Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOR156C
Length:
726
Number of sequences:
5887
Description:
YOR156C NFI1 SGDID:S000005682, Chr XV from 630540-628360, Genome Release 64-1-1, reverse complement, Verified ORF, "SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q12216    726   SIZ2_YEAST E3 SUMO-protein ligase SIZ2 OS=Sac...7260     1508     100     100GO:0005737; C:cytoplasm; IDA:SGD.::GO:0000790; C:nuclear chromatin; IDA:SGD.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0019789; F:SUMO ligase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030261; P:chromosome condensation; TAS:SGD.::GO:0007059; P:chromosome segregation; IMP:SGD.::GO:0016925; P:protein sumoylation; IDA:SGD.
2Q04195    904   SIZ1_YEAST E3 SUMO-protein ligase SIZ1 OS=Sac...4928e-113     369     41     58GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0000790; C:nuclear chromatin; IDA:SGD.::GO:0005940; C:septin ring; IDA:SGD.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0019789; F:SUMO ligase activity; IMP:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007059; P:chromosome segregation; IMP:SGD.::GO:0016925; P:protein sumoylation; IMP:SGD.
3O94451    727   PLI1_SCHPO E3 SUMO-protein ligase pli1 OS=Sch...4001e-39     159     31     49GO:0005634; C:nucleus; IDA:PomBase.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0019789; F:SUMO ligase activity; IDA:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030999; P:linear element assembly; IMP:PomBase.::GO:0016925; P:protein sumoylation; IMP:PomBase.::GO:0007131; P:reciprocal meiotic recombination; IMP:PomBase.::GO:0051983; P:regulation of chromosome segregation; IMP:PomBase.::GO:0000019; P:regulation of mitotic recombination; IMP:PomBase.::GO:0032204; P:regulation of telomere maintenance; IMP:PomBase.
4Q8N2W9    510   PIAS4_HUMAN E3 SUMO-protein ligase PIAS4 OS=H...1736e-28     122     34     54GO:0005737; C:cytoplasm; IDA:BHF-UCL.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0019789; F:SUMO ligase activity; IDA:BHF-UCL.::GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0033235; P:positive regulation of protein sumoylation; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
5Q9JM05    507   PIAS4_MOUSE E3 SUMO-protein ligase PIAS4 OS=M...1737e-27     118     32     54GO:0016363; C:nuclear matrix; IDA:MGI.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IDA:MGI.::GO:0019789; F:SUMO ligase activity; IDA:MGI.::GO:0003714; F:transcription corepressor activity; IDA:MGI.::GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; NAS:UniProtKB.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0043065; P:positive regulation of apoptotic process; IDA:BHF-UCL.::GO:0033235; P:positive regulation of protein sumoylation; ISS:UniProtKB.::GO:0016925; P:protein sumoylation; IDA:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
6Q6AZ28    572   PIAS2_RAT E3 SUMO-protein ligase PIAS2 OS=Rat...2873e-22     105     26     45GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; IPI:MGI.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0035259; F:glucocorticoid receptor binding; IPI:RGD.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0019904; F:protein domain specific binding; IPI:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030521; P:androgen receptor signaling pathway; IMP:RGD.::GO:0050775; P:positive regulation of dendrite morphogenesis; IMP:RGD.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:RGD.::GO:0060765; P:regulation of androgen receptor signaling pathway; IDA:MGI.::GO:0033574; P:response to testosterone stimulus; IEP:RGD.::GO:0007283; P:spermatogenesis; IEP:RGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
7O75928    621   PIAS2_HUMAN E3 SUMO-protein ligase PIAS2 OS=H...2874e-22     105     26     45GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; NAS:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0019789; F:SUMO ligase activity; IDA:BHF-UCL.::GO:0003713; F:transcription coactivator activity; NAS:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0030521; P:androgen receptor signaling pathway; NAS:UniProtKB.::GO:0060766; P:negative regulation of androgen receptor signaling pathway; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
8Q8C5D8    621   PIAS2_MOUSE E3 SUMO-protein ligase PIAS2 OS=M...2876e-22     104     26     45GO:0016604; C:nuclear body; IDA:MGI.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:MGI.::GO:0019789; F:SUMO ligase activity; IDA:MGI.::GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0016925; P:protein sumoylation; IDA:MGI.::GO:0045667; P:regulation of osteoblast differentiation; IMP:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
9O88907    651   PIAS1_MOUSE E3 SUMO-protein ligase PIAS1 OS=M...2131e-20     100     29     49GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0033235; P:positive regulation of protein sumoylation; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
10O75925    651   PIAS1_HUMAN E3 SUMO-protein ligase PIAS1 OS=H...1791e-19     97.4     30     51GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; NAS:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0019789; F:SUMO ligase activity; IDA:BHF-UCL.::GO:0003713; F:transcription coactivator activity; NAS:UniProtKB.::GO:0003714; F:transcription corepressor activity; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030521; P:androgen receptor signaling pathway; NAS:UniProtKB.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0007259; P:JAK-STAT cascade; TAS:ProtInc.::GO:0033235; P:positive regulation of protein sumoylation; IDA:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; NAS:UniProtKB.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
11Q9Y6X2    628   PIAS3_HUMAN E3 SUMO-protein ligase PIAS3 OS=H...1728e-19     94.7     31     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0033235; P:positive regulation of protein sumoylation; IDA:UniProtKB.::GO:0016925; P:protein sumoylation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
12O70260    628   PIAS3_RAT E3 SUMO-protein ligase PIAS3 OS=Rat...1729e-19     94.4     31     52GO:0030425; C:dendrite; IDA:RGD.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IDA:RGD.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0015459; F:potassium channel regulator activity; IDA:RGD.::GO:0008022; F:protein C-terminus binding; IDA:RGD.::GO:0047485; F:protein N-terminus binding; IDA:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0010628; P:positive regulation of gene expression; IDA:RGD.::GO:0045838; P:positive regulation of membrane potential; IDA:RGD.::GO:0016925; P:protein sumoylation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0009725; P:response to hormone stimulus; IEP:RGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
13O54714    628   PIAS3_MOUSE E3 SUMO-protein ligase PIAS3 OS=M...1729e-19     94.4     31     52GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0019789; F:SUMO ligase activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0033235; P:positive regulation of protein sumoylation; ISS:UniProtKB.::GO:0016925; P:protein sumoylation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
14Q8NF64    920   ZMIZ2_HUMAN Zinc finger MIZ domain-containing...1170.000000000000003     83.6     32     55GO:0005739; C:mitochondrion; IDA:HPA.::GO:0043596; C:nuclear replication fork; IDA:UniProtKB.
GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
15Q8CIE2    920   ZMIZ2_MOUSE Zinc finger MIZ domain-containing...1170.000000000000003     83.6     32     55GO:0043596; C:nuclear replication fork; ISS:UniProtKB.
GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
16Q94361    793   GEI17_CAEEL E3 SUMO-protein ligase gei-17 OS=...2180.000000000000004     83.2     24     47
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:WormBase.::GO:0019789; F:SUMO ligase activity; IDA:WormBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0016925; P:protein sumoylation; IDA:WormBase.
17Q6L4L4    875   SIZ1_ORYSJ E3 SUMO-protein ligase SIZ1 OS=Ory...1180.00000000000006     79.3     32     52GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
18Q9ULJ6    1067   ZMIZ1_HUMAN Zinc finger MIZ domain-containing...1470.0000000000003     77.4     29     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
19Q6P1E1    1072   ZMIZ1_MOUSE Zinc finger MIZ domain-containing...1470.0000000000003     77     29     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
20Q6ASW7    813   SIZ2_ORYSJ E3 SUMO-protein ligase SIZ2 OS=Ory...980.000000000003     73.6     31     56GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
21Q680Q4    884   SIZ1_ARATH E3 SUMO-protein ligase SIZ1 OS=Ara...1550.0000000002     68.2     26     46GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0019789; F:SUMO ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IMP:TAIR.::GO:0016049; P:cell growth; IMP:TAIR.::GO:0016036; P:cellular response to phosphate starvation; IMP:TAIR.::GO:0006952; P:defense response; IEA:UniProtKB-KW.::GO:0010247; P:detection of phosphate ion; IDA:TAIR.::GO:0048589; P:developmental growth; IMP:UniProtKB.::GO:0009908; P:flower development; IEA:UniProtKB-KW.::GO:0010286; P:heat acclimation; IMP:UniProtKB.::GO:0009910; P:negative regulation of flower development; IMP:TAIR.::GO:0010113; P:negative regulation of systemic acquired resistance; IMP:UniProtKB.::GO:0016925; P:protein sumoylation; IDA:UniProtKB.::GO:0009787; P:regulation of abscisic acid mediated signaling pathway; IMP:TAIR.::GO:0040008; P:regulation of growth; IMP:TAIR.::GO:0090352; P:regulation of nitrate assimilation; IMP:TAIR.::GO:2000070; P:regulation of response to water deprivation; IMP:TAIR.::GO:0010337; P:regulation of salicylic acid metabolic process; IMP:TAIR.::GO:0050826; P:response to freezing; IMP:TAIR.::GO:0009414; P:response to water deprivation; IMP:UniProtKB.
22Q8K243    485   TRI68_MOUSE E3 ubiquitin-protein ligase TRIM6...820.038     40.8     28     49GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0035035; F:histone acetyltransferase binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
23O54952    1817   BRCA1_RAT Breast cancer type 1 susceptibility...690.084     40     33     55GO:0031436; C:BRCA1-BARD1 complex; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; IDA:RGD.
GO:0003684; F:damaged DNA binding; TAS:RGD.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007420; P:brain development; IEP:RGD.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.::GO:0032355; P:response to estradiol stimulus; IEP:RGD.::GO:0033993; P:response to lipid; IEP:RGD.::GO:0007584; P:response to nutrient; IEP:RGD.
24Q6AZZ1    485   TRI68_HUMAN E3 ubiquitin-protein ligase TRIM6...810.14     38.9     26     48GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0005730; C:nucleolus; IDA:HPA.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; IPI:UniProtKB.::GO:0035035; F:histone acetyltransferase binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.::GO:0060765; P:regulation of androgen receptor signaling pathway; IDA:UniProtKB.
25Q864U1    1849   BRCA1_BOVIN Breast cancer type 1 susceptibili...690.24     38.5     32     55GO:0031436; C:BRCA1-BARD1 complex; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.
26Q9Y6R7    5405   FCGBP_HUMAN IgGFc-binding protein OS=Homo sap...1172.2     35.4     27     45GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.
27Q95153    1878   BRCA1_CANFA Breast cancer type 1 susceptibili...690.28     38.5     32     55GO:0031436; C:BRCA1-BARD1 complex; ISS:UniProtKB.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.
28Q96MF7    247   NSE2_HUMAN E3 SUMO-protein ligase NSE2 OS=Hom...862.1     34.7     31     44GO:0000781; C:chromosome, telomeric region; IDA:UniProtKB.::GO:0016605; C:PML body; IDA:UniProtKB.::GO:0030915; C:Smc5-Smc6 complex; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0019789; F:SUMO ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0090398; P:cellular senescence; IMP:UniProtKB.::GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0034184; P:positive regulation of maintenance of mitotic sister chromatid cohesion; IMP:UniProtKB.::GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IMP:UniProtKB.::GO:0000722; P:telomere maintenance via recombination; IMP:UniProtKB.
29Q99728    777   BARD1_HUMAN BRCA1-associated RING domain prot...693.8     34.7     28     46GO:0070531; C:BRCA1-A complex; IDA:UniProtKB.::GO:0031436; C:BRCA1-BARD1 complex; IDA:UniProtKB.::GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0019900; F:kinase binding; NAS:UniProtKB.::GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0003723; F:RNA binding; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; NAS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007050; P:cell cycle arrest; NAS:UniProtKB.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0031441; P:negative regulation of mRNA 3'-end processing; NAS:UniProtKB.::GO:0046826; P:negative regulation of protein export from nucleus; IDA:UniProtKB.::GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.::GO:0045732; P:positive regulation of protein catabolic process; NAS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.::GO:0042325; P:regulation of phosphorylation; IMP:UniProtKB.::GO:0001894; P:tissue homeostasis; TAS:UniProtKB.
30Q2H0I3    622   KU70_CHAGB ATP-dependent DNA helicase II subu...614.5     34.3     31     61GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005958; C:DNA-dependent protein kinase-DNA ligase 4 complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.::GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
31P38632    267   NSE2_YEAST E3 SUMO-protein ligase MMS21 OS=Sa...597.1     33.1     32     46GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005635; C:nuclear envelope; IDA:SGD.::GO:0030915; C:Smc5-Smc6 complex; IDA:SGD.
GO:0019789; F:SUMO ligase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IMP:SGD.
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