Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOR089C
Length:
210
Number of sequences:
5887
Description:
YOR089C VPS21 SGDID:S000005615, Chr XV from 490828-490196, Genome Release 64-1-1, reverse complement, Verified ORF, "Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
631P17081    205   RHOQ_HUMAN Rho-related GTP-binding protein Rh...1682e-19     86.7     31     52GO:0005884; C:actin filament; IDA:BHF-UCL.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:BHF-UCL.
GO:0032427; F:GBD domain binding; IPI:BHF-UCL.::GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IDA:BHF-UCL.::GO:0005522; F:profilin binding; IPI:BHF-UCL.
GO:0030866; P:cortical actin cytoskeleton organization; IMP:BHF-UCL.::GO:0008286; P:insulin receptor signaling pathway; IMP:BHF-UCL.::GO:0090005; P:negative regulation of establishment of protein localization in plasma membrane; IMP:BHF-UCL.::GO:0051491; P:positive regulation of filopodium assembly; IDA:BHF-UCL.::GO:0046326; P:positive regulation of glucose import; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0032956; P:regulation of actin cytoskeleton organization; IC:BHF-UCL.::GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
632Q5R573    229   RBL2A_PONAB Rab-like protein 2A OS=Pongo abel...1742e-19     87     32     51
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
633Q9SU67    208   RAC8_ARATH Rac-like GTP-binding protein ARAC8...1662e-19     86.7     33     52GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0009738; P:abscisic acid mediated signaling pathway; TAS:TAIR.::GO:0009788; P:negative regulation of abscisic acid mediated signaling pathway; TAS:TAIR.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
634Q9XGU0    209   RAC9_ARATH Rac-like GTP-binding protein ARAC9...1663e-19     86.7     34     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
635Q67VP4    215   RAC4_ORYSJ Rac-like GTP-binding protein 4 OS=...1663e-19     86.7     33     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
636P32252    197   RASB_DICDI Ras-like protein rasB OS=Dictyoste...1693e-19     86.3     33     54GO:0016363; C:nuclear matrix; IDA:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; ISS:dictyBase.::GO:0003924; F:GTPase activity; ISS:dictyBase.::GO:0005515; F:protein binding; IPI:dictyBase.
GO:0000910; P:cytokinesis; IMP:dictyBase.::GO:0045806; P:negative regulation of endocytosis; IMP:dictyBase.::GO:0007265; P:Ras protein signal transduction; ISS:dictyBase.::GO:0051726; P:regulation of cell cycle; IEP:dictyBase.::GO:0042127; P:regulation of cell proliferation; IMP:dictyBase.::GO:0051270; P:regulation of cellular component movement; IGI:dictyBase.
637P20171    189   RASH_RAT GTPase HRas OS=Rattus norvegicus (Ra...1683e-19     86.3     32     54GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0005525; F:GTP binding; ISS:UniProtKB.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0006915; P:apoptotic process; IMP:RGD.::GO:0045740; P:positive regulation of DNA replication; IMP:RGD.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:RGD.::GO:0007265; P:Ras protein signal transduction; IMP:RGD.::GO:0035176; P:social behavior; IEP:RGD.
638Q61411    189   RASH_MOUSE GTPase HRas OS=Mus musculus (Mouse...1683e-19     86.3     32     54GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005525; F:GTP binding; IDA:MGI.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0008283; P:cell proliferation; IPI:MGI.::GO:0006897; P:endocytosis; IDA:MGI.::GO:0008629; P:induction of apoptosis by intracellular signals; IMP:MGI.::GO:0043524; P:negative regulation of neuron apoptotic process; IDA:MGI.::GO:0010628; P:positive regulation of gene expression; IDA:MGI.::GO:0007265; P:Ras protein signal transduction; TAS:MGI.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
639P01112    189   RASH_HUMAN GTPase HRas OS=Homo sapiens (Human...1683e-19     86.3     32     54GO:0005829; C:cytosol; TAS:Reactome.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007050; P:cell cycle arrest; IDA:BHF-UCL.::GO:0090398; P:cellular senescence; IDA:BHF-UCL.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0000165; P:MAPK cascade; TAS:Reactome.::GO:0031575; P:mitotic cell cycle G1/S transition checkpoint; IDA:BHF-UCL.::GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0009887; P:organ morphogenesis; TAS:ProtInc.::GO:0045740; P:positive regulation of DNA replication; IDA:BHF-UCL.::GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:BHF-UCL.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL.::GO:0046330; P:positive regulation of JNK cascade; IDA:BHF-UCL.::GO:0001934; P:positive regulation of protein phosphorylation; IDA:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome.
640Q24192    190   RHOL_DROME Ras-like GTP-binding protein RhoL ...1643e-19     85.9     29     52GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; NAS:FlyBase.::GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; TAS:FlyBase.
GO:0007298; P:border follicle cell migration; IMP:FlyBase.::GO:0007155; P:cell adhesion; IMP:FlyBase.::GO:0007516; P:hemocyte development; IMP:UniProtKB.::GO:0007498; P:mesoderm development; IEP:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.::GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
641P40793    191   CDC42_DROME Cdc42 homolog OS=Drosophila melan...1693e-19     85.9     31     51GO:0005912; C:adherens junction; IDA:UniProtKB.::GO:0030424; C:axon; IDA:FlyBase.::GO:0005737; C:cytoplasm; IDA:FlyBase.::GO:0030426; C:growth cone; IDA:FlyBase.::GO:0005634; C:nucleus; IDA:FlyBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0016028; C:rhabdomere; IMP:FlyBase.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; NAS:FlyBase.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0030041; P:actin filament polymerization; IMP:FlyBase.::GO:0060446; P:branching involved in open tracheal system development; IMP:FlyBase.::GO:0030031; P:cell projection assembly; IMP:FlyBase.::GO:0007349; P:cellularization; TAS:FlyBase.::GO:0030866; P:cortical actin cytoskeleton organization; IMP:FlyBase.::GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.::GO:0046843; P:dorsal appendage formation; IMP:FlyBase.::GO:0045200; P:establishment of neuroblast polarity; IMP:FlyBase.::GO:0035099; P:hemocyte migration; IMP:FlyBase.::GO:0035318; P:imaginal disc-derived wing hair outgrowth; IMP:FlyBase.::GO:0007254; P:JNK cascade; TAS:FlyBase.::GO:0030011; P:maintenance of cell polarity; IMP:FlyBase.::GO:0045185; P:maintenance of protein location; IMP:UniProtKB.::GO:0008045; P:motor axon guidance; IMP:FlyBase.::GO:0007274; P:neuromuscular synaptic transmission; IGI:FlyBase.::GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.::GO:0045860; P:positive regulation of protein kinase activity; IMP:UniProtKB.::GO:0030833; P:regulation of actin filament polymerization; IDA:FlyBase.::GO:0050770; P:regulation of axonogenesis; IGI:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.::GO:0008582; P:regulation of synaptic growth at neuromuscular junction; IDA:FlyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0007396; P:suture of dorsal opening; TAS:FlyBase.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:FlyBase.::GO:0042060; P:wound healing; IMP:FlyBase.
642Q29HY3    191   CDC42_DROPS Cdc42 homolog OS=Drosophila pseud...1693e-19     85.9     31     51GO:0005912; C:adherens junction; ISS:UniProtKB.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0045185; P:maintenance of protein location; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
643Q05147    187   RASK_XENLA GTPase KRas OS=Xenopus laevis (Afr...1683e-19     85.9     33     56GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
644Q54SV1    236   RABY_DICDI Ras-related protein RabY OS=Dictyo...1594e-19     86.7     31     52GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0015031; P:protein transport; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
645Q17031    191   CDC42_ANOGA Cdc42 homolog OS=Anopheles gambia...1694e-19     85.9     31     51GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
646Q96S21    281   RB40C_HUMAN Ras-related protein Rab-40C OS=Ho...1734e-19     86.7     32     53GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0015031; P:protein transport; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
647Q8VHQ4    281   RB40C_MOUSE Ras-related protein Rab-40C OS=Mu...1734e-19     86.7     32     53GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0015031; P:protein transport; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
648Q16YG0    191   CDC42_AEDAE Cdc42 homolog OS=Aedes aegypti (Y...1694e-19     85.5     31     51GO:0005912; C:adherens junction; ISS:UniProtKB.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0045185; P:maintenance of protein location; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
649Q35638    197   RHO1_PEA Rac-like GTP-binding protein RHO1 OS...1664e-19     85.9     31     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
650P08647    219   RAS_SCHPO Ras-like protein 1 OS=Schizosacchar...2074e-19     86.3     29     53GO:0071521; C:Cdc42 GTPase complex; TAS:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; TAS:PomBase.
GO:0030437; P:ascospore formation; TAS:PomBase.::GO:0032488; P:Cdc42 protein signal transduction; IC:PomBase.::GO:0000751; P:cell cycle arrest in response to pheromone; TAS:PomBase.::GO:0033205; P:cell cycle cytokinesis; IGI:PomBase.::GO:0006995; P:cellular response to nitrogen starvation; IGI:PomBase.::GO:0007163; P:establishment or maintenance of cell polarity; TAS:PomBase.::GO:0009272; P:fungal-type cell wall biogenesis; IMP:PomBase.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IGI:PomBase.::GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.::GO:0031137; P:regulation of conjugation with cellular fusion; IMP:PomBase.::GO:0032005; P:signal transduction involved in conjugation with cellular fusion; TAS:PomBase.::GO:0007051; P:spindle organization; IGI:PomBase.
651P08642    189   RASH_CHICK GTPase HRas OS=Gallus gallus (Chic...1684e-19     85.5     32     54GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
652O42825    198   RHO1_CANAL GTP-binding protein RHO1 OS=Candid...1686e-19     85.1     32     52GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IDA:CGD.
GO:0005525; F:GTP binding; IDA:CGD.::GO:0003924; F:GTPase activity; ISS:CGD.::GO:0004871; F:signal transducer activity; IDA:CGD.
GO:0006075; P:(1->3)-beta-D-glucan biosynthetic process; IMP:CGD.::GO:0035690; P:cellular response to drug; IMP:CGD.::GO:0007266; P:Rho protein signal transduction; IDA:CGD.
653P41915    225   RAN_TETTH GTP-binding nuclear protein Ran OS=...1687e-19     85.5     33     52GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
654Q9HF56    191   CDC42_ASHGO Cell division control protein 42 ...1697e-19     85.1     30     50GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
655Q12829    278   RB40B_HUMAN Ras-related protein Rab-40B OS=Ho...1721e-18     85.9     28     49GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0015031; P:protein transport; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
656O82481    215   RAC10_ARATH Rac-like GTP-binding protein ARAC...1661e-18     85.1     31     53GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
657Q9HF54    207   RHO1_ASHGO GTP-binding protein RHO1 OS=Y-1056...1671e-18     84.7     29     54GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
658Q8SS11    214   GSP1_ENCCU GTP-binding nuclear protein GSP1 O...1641e-18     85.1     32     52GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
659P79737    188   RASN_DANRE GTPase NRas OS=Danio rerio (Zebraf...1841e-18     84.3     30     54GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
660P22126    213   RAS1_NEUCR Protein ras-1 OS=1257 / FGSC 987)....1531e-18     84.7     32     55GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
661Q15669    191   RHOH_HUMAN Rho-related GTP-binding protein Rh...1701e-18     84.3     32     52GO:0005829; C:cytosol; TAS:Reactome.::GO:0005739; C:mitochondrion; IDA:HPA.
GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0005095; F:GTPase inhibitor activity; NAS:UniProtKB.::GO:0019210; F:kinase inhibitor activity; IDA:UniProtKB.::GO:0017048; F:Rho GTPase binding; NAS:UniProtKB.
GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0030217; P:T cell differentiation; NAS:UniProtKB.
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