| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
121 | D4CZ60 | 400 | SUB11_TRIVH Subtilisin-like protease 11 OS=Tr... | 413 | 2e-58 | 204 | 33 | 52 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 122 | E4V5C5 | 400 | SUB11_ARTGP Subtilisin-like protease 11 OS=gy... | 409 | 3e-58 | 203 | 33 | 53 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 123 | Q03420 | 409 | ALP_HYPAT Alkaline proteinase OS=Hypocrea atr... | 419 | 7e-58 | 202 | 32 | 50 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 124 | E4UY04 | 397 | SUB12_ARTGP Subtilisin-like protease 12 OS=gy... | 406 | 7e-57 | 199 | 33 | 52 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 125 | D4D1U5 | 397 | SUB12_TRIVH Subtilisin-like protease 12 OS=Tr... | 405 | 1e-56 | 199 | 32 | 53 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 126 | C5NZT2 | 377 | SUB4B_COCP7 Subtilisin-like protease CPC735_0... | 403 | 4e-55 | 194 | 33 | 49 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 127 | P25381 | 491 | RRT12_YEAST Subtilase-type proteinase RRT12 O... | 416 | 8e-55 | 196 | 35 | 50 | GO:0005619; C:ascospore wall; IDA:SGD.::GO:0005635; C:nuclear envelope; IDA:SGD. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome. | | | | | | | | | | GO:0030476; P:ascospore wall assembly; IMP:SGD.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IBA:RefGenome. | 128 | D4DIS6 | 522 | SUB10_TRIVH Subtilisin-like protease 10 OS=Tr... | 409 | 1e-54 | 196 | 35 | 50 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 129 | C5NZ70 | 407 | SUB2C_COCP7 Subtilisin-like protease CPC735_0... | 406 | 3e-54 | 192 | 31 | 51 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 130 | D4AQA9 | 416 | SUB12_ARTBC Subtilisin-like protease 12 OS=(T... | 428 | 4e-53 | 190 | 30 | 50 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 131 | D4AQG0 | 522 | SUB10_ARTBC Subtilisin-like protease 10 OS=(T... | 412 | 3e-52 | 189 | 35 | 49 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 132 | C5FX37 | 401 | SUB10_ARTOC Subtilisin-like protease 10 OS=ca... | 416 | 3e-49 | 179 | 32 | 51 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 133 | P09230 | 454 | AEP_YARLI Alkaline extracellular protease OS=... | 422 | 3e-49 | 180 | 35 | 51 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 134 | P59996 | 691 | PCSK9_RAT Proprotein convertase subtilisin/ke... | 417 | 2e-38 | 151 | 29 | 46 | GO:0005615; C:extracellular space; ISS:HGNC.::GO:0005791; C:rough endoplasmic reticulum; IDA:RGD. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0050750; F:low-density lipoprotein particle receptor binding; ISS:HGNC.::GO:0004252; F:serine-type endopeptidase activity; ISS:HGNC. | | | | | | | | | | GO:0032869; P:cellular response to insulin stimulus; IDA:HGNC.::GO:0009267; P:cellular response to starvation; IDA:HGNC.::GO:0042632; P:cholesterol homeostasis; IEP:RGD.::GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; IMP:RGD.::GO:0001822; P:kidney development; IEP:HGNC.::GO:0001889; P:liver development; IEP:HGNC.::GO:0032802; P:low-density lipoprotein particle receptor catabolic process; ISS:HGNC.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0030182; P:neuron differentiation; ISS:HGNC.::GO:0043525; P:positive regulation of neuron apoptotic process; IDA:HGNC.::GO:0016540; P:protein autoprocessing; IDA:RGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 135 | Q80W65 | 694 | PCSK9_MOUSE Proprotein convertase subtilisin/... | 400 | 8e-38 | 150 | 29 | 46 | GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.::GO:0005615; C:extracellular space; IDA:HGNC. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0050750; F:low-density lipoprotein particle receptor binding; IDA:HGNC.::GO:0004252; F:serine-type endopeptidase activity; ISS:HGNC. | | | | | | | | | | GO:0032869; P:cellular response to insulin stimulus; IDA:HGNC.::GO:0009267; P:cellular response to starvation; IDA:HGNC.::GO:0042632; P:cholesterol homeostasis; ISS:HGNC.::GO:0008203; P:cholesterol metabolic process; IDA:MGI.::GO:0001822; P:kidney development; IEP:HGNC.::GO:0042157; P:lipoprotein metabolic process; IDA:MGI.::GO:0001889; P:liver development; IEP:HGNC.::GO:0032802; P:low-density lipoprotein particle receptor catabolic process; ISS:HGNC.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0030182; P:neuron differentiation; IDA:HGNC.::GO:0006644; P:phospholipid metabolic process; IDA:MGI.::GO:0043525; P:positive regulation of neuron apoptotic process; ISS:HGNC.::GO:0016540; P:protein autoprocessing; ISS:HGNC.::GO:0006508; P:proteolysis; IBA:RefGenome.::GO:0032803; P:regulation of low-density lipoprotein particle receptor catabolic process; IMP:MGI.::GO:0006641; P:triglyceride metabolic process; IDA:MGI. | 136 | P27693 | 380 | ELYA_BACAO Alkaline protease OS=Bacillus alca... | 291 | 2e-36 | 142 | 36 | 52 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 137 | P29599 | 269 | SUBB_BACLE Subtilisin BL OS=Bacillus lentus. ... | 259 | 2e-36 | 140 | 37 | 53 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW. | 138 | Q99405 | 380 | PRTM_BACSK M-protease OS=Bacillus clausii (st... | 291 | 3e-36 | 142 | 36 | 52 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 139 | P41362 | 380 | ELYA_BACCS Alkaline protease OS=Bacillus clau... | 291 | 1e-35 | 140 | 36 | 52 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 140 | A8T655 | 692 | PCSK9_PANPA Proprotein convertase subtilisin/... | 402 | 2e-35 | 143 | 29 | 47 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 141 | A8T644 | 692 | PCSK9_PANTR Proprotein convertase subtilisin/... | 402 | 2e-35 | 143 | 29 | 47 | GO:0005615; C:extracellular space; ISS:RefGenome. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; ISS:RefGenome. | 142 | Q8NBP7 | 692 | PCSK9_HUMAN Proprotein convertase subtilisin/... | 402 | 2e-35 | 143 | 29 | 47 | GO:0005615; C:extracellular space; IDA:HGNC.::GO:0031232; C:extrinsic to external side of plasma membrane; IC:BHF-UCL.::GO:0005770; C:late endosome; IDA:BHF-UCL.::GO:0005764; C:lysosome; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL. | | | | | | | | | | GO:0034190; F:apolipoprotein receptor binding; IDA:BHF-UCL.::GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0050750; F:low-density lipoprotein particle receptor binding; IPI:BHF-UCL.::GO:0004252; F:serine-type endopeptidase activity; IDA:HGNC.::GO:0070326; F:very-low-density lipoprotein particle receptor binding; IDA:BHF-UCL. | | | | | | | | | | GO:0032869; P:cellular response to insulin stimulus; ISS:HGNC.::GO:0009267; P:cellular response to starvation; ISS:HGNC.::GO:0042632; P:cholesterol homeostasis; IMP:HGNC.::GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0001822; P:kidney development; ISS:HGNC.::GO:0001889; P:liver development; ISS:HGNC.::GO:0032802; P:low-density lipoprotein particle receptor catabolic process; IDA:HGNC.::GO:0007041; P:lysosomal transport; IDA:BHF-UCL.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0010989; P:negative regulation of low-density lipoprotein particle clearance; IDA:BHF-UCL.::GO:0001920; P:negative regulation of receptor recycling; IDA:BHF-UCL.::GO:0030182; P:neuron differentiation; ISS:HGNC.::GO:0043525; P:positive regulation of neuron apoptotic process; IMP:HGNC.::GO:0002092; P:positive regulation of receptor internalization; IDA:BHF-UCL.::GO:0016540; P:protein autoprocessing; IDA:HGNC.::GO:0006508; P:proteolysis; IBA:RefGenome.::GO:0010469; P:regulation of receptor activity; IDA:BHF-UCL. | 143 | A8T650 | 690 | PCSK9_GORGO Proprotein convertase subtilisin/... | 402 | 2e-35 | 143 | 29 | 47 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 144 | A8T658 | 690 | PCSK9_PONPY Proprotein convertase subtilisin/... | 403 | 4e-34 | 139 | 29 | 47 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 145 | Q45670 | 401 | THES_BACSJ Thermophilic serine proteinase OS=... | 295 | 4e-33 | 133 | 37 | 49 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 146 | P29600 | 269 | SUBS_BACLE Subtilisin Savinase OS=Bacillus le... | 259 | 1e-32 | 129 | 38 | 53 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW. | 147 | A8T688 | 690 | PCSK9_CALJA Proprotein convertase subtilisin/... | 336 | 3e-32 | 134 | 31 | 50 | | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 148 | A8T695 | 691 | PCSK9_SAIBB Proprotein convertase subtilisin/... | 336 | 8e-32 | 132 | 31 | 50 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 149 | A8T672 | 692 | PCSK9_COLGU Proprotein convertase subtilisin/... | 402 | 2e-31 | 131 | 28 | 46 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 150 | A8T662 | 692 | PCSK9_MACNE Proprotein convertase subtilisin/... | 402 | 2e-31 | 131 | 28 | 46 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 151 | A8T666 | 692 | PCSK9_MACMU Proprotein convertase subtilisin/... | 402 | 3e-31 | 131 | 28 | 46 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
