Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOR123C
Length:
464
Number of sequences:
5887
Description:
YOR123C LEO1 SGDID:S000005649, Chr XV from 554570-553176, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P38439    464   LEO1_YEAST RNA polymerase-associated protein ...4640     937     100     100GO:0016593; C:Cdc73/Paf1 complex; IPI:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0003723; F:RNA binding; IDA:SGD.::GO:0001076; F:RNA polymerase II transcription factor binding transcription factor activity; IPI:SGD.
GO:0080182; P:histone H3-K4 trimethylation; IMP:SGD.::GO:2001209; P:positive regulation of transcription elongation from RNA polymerase I promoter; IDA:SGD.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IMP:SGD.::GO:2001173; P:regulation of histone H2B conserved C-terminal lysine ubiquitination; IDA:SGD.
2Q641X2    678   LEO1_RAT RNA polymerase-associated protein LE...2083e-26     115     32     55GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
GO:0001711; P:endodermal cell fate commitment; ISS:UniProtKB.::GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.::GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.::GO:0031442; P:positive regulation of mRNA 3'-end processing; ISS:UniProtKB.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0019827; P:stem cell maintenance; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
3Q5XJE5    667   LEO1_MOUSE RNA polymerase-associated protein ...2083e-26     115     32     55GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
GO:0001711; P:endodermal cell fate commitment; IMP:UniProtKB.::GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.::GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.::GO:0031442; P:positive regulation of mRNA 3'-end processing; ISS:UniProtKB.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0019827; P:stem cell maintenance; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
4Q8WVC0    666   LEO1_HUMAN RNA polymerase-associated protein ...2083e-26     115     32     55GO:0016593; C:Cdc73/Paf1 complex; IDA:UniProtKB.::GO:0005730; C:nucleolus; IDA:HPA.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0001711; P:endodermal cell fate commitment; ISS:UniProtKB.::GO:0033523; P:histone H2B ubiquitination; IDA:UniProtKB.::GO:0010390; P:histone monoubiquitination; IDA:UniProtKB.::GO:0006378; P:mRNA polyadenylation; IMP:UniProtKB.::GO:0045638; P:negative regulation of myeloid cell differentiation; IDA:UniProtKB.::GO:0031442; P:positive regulation of mRNA 3'-end processing; IMP:UniProtKB.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IDA:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0019827; P:stem cell maintenance; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
5Q5R4D6    666   LEO1_PONAB RNA polymerase-associated protein ...2084e-25     112     32     55GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
GO:0001711; P:endodermal cell fate commitment; ISS:UniProtKB.::GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.::GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.::GO:0031442; P:positive regulation of mRNA 3'-end processing; ISS:UniProtKB.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0019827; P:stem cell maintenance; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
6Q6NYV9    696   LEO1_DANRE RNA polymerase-associated protein ...2081e-24     110     32     55GO:0016593; C:Cdc73/Paf1 complex; IDA:ZFIN.
GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:ZFIN.::GO:0021782; P:glial cell development; IMP:ZFIN.::GO:0007507; P:heart development; IMP:ZFIN.::GO:0030318; P:melanocyte differentiation; IMP:ZFIN.::GO:0014032; P:neural crest cell development; IMP:ZFIN.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0050936; P:xanthophore differentiation; IMP:ZFIN.
7Q52KV5    703   LEO1_XENLA RNA polymerase-associated protein ...2084e-24     109     31     55GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
8Q9P6R2    429   YOH8_SCHPO Uncharacterized protein C13E7.08c ...3184e-22     101     27     47GO:0016593; C:Cdc73/Paf1 complex; ISS:PomBase.
GO:0003723; F:RNA binding; ISS:PomBase.
GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:PomBase.
9Q54MB8    487   LEO1_DICDI RNA polymerase-associated protein ...1832e-17     88.2     33     54GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
10Q94546    725   ATU_DROME Another transcription unit protein ...2100.000000000000003     82     29     49
11Q18DN4    9159   HMU_HALWD Halomucin OS=Haloquadratum walsbyi ...978     33.1     25     45GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:InterPro.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0030246; F:carbohydrate binding; IEA:InterPro.::GO:0004180; F:carboxypeptidase activity; IEA:InterPro.
GO:0007156; P:homophilic cell adhesion; IEA:InterPro.
12P0C6U5    4421   R1A_CVHN5 Replicase polyprotein 1a OS=Human c...1210.019     41.6     21     52GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
13P0C6X4    7132   R1AB_CVHN5 Replicase polyprotein 1ab OS=Human...1210.019     41.6     21     52GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.::GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008168; F:methyltransferase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:InterPro.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
14P0C6U3    4471   R1A_CVHN1 Replicase polyprotein 1a OS=Human c...1180.98     35.8     25     42GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
15P0C6X2    7182   R1AB_CVHN1 Replicase polyprotein 1ab OS=Human...1180.99     35.8     25     42GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.::GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008168; F:methyltransferase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:InterPro.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
16P0C6U4    4441   R1A_CVHN2 Replicase polyprotein 1a OS=Human c...1180.98     35.8     25     42GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
17P0C6X3    7152   R1AB_CVHN2 Replicase polyprotein 1ab OS=Human...1180.99     35.8     25     42GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.::GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008168; F:methyltransferase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:InterPro.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
18Q9CGJ9    80   YLAC_LACLA UPF0291 protein ylaC OS=lactis). G...580.36     34.3     33     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
19A2RL87    80   Y1475_LACLM UPF0291 protein llmg_1475 OS=Lact...580.36     34.3     33     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
20Q02Z92    80   Y1198_LACLS UPF0291 protein LACR_1198 OS=Lact...581.1     33.1     33     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
21Q5ALX5    1665   SSN2_CANAL Mediator of RNA polymerase II tran...247.3     33.1     63     71GO:0016021; C:integral to membrane; IEA:InterPro.::GO:0016592; C:mediator complex; IEA:InterPro.
GO:0001104; F:RNA polymerase II transcription cofactor activity; IEA:InterPro.
GO:0030447; P:filamentous growth; IMP:CGD.
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