rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | O14127 | 611 | YF51_SCHPO Uncharacterized protein C3C7.01c O... | 411 | 3e-45 | 177 | 33 | 47 | GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.::GO:0000139; C:Golgi membrane; ISS:PomBase.::GO:0005739; C:mitochondrion; ISS:PomBase. | | | | | | | | | | GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro. | | | | | | | | | | GO:0006887; P:exocytosis; ISS:PomBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase. | 32 | O14306 | 1191 | YE8A_SCHPO Probable inositol polyphosphate 5-... | 503 | 4e-43 | 174 | 30 | 48 | GO:0030479; C:actin cortical patch; ISS:PomBase.::GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; ISS:PomBase. | | | | | | | | | | GO:0006897; P:endocytosis; ISS:PomBase.::GO:0031505; P:fungal-type cell wall organization; ISS:PomBase.::GO:0048017; P:inositol lipid-mediated signaling; IC:PomBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 33 | Q9WVR1 | 647 | INP5E_RAT 72 kDa inositol polyphosphate 5-pho... | 313 | 8e-42 | 167 | 32 | 49 | GO:0035085; C:cilium axoneme; ISS:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:RGD. | | | | | | | | | | GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IMP:RGD.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC. | | | | | | | | | | GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0010976; P:positive regulation of neuron projection development; IMP:RGD. | 34 | A0FI79 | 644 | INP5E_PANTR 72 kDa inositol polyphosphate 5-p... | 313 | 8e-42 | 167 | 32 | 49 | GO:0035085; C:cilium axoneme; ISS:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC. | | | | | | | | | | GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 35 | Q9NRR6 | 644 | INP5E_HUMAN 72 kDa inositol polyphosphate 5-p... | 313 | 9e-42 | 167 | 32 | 49 | GO:0035085; C:cilium axoneme; IDA:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; TAS:UniProtKB.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC. | | | | | | | | | | GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 36 | Q9JII1 | 647 | INP5E_MOUSE 72 kDa inositol polyphosphate 5-p... | 313 | 2e-41 | 166 | 31 | 49 | GO:0035085; C:cilium axoneme; IDA:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:MGI. | | | | | | | | | | GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:MGI.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 37 | Q84W55 | 1101 | IP5P4_ARATH Type II inositol 1,4,5-trisphosph... | 386 | 4e-37 | 155 | 28 | 45 | | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC. | | | | | | | | | | GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 38 | O80560 | 1305 | IP5PC_ARATH Type I inositol 1,4,5-trisphospha... | 388 | 1e-36 | 154 | 28 | 45 | | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IDA:TAIR.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046855; P:inositol phosphate dephosphorylation; IDA:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 39 | Q84MA2 | 590 | IP5P1_ARATH Type I inositol 1,4,5-trisphospha... | 91 | 0.00001 | 52.8 | 33 | 57 | | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:TAIR. | | | | | | | | | | GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:TAIR.::GO:0032957; P:inositol trisphosphate metabolic process; IDA:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 40 | Q9FUR2 | 646 | IP5P2_ARATH Type I inositol 1,4,5-trisphospha... | 88 | 0.052 | 41.2 | 28 | 52 | | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:TAIR. | | | | | | | | | | GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:TAIR.::GO:0032957; P:inositol trisphosphate metabolic process; IMP:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0009845; P:seed germination; IMP:TAIR. | 41 | P59644 | 1003 | PI5PA_MOUSE Phosphatidylinositol 4,5-bisphosp... | 290 | 3e-35 | 149 | 31 | 50 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0043198; C:dendritic shaft; IDA:MGI.::GO:0030426; C:growth cone; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:MGI.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0010977; P:negative regulation of neuron projection development; IMP:MGI.::GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IMP:MGI.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 42 | Q9JMC1 | 1001 | PI5PA_RAT Phosphatidylinositol 4,5-bisphospha... | 328 | 3e-35 | 149 | 30 | 48 | GO:0005737; C:cytoplasm; IDA:RGD.::GO:0030426; C:growth cone; IDA:RGD.::GO:0001726; C:ruffle; IDA:RGD. | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:RGD.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0031115; P:negative regulation of microtubule polymerization; IMP:RGD.::GO:0010977; P:negative regulation of neuron projection development; IMP:RGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 43 | Q15735 | 1006 | PI5PA_HUMAN Phosphatidylinositol 4,5-bisphosp... | 296 | 4e-35 | 149 | 31 | 50 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0001726; C:ruffle; IDA:MGI. | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 44 | Q9SYK4 | 1136 | IP5PD_ARATH Type I inositol 1,4,5-trisphospha... | 385 | 7e-35 | 148 | 29 | 43 | GO:0005634; C:nucleus; IDA:TAIR. | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IDA:TAIR.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0010252; P:auxin homeostasis; IMP:TAIR.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:TAIR.::GO:0010087; P:phloem or xylem histogenesis; IMP:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0009737; P:response to abscisic acid stimulus; IMP:TAIR.::GO:0009637; P:response to blue light; IEP:TAIR.::GO:0007584; P:response to nutrient; IMP:TAIR.::GO:0009611; P:response to wounding; IEP:TAIR.::GO:0048364; P:root development; IMP:TAIR.::GO:0010182; P:sugar mediated signaling pathway; IMP:TAIR. | 45 | Q9LR47 | 617 | IP5P3_ARATH Type I inositol 1,4,5-trisphospha... | 74 | 0.015 | 43.1 | 34 | 55 | | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC. | | | | | | | | | | GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0010588; P:cotyledon vascular tissue pattern formation; IMP:TAIR.::GO:0046855; P:inositol phosphate dephosphorylation; IMP:TAIR.::GO:0048016; P:inositol phosphate-mediated signaling; IC:TAIR.::GO:0032957; P:inositol trisphosphate metabolic process; IMP:TAIR.::GO:0010305; P:leaf vascular tissue pattern formation; IMP:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0010067; P:procambium histogenesis; IMP:TAIR. | 46 | Q9SKB7 | 1144 | IP5PE_ARATH Type II inositol 1,4,5-trisphosph... | 387 | 2e-32 | 140 | 27 | 43 | | | | | | | | | | | GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IDA:TAIR.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:TAIR.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:TAIR. | | | | | | | | | | GO:0046855; P:inositol phosphate dephosphorylation; IDA:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 47 | P42837 | 879 | FIG4_YEAST Polyphosphoinositide phosphatase O... | 519 | 2e-31 | 137 | 25 | 44 | GO:0019898; C:extrinsic to membrane; IDA:SGD.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0070772; C:PAS complex; IDA:SGD. | | | | | | | | | | GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD. | 48 | Q6P4S2 | 1019 | SHIP1_XENLA Phosphatidylinositol 3,4,5-trisph... | 337 | 7e-31 | 135 | 28 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 49 | Q8C5L6 | 468 | INP5K_MOUSE Inositol polyphosphate 5-phosphat... | 315 | 2e-30 | 130 | 30 | 48 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0043005; C:neuron projection; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0032587; C:ruffle membrane; ISS:UniProtKB.::GO:0005802; C:trans-Golgi network; ISS:UniProtKB. | | | | | | | | | | GO:0016312; F:inositol bisphosphate phosphatase activity; IMP:UniProtKB.::GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:UniProtKB.::GO:0005000; F:vasopressin receptor activity; IDA:UniProtKB. | | | | | | | | | | GO:0071320; P:cellular response to cAMP; IDA:UniProtKB.::GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; ISS:UniProtKB.::GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.::GO:0042593; P:glucose homeostasis; IMP:UniProtKB.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0043922; P:negative regulation by host of viral transcription; ISS:UniProtKB.::GO:0051926; P:negative regulation of calcium ion transport; ISS:UniProtKB.::GO:0035305; P:negative regulation of dephosphorylation; IMP:UniProtKB.::GO:0010829; P:negative regulation of glucose transport; ISS:UniProtKB.::GO:2000466; P:negative regulation of glycogen (starch) synthase activity; IMP:UniProtKB.::GO:0045719; P:negative regulation of glycogen biosynthetic process; IMP:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.::GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IMP:UniProtKB.::GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; ISS:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0090315; P:negative regulation of protein targeting to membrane; ISS:UniProtKB.::GO:0045869; P:negative regulation of retroviral genome replication; ISS:UniProtKB.::GO:0051497; P:negative regulation of stress fiber assembly; ISS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:2001153; P:positive regulation of renal water transport; IDA:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0035810; P:positive regulation of urine volume; IDA:UniProtKB.::GO:0072661; P:protein targeting to plasma membrane; IDA:UniProtKB.::GO:0097178; P:ruffle assembly; ISS:UniProtKB. | 50 | Q5EAF2 | 334 | IP5PB_ARATH Type I inositol 1,4,5-trisphospha... | 304 | 8e-30 | 126 | 31 | 50 | | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:TAIR.::GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; IDA:TAIR.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:TAIR. | | | | | | | | | | GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0009737; P:response to abscisic acid stimulus; IEP:TAIR.::GO:0009733; P:response to auxin stimulus; IEP:TAIR.::GO:0009753; P:response to jasmonic acid stimulus; IEP:TAIR. | 51 | P97573 | 1190 | SHIP1_RAT Phosphatidylinositol 3,4,5-trisphos... | 338 | 1e-29 | 131 | 28 | 46 | GO:0005884; C:actin filament; IDA:RGD.::GO:0030863; C:cortical cytoskeleton; IDA:RGD.::GO:0005829; C:cytosol; IDA:RGD.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0030487; F:inositol-4,5-bisphosphate 5-phosphatase activity; IDA:RGD.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 52 | Q9ES52 | 1191 | SHIP1_MOUSE Phosphatidylinositol 3,4,5-trisph... | 338 | 2e-29 | 130 | 28 | 45 | GO:0005622; C:intracellular; IMP:GOC.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:MGI.::GO:0034594; F:phosphatidylinositol trisphosphate phosphatase activity; IDA:MGI.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0051425; F:PTB domain binding; IDA:MGI.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0008340; P:determination of adult lifespan; IMP:MGI.::GO:0016064; P:immunoglobulin mediated immune response; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IMP:MGI.::GO:0050869; P:negative regulation of B cell activation; IMP:MGI.::GO:0030889; P:negative regulation of B cell proliferation; IMP:MGI.::GO:0045779; P:negative regulation of bone resorption; IMP:MGI.::GO:0050777; P:negative regulation of immune response; IMP:MGI.::GO:0045409; P:negative regulation of interleukin-6 biosynthetic process; IMP:MGI.::GO:0045656; P:negative regulation of monocyte differentiation; IMP:MGI.::GO:0045659; P:negative regulation of neutrophil differentiation; IMP:MGI.::GO:0045671; P:negative regulation of osteoclast differentiation; IMP:MGI.::GO:0009968; P:negative regulation of signal transduction; IMP:MGI.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0043065; P:positive regulation of apoptotic process; IMP:MGI.::GO:0045579; P:positive regulation of B cell differentiation; IMP:MGI.::GO:0045648; P:positive regulation of erythrocyte differentiation; IMP:MGI. | 53 | Q2I6J1 | 1266 | SHP2A_DANRE Phosphatidylinositol 3,4,5-trisph... | 345 | 3e-29 | 130 | 29 | 47 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030509; P:BMP signaling pathway; IMP:ZFIN.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IMP:ZFIN.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 54 | Q91WF7 | 907 | FIG4_MOUSE Polyphosphoinositide phosphatase O... | 521 | 3e-29 | 129 | 26 | 43 | GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro. | | | | | | | | | | GO:0008219; P:cell death; IEA:UniProtKB-KW.::GO:0007626; P:locomotory behavior; IMP:MGI.::GO:0048666; P:neuron development; IMP:MGI.::GO:0046488; P:phosphatidylinositol metabolic process; IMP:MGI.::GO:0043473; P:pigmentation; IMP:MGI.::GO:0007033; P:vacuole organization; IMP:MGI. | 55 | Q92562 | 907 | FIG4_HUMAN Polyphosphoinositide phosphatase O... | 521 | 2e-28 | 127 | 25 | 43 | GO:0010008; C:endosome membrane; IDA:UniProtKB. | | | | | | | | | | GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0008219; P:cell death; IEA:UniProtKB-KW. | 56 | Q92835 | 1189 | SHIP1_HUMAN Phosphatidylinositol 3,4,5-trisph... | 341 | 3e-28 | 127 | 28 | 46 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; TAS:ProtInc.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome. | 57 | Q9BT40 | 448 | INP5K_HUMAN Inositol polyphosphate 5-phosphat... | 315 | 3e-28 | 123 | 30 | 48 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0043005; C:neuron projection; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IDA:UniProtKB.::GO:0005802; C:trans-Golgi network; IDA:UniProtKB. | | | | | | | | | | GO:0016312; F:inositol bisphosphate phosphatase activity; IDA:UniProtKB.::GO:0046030; F:inositol trisphosphate phosphatase activity; IDA:MGI.::GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0042577; F:lipid phosphatase activity; NAS:UniProtKB.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005000; F:vasopressin receptor activity; ISS:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.::GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.::GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; IDA:UniProtKB.::GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.::GO:0043922; P:negative regulation by host of viral transcription; IDA:UniProtKB.::GO:0051926; P:negative regulation of calcium ion transport; IDA:UniProtKB.::GO:0035305; P:negative regulation of dephosphorylation; ISS:UniProtKB.::GO:0010829; P:negative regulation of glucose transport; IDA:UniProtKB.::GO:2000466; P:negative regulation of glycogen (starch) synthase activity; ISS:UniProtKB.::GO:0045719; P:negative regulation of glycogen biosynthetic process; IDA:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IDA:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; IDA:UniProtKB.::GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IDA:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IDA:UniProtKB.::GO:0090315; P:negative regulation of protein targeting to membrane; IDA:UniProtKB.::GO:0045869; P:negative regulation of retroviral genome replication; IDA:UniProtKB.::GO:0051497; P:negative regulation of stress fiber assembly; IDA:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:2001153; P:positive regulation of renal water transport; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0035810; P:positive regulation of urine volume; ISS:UniProtKB.::GO:0072661; P:protein targeting to plasma membrane; ISS:UniProtKB.::GO:0097178; P:ruffle assembly; IDA:UniProtKB. | 58 | Q7Z9H9 | 832 | FIG4_SCHPO Polyphosphoinositide phosphatase O... | 464 | 1e-27 | 124 | 26 | 43 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0019898; C:extrinsic to membrane; ISS:PomBase.::GO:0000329; C:fungal-type vacuole membrane; ISS:PomBase. | | | | | | | | | | GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro. | | | | | | | | | | GO:0000753; P:cell morphogenesis involved in conjugation with cellular fusion; ISS:PomBase.::GO:0046488; P:phosphatidylinositol metabolic process; NAS:PomBase.::GO:0048015; P:phosphatidylinositol-mediated signaling; NAS:PomBase. | 59 | Q2I6J0 | 1226 | SHP2B_DANRE Phosphatidylinositol 3,4,5-trisph... | 356 | 1e-27 | 125 | 26 | 46 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 60 | Q9WVR3 | 1257 | SHIP2_RAT Phosphatidylinositol 3,4,5-trisphos... | 338 | 6e-26 | 119 | 27 | 46 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:RGD. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:RGD.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:RGD.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007420; P:brain development; IEP:RGD.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0032957; P:inositol trisphosphate metabolic process; IDA:RGD.::GO:0008156; P:negative regulation of DNA replication; IMP:RGD.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:RGD.::GO:0043569; P:negative regulation of insulin-like growth factor receptor signaling pathway; IMP:RGD.::GO:0043407; P:negative regulation of MAP kinase activity; IMP:RGD.::GO:0010977; P:negative regulation of neuron projection development; IMP:RGD.::GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IMP:RGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0042493; P:response to drug; IEP:RGD. | 61 | O15357 | 1258 | SHIP2_HUMAN Phosphatidylinositol 3,4,5-trisph... | 338 | 8e-26 | 119 | 27 | 46 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IDA:HPA. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:UniProtKB.::GO:0007155; P:cell adhesion; TAS:UniProtKB.::GO:0006897; P:endocytosis; IMP:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. |