Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOR086C
Length:
1186
Number of sequences:
5887
Description:
YOR086C TCB1 SGDID:S000005612, Chr XV from 486779-483219, Genome Release 64-1-1, reverse complement, Verified ORF, "Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
121Q8L7A4    385   AGD11_ARATH Probable ADP-ribosylation factor ...670.029     42     37     57
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
122Q6XYQ8    523   SYT10_HUMAN Synaptotagmin-10 OS=Homo sapiens ...1430.0004     48.1     29     48GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005215; F:transporter activity; IEA:InterPro.
123Q55A55    986   Y9848_DICDI Probable serine/threonine-protein...950.0004     48.1     34     54
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
124Q9ERC5    1993   OTOF_RAT Otoferlin OS=Rattus norvegicus (Rat)...891     37.4     28     53GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.::GO:0016079; P:synaptic vesicle exocytosis; ISS:UniProtKB.
125Q50L42    875   PA24E_MOUSE Cytosolic phospholipase A2 epsilo...1080.0006     47.8     24     52GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004623; F:phospholipase A2 activity; IDA:MGI.
GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
126Q9ESF1    1997   OTOF_MOUSE Otoferlin OS=Mus musculus (Mouse)....891.1     37.4     28     53GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; IDA:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.::GO:0016079; P:synaptic vesicle exocytosis; IDA:UniProtKB.
127Q9Z0R4    1714   ITSN1_MOUSE Intersectin-1 OS=Mus musculus (Mo...1003.4     35.8     27     44GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0030139; C:endocytic vesicle; IDA:MGI.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019209; F:kinase activator activity; IDA:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI.
128Q15811    1721   ITSN1_HUMAN Intersectin-1 OS=Homo sapiens (Hu...1003.7     35.4     27     44GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005905; C:coated pit; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0032947; F:protein complex scaffold; IDA:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0048488; P:synaptic vesicle endocytosis; TAS:ProtInc.
129B1WAZ6    749   PA24A_XENTR Cytosolic phospholipase A2 OS=Xen...780.0008     47.4     31     55GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0004622; F:lysophospholipase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004623; F:phospholipase A2 activity; IEA:EC.
GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
130P46935    887   NEDD4_MOUSE E3 ubiquitin-protein ligase NEDD4...1340.53     38.1     27     43GO:0005829; C:cytosol; IDA:MGI.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; IPI:MGI.
GO:0050815; F:phosphoserine binding; IDA:BHF-UCL.::GO:0050816; F:phosphothreonine binding; IDA:BHF-UCL.::GO:0070064; F:proline-rich region binding; IPI:MGI.::GO:0019871; F:sodium channel inhibitor activity; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.
GO:0010766; P:negative regulation of sodium ion transport; IDA:MGI.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; IDA:UniProtKB.::GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0048814; P:regulation of dendrite morphogenesis; IMP:UniProtKB.
131P0C869    781   PA24B_HUMAN Cytosolic phospholipase A2 beta O...870.0008     47.4     28     51GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; TAS:UniProtKB.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0047498; F:calcium-dependent phospholipase A2 activity; IDA:UniProtKB.::GO:0005544; F:calcium-dependent phospholipid binding; NAS:UniProtKB.::GO:0004622; F:lysophospholipase activity; NAS:UniProtKB.
GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.::GO:0019369; P:arachidonic acid metabolic process; NAS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; NAS:UniProtKB.::GO:0046475; P:glycerophospholipid catabolic process; IDA:UniProtKB.::GO:0006954; P:inflammatory response; NAS:UniProtKB.::GO:0007567; P:parturition; NAS:UniProtKB.
132Q9VVI3    1007   NEDD4_DROME E3 ubiquitin-protein ligase Nedd-...970.24     39.3     30     45GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:FlyBase.
GO:0005112; F:Notch binding; IPI:UniProtKB.::GO:0019904; F:protein domain specific binding; IDA:FlyBase.::GO:0004842; F:ubiquitin-protein ligase activity; NAS:UniProtKB.
GO:0016199; P:axon midline choice point recognition; IMP:UniProtKB.::GO:0045746; P:negative regulation of Notch signaling pathway; IMP:UniProtKB.::GO:0007528; P:neuromuscular junction development; IMP:FlyBase.::GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.::GO:0002092; P:positive regulation of receptor internalization; IMP:FlyBase.::GO:0051965; P:positive regulation of synapse assembly; IMP:FlyBase.::GO:0031623; P:receptor internalization; IMP:UniProtKB.
133Q16974    649   KPC1_APLCA Calcium-dependent protein kinase C...1020.001     47     37     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004697; F:protein kinase C activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
134Q62940    887   NEDD4_RAT E3 ubiquitin-protein ligase NEDD4 O...1340.4     38.5     27     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005902; C:microvillus; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008022; F:protein C-terminus binding; IDA:RGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0006955; P:immune response; IEP:RGD.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0048814; P:regulation of dendrite morphogenesis; IDA:UniProtKB.
135Q9C8S6    147   Y1322_ARATH C2 domain-containing protein At1g...931.9     34.7     18     41
136Q5R8A5    749   PA24A_PONAB Cytosolic phospholipase A2 OS=Pon...790.001     47     30     54GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.::GO:0005544; F:calcium-dependent phospholipid binding; ISS:UniProtKB.::GO:0004622; F:lysophospholipase activity; IEA:EC.::GO:0004623; F:phospholipase A2 activity; IEA:EC.
GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
137Q9R0N4    523   SYT10_MOUSE Synaptotagmin-10 OS=Mus musculus ...1430.001     47     29     48GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.::GO:0005215; F:transporter activity; IEA:InterPro.
138Q5SPC5    1992   OTOF_DANRE Otoferlin OS=Danio rerio (Zebrafis...871.7     36.6     30     52GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; ISS:UniProtKB.
139P47713    748   PA24A_MOUSE Cytosolic phospholipase A2 OS=Mus...790.001     47     30     54GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; IDA:MGI.::GO:0005794; C:Golgi apparatus; IDA:MGI.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.::GO:0005544; F:calcium-dependent phospholipid binding; ISS:UniProtKB.::GO:0004622; F:lysophospholipase activity; IEA:EC.
GO:0050482; P:arachidonic acid secretion; IDA:UniProtKB.::GO:0071236; P:cellular response to antibiotic; IDA:MGI.::GO:0046456; P:icosanoid biosynthetic process; IMP:MGI.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
140O08625    523   SYT10_RAT Synaptotagmin-10 OS=Rattus norvegic...1430.001     46.6     29     48GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005215; F:transporter activity; IEA:InterPro.
GO:0050803; P:regulation of synapse structure and activity; NAS:RGD.::GO:0006950; P:response to stress; IEP:RGD.
141P50393    752   PA24A_RAT Cytosolic phospholipase A2 OS=Rattu...790.001     47     30     54GO:0005829; C:cytosol; IDA:RGD.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.::GO:0042588; C:zymogen granule; IDA:RGD.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.::GO:0047498; F:calcium-dependent phospholipase A2 activity; IDA:RGD.::GO:0005544; F:calcium-dependent phospholipid binding; ISS:UniProtKB.::GO:0004622; F:lysophospholipase activity; IEA:EC.
GO:0007568; P:aging; IEP:RGD.::GO:0019369; P:arachidonic acid metabolic process; IMP:RGD.::GO:0046697; P:decidualization; IMP:RGD.::GO:0001554; P:luteolysis; IEP:RGD.::GO:0001542; P:ovulation from ovarian follicle; IMP:RGD.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.::GO:0030501; P:positive regulation of bone mineralization; IEP:RGD.::GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.::GO:0031622; P:positive regulation of fever generation; IEP:RGD.::GO:0031394; P:positive regulation of prostaglandin biosynthetic process; IMP:RGD.::GO:0031340; P:positive regulation of vesicle fusion; IMP:RGD.::GO:0051592; P:response to calcium ion; IMP:RGD.::GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.::GO:0009408; P:response to heat; IEP:RGD.::GO:0042542; P:response to hydrogen peroxide; IEP:RGD.::GO:0032496; P:response to lipopolysaccharide; IEP:RGD.::GO:0051597; P:response to methylmercury; IEP:RGD.::GO:0010243; P:response to organic nitrogen; IEP:RGD.::GO:0033280; P:response to vitamin D; IEP:RGD.::GO:0043129; P:surfactant homeostasis; IMP:RGD.
142Q8AVG0    862   ABR_XENLA Active breakpoint cluster region-re...1740.001     47     29     45GO:0005622; C:intracellular; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
143P50392    741   PA24A_DANRE Cytosolic phospholipase A2 OS=Dan...1210.001     46.6     25     51GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0004622; F:lysophospholipase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004623; F:phospholipase A2 activity; IEA:EC.
GO:0001541; P:ovarian follicle development; IEP:ZFIN.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
144Q9HC10    1997   OTOF_HUMAN Otoferlin OS=Homo sapiens (Human)....891.2     37.4     28     53GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; TAS:ProtInc.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; TAS:ProtInc.::GO:0005624; C:membrane fraction; TAS:ProtInc.::GO:0030672; C:synaptic vesicle membrane; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO:0006944; P:cellular membrane fusion; TAS:ProtInc.::GO:0007605; P:sensory perception of sound; TAS:ProtInc.::GO:0016079; P:synaptic vesicle exocytosis; ISS:UniProtKB.
145Q9TT38    748   PA24A_RABIT Cytosolic phospholipase A2 OS=Ory...790.002     46.6     30     53GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.::GO:0005544; F:calcium-dependent phospholipid binding; ISS:UniProtKB.::GO:0004622; F:lysophospholipase activity; IEA:EC.::GO:0004623; F:phospholipase A2 activity; IEA:EC.
GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
146O75131    537   CPNE3_HUMAN Copine-3 OS=Homo sapiens (Human)....955.9     34.7     26     45GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005544; F:calcium-dependent phospholipid binding; TAS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0005215; F:transporter activity; TAS:ProtInc.
GO:0006629; P:lipid metabolic process; TAS:ProtInc.::GO:0016192; P:vesicle-mediated transport; TAS:ProtInc.
147Q7T0T9    749   PA24A_XENLA Cytosolic phospholipase A2 OS=Xen...780.002     45.8     31     54GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0004622; F:lysophospholipase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004623; F:phospholipase A2 activity; IEA:EC.
GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
148A6QQP7    2107   DYSF_BOVIN Dysferlin OS=Bos taurus (Bovine). ...933.5     35.8     27     47GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0042383; C:sarcolemma; ISS:UniProtKB.
GO:0006906; P:vesicle fusion; ISS:UniProtKB.
149Q62770    2204   UN13C_RAT Protein unc-13 homolog C OS=Rattus ...1030.041     42     32     48GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:RGD.::GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046928; P:regulation of neurotransmitter secretion; TAS:RGD.
150A4IFJ5    749   PA24A_BOVIN Cytosolic phospholipase A2 OS=Bos...790.003     45.4     28     54GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.::GO:0005544; F:calcium-dependent phospholipid binding; ISS:UniProtKB.::GO:0004622; F:lysophospholipase activity; IEA:EC.::GO:0004623; F:phospholipase A2 activity; ISS:UniProtKB.
GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
151Q8BT60    533   CPNE3_MOUSE Copine-3 OS=Mus musculus (Mouse)....951.1     37     26     48GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
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