Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOR127W
Length:
1007
Number of sequences:
5887
Description:
YOR127W RGA1 SGDID:S000005653, Chr XV from 561170-564193, Genome Release 64-1-1, Verified ORF, "GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
241Q9P2N2    729   RHG28_HUMAN Rho GTPase-activating protein 28 ...2110.002     45.8     24     43GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
242Q679P3    416   PDLI7_CHICK PDZ and LIM domain protein 7 OS=G...1260.003     45.1     28     39GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0001503; P:ossification; IEA:UniProtKB-KW.
243O54834    987   RHG06_MOUSE Rho GTPase-activating protein 6 O...1780.003     45.1     22     47GO:0015629; C:actin cytoskeleton; IDA:MGI.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005100; F:Rho GTPase activator activity; IDA:MGI.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007015; P:actin filament organization; IDA:MGI.::GO:0048041; P:focal adhesion assembly; IDA:MGI.::GO:0007165; P:signal transduction; IEA:InterPro.
244Q54L00    650   LIMKA_DICDI Probable LIM domain-containing se...1190.003     45.1     26     44
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
245Q9R0Z9    1092   RHG07_MOUSE Rho GTPase-activating protein 7 O...1960.004     44.7     23     42GO:0005737; C:cytoplasm; NAS:UniProtKB.
GO:0005100; F:Rho GTPase activator activity; NAS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; IMP:MGI.::GO:0048041; P:focal adhesion assembly; IMP:MGI.::GO:0030900; P:forebrain development; IMP:MGI.::GO:0003007; P:heart morphogenesis; IMP:MGI.::GO:0021575; P:hindbrain morphogenesis; IMP:MGI.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0001843; P:neural tube closure; IMP:MGI.::GO:0007165; P:signal transduction; IEA:InterPro.
246A8DZE6    648   WTIP_DANRE Wilms tumor protein 1-interacting ...1370.004     44.7     25     42GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.::GO:0014032; P:neural crest cell development; ISS:UniProtKB.::GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
247Q63744    1091   RHG07_RAT Rho GTPase-activating protein 7 OS=...1960.004     44.7     23     42GO:0005737; C:cytoplasm; NAS:UniProtKB.
GO:0043274; F:phospholipase binding; IPI:RGD.::GO:0005100; F:Rho GTPase activator activity; IDA:RGD.::GO:0017166; F:vinculin binding; IPI:RGD.
GO:0007202; P:activation of phospholipase C activity; IDA:RGD.::GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.::GO:0007010; P:cytoskeleton organization; NAS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0007266; P:Rho protein signal transduction; NAS:RGD.
248B9VTT2    1091   RHG07_CANFA Rho GTPase-activating protein 7 O...1900.005     44.7     23     40GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
249O75112    727   LDB3_HUMAN LIM domain-binding protein 3 OS=Ho...1250.005     44.7     26     35GO:0005856; C:cytoskeleton; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.::GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
GO:0008092; F:cytoskeletal protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
250Q8N103    731   TAGAP_HUMAN T-cell activation Rho GTPase-acti...1900.005     44.3     20     45GO:0005829; C:cytosol; TAS:Reactome.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
251Q801P0    171   LMO4B_XENLA LIM domain transcription factor L...760.005     42.4     26     39
GO:0003712; F:transcription cofactor activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007369; P:gastrulation; IEA:UniProtKB-KW.::GO:0007498; P:mesoderm development; ISS:UniProtKB.::GO:0045665; P:negative regulation of neuron differentiation; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
252Q8AW92    171   LMO4A_XENLA LIM domain transcription factor L...760.005     42.4     26     39
GO:0003712; F:transcription cofactor activity; IMP:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007369; P:gastrulation; IEA:UniProtKB-KW.::GO:0007498; P:mesoderm development; IMP:UniProtKB.::GO:0045665; P:negative regulation of neuron differentiation; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
253Q96MT3    831   PRIC1_HUMAN Prickle-like protein 1 OS=Homo sa...652.3     35.8     32     46GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IDA:BHF-UCL.::GO:2000691; P:negative regulation of cardiac muscle cell myoblast differentiation; IDA:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0001843; P:neural tube closure; IMP:UniProtKB.::GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.::GO:0031398; P:positive regulation of protein ubiquitination; IDA:BHF-UCL.::GO:0006606; P:protein import into nucleus; IDA:UniProtKB.
254Q71QF9    831   PRIC1_RAT Prickle-like protein 1 OS=Rattus no...1160.007     44.3     23     37GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0008134; F:transcription factor binding; IPI:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006606; P:protein import into nucleus; IDA:RGD.
255Q96QB1    1528   RHG07_HUMAN Rho GTPase-activating protein 7 O...1960.007     44.3     23     41GO:0005901; C:caveola; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005100; F:Rho GTPase activator activity; IDA:UniProtKB.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.::GO:0048041; P:focal adhesion assembly; ISS:UniProtKB.::GO:0030900; P:forebrain development; ISS:UniProtKB.::GO:0003007; P:heart morphogenesis; ISS:UniProtKB.::GO:0021575; P:hindbrain morphogenesis; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; IDA:UniProtKB.::GO:0030336; P:negative regulation of cell migration; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.::GO:0035024; P:negative regulation of Rho protein signal transduction; IMP:UniProtKB.::GO:0051497; P:negative regulation of stress fiber assembly; IDA:UniProtKB.::GO:0001843; P:neural tube closure; ISS:UniProtKB.::GO:0035307; P:positive regulation of protein dephosphorylation; IDA:UniProtKB.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
256Q174I2    916   PRIC1_AEDAE Protein prickle OS=Aedes aegypti ...801     37     29     41GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009948; P:anterior/posterior axis specification; ISS:UniProtKB.::GO:0001736; P:establishment of planar polarity; ISS:UniProtKB.
257Q6INU3    421   PDLI7_XENLA PDZ and LIM domain protein 7 OS=X...1240.008     43.5     27     39GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
258Q62920    591   PDLI5_RAT PDZ and LIM domain protein 5 OS=Rat...1270.008     43.5     26     36GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0014069; C:postsynaptic density; IDA:UniProtKB.::GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IDA:UniProtKB.::GO:0042805; F:actinin binding; IDA:UniProtKB.::GO:0005080; F:protein kinase C binding; IDA:UniProtKB.::GO:0047485; F:protein N-terminus binding; IMP:RGD.::GO:0030159; F:receptor signaling complex scaffold activity; NAS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007507; P:heart development; NAS:UniProtKB.::GO:0061001; P:regulation of dendritic spine morphogenesis; IDA:UniProtKB.::GO:0051963; P:regulation of synapse assembly; IDA:UniProtKB.
259Q923Q2    1113   STA13_MOUSE StAR-related lipid transfer prote...1910.008     43.9     22     43GO:0005811; C:lipid particle; IEA:UniProtKB-SubCell.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; IEA:InterPro.
260Q80Y24    845   PRIC2_MOUSE Prickle-like protein 2 OS=Mus mus...820.3     38.9     30     43GO:0016327; C:apicolateral plasma membrane; IDA:MGI.::GO:0016328; C:lateral plasma membrane; IDA:MGI.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IDA:MGI.::GO:0031175; P:neuron projection development; IMP:MGI.
261Q3U5C7    832   PRIC1_MOUSE Prickle-like protein 1 OS=Mus mus...1160.008     43.9     23     37GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
262O43052    1150   RGA1_SCHPO Rho-type GTPase-activating protein...1750.008     43.9     22     43GO:0032153; C:cell division site; IDA:PomBase.::GO:0030428; C:cell septum; IEA:UniProtKB-SubCell.::GO:0051286; C:cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005100; F:Rho GTPase activator activity; ISS:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051666; P:actin cortical patch localization; IMP:PomBase.::GO:0030036; P:actin cytoskeleton organization; IMP:PomBase.::GO:0071937; P:barrier septum assembly involved in cell cycle cytokinesis; IMP:PomBase.::GO:0009272; P:fungal-type cell wall biogenesis; IMP:PomBase.::GO:0008360; P:regulation of cell shape; IMP:PomBase.::GO:0007165; P:signal transduction; IEA:InterPro.
263Q9JKS4    723   LDB3_MOUSE LIM domain-binding protein 3 OS=Mu...1260.009     43.9     25     33GO:0005856; C:cytoskeleton; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.::GO:0030018; C:Z disc; IDA:MGI.
GO:0005080; F:protein kinase C binding; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
264Q54VW7    1203   GACGG_DICDI Rho GTPase-activating protein gac...1950.01     43.5     24     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
265Q7QJT4    923   PRIC1_ANOGA Protein prickle OS=Anopheles gamb...750.59     37.7     32     44GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009948; P:anterior/posterior axis specification; ISS:UniProtKB.::GO:0001736; P:establishment of planar polarity; ISS:UniProtKB.
266Q7Z3G6    844   PRIC2_HUMAN Prickle-like protein 2 OS=Homo sa...820.23     39.3     30     44GO:0005737; C:cytoplasm; IDA:LIFEdb.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
267Q9Y3M8    1113   STA13_HUMAN StAR-related lipid transfer prote...1910.011     43.5     21     41GO:0005829; C:cytosol; TAS:Reactome.::GO:0005811; C:lipid particle; IEA:UniProtKB-SubCell.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
268Q8CI51    591   PDLI5_MOUSE PDZ and LIM domain protein 5 OS=M...1270.011     43.1     26     36GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0014069; C:postsynaptic density; ISS:UniProtKB.::GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.::GO:0030018; C:Z disc; IDA:MGI.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0051963; P:regulation of synapse assembly; ISS:UniProtKB.
269E9Q6X9    672   RHG40_MOUSE Rho GTPase-activating protein 40 ...1630.012     43.1     26     44GO:0005622; C:intracellular; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
270Q96HC4    596   PDLI5_HUMAN PDZ and LIM domain protein 5 OS=H...1260.012     43.1     25     36GO:0015629; C:actin cytoskeleton; IDA:LIFEdb.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0014069; C:postsynaptic density; ISS:UniProtKB.::GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; ISS:UniProtKB.::GO:0042805; F:actinin binding; ISS:UniProtKB.::GO:0005080; F:protein kinase C binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0051963; P:regulation of synapse assembly; ISS:UniProtKB.
271P27986    724   P85A_HUMAN Phosphatidylinositol 3-kinase regu...1270.013     43.1     25     49GO:0005943; C:1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; ISS:UniProtKB.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005545; F:1-phosphatidylinositol binding; NAS:UniProtKB.::GO:0043125; F:ErbB-3 class receptor binding; IDA:UniProtKB.::GO:0043559; F:insulin binding; IDA:UniProtKB.::GO:0005158; F:insulin receptor binding; IPI:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:BHF-UCL.::GO:0005159; F:insulin-like growth factor receptor binding; IPI:UniProtKB.::GO:0005168; F:neurotrophin TRKA receptor binding; IPI:UniProtKB.::GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; ISS:UniProtKB.::GO:0019903; F:protein phosphatase binding; IPI:UniProtKB.
GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0060396; P:growth hormone receptor signaling pathway; IDA:BHF-UCL.::GO:0008286; P:insulin receptor signaling pathway; IPI:UniProtKB.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; IPI:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; IDA:BHF-UCL.::GO:0046854; P:phosphatidylinositol phosphorylation; ISS:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; ISS:BHF-UCL.::GO:0046326; P:positive regulation of glucose import; ISS:BHF-UCL.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
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