Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOR208W
Length:
750
Number of sequences:
5887
Description:
YOR208W PTP2 SGDID:S000005734, Chr XV from 733925-736177, Genome Release 64-1-1, Verified ORF, "Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
61P26045    913   PTN3_HUMAN Tyrosine-protein phosphatase non-r...3374e-16     86.7     26     40GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0009898; C:internal side of plasma membrane; IDA:UniProtKB.
GO:0051117; F:ATPase binding; IPI:BHF-UCL.::GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.::GO:0001784; F:phosphotyrosine binding; IPI:BHF-UCL.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB.
GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; IMP:BHF-UCL.::GO:0045930; P:negative regulation of mitotic cell cycle; IDA:BHF-UCL.
62Q64612    1711   PTPRV_RAT Receptor-type tyrosine-protein phos...3394e-16     87     28     39GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
GO:0046849; P:bone remodeling; IEP:RGD.
63P29350    595   PTN6_HUMAN Tyrosine-protein phosphatase non-r...3404e-16     85.9     27     41GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; TAS:ProtInc.::GO:0005634; C:nucleus; IDA:BHF-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; IDA:UniProtKB.
GO:0006915; P:apoptotic process; TAS:ProtInc.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0030154; P:cell differentiation; IDA:UniProtKB.::GO:0008283; P:cell proliferation; IDA:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IMP:BHF-UCL.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:BHF-UCL.::GO:0070372; P:regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.::GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IMP:BHF-UCL.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
64Q99M80    1454   PTPRT_MOUSE Receptor-type tyrosine-protein ph...2760.002     45.4     24     37GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0051393; F:alpha-actinin binding; IDA:MGI.::GO:0045294; F:alpha-catenin binding; IDA:MGI.::GO:0008013; F:beta-catenin binding; IDA:MGI.::GO:0045296; F:cadherin binding; IPI:MGI.::GO:0070097; F:delta-catenin binding; IPI:MGI.::GO:0045295; F:gamma-catenin binding; IPI:MGI.::GO:0004725; F:protein tyrosine phosphatase activity; IMP:MGI.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0016790; F:thiolester hydrolase activity; IDA:MGI.
65O14522    1441   PTPRT_HUMAN Receptor-type tyrosine-protein ph...2770.006     43.9     24     38GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0016021; C:integral to membrane; NAS:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0045294; F:alpha-catenin binding; IDA:UniProtKB.::GO:0008013; F:beta-catenin binding; IPI:UniProtKB.::GO:0045296; F:cadherin binding; IPI:UniProtKB.::GO:0070097; F:delta-catenin binding; IPI:UniProtKB.::GO:0045295; F:gamma-catenin binding; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IMP:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0007156; P:homophilic cell adhesion; IDA:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IMP:UniProtKB.
66A2ALK8    913   PTN3_MOUSE Tyrosine-protein phosphatase non-r...3388e-16     85.5     25     39GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.::GO:0004725; F:protein tyrosine phosphatase activity; ISS:UniProtKB.
67P16620    1462   PTP69_DROME Tyrosine-protein phosphatase 69D ...3440.00003     51.6     21     37GO:0030424; C:axon; IDA:FlyBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004725; F:protein tyrosine phosphatase activity; IDA:FlyBase.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0007415; P:defasciculation of motor neuron axon; IMP:FlyBase.::GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.::GO:0008045; P:motor axon guidance; IMP:FlyBase.
68P34137    522   PTP1_DICDI Tyrosine-protein phosphatase 1 OS=...570.15     38.9     40     61GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
69O82656    340   PTP1_ARATH Protein-tyrosine-phosphatase PTP1 ...3360.000000000000001     82.4     24     39GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
GO:0007243; P:intracellular protein kinase cascade; TAS:TAIR.
70P27574    550   PYP1_SCHPO Tyrosine-protein phosphatase 1 OS=...3350.000000000000002     83.6     27     41GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0004725; F:protein tyrosine phosphatase activity; TAS:PomBase.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045930; P:negative regulation of mitotic cell cycle; IMP:PomBase.::GO:0032873; P:negative regulation of stress-activated MAPK cascade; TAS:PomBase.::GO:0045014; P:negative regulation of transcription by glucose; IMP:PomBase.
71P34138    377   PTP2_DICDI Tyrosine-protein phosphatase 2 OS=...3560.000000000000003     81.6     23     39
GO:0004725; F:protein tyrosine phosphatase activity; IDA:dictyBase.
GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
72Q90687    593   PTN11_CHICK Tyrosine-protein phosphatase non-...3420.00000000000001     81.3     27     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
73P18052    829   PTPRA_MOUSE Receptor-type tyrosine-protein ph...1340.001     46.2     28     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
GO:0008286; P:insulin receptor signaling pathway; IMP:MGI.::GO:0006468; P:protein phosphorylation; IDA:MGI.
74P35235    597   PTN11_MOUSE Tyrosine-protein phosphatase non-...3420.00000000000005     79.3     28     42GO:0005829; C:cytosol; TAS:Reactome.
GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; ISS:UniProtKB.::GO:0051428; F:peptide hormone receptor binding; IPI:MGI.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.
GO:0000187; P:activation of MAPK activity; IMP:MGI.::GO:0007409; P:axonogenesis; IMP:MGI.::GO:0000077; P:DNA damage checkpoint; IMP:MGI.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0042593; P:glucose homeostasis; IMP:MGI.::GO:0042445; P:hormone metabolic process; IMP:MGI.::GO:0009755; P:hormone-mediated signaling pathway; IDA:MGI.::GO:0048609; P:multicellular organismal reproductive process; IMP:MGI.::GO:0051463; P:negative regulation of cortisol secretion; IMP:MGI.::GO:0060125; P:negative regulation of growth hormone secretion; IMP:MGI.::GO:0046676; P:negative regulation of insulin secretion; IMP:MGI.::GO:0048011; P:nerve growth factor receptor signaling pathway; IMP:MGI.::GO:0035265; P:organ growth; IMP:MGI.::GO:0046887; P:positive regulation of hormone secretion; IMP:MGI.::GO:0009967; P:positive regulation of signal transduction; IMP:MGI.::GO:0033628; P:regulation of cell adhesion mediated by integrin; ISS:UniProtKB.::GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.::GO:0046825; P:regulation of protein export from nucleus; IMP:MGI.::GO:0006641; P:triglyceride metabolic process; IMP:MGI.
75Q06124    597   PTN11_HUMAN Tyrosine-protein phosphatase non-...3420.00000000000005     79.3     28     42GO:0005829; C:cytosol; TAS:Reactome.
GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IMP:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0033628; P:regulation of cell adhesion mediated by integrin; IMP:UniProtKB.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
76P41499    597   PTN11_RAT Tyrosine-protein phosphatase non-re...3450.0000000000001     77.8     27     40GO:0005829; C:cytosol; IDA:RGD.::GO:0005739; C:mitochondrion; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0005158; F:insulin receptor binding; IDA:RGD.::GO:0043560; F:insulin receptor substrate binding; IPI:RGD.::GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; ISS:UniProtKB.::GO:0043274; F:phospholipase binding; IDA:RGD.::GO:0019904; F:protein domain specific binding; IPI:RGD.
GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; ISS:UniProtKB.
77Q641Z2    593   PTN9_RAT Tyrosine-protein phosphatase non-rec...3470.0000000000004     76.6     24     39
GO:0004725; F:protein tyrosine phosphatase activity; ISS:UniProtKB.
78Q5I146    325   PTPH2_MDBVW Tyrosine phosphatase H2 OS=Microp...3290.000000000002     72.8     26     39GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.
79Q9WU22    926   PTN4_MOUSE Tyrosine-protein phosphatase non-r...3360.000000000002     74.7     24     37GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.::GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IDA:MGI.
80P43378    593   PTN9_HUMAN Tyrosine-protein phosphatase non-r...3470.000000000002     74.3     24     39GO:0044444; C:cytoplasmic part; IDA:UniProtKB.
GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; TAS:ProtInc.::GO:0005515; F:protein binding; IPI:IntAct.
81P28191    1026   PTP1_CAEEL Tyrosine-protein phosphatase 1 OS=...3320.000000000003     74.3     24     36GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
82O35239    593   PTN9_MOUSE Tyrosine-protein phosphatase non-r...3470.000000000003     73.6     24     39
GO:0004725; F:protein tyrosine phosphatase activity; ISS:UniProtKB.
83P40048    928   PTP3_YEAST Tyrosine-protein phosphatase 3 OS=...1560.000000000006     73.2     33     48GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
GO:0004725; F:protein tyrosine phosphatase activity; IDA:SGD.
GO:0071511; P:inactivation of MAPK activity involved in conjugation with cellular fusion; IMP:SGD.::GO:0000173; P:inactivation of MAPK activity involved in osmosensory signaling pathway; IMP:SGD.::GO:0032880; P:regulation of protein localization; IMP:SGD.::GO:0043937; P:regulation of sporulation; IGI:SGD.
84P18031    435   PTN1_HUMAN Tyrosine-protein phosphatase non-r...3320.0000000001     68.2     23     39GO:0005829; C:cytosol; TAS:Reactome.::GO:0005769; C:early endosome; IDA:UniProtKB.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0031532; P:actin cytoskeleton reorganization; IMP:UniProtKB.::GO:0030968; P:endoplasmic reticulum unfolded protein response; IDA:UniProtKB.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; NAS:BHF-UCL.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0030100; P:regulation of endocytosis; IDA:UniProtKB.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome.::GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
85Q92729    1446   PTPRU_HUMAN Receptor-type tyrosine-protein ph...2790.005     43.9     24     37GO:0005911; C:cell-cell junction; IDA:UniProtKB.::GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.::GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; NAS:UniProtKB.
GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:UniProtKB.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0030336; P:negative regulation of cell migration; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.::GO:0034394; P:protein localization at cell surface; IDA:UniProtKB.::GO:0007185; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; NAS:UniProtKB.
86P20417    432   PTN1_RAT Tyrosine-protein phosphatase non-rec...3290.0000000002     67     23     38GO:0031225; C:anchored to membrane; NAS:RGD.::GO:0031410; C:cytoplasmic vesicle; IDA:RGD.::GO:0005829; C:cytosol; IDA:RGD.::GO:0005769; C:early endosome; ISS:UniProtKB.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005626; C:insoluble fraction; IDA:RGD.
GO:0005158; F:insulin receptor binding; IDA:RGD.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:RGD.
GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0030968; P:endoplasmic reticulum unfolded protein response; ISS:UniProtKB.::GO:0030100; P:regulation of endocytosis; ISS:UniProtKB.::GO:0046626; P:regulation of insulin receptor signaling pathway; IMP:RGD.
87P35821    432   PTN1_MOUSE Tyrosine-protein phosphatase non-r...3320.0000000004     66.2     23     39GO:0005829; C:cytosol; TAS:Reactome.::GO:0005769; C:early endosome; ISS:UniProtKB.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; ISS:UniProtKB.
GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0030968; P:endoplasmic reticulum unfolded protein response; ISS:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; IMP:MGI.::GO:0030100; P:regulation of endocytosis; ISS:UniProtKB.
88O13016    434   PTN1_CHICK Tyrosine-protein phosphatase non-r...3510.0000000004     66.2     23     38GO:0005769; C:early endosome; ISS:UniProtKB.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; ISS:UniProtKB.
GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0030968; P:endoplasmic reticulum unfolded protein response; ISS:UniProtKB.::GO:0030100; P:regulation of endocytosis; ISS:UniProtKB.::GO:0009966; P:regulation of signal transduction; ISS:UniProtKB.
89P35234    369   PTN5_RAT Tyrosine-protein phosphatase non-rec...3280.0000000005     65.5     24     38GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
90B1AUH1    1446   PTPRU_MOUSE Receptor-type tyrosine-protein ph...2800.001     46.2     25     37GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008013; F:beta-catenin binding; IPI:MGI.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0034109; P:homotypic cell-cell adhesion; IDA:MGI.
91E9Q612    1226   PTPRO_MOUSE Receptor-type tyrosine-protein ph...840.000003     54.7     37     56GO:0016324; C:apical plasma membrane; IDA:UniProtKB.::GO:0043197; C:dendritic spine; IDA:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0016328; C:lateral plasma membrane; IDA:UniProtKB.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0017147; F:Wnt-protein binding; IDA:UniProtKB.
GO:0007411; P:axon guidance; IMP:UniProtKB.::GO:0072112; P:glomerular visceral epithelial cell differentiation; IMP:UniProtKB.::GO:0030032; P:lamellipodium assembly; IMP:UniProtKB.::GO:0002548; P:monocyte chemotaxis; ISS:UniProtKB.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IDA:UniProtKB.::GO:0003105; P:negative regulation of glomerular filtration; ISS:UniProtKB.::GO:0036060; P:slit diaphragm assembly; IMP:UniProtKB.
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