Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOR109W
Length:
1107
Number of sequences:
5887
Description:
YOR109W INP53 SGDID:S000005635, Chr XV from 525278-528601, Genome Release 64-1-1, Verified ORF, "Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31O14127    611   YF51_SCHPO Uncharacterized protein C3C7.01c O...4113e-45     177     33     47GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.::GO:0000139; C:Golgi membrane; ISS:PomBase.::GO:0005739; C:mitochondrion; ISS:PomBase.
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
GO:0006887; P:exocytosis; ISS:PomBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.
32O14306    1191   YE8A_SCHPO Probable inositol polyphosphate 5-...5034e-43     174     30     48GO:0030479; C:actin cortical patch; ISS:PomBase.::GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.
GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; ISS:PomBase.
GO:0006897; P:endocytosis; ISS:PomBase.::GO:0031505; P:fungal-type cell wall organization; ISS:PomBase.::GO:0048017; P:inositol lipid-mediated signaling; IC:PomBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
33Q9WVR1    647   INP5E_RAT 72 kDa inositol polyphosphate 5-pho...3138e-42     167     32     49GO:0035085; C:cilium axoneme; ISS:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:RGD.
GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IMP:RGD.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0010976; P:positive regulation of neuron projection development; IMP:RGD.
34A0FI79    644   INP5E_PANTR 72 kDa inositol polyphosphate 5-p...3138e-42     167     32     49GO:0035085; C:cilium axoneme; ISS:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
35Q9NRR6    644   INP5E_HUMAN 72 kDa inositol polyphosphate 5-p...3139e-42     167     32     49GO:0035085; C:cilium axoneme; IDA:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; TAS:UniProtKB.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
36Q9JII1    647   INP5E_MOUSE 72 kDa inositol polyphosphate 5-p...3132e-41     166     31     49GO:0035085; C:cilium axoneme; IDA:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:MGI.
GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:MGI.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
37Q84W55    1101   IP5P4_ARATH Type II inositol 1,4,5-trisphosph...3864e-37     155     28     45
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
38O80560    1305   IP5PC_ARATH Type I inositol 1,4,5-trisphospha...3881e-36     154     28     45
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IDA:TAIR.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0046855; P:inositol phosphate dephosphorylation; IDA:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
39Q84MA2    590   IP5P1_ARATH Type I inositol 1,4,5-trisphospha...910.00001     52.8     33     57
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:TAIR.
GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:TAIR.::GO:0032957; P:inositol trisphosphate metabolic process; IDA:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
40Q9FUR2    646   IP5P2_ARATH Type I inositol 1,4,5-trisphospha...880.052     41.2     28     52
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:TAIR.
GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:TAIR.::GO:0032957; P:inositol trisphosphate metabolic process; IMP:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0009845; P:seed germination; IMP:TAIR.
41P59644    1003   PI5PA_MOUSE Phosphatidylinositol 4,5-bisphosp...2903e-35     149     31     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0043198; C:dendritic shaft; IDA:MGI.::GO:0030426; C:growth cone; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI.
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:MGI.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0010977; P:negative regulation of neuron projection development; IMP:MGI.::GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IMP:MGI.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
42Q9JMC1    1001   PI5PA_RAT Phosphatidylinositol 4,5-bisphospha...3283e-35     149     30     48GO:0005737; C:cytoplasm; IDA:RGD.::GO:0030426; C:growth cone; IDA:RGD.::GO:0001726; C:ruffle; IDA:RGD.
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:RGD.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0031115; P:negative regulation of microtubule polymerization; IMP:RGD.::GO:0010977; P:negative regulation of neuron projection development; IMP:RGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
43Q15735    1006   PI5PA_HUMAN Phosphatidylinositol 4,5-bisphosp...2964e-35     149     31     50GO:0005737; C:cytoplasm; IDA:MGI.::GO:0001726; C:ruffle; IDA:MGI.
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
44Q9SYK4    1136   IP5PD_ARATH Type I inositol 1,4,5-trisphospha...3857e-35     148     29     43GO:0005634; C:nucleus; IDA:TAIR.
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IDA:TAIR.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0010252; P:auxin homeostasis; IMP:TAIR.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:TAIR.::GO:0010087; P:phloem or xylem histogenesis; IMP:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0009737; P:response to abscisic acid stimulus; IMP:TAIR.::GO:0009637; P:response to blue light; IEP:TAIR.::GO:0007584; P:response to nutrient; IMP:TAIR.::GO:0009611; P:response to wounding; IEP:TAIR.::GO:0048364; P:root development; IMP:TAIR.::GO:0010182; P:sugar mediated signaling pathway; IMP:TAIR.
45Q9LR47    617   IP5P3_ARATH Type I inositol 1,4,5-trisphospha...740.015     43.1     34     55
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.
GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0010588; P:cotyledon vascular tissue pattern formation; IMP:TAIR.::GO:0046855; P:inositol phosphate dephosphorylation; IMP:TAIR.::GO:0048016; P:inositol phosphate-mediated signaling; IC:TAIR.::GO:0032957; P:inositol trisphosphate metabolic process; IMP:TAIR.::GO:0010305; P:leaf vascular tissue pattern formation; IMP:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0010067; P:procambium histogenesis; IMP:TAIR.
46Q9SKB7    1144   IP5PE_ARATH Type II inositol 1,4,5-trisphosph...3872e-32     140     27     43
GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IDA:TAIR.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:TAIR.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:TAIR.
GO:0046855; P:inositol phosphate dephosphorylation; IDA:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
47P42837    879   FIG4_YEAST Polyphosphoinositide phosphatase O...5192e-31     137     25     44GO:0019898; C:extrinsic to membrane; IDA:SGD.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0070772; C:PAS complex; IDA:SGD.
GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD.
48Q6P4S2    1019   SHIP1_XENLA Phosphatidylinositol 3,4,5-trisph...3377e-31     135     28     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
49Q8C5L6    468   INP5K_MOUSE Inositol polyphosphate 5-phosphat...3152e-30     130     30     48GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0043005; C:neuron projection; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0032587; C:ruffle membrane; ISS:UniProtKB.::GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
GO:0016312; F:inositol bisphosphate phosphatase activity; IMP:UniProtKB.::GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:UniProtKB.::GO:0005000; F:vasopressin receptor activity; IDA:UniProtKB.
GO:0071320; P:cellular response to cAMP; IDA:UniProtKB.::GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; ISS:UniProtKB.::GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.::GO:0042593; P:glucose homeostasis; IMP:UniProtKB.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0043922; P:negative regulation by host of viral transcription; ISS:UniProtKB.::GO:0051926; P:negative regulation of calcium ion transport; ISS:UniProtKB.::GO:0035305; P:negative regulation of dephosphorylation; IMP:UniProtKB.::GO:0010829; P:negative regulation of glucose transport; ISS:UniProtKB.::GO:2000466; P:negative regulation of glycogen (starch) synthase activity; IMP:UniProtKB.::GO:0045719; P:negative regulation of glycogen biosynthetic process; IMP:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.::GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IMP:UniProtKB.::GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; ISS:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0090315; P:negative regulation of protein targeting to membrane; ISS:UniProtKB.::GO:0045869; P:negative regulation of retroviral genome replication; ISS:UniProtKB.::GO:0051497; P:negative regulation of stress fiber assembly; ISS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:2001153; P:positive regulation of renal water transport; IDA:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0035810; P:positive regulation of urine volume; IDA:UniProtKB.::GO:0072661; P:protein targeting to plasma membrane; IDA:UniProtKB.::GO:0097178; P:ruffle assembly; ISS:UniProtKB.
50Q5EAF2    334   IP5PB_ARATH Type I inositol 1,4,5-trisphospha...3048e-30     126     31     50
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:TAIR.::GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; IDA:TAIR.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:TAIR.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0009737; P:response to abscisic acid stimulus; IEP:TAIR.::GO:0009733; P:response to auxin stimulus; IEP:TAIR.::GO:0009753; P:response to jasmonic acid stimulus; IEP:TAIR.
51P97573    1190   SHIP1_RAT Phosphatidylinositol 3,4,5-trisphos...3381e-29     131     28     46GO:0005884; C:actin filament; IDA:RGD.::GO:0030863; C:cortical cytoskeleton; IDA:RGD.::GO:0005829; C:cytosol; IDA:RGD.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0030487; F:inositol-4,5-bisphosphate 5-phosphatase activity; IDA:RGD.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
52Q9ES52    1191   SHIP1_MOUSE Phosphatidylinositol 3,4,5-trisph...3382e-29     130     28     45GO:0005622; C:intracellular; IMP:GOC.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:MGI.::GO:0034594; F:phosphatidylinositol trisphosphate phosphatase activity; IDA:MGI.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0051425; F:PTB domain binding; IDA:MGI.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0008340; P:determination of adult lifespan; IMP:MGI.::GO:0016064; P:immunoglobulin mediated immune response; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IMP:MGI.::GO:0050869; P:negative regulation of B cell activation; IMP:MGI.::GO:0030889; P:negative regulation of B cell proliferation; IMP:MGI.::GO:0045779; P:negative regulation of bone resorption; IMP:MGI.::GO:0050777; P:negative regulation of immune response; IMP:MGI.::GO:0045409; P:negative regulation of interleukin-6 biosynthetic process; IMP:MGI.::GO:0045656; P:negative regulation of monocyte differentiation; IMP:MGI.::GO:0045659; P:negative regulation of neutrophil differentiation; IMP:MGI.::GO:0045671; P:negative regulation of osteoclast differentiation; IMP:MGI.::GO:0009968; P:negative regulation of signal transduction; IMP:MGI.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0043065; P:positive regulation of apoptotic process; IMP:MGI.::GO:0045579; P:positive regulation of B cell differentiation; IMP:MGI.::GO:0045648; P:positive regulation of erythrocyte differentiation; IMP:MGI.
53Q2I6J1    1266   SHP2A_DANRE Phosphatidylinositol 3,4,5-trisph...3453e-29     130     29     47GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
GO:0030509; P:BMP signaling pathway; IMP:ZFIN.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IMP:ZFIN.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
54Q91WF7    907   FIG4_MOUSE Polyphosphoinositide phosphatase O...5213e-29     129     26     43GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
GO:0008219; P:cell death; IEA:UniProtKB-KW.::GO:0007626; P:locomotory behavior; IMP:MGI.::GO:0048666; P:neuron development; IMP:MGI.::GO:0046488; P:phosphatidylinositol metabolic process; IMP:MGI.::GO:0043473; P:pigmentation; IMP:MGI.::GO:0007033; P:vacuole organization; IMP:MGI.
55Q92562    907   FIG4_HUMAN Polyphosphoinositide phosphatase O...5212e-28     127     25     43GO:0010008; C:endosome membrane; IDA:UniProtKB.
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0008219; P:cell death; IEA:UniProtKB-KW.
56Q92835    1189   SHIP1_HUMAN Phosphatidylinositol 3,4,5-trisph...3413e-28     127     28     46GO:0005829; C:cytosol; TAS:Reactome.
GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; TAS:ProtInc.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
57Q9BT40    448   INP5K_HUMAN Inositol polyphosphate 5-phosphat...3153e-28     123     30     48GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0043005; C:neuron projection; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IDA:UniProtKB.::GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0016312; F:inositol bisphosphate phosphatase activity; IDA:UniProtKB.::GO:0046030; F:inositol trisphosphate phosphatase activity; IDA:MGI.::GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0042577; F:lipid phosphatase activity; NAS:UniProtKB.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005000; F:vasopressin receptor activity; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.::GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.::GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; IDA:UniProtKB.::GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.::GO:0043922; P:negative regulation by host of viral transcription; IDA:UniProtKB.::GO:0051926; P:negative regulation of calcium ion transport; IDA:UniProtKB.::GO:0035305; P:negative regulation of dephosphorylation; ISS:UniProtKB.::GO:0010829; P:negative regulation of glucose transport; IDA:UniProtKB.::GO:2000466; P:negative regulation of glycogen (starch) synthase activity; ISS:UniProtKB.::GO:0045719; P:negative regulation of glycogen biosynthetic process; IDA:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IDA:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; IDA:UniProtKB.::GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IDA:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IDA:UniProtKB.::GO:0090315; P:negative regulation of protein targeting to membrane; IDA:UniProtKB.::GO:0045869; P:negative regulation of retroviral genome replication; IDA:UniProtKB.::GO:0051497; P:negative regulation of stress fiber assembly; IDA:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:2001153; P:positive regulation of renal water transport; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0035810; P:positive regulation of urine volume; ISS:UniProtKB.::GO:0072661; P:protein targeting to plasma membrane; ISS:UniProtKB.::GO:0097178; P:ruffle assembly; IDA:UniProtKB.
58Q7Z9H9    832   FIG4_SCHPO Polyphosphoinositide phosphatase O...4641e-27     124     26     43GO:0005829; C:cytosol; IDA:PomBase.::GO:0019898; C:extrinsic to membrane; ISS:PomBase.::GO:0000329; C:fungal-type vacuole membrane; ISS:PomBase.
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
GO:0000753; P:cell morphogenesis involved in conjugation with cellular fusion; ISS:PomBase.::GO:0046488; P:phosphatidylinositol metabolic process; NAS:PomBase.::GO:0048015; P:phosphatidylinositol-mediated signaling; NAS:PomBase.
59Q2I6J0    1226   SHP2B_DANRE Phosphatidylinositol 3,4,5-trisph...3561e-27     125     26     46GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
60Q9WVR3    1257   SHIP2_RAT Phosphatidylinositol 3,4,5-trisphos...3386e-26     119     27     46GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:RGD.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:RGD.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:RGD.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007420; P:brain development; IEP:RGD.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0032957; P:inositol trisphosphate metabolic process; IDA:RGD.::GO:0008156; P:negative regulation of DNA replication; IMP:RGD.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:RGD.::GO:0043569; P:negative regulation of insulin-like growth factor receptor signaling pathway; IMP:RGD.::GO:0043407; P:negative regulation of MAP kinase activity; IMP:RGD.::GO:0010977; P:negative regulation of neuron projection development; IMP:RGD.::GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IMP:RGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0042493; P:response to drug; IEP:RGD.
61O15357    1258   SHIP2_HUMAN Phosphatidylinositol 3,4,5-trisph...3388e-26     119     27     46GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IDA:HPA.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007015; P:actin filament organization; IMP:UniProtKB.::GO:0007155; P:cell adhesion; TAS:UniProtKB.::GO:0006897; P:endocytosis; IMP:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
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