UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YOR074C

Length:

304

Number of sequences:

5887

Description:

YOR074C CDC21 SGDID:S000005600, Chr XV from 467589-466675, Genome Release 64-1-1, reverse complement, Verified ORF, "Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P06785	304	TYSY_YEAST Thymidylate synthase OS=Saccharomy...	304	0	630	100	100	GO:0005634; C:nucleus; IDA:SGD.
									GO:0004799; F:thymidylate synthase activity; IDA:SGD.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
2	P12461	315	TYSY_CANAL Thymidylate synthase OS=Candida al...	310	3e-167	474	74	82
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
3	P13100	297	TYSY_PNECA Thymidylate synthase OS=Pneumocyst...	298	5e-150	430	64	81
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
4	Q9UTI7	625	TYSY_SCHPO Probable thymidylate synthase OS=S...	303	1e-144	427	66	79	GO:0005829; C:cytosol; IDA:PomBase.
									GO:0004799; F:thymidylate synthase activity; ISS:PomBase.
									GO:0006231; P:dTMP biosynthetic process; ISS:PomBase.
5	P0CS12	317	TYSY_CRYNJ Thymidylate synthase OS=ATCC MYA-5...	301	3e-143	413	64	77
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
6	P0CS13	317	TYSY_CRYNB Thymidylate synthase OS=(Filobasid...	301	3e-143	413	64	77
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
7	O76511	321	TYSY_DROME Thymidylate synthase OS=Drosophila...	298	1e-142	412	66	78
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
8	Q9P4T7	296	TYSY_AGABI Thymidylate synthase OS=Agaricus b...	297	4e-141	407	63	78
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
9	P06854	294	TYSY_SHV21 Thymidylate synthase OS=Saimiriine...	295	4e-132	384	63	75
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
10	P12462	290	TYSY_HSVAT Thymidylate synthase OS=Herpesviru...	295	1e-130	380	62	74
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
11	P07607	307	TYSY_MOUSE Thymidylate synthase OS=Mus muscul...	304	2e-130	380	62	75	GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
12	P45352	307	TYSY_RAT Thymidylate synthase OS=Rattus norve...	295	3e-129	377	63	76	GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.::GO:0005730; C:nucleolus; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD.
									GO:0048037; F:cofactor binding; IDA:RGD.::GO:0008144; F:drug binding; IPI:RGD.::GO:0005542; F:folic acid binding; IDA:RGD.::GO:0003729; F:mRNA binding; IPI:RGD.::GO:0000166; F:nucleotide binding; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD.::GO:0004799; F:thymidylate synthase activity; IDA:RGD.
									GO:0007568; P:aging; IEP:RGD.::GO:0051216; P:cartilage development; IEP:RGD.::GO:0007623; P:circadian rhythm; IEP:RGD.::GO:0048589; P:developmental growth; IEP:RGD.::GO:0006231; P:dTMP biosynthetic process; IDA:RGD.::GO:0046078; P:dUMP metabolic process; IDA:RGD.::GO:0019088; P:immortalization of host cell by virus; IEP:RGD.::GO:0060574; P:intestinal epithelial cell maturation; IEP:RGD.::GO:0031100; P:organ regeneration; IEP:RGD.::GO:0005976; P:polysaccharide metabolic process; IEP:RGD.::GO:0034097; P:response to cytokine stimulus; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0045471; P:response to ethanol; IEP:RGD.::GO:0051593; P:response to folic acid; IEP:RGD.::GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IEP:RGD.::GO:0032570; P:response to progesterone stimulus; IEP:RGD.::GO:0033189; P:response to vitamin A; IEP:RGD.::GO:0046653; P:tetrahydrofolate metabolic process; IEP:RGD.::GO:0019860; P:uracil metabolic process; IEP:RGD.
13	P04818	313	TYSY_HUMAN Thymidylate synthase OS=Homo sapie...	295	2e-128	375	62	76	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.::GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome.
									GO:0004799; F:thymidylate synthase activity; TAS:Reactome.
									GO:0006281; P:DNA repair; NAS:UniProtKB.::GO:0006260; P:DNA replication; NAS:UniProtKB.::GO:0048015; P:phosphatidylinositol-mediated signaling; NAS:UniProtKB.::GO:0006206; P:pyrimidine base metabolic process; TAS:Reactome.::GO:0046134; P:pyrimidine nucleoside biosynthetic process; TAS:Reactome.::GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; TAS:Reactome.::GO:0046683; P:response to organophosphorus; IEP:UniProtKB.
14	P07382	520	DRTS_LEIMA Bifunctional dihydrofolate reducta...	299	5e-126	377	58	75
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
15	O81395	521	DRTS_MAIZE Bifunctional dihydrofolate reducta...	296	1e-125	375	60	77
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
16	P90463	337	TYSY_HHV8P Thymidylate synthase OS=sarcoma-as...	296	7e-125	367	62	73
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
17	P16126	520	DRTS_LEIAM Bifunctional dihydrofolate reducta...	299	2e-124	372	58	74
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
18	Q05763	565	DRTS2_ARATH Bifunctional dihydrofolate reduct...	296	3e-124	374	61	75
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
19	Q27828	462	DRTS_PARTE Bifunctional dihydrofolate reducta...	296	4e-124	370	58	75
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
20	Q2QRX6	494	DRTS_ORYSJ Putative bifunctional dihydrofolat...	296	6e-124	370	60	76
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
21	Q05762	519	DRTS1_ARATH Bifunctional dihydrofolate reduct...	296	7e-124	371	61	75	GO:0005829; C:cytosol; IDA:TAIR.
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
22	P51820	530	DRTS_SOYBN Bifunctional dihydrofolate reducta...	302	2e-123	370	60	74
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
23	Q89940	289	TYSY_EHV2 Thymidylate synthase OS=Equine herp...	295	3e-123	361	59	74
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
24	Q27783	527	DRTS_TRYBB Bifunctional dihydrofolate reducta...	299	5e-123	369	58	74
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
25	Q27793	521	DRTS_TRYCR Bifunctional dihydrofolate reducta...	299	2e-122	367	58	73
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
26	Q07422	610	DRTS_TOXGO Bifunctional dihydrofolate reducta...	301	5e-122	369	59	74
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
27	Q2TA32	354	TYSY_BOVIN Thymidylate synthase OS=Bos taurus...	333	1e-121	359	56	68	GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
28	P45350	528	DRTS_DAUCA Bifunctional dihydrofolate reducta...	297	7e-119	358	60	74
									GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
29	O96650	294	TYSY_ASCSU Thymidylate synthase OS=Ascaris su...	298	9e-119	350	58	70
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
30	O62584	294	TYS1_ENCCU Thymidylate synthase 1/2 OS=Enceph...	297	9e-114	337	55	73
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
31	Q8SRG2	294	TYS3_ENCCU Thymidylate synthase 3 OS=Encephal...	297	2e-113	337	55	73
									GO:0004799; F:thymidylate synthase activity; IEA:EC.
									GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.

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