Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOR136W
Length:
369
Number of sequences:
5887
Description:
YOR136W IDH2 SGDID:S000005662, Chr XV from 580250-581359, Genome Release 64-1-1, Verified ORF, "Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P28241    369   IDH2_YEAST Isocitrate dehydrogenase [NAD] sub...3690     753     100     100GO:0005962; C:mitochondrial isocitrate dehydrogenase complex (NAD+); IDA:SGD.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0006537; P:glutamate biosynthetic process; TAS:SGD.::GO:0006102; P:isocitrate metabolic process; TAS:SGD.::GO:0006099; P:tricarboxylic acid cycle; TAS:SGD.
2O94230    368   IDH2_KLULA Isocitrate dehydrogenase [NAD] sub...3690     644     84     92GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
3Q9USP8    378   IDH2_SCHPO Isocitrate dehydrogenase [NAD] sub...3657e-161     463     62     77GO:0005759; C:mitochondrial matrix; ISS:PomBase.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IMP:PomBase.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0006537; P:glutamate biosynthetic process; IMP:PomBase.::GO:0006102; P:isocitrate metabolic process; IMP:PomBase.::GO:0006099; P:tricarboxylic acid cycle; IMP:PomBase.
4Q9VWH4    377   IDH3A_DROME Probable isocitrate dehydrogenase...3381e-131     388     57     73GO:0005811; C:lipid particle; IDA:FlyBase.::GO:0005875; C:microtubule associated complex; IDA:FlyBase.::GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; ISS:UniProtKB.
5Q93714    358   IDH3A_CAEEL Probable isocitrate dehydrogenase...3329e-130     383     59     72GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.::GO:0016246; P:RNA interference; IMP:WormBase.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
6Q945K7    374   IDH5_ARATH Isocitrate dehydrogenase [NAD] cat...3422e-121     362     54     72GO:0009507; C:chloroplast; IDA:TAIR.::GO:0005739; C:mitochondrion; IDA:TAIR.
GO:0005524; F:ATP binding; IDA:TAIR.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IMP:TAIR.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IDA:TAIR.
GO:0006102; P:isocitrate metabolic process; IMP:TAIR.::GO:0006099; P:tricarboxylic acid cycle; TAS:TAIR.
7Q9D6R2    366   IDH3A_MOUSE Isocitrate dehydrogenase [NAD] su...3373e-120     359     56     71GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
8P50213    366   IDH3A_HUMAN Isocitrate dehydrogenase [NAD] su...3371e-119     357     55     70GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0005975; P:carbohydrate metabolic process; NAS:ProtInc.::GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome.
9Q55BI2    354   IDHA_DICDI Isocitrate dehydrogenase [NAD] reg...3322e-119     357     55     73GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
10Q5R678    366   IDH3A_PONAB Isocitrate dehydrogenase [NAD] su...3372e-119     357     55     70GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
11Q28480    347   IDH3A_MACFA Isocitrate dehydrogenase [NAD] su...3373e-119     356     55     70GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
12P41563    366   IDH3A_BOVIN Isocitrate dehydrogenase [NAD] su...3374e-119     356     55     70GO:0005739; C:mitochondrion; ISS:AgBase.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
13Q99NA5    366   IDH3A_RAT Isocitrate dehydrogenase [NAD] subu...3374e-118     353     55     70GO:0005962; C:mitochondrial isocitrate dehydrogenase complex (NAD+); IC:RGD.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IDA:RGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; IDA:RGD.::GO:0006102; P:isocitrate metabolic process; IDA:RGD.::GO:0006734; P:NADH metabolic process; IDA:RGD.::GO:0006099; P:tricarboxylic acid cycle; IDA:RGD.
14Q8LG77    374   IDH6_ARATH Isocitrate dehydrogenase [NAD] cat...3352e-117     352     55     72GO:0005739; C:mitochondrion; IDA:TAIR.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; TAS:TAIR.
15P29696    357   LEU3_SOLTU 3-isopropylmalate dehydrogenase, c...3106e-112     337     56     73GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:InterPro.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
16Q54B68    360   IDHB_DICDI Isocitrate dehydrogenase [NAD] reg...3343e-105     320     51     67GO:0005739; C:mitochondrion; ISS:UniProtKB.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
17O94229    361   IDH1_KLULA Isocitrate dehydrogenase [NAD] sub...3457e-95     294     46     64GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
18O13302    388   IDH1_AJECA Isocitrate dehydrogenase [NAD] sub...3701e-94     294     42     62GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
19P28834    360   IDH1_YEAST Isocitrate dehydrogenase [NAD] sub...3665e-90     281     42     63GO:0005829; C:cytosol; TAS:Reactome.::GO:0005758; C:mitochondrial intermembrane space; TAS:Reactome.::GO:0005962; C:mitochondrial isocitrate dehydrogenase complex (NAD+); IDA:SGD.::GO:0042645; C:mitochondrial nucleoid; IDA:SGD.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0006537; P:glutamate biosynthetic process; TAS:SGD.::GO:0006102; P:isocitrate metabolic process; TAS:SGD.::GO:0006099; P:tricarboxylic acid cycle; TAS:SGD.
20Q8LFC0    367   IDH1_ARATH Isocitrate dehydrogenase [NAD] reg...3477e-89     278     43     64GO:0005739; C:mitochondrion; IDA:TAIR.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IDA:TAIR.
GO:0006102; P:isocitrate metabolic process; IMP:TAIR.::GO:0006099; P:tricarboxylic acid cycle; TAS:TAIR.
21O81796    368   IDH3_ARATH Isocitrate dehydrogenase [NAD] reg...3672e-87     275     42     61GO:0005739; C:mitochondrion; IDA:TAIR.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IGI:TAIR.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006102; P:isocitrate metabolic process; IGI:TAIR.::GO:0006099; P:tricarboxylic acid cycle; TAS:TAIR.
22P33197    496   IDH_THET8 Isocitrate dehydrogenase [NADP] OS=...3422e-87     279     44     64
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
23O13696    356   IDH1_SCHPO Isocitrate dehydrogenase [NAD] sub...3454e-87     274     44     63GO:0005759; C:mitochondrial matrix; ISS:PomBase.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IMP:PomBase.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0006537; P:glutamate biosynthetic process; IMP:PomBase.::GO:0006102; P:isocitrate metabolic process; IMP:PomBase.::GO:0006099; P:tricarboxylic acid cycle; IMP:PomBase.
24P93032    367   IDH2_ARATH Isocitrate dehydrogenase [NAD] reg...3775e-87     274     40     62GO:0005739; C:mitochondrion; IDA:TAIR.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; TAS:TAIR.
25Q1RJU4    483   IDH_RICBR Isocitrate dehydrogenase [NADP] OS=...3355e-78     254     44     61
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
26P41564    355   IDH3G_MACFA Isocitrate dehydrogenase [NAD] su...3396e-78     250     41     63GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
27P51553    393   IDH3G_HUMAN Isocitrate dehydrogenase [NAD] su...3392e-77     249     41     63GO:0005759; C:mitochondrial matrix; TAS:Reactome.::GO:0005730; C:nucleolus; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0005975; P:carbohydrate metabolic process; NAS:ProtInc.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome.
28P70404    393   IDHG1_MOUSE Isocitrate dehydrogenase [NAD] su...3394e-77     249     40     63GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
29P41565    393   IDHG1_RAT Isocitrate dehydrogenase [NAD] subu...3394e-77     249     40     63GO:0005962; C:mitochondrial isocitrate dehydrogenase complex (NAD+); IC:RGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; IDA:RGD.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006734; P:NADH metabolic process; IDA:RGD.::GO:0045926; P:negative regulation of growth; IMP:RGD.::GO:0006099; P:tricarboxylic acid cycle; IDA:RGD.
30Q58CP0    392   IDH3G_BOVIN Isocitrate dehydrogenase [NAD] su...3431e-76     248     40     62GO:0005739; C:mitochondrion; ISS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
31O77784    385   IDH3B_BOVIN Isocitrate dehydrogenase [NAD] su...3585e-76     246     39     62GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
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