Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOR109W
Length:
1107
Number of sequences:
5887
Description:
YOR109W INP53 SGDID:S000005635, Chr XV from 525278-528601, Genome Release 64-1-1, Verified ORF, "Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q12271    1107   INP53_YEAST Polyphosphatidylinositol phosphat...11070     2291     100     100GO:0030479; C:actin cortical patch; IDA:SGD.::GO:0042598; C:vesicular fraction; IDA:SGD.
GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; IDA:SGD.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:SGD.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:SGD.::GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IDA:SGD.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
2P50942    1183   INP52_YEAST Polyphosphatidylinositol phosphat...10790     1345     60     76GO:0030479; C:actin cortical patch; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.::GO:0042598; C:vesicular fraction; IDA:SGD.
GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; IDA:SGD.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:SGD.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:SGD.::GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
3O43001    1076   SYJ1_SCHPO Inositol-1,4,5-trisphosphate 5-pho...8920     699     43     62GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.
GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:PomBase.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.
GO:0006897; P:endocytosis; NAS:PomBase.::GO:0048017; P:inositol lipid-mediated signaling; IC:PomBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
4P40559    946   INP51_YEAST Phosphatidylinositol 4,5-bisphosp...9061e-144     465     32     52GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:SGD.
GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
5Q8CHC4    1574   SYNJ1_MOUSE Synaptojanin-1 OS=Mus musculus (M...8082e-127     431     35     51GO:0030118; C:clathrin coat; TAS:MGI.
GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IMP:MGI.::GO:0005515; F:protein binding; IPI:MGI.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0046855; P:inositol phosphate dephosphorylation; IMP:MGI.::GO:0007612; P:learning; IMP:MGI.::GO:0046856; P:phosphatidylinositol dephosphorylation; IMP:MGI.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:MGI.::GO:0016082; P:synaptic vesicle priming; IMP:MGI.::GO:0016191; P:synaptic vesicle uncoating; IMP:MGI.
6Q62910    1574   SYNJ1_RAT Synaptojanin-1 OS=Rattus norvegicus...8072e-126     429     35     51GO:0019717; C:synaptosome; IDA:RGD.
GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.::GO:0008022; F:protein C-terminus binding; IPI:RGD.::GO:0032403; F:protein complex binding; IDA:RGD.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IDA:RGD.
GO:0007420; P:brain development; IEP:RGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0014015; P:positive regulation of gliogenesis; IMP:RGD.::GO:0048260; P:positive regulation of receptor-mediated endocytosis; IMP:RGD.::GO:0034097; P:response to cytokine stimulus; IMP:RGD.::GO:0032526; P:response to retinoic acid; IMP:RGD.
7O18964    1324   SYNJ1_BOVIN Synaptojanin-1 OS=Bos taurus (Bov...8066e-126     423     34     51GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
8O43426    1573   SYNJ1_HUMAN Synaptojanin-1 OS=Homo sapiens (H...8065e-125     424     34     51
GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; TAS:ProtInc.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
9Q9USQ6    889   SYJ2_SCHPO Inositol-1,4,5-trisphosphate 5-pho...9212e-122     404     32     48GO:0005737; C:cytoplasm; IDA:PomBase.
GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; ISS:PomBase.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.
GO:0033554; P:cellular response to stress; IEP:PomBase.::GO:0006897; P:endocytosis; ISS:PomBase.::GO:0048017; P:inositol lipid-mediated signaling; IC:PomBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
10O15056    1496   SYNJ2_HUMAN Synaptojanin-2 OS=Homo sapiens (H...8807e-119     406     33     50
GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
11Q9D2G5    1434   SYNJ2_MOUSE Synaptojanin-2 OS=Mus musculus (M...8762e-115     395     33     49
GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:MGI.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
12O55207    1496   SYNJ2_RAT Synaptojanin-2 OS=Rattus norvegicus...8836e-114     392     32     48GO:0043679; C:axon terminus; IDA:RGD.::GO:0005881; C:cytoplasmic microtubule; IDA:RGD.::GO:0031315; C:extrinsic to mitochondrial outer membrane; IDA:RGD.::GO:0005626; C:insoluble fraction; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.::GO:0032587; C:ruffle membrane; IDA:RGD.
GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:RGD.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0030165; F:PDZ domain binding; IPI:RGD.::GO:0052744; F:phosphatidylinositol monophosphate phosphatase activity; IDA:RGD.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IPI:RGD.
GO:0007420; P:brain development; IEP:RGD.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:RGD.::GO:0048312; P:intracellular distribution of mitochondria; IDA:RGD.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:RGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
13P32019    993   I5P2_HUMAN Type II inositol 1,4,5-trisphospha...3262e-56     216     38     56GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0016020; C:membrane; IDA:UniProtKB.::GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IDA:UniProtKB.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
14P32368    623   SAC1_YEAST Phosphoinositide phosphatase SAC1 ...5642e-56     211     29     50GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:SGD.::GO:0030173; C:integral to Golgi membrane; IDA:SGD.::GO:0005741; C:mitochondrial outer membrane; IDA:SGD.::GO:0035339; C:SPOTS complex; IDA:UniProtKB.
GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; IDA:SGD.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:SGD.::GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD.
15Q8K337    993   I5P2_MOUSE Type II inositol 1,4,5-trisphospha...3361e-55     213     35     54GO:0005829; C:cytosol; IDA:MGI.::GO:0016021; C:integral to membrane; IDA:MGI.
GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IDA:UniProtKB.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:UniProtKB.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0070613; P:regulation of protein processing; IMP:MGI.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0030317; P:sperm motility; IMP:MGI.::GO:0007283; P:spermatogenesis; IMP:MGI.
16Q6GM29    586   SAC1_XENLA Phosphatidylinositide phosphatase ...4902e-53     202     30     49GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
17A8E7C5    1120   SAC2_DANRE Phosphatidylinositide phosphatase ...4161e-52     205     30     50
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
18Q01968    901   OCRL_HUMAN Inositol polyphosphate 5-phosphata...3212e-51     200     33     54GO:0030136; C:clathrin-coated vesicle; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005769; C:early endosome; IDA:UniProtKB.::GO:0005795; C:Golgi stack; TAS:ProtInc.::GO:0005798; C:Golgi-associated vesicle; TAS:ProtInc.
GO:0004437; F:inositol or phosphatidylinositol phosphatase activity; TAS:ProtInc.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; TAS:ProtInc.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
19A4VCH0    586   SAC1B_DANRE Phosphatidylinositide phosphatase...4804e-51     195     31     48GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
20O60162    598   YG23_SCHPO Uncharacterized protein C19F5.03 O...4054e-51     195     33     50GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:PomBase.::GO:0030173; C:integral to Golgi membrane; ISS:PomBase.::GO:0005741; C:mitochondrial outer membrane; ISS:PomBase.
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.::GO:0016192; P:vesicle-mediated transport; ISS:PomBase.
21Q9EP69    587   SAC1_MOUSE Phosphatidylinositide phosphatase ...4809e-51     194     30     47
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
22Q55AW9    581   SAC1_DICDI Phosphatidylinositide phosphatase ...4172e-50     192     34     51GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; ISS:dictyBase.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:dictyBase.::GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; ISS:dictyBase.
GO:0048017; P:inositol lipid-mediated signaling; ISS:dictyBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:dictyBase.
23A1L244    586   SAC1A_DANRE Phosphatidylinositide phosphatase...4945e-50     192     30     48GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
24Q9Y2H2    1132   SAC2_HUMAN Phosphatidylinositide phosphatase ...4188e-49     193     30     47
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
25Q9ES21    587   SAC1_RAT Phosphatidylinositide phosphatase SA...4801e-48     187     30     47GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:RGD.
GO:0034593; F:phosphatidylinositol bisphosphate phosphatase activity; IDA:RGD.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:RGD.::GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IDA:RGD.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:RGD.
26Q9W0I6    592   SAC1_DROME Phosphatidylinositide phosphatase ...4259e-48     185     30     50GO:0030424; C:axon; IDA:FlyBase.::GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0043025; C:neuronal cell body; IDA:FlyBase.::GO:0071683; C:sensory dendrite; IDA:FlyBase.
GO:0052866; F:phosphatidylinositol phosphate phosphatase activity; IDA:FlyBase.
GO:0016199; P:axon midline choice point recognition; IMP:FlyBase.::GO:0046664; P:dorsal closure, amnioserosa morphology change; IMP:FlyBase.::GO:0046329; P:negative regulation of JNK cascade; IMP:FlyBase.
27Q8CDA1    1132   SAC2_MOUSE Phosphatidylinositide phosphatase ...4143e-47     188     29     47
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
28A6QL88    587   SAC1_BOVIN Phosphatidylinositide phosphatase ...4796e-47     182     28     46GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
29Q5R921    587   SAC1_PONAB Phosphatidylinositide phosphatase ...4828e-47     182     29     47GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
30Q9NTJ5    587   SAC1_HUMAN Phosphatidylinositide phosphatase ...4821e-46     182     29     47GO:0005794; C:Golgi apparatus; IDA:LIFEdb.
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
31O14127    611   YF51_SCHPO Uncharacterized protein C3C7.01c O...4113e-45     177     33     47GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.::GO:0000139; C:Golgi membrane; ISS:PomBase.::GO:0005739; C:mitochondrion; ISS:PomBase.
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
GO:0006887; P:exocytosis; ISS:PomBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.
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