| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
181 | Q8R5G7 | 1538 | ARAP3_MOUSE Arf-GAP with Rho-GAP domain, ANK ... | 163 | 0.0001 | 48.5 | 25 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005100; F:Rho GTPase activator activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0030336; P:negative regulation of cell migration; IDA:MGI.::GO:0035021; P:negative regulation of Rac protein signal transduction; IDA:MGI.::GO:0035024; P:negative regulation of Rho protein signal transduction; IDA:MGI.::GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.::GO:0008360; P:regulation of cell shape; IDA:MGI.::GO:0007165; P:signal transduction; IEA:InterPro. | 182 | Q6INE5 | 507 | RHG19_XENLA Rho GTPase-activating protein 19 ... | 150 | 0.0001 | 48.1 | 35 | 55 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 183 | Q54VW7 | 1203 | GACGG_DICDI Rho GTPase-activating protein gac... | 183 | 0.0001 | 48.1 | 27 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 184 | Q9HF75 | 2071 | BEM2_ASHGO GTPase-activating protein BEM2 OS=... | 188 | 0.0001 | 48.5 | 26 | 40 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 185 | Q8K2H3 | 851 | FA13B_MOUSE Protein FAM13B OS=Mus musculus (M... | 195 | 0.0001 | 47.8 | 22 | 49 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 186 | Q54F80 | 514 | GACD_DICDI Rho GTPase-activating protein gacD... | 248 | 0.0001 | 47.4 | 25 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 187 | Q9PT60 | 655 | RBP1A_XENLA RalA-binding protein 1-A OS=Xenop... | 180 | 0.0002 | 47.4 | 22 | 47 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0017160; F:Ral GTPase binding; IPI:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IMP:UniProtKB.::GO:0001702; P:gastrulation with mouth forming second; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IPI:UniProtKB. | 188 | Q553X3 | 799 | GACI_DICDI Rho GTPase-activating protein gacI... | 275 | 0.0002 | 47 | 20 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 189 | Q6ZUM4 | 889 | RHG27_HUMAN Rho GTPase-activating protein 27 ... | 194 | 0.0003 | 47 | 23 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; ISS:HGNC.::GO:0017124; F:SH3 domain binding; ISS:HGNC. | | | | | | | | | | GO:0043089; P:positive regulation of Cdc42 GTPase activity; ISS:HGNC.::GO:0006898; P:receptor-mediated endocytosis; ISS:HGNC.::GO:0007165; P:signal transduction; IEA:InterPro. | 190 | Q54PG5 | 399 | GACC_DICDI Rho GTPase-activating protein gacC... | 181 | 0.0003 | 46.6 | 27 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 191 | Q20498 | 759 | RRC1_CAEEL GTPase-activating protein rrc-1 OS... | 161 | 0.0003 | 46.6 | 22 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 192 | P39960 | 2167 | BEM2_YEAST GTPase-activating protein BEM2/IPL... | 191 | 0.0003 | 47 | 25 | 44 | GO:0005938; C:cell cortex; IDA:SGD.::GO:0005934; C:cellular bud tip; IDA:SGD.::GO:0000131; C:incipient cellular bud site; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005886; C:plasma membrane; IDA:SGD. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005100; F:Rho GTPase activator activity; IDA:SGD. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IGI:SGD.::GO:0030010; P:establishment of cell polarity; TAS:SGD.::GO:0031505; P:fungal-type cell wall organization; TAS:SGD.::GO:0035024; P:negative regulation of Rho protein signal transduction; IMP:SGD.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 193 | Q6GPD0 | 1940 | RHG32_XENLA Rho GTPase-activating protein 32 ... | 216 | 0.0004 | 46.6 | 23 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0035091; F:phosphatidylinositol binding; IEA:InterPro. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 194 | Q54BP9 | 520 | GACV_DICDI Rho GTPase-activating protein gacV... | 120 | 0.0004 | 45.8 | 32 | 50 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 195 | Q9VDG2 | 625 | RLIP_DROME RalA-binding protein 1 OS=Drosophi... | 186 | 0.0005 | 46.2 | 24 | 48 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0017160; F:Ral GTPase binding; IPI:FlyBase. | | | | | | | | | | GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006898; P:receptor-mediated endocytosis; IMP:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 196 | Q96P48 | 1450 | ARAP1_HUMAN Arf-GAP with Rho-GAP domain, ANK ... | 199 | 0.0005 | 46.2 | 25 | 42 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008060; F:ARF GTPase activator activity; IDA:UniProtKB.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005100; F:Rho GTPase activator activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0030037; P:actin filament reorganization involved in cell cycle; TAS:UniProtKB.::GO:0051497; P:negative regulation of stress fiber assembly; IMP:UniProtKB.::GO:0043089; P:positive regulation of Cdc42 GTPase activity; IDA:UniProtKB.::GO:0051491; P:positive regulation of filopodium assembly; IMP:UniProtKB.::GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.::GO:0051270; P:regulation of cellular component movement; IMP:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 197 | Q9NYF5 | 915 | FA13B_HUMAN Protein FAM13B OS=Homo sapiens (H... | 205 | 0.0005 | 46.2 | 23 | 46 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 198 | Q4LDD4 | 1452 | ARAP1_MOUSE Arf-GAP with Rho-GAP domain, ANK ... | 200 | 0.0008 | 45.4 | 26 | 45 | GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070412; F:R-SMAD binding; ISS:BHF-UCL.::GO:0005100; F:Rho GTPase activator activity; ISS:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.::GO:0008134; F:transcription factor binding; ISS:BHF-UCL.::GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.::GO:0007184; P:SMAD protein import into nucleus; ISS:UniProtKB.::GO:0060395; P:SMAD protein signal transduction; ISS:UniProtKB.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB. | 199 | Q6ZW31 | 735 | SYDE1_HUMAN Rho GTPase-activating protein SYD... | 194 | 0.001 | 45.1 | 25 | 38 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005100; F:Rho GTPase activator activity; ISS:UniProtKB. | | | | | | | | | | GO:0032862; P:activation of Rho GTPase activity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 200 | Q9VX32 | 1561 | RG190_DROME Rho GTPase-activating protein 190... | 199 | 0.001 | 44.7 | 26 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:InterPro.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016319; P:mushroom body development; IMP:FlyBase.::GO:0050770; P:regulation of axonogenesis; IGI:FlyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 201 | Q55CK2 | 877 | MGP2_DICDI Mental retardation GTPase activati... | 206 | 0.002 | 43.9 | 25 | 43 | GO:0000331; C:contractile vacuole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0033298; P:contractile vacuole organization; IGI:dictyBase.::GO:0006887; P:exocytosis; IGI:dictyBase.::GO:0051490; P:negative regulation of filopodium assembly; IMP:dictyBase.::GO:0042331; P:phototaxis; IGI:dictyBase.::GO:0051270; P:regulation of cellular component movement; IMP:dictyBase.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase. | 202 | Q86NH1 | 987 | SYD1_CAEEL Rho GTPase-activating protein syd-... | 165 | 0.003 | 43.5 | 25 | 44 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0042734; C:presynaptic membrane; IDA:WormBase. | | | | | | | | | | GO:0005100; F:Rho GTPase activator activity; IMP:UniProtKB. | | | | | | | | | | GO:0032862; P:activation of Rho GTPase activity; IMP:UniProtKB.::GO:0008088; P:axon cargo transport; IGI:WormBase.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0030030; P:cell projection organization; IMP:UniProtKB.::GO:0034613; P:cellular protein localization; IGI:WormBase.::GO:0040011; P:locomotion; IGI:WormBase.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; IEA:InterPro. | 203 | O43027 | 733 | RGA6_SCHPO Probable Rho-GTPase-activating pro... | 229 | 0.003 | 43.5 | 24 | 40 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 204 | O74360 | 933 | RGA4_SCHPO Probable Rho-type GTPase-activatin... | 192 | 0.016 | 41.2 | 20 | 43 | GO:0032153; C:cell division site; IDA:PomBase.::GO:0071944; C:cell periphery; IDA:PomBase.::GO:0005737; C:cytoplasm; IDA:PomBase. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0070650; P:actin filament bundle distribution; IMP:PomBase.::GO:0034613; P:cellular protein localization; IGI:PomBase.::GO:0060583; P:regulation of actin cortical patch localization; IMP:PomBase.::GO:0032231; P:regulation of actin filament bundle assembly; IMP:PomBase.::GO:0060305; P:regulation of cell diameter; IMP:PomBase.::GO:0007165; P:signal transduction; IEA:InterPro. | 205 | Q9DBZ9 | 737 | SYDE1_MOUSE Rho GTPase-activating protein SYD... | 116 | 0.019 | 40.8 | 28 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005100; F:Rho GTPase activator activity; ISS:UniProtKB. | | | | | | | | | | GO:0032862; P:activation of Rho GTPase activity; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 206 | Q55GP8 | 684 | GACO_DICDI Rho GTPase-activating protein gacO... | 142 | 0.026 | 40.4 | 27 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 207 | Q8UUU2 | 722 | P85AA_XENLA Phosphatidylinositol 3-kinase reg... | 158 | 0.035 | 40 | 26 | 45 | GO:0005943; C:1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; ISS:UniProtKB. | | | | | | | | | | GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.::GO:0005158; F:insulin receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.::GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.::GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; ISS:UniProtKB. | | | | | | | | | | GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; ISS:UniProtKB. | 208 | Q61CA4 | 962 | SYD1_CAEBR Rho GTPase-activating protein syd-... | 211 | 0.041 | 40 | 24 | 41 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0045202; C:synapse; ISS:UniProtKB. | | | | | | | | | | GO:0005100; F:Rho GTPase activator activity; ISS:UniProtKB. | | | | | | | | | | GO:0032862; P:activation of Rho GTPase activity; ISS:UniProtKB.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0030030; P:cell projection organization; ISS:UniProtKB.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; IEA:InterPro. | 209 | P39083 | 1007 | RGA1_YEAST Rho-type GTPase-activating protein... | 226 | 0.042 | 40 | 19 | 39 | GO:0032177; C:cellular bud neck split septin rings; IDA:SGD. | | | | | | | | | | GO:0005100; F:Rho GTPase activator activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:SGD.::GO:0007118; P:budding cell apical bud growth; IPI:SGD.::GO:0007119; P:budding cell isotropic bud growth; IPI:SGD.::GO:0030010; P:establishment of cell polarity; IMP:SGD.::GO:0001403; P:invasive growth in response to glucose limitation; IPI:SGD.::GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IGI:SGD.::GO:0007124; P:pseudohyphal growth; IPI:SGD.::GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD. | 210 | D2H9U0 | 547 | RHG36_AILME Rho GTPase-activating protein 36 ... | 183 | 0.048 | 39.7 | 27 | 43 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 211 | Q54E35 | 570 | GACEE_DICDI Rho GTPase-activating protein gac... | 149 | 0.084 | 38.9 | 28 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. |
