UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YOL136C

Length:

397

Number of sequences:

5887

Description:

YOL136C PFK27 SGDID:S000005496, Chr XV from 68754-67561, Genome Release 64-1-1, reverse complement, Verified ORF, "6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	Q12471	397	6P22_YEAST 6-phosphofructo-2-kinase 2 OS=Sacc...	397	0	810	100	100
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IMP:SGD.::GO:0006110; P:regulation of glycolysis; IMP:SGD.
2	P40433	827	6P21_YEAST 6-phosphofructo-2-kinase 1 OS=Sacc...	192	1e-17	88.6	34	51
									GO:0003873; F:6-phosphofructo-2-kinase activity; IDA:SGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:InterPro.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
3	Q8TFH0	668	YIKE_SCHPO Probable 6-phosphofructo-2-kinase ...	210	9e-17	85.5	30	46	GO:0005737; C:cytoplasm; ISS:PomBase.
									GO:0003873; F:6-phosphofructo-2-kinase activity; ISS:PomBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:InterPro.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; ISS:PomBase.::GO:0006110; P:regulation of glycolysis; ISS:PomBase.
4	Q9UTE1	592	YFMD_SCHPO Probable 6-phosphofructo-2-kinase ...	243	0.000000000000003	80.9	28	47	GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
									GO:0003873; F:6-phosphofructo-2-kinase activity; ISS:PomBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:InterPro.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; ISS:PomBase.
5	Q21122	457	F26_CAEEL Probable 6-phosphofructo-2-kinase/f...	219	0.00000000000002	78.2	33	47
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
6	P07953	471	F261_RAT 6-phosphofructo-2-kinase/fructose-2,...	239	0.000000000009	70.1	26	44	GO:0043540; C:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex; ISS:UniProtKB.
									GO:0003873; F:6-phosphofructo-2-kinase activity; IDA:RGD.::GO:0005524; F:ATP binding; IDA:RGD.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; ISS:UniProtKB.::GO:0070095; F:fructose-6-phosphate binding; IDA:RGD.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0019900; F:kinase binding; IPI:RGD.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; ISS:UniProtKB.::GO:0031100; P:organ regeneration; IEP:RGD.::GO:0033133; P:positive regulation of glucokinase activity; IMP:RGD.::GO:0051591; P:response to cAMP; IEP:RGD.::GO:0033762; P:response to glucagon stimulus; IEP:RGD.::GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.::GO:0032868; P:response to insulin stimulus; IEP:RGD.::GO:0042594; P:response to starvation; IEP:RGD.
7	P16118	471	F261_HUMAN 6-phosphofructo-2-kinase/fructose-...	238	0.00000000002	68.9	26	45	GO:0043540; C:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex; IDA:UniProtKB.
									GO:0003873; F:6-phosphofructo-2-kinase activity; TAS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IDA:UniProtKB.
									GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IDA:UniProtKB.::GO:0006094; P:gluconeogenesis; TAS:UniProtKB.::GO:0006096; P:glycolysis; TAS:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; TAS:Reactome.
8	P70266	471	F261_MOUSE 6-phosphofructo-2-kinase/fructose-...	235	0.00000000005	67.8	26	45	GO:0043540; C:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex; ISS:UniProtKB.
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; ISS:UniProtKB.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; ISS:UniProtKB.
9	P32604	452	F26_YEAST Fructose-2,6-bisphosphatase OS=Sacc...	189	0.0000000001	66.6	28	49
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IMP:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.::GO:0006006; P:glucose metabolic process; IMP:SGD.
10	P49872	471	F261_BOVIN 6-phosphofructo-2-kinase/fructose-...	238	0.0000000001	66.2	26	45	GO:0043540; C:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex; ISS:UniProtKB.
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; ISS:UniProtKB.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; ISS:UniProtKB.
11	Q5NVT1	530	F262_PONAB 6-phosphofructo-2-kinase/fructose-...	218	0.0000000002	65.9	28	44
									GO:0003873; F:6-phosphofructo-2-kinase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.::GO:0006096; P:glycolysis; ISS:UniProtKB.
12	O60825	505	F262_HUMAN 6-phosphofructo-2-kinase/fructose-...	218	0.0000000002	65.5	28	44	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0003873; F:6-phosphofructo-2-kinase activity; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.::GO:0006096; P:glycolysis; IDA:UniProtKB.
13	P26285	531	F262_BOVIN 6-phosphofructo-2-kinase/fructose-...	218	0.0000000004	65.1	28	43
									GO:0003873; F:6-phosphofructo-2-kinase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.::GO:0006096; P:glycolysis; ISS:UniProtKB.
14	Q91309	470	F26_LITCT 6-phosphofructo-2-kinase/fructose-2...	238	0.0000000005	64.3	27	43
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
15	Q91348	470	F26L_CHICK 6-phosphofructo-2-kinase/fructose-...	255	0.000000002	62.4	25	44	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0003873; F:6-phosphofructo-2-kinase activity; TAS:Reactome.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; TAS:Reactome.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.::GO:0006094; P:gluconeogenesis; TAS:Reactome.::GO:0006096; P:glycolysis; TAS:Reactome.
16	O35552	555	F263_RAT 6-phosphofructo-2-kinase/fructose-2,...	229	0.000000003	62.4	27	42
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
17	P70265	519	F262_MOUSE 6-phosphofructo-2-kinase/fructose-...	218	0.000000004	61.6	27	43
									GO:0003873; F:6-phosphofructo-2-kinase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.::GO:0006096; P:glycolysis; ISS:UniProtKB.
18	Q9JJH5	557	F262_RAT 6-phosphofructo-2-kinase/fructose-2,...	218	0.000000006	61.2	27	43	GO:0005737; C:cytoplasm; IDA:RGD.
									GO:0003873; F:6-phosphofructo-2-kinase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; TAS:RGD.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; TAS:RGD.::GO:0006096; P:glycolysis; ISS:UniProtKB.::GO:0006089; P:lactate metabolic process; IDA:RGD.::GO:0033133; P:positive regulation of glucokinase activity; IDA:RGD.::GO:0032024; P:positive regulation of insulin secretion; IDA:RGD.::GO:0006090; P:pyruvate metabolic process; IDA:RGD.::GO:0009749; P:response to glucose stimulus; IDA:RGD.
19	Q16875	520	F263_HUMAN 6-phosphofructo-2-kinase/fructose-...	229	0.00000001	60.5	26	41	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0003873; F:6-phosphofructo-2-kinase activity; NAS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; NAS:UniProtKB.::GO:0006096; P:glycolysis; TAS:Reactome.
20	Q5R9C1	514	F263_PONAB 6-phosphofructo-2-kinase/fructose-...	229	0.00000001	60.1	26	41
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
21	Q9MB58	744	F26_ARATH 6-phosphofructo-2-kinase/fructose-2...	189	0.00000004	58.9	28	44	GO:0005829; C:cytosol; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.::GO:2001070; F:starch binding; IEA:InterPro.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IDA:UniProtKB.::GO:0006002; P:fructose 6-phosphate metabolic process; IDA:UniProtKB.::GO:0043609; P:regulation of carbon utilization; IMP:UniProtKB.
22	Q6DTY7	469	F264_MOUSE 6-phosphofructo-2-kinase/fructose-...	258	0.00000008	57.8	25	43
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
23	Q16877	469	F264_HUMAN 6-phosphofructo-2-kinase/fructose-...	218	0.0000001	57.4	26	45	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0003873; F:6-phosphofructo-2-kinase activity; NAS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; NAS:UniProtKB.::GO:0006096; P:glycolysis; TAS:Reactome.
24	P25114	469	F264_RAT 6-phosphofructo-2-kinase/fructose-2,...	258	0.0000001	57	26	43
									GO:0003873; F:6-phosphofructo-2-kinase activity; IDA:RGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IDA:RGD.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
25	Q4R8B6	469	F264_MACFA 6-phosphofructo-2-kinase/fructose-...	218	0.0000001	57	26	45
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
26	Q28901	463	F263_BOVIN 6-phosphofructo-2-kinase/fructose-...	202	0.0000005	55.1	28	44
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
27	Q9UTK9	449	YIVH_SCHPO Putative 6-phosphofructo-2-kinase/...	180	0.011	41.2	22	44	GO:0005829; C:cytosol; IDA:PomBase.
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IC:PomBase.
28	Q49435	270	RBGA_MYCGE Probable ribosome biogenesis GTPas...	103	1	34.7	28	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
									GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
29	A6L1P5	288	ISPH_BACV8 4-hydroxy-3-methylbut-2-enyl dipho...	63	1.7	34.3	37	54
									GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0051745; F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0019288; P:isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; IEA:InterPro.
30	B1HUK4	908	SYA_LYSSC Alanine--tRNA ligase OS=Lysinibacil...	50	2.3	34.3	28	60	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004813; F:alanine-tRNA ligase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
									GO:0006419; P:alanyl-tRNA aminoacylation; IEA:InterPro.
31	Q9URZ7	408	YK72_SCHPO Probable fructose-2,6-bisphosphata...	190	2.8	33.9	22	39	GO:0005829; C:cytosol; ISS:PomBase.
									GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; ISS:PomBase.
									GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.::GO:0006006; P:glucose metabolic process; ISS:PomBase.

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