAVN Bifunctional dihydrofolate reducta...	154	0.0000000000002	69.3	30	49
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
43	Q8K9Z8	161	DYR_BUCAP Dihydrofolate reductase OS=Buchnera...	124	0.000000000002	66.2	31	56
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
44	P31074	159	DYR_ENTAE Dihydrofolate reductase OS=Enteroba...	162	0.000000000004	65.1	31	47
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
45	Q89AV2	164	DYR_BUCBP Dihydrofolate reductase OS=Buchnera...	135	0.000000000005	64.7	29	53
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
46	P04174	162	DYR_NEIGO Dihydrofolate reductase OS=Neisseri...	136	0.00000000001	63.9	29	49
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
47	P31073	159	DYR_CITFR Dihydrofolate reductase OS=Citrobac...	163	0.00000000002	63.2	33	47
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
48	P0ABQ6	159	DYR_SHIFL Dihydrofolate reductase OS=Shigella...	162	0.00000000003	62.8	31	45
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
49	P0ABQ4	159	DYR_ECOLI Dihydrofolate reductase OS=Escheric...	162	0.00000000003	62.8	31	45
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; IDA:EcoliWiki.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0042493; P:response to drug; IDA:EcoliWiki.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.
50	P0ABQ5	159	DYR_ECOL6 Dihydrofolate reductase OS=Escheric...	162	0.00000000003	62.8	31	45
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
51	Q27713	587	DRTS_PLABA Bifunctional dihydrofolate reducta...	159	0.00000000009	64.3	30	47
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
52	Q59397	177	DYR9_ECOLX Dihydrofolate reductase type 9 OS=...	135	0.0000000001	61.2	28	52
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.
53	P0C0P1	161	DYR_STAES Dihydrofolate reductase OS=Staphylo...	136	0.0000000001	60.8	30	50
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
54	Q5HPB1	161	DYR_STAEQ Dihydrofolate reductase OS=Staphylo...	136	0.0000000001	60.8	30	50
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
55	P0C0P0	161	DYR_STAEP Dihydrofolate reductase OS=Staphylo...	136	0.0000000001	60.8	30	50
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
56	P13955	161	DYRA_STAAU Dihydrofolate reductase type 1 fro...	136	0.0000000001	60.8	30	49
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.
57	P12833	162	DYR3_SALTM Dihydrofolate reductase type 3 OS=...	137	0.0000000002	60.1	28	53
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.
58	Q5UQG3	563	DRTS_MIMIV Bifunctional dihydrofolate reducta...	210	0.0000000004	62.4	25	46
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
59	Q59408	165	DYR13_ECOLX Dihydrofolate reductase type A13 ...	162	0.0000000004	59.3	27	48
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.
60	Q5V600	167	DYR2_HALMA Dihydrofolate reductase 2 OS=B-180...	136	0.0000000005	59.3	26	47
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
61	Q9JSQ9	162	DYR_NEIMA Dihydrofolate reductase OS=Neisseri...	139	0.0000000006	58.9	29	47
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.

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