Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOL126C
Length:
377
Number of sequences:
5887
Description:
YOL126C MDH2 SGDID:S000005486, Chr XV from 82920-81787, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P22133    377   MDHC_YEAST Malate dehydrogenase, cytoplasmic ...3770     767     100     100GO:0005829; C:cytosol; IDA:SGD.
GO:0030060; F:L-malate dehydrogenase activity; IDA:SGD.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006094; P:gluconeogenesis; IMP:SGD.::GO:0006108; P:malate metabolic process; TAS:SGD.::GO:0016558; P:protein import into peroxisome matrix; IMP:SGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
2P83778    337   MDHC_CANAL Malate dehydrogenase, cytoplasmic ...3646e-82     260     43     61GO:0005739; C:mitochondrion; NAS:CGD.::GO:0005625; C:soluble fraction; IDA:CGD.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; NAS:CGD.
3P17505    334   MDHM_YEAST Malate dehydrogenase, mitochondria...3635e-70     229     43     56GO:0005759; C:mitochondrial matrix; IDA:SGD.
GO:0030060; F:L-malate dehydrogenase activity; IDA:SGD.::GO:0003729; F:mRNA binding; IDA:SGD.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0001300; P:chronological cell aging; IMP:SGD.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0001302; P:replicative cell aging; IMP:SGD.::GO:0006099; P:tricarboxylic acid cycle; IMP:SGD.
4Q5NVR2    338   MDHM_PONAB Malate dehydrogenase, mitochondria...3664e-67     222     41     56GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006475; P:internal protein amino acid acetylation; ISS:UniProtKB.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
5P40926    338   MDHM_HUMAN Malate dehydrogenase, mitochondria...3665e-67     221     41     56GO:0005759; C:mitochondrial matrix; TAS:Reactome.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0030060; F:L-malate dehydrogenase activity; IDA:UniProtKB.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006094; P:gluconeogenesis; TAS:Reactome.::GO:0006475; P:internal protein amino acid acetylation; IDA:UniProtKB.::GO:0006108; P:malate metabolic process; IDA:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome.
6P04636    338   MDHM_RAT Malate dehydrogenase, mitochondrial ...3649e-67     221     41     56GO:0005759; C:mitochondrial matrix; IDA:RGD.
GO:0030060; F:L-malate dehydrogenase activity; IDA:RGD.::GO:0046554; F:malate dehydrogenase (NADP+) activity; IDA:RGD.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0043621; F:protein self-association; IDA:RGD.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006475; P:internal protein amino acid acetylation; ISS:UniProtKB.::GO:0006108; P:malate metabolic process; IDA:RGD.::GO:0006734; P:NADH metabolic process; IDA:RGD.::GO:0006107; P:oxaloacetate metabolic process; IDA:RGD.::GO:0006099; P:tricarboxylic acid cycle; IDA:RGD.
7P08249    338   MDHM_MOUSE Malate dehydrogenase, mitochondria...3641e-66     220     41     56GO:0005743; C:mitochondrial inner membrane; IDA:MGI.::GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IDA:MGI.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006475; P:internal protein amino acid acetylation; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
8Q32LG3    338   MDHM_BOVIN Malate dehydrogenase, mitochondria...3644e-66     219     41     56GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006475; P:internal protein amino acid acetylation; ISS:UniProtKB.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
9Q9Y7R8    341   MDHM_SCHPO Malate dehydrogenase, mitochondria...3617e-66     218     41     55GO:0005759; C:mitochondrial matrix; ISS:PomBase.
GO:0030060; F:L-malate dehydrogenase activity; ISS:PomBase.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0033554; P:cellular response to stress; IEP:PomBase.::GO:0006108; P:malate metabolic process; ISS:PomBase.::GO:0006099; P:tricarboxylic acid cycle; ISS:PomBase.
10P00346    338   MDHM_PIG Malate dehydrogenase, mitochondrial ...3641e-65     218     41     56GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006475; P:internal protein amino acid acetylation; ISS:UniProtKB.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
11P32419    343   MDHP_YEAST Malate dehydrogenase, peroxisomal ...3722e-65     217     40     57GO:0005777; C:peroxisome; IDA:SGD.
GO:0030060; F:L-malate dehydrogenase activity; IMP:SGD.::GO:0003729; F:mRNA binding; IDA:SGD.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006635; P:fatty acid beta-oxidation; TAS:SGD.::GO:0006097; P:glyoxylate cycle; TAS:SGD.::GO:0006108; P:malate metabolic process; TAS:SGD.::GO:0006735; P:NADH regeneration; TAS:SGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
12Q4R568    338   MDHM_MACFA Malate dehydrogenase, mitochondria...3646e-65     216     40     55GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006475; P:internal protein amino acid acetylation; ISS:UniProtKB.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
13O02640    341   MDHM_CAEEL Probable malate dehydrogenase, mit...3583e-64     214     40     55GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; ISS:WormBase.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0006108; P:malate metabolic process; ISS:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.::GO:0071688; P:striated muscle myosin thick filament assembly; IMP:WormBase.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
14P37228    353   MDHG_SOYBN Malate dehydrogenase, glyoxysomal ...3572e-62     210     41     56GO:0009514; C:glyoxysome; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
15Q42972    356   MDHG_ORYSJ Malate dehydrogenase, glyoxysomal ...3586e-62     209     41     55GO:0009514; C:glyoxysome; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
16P19446    356   MDHG_CITLA Malate dehydrogenase, glyoxysomal ...3592e-61     207     40     56GO:0009514; C:glyoxysome; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
17O82399    354   MDHG2_ARATH Probable malate dehydrogenase, gl...2794e-61     206     45     61GO:0009507; C:chloroplast; IDA:TAIR.::GO:0009514; C:glyoxysome; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0031998; P:regulation of fatty acid beta-oxidation; IGI:TAIR.::GO:0080093; P:regulation of photorespiration; IMP:TAIR.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
18P46488    356   MDHG_CUCSA Malate dehydrogenase, glyoxysomal ...3586e-61     206     41     55GO:0009514; C:glyoxysome; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
19Q9ZP05    354   MDHG1_ARATH Malate dehydrogenase, glyoxysomal...3572e-60     205     41     55GO:0048046; C:apoplast; IDA:TAIR.::GO:0009941; C:chloroplast envelope; IDA:TAIR.::GO:0009514; C:glyoxysome; IEA:UniProtKB-SubCell.::GO:0005773; C:vacuole; IDA:TAIR.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0031998; P:regulation of fatty acid beta-oxidation; IGI:TAIR.::GO:0080093; P:regulation of photorespiration; IMP:TAIR.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
20Q42686    373   MDHM_CHLRE Malate dehydrogenase, mitochondria...3591e-59     203     40     55GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
21Q9XFW3    358   MDHG2_BRANA Malate dehydrogenase 2, glyoxysom...3574e-59     201     40     55GO:0009514; C:glyoxysome; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
22Q43743    358   MDHG1_BRANA Malate dehydrogenase 1, glyoxysom...3575e-59     201     40     55GO:0009514; C:glyoxysome; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
23P37226    312   MDH_PHOPR Malate dehydrogenase OS=Photobacter...3678e-59     199     40     53
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
24P83373    339   MDHM_FRAAN Malate dehydrogenase, mitochondria...2581e-58     199     47     63GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
25Q9SN86    403   MDHP_ARATH Malate dehydrogenase, chloroplasti...3642e-58     201     38     55GO:0048046; C:apoplast; IDA:TAIR.::GO:0009941; C:chloroplast envelope; IDA:TAIR.::GO:0009570; C:chloroplast stroma; IDA:TAIR.::GO:0005739; C:mitochondrion; IDA:TAIR.::GO:0010319; C:stromule; IDA:TAIR.::GO:0005774; C:vacuolar membrane; IDA:TAIR.
GO:0030060; F:L-malate dehydrogenase activity; IDA:TAIR.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0009409; P:response to cold; IEP:TAIR.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
26Q9LKA3    341   MDHM2_ARATH Malate dehydrogenase 2, mitochond...3583e-58     198     40     56GO:0048046; C:apoplast; IDA:TAIR.::GO:0016020; C:membrane; IDA:TAIR.::GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005507; F:copper ion binding; IDA:TAIR.::GO:0030060; F:L-malate dehydrogenase activity; IGI:TAIR.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0042742; P:defense response to bacterium; IEP:TAIR.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
27Q3IFH4    310   MDH_PSEHT Malate dehydrogenase OS=Pseudoalter...3594e-58     197     38     53
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
28B4F2A1    312   MDH_PROMH Malate dehydrogenase OS=Proteus mir...3666e-57     194     39     55
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
29Q9ZP06    341   MDHM1_ARATH Malate dehydrogenase 1, mitochond...3587e-57     195     41     54GO:0005618; C:cell wall; IDA:TAIR.::GO:0009507; C:chloroplast; IDA:TAIR.::GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005507; F:copper ion binding; IDA:TAIR.::GO:0030060; F:L-malate dehydrogenase activity; IMP:TAIR.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0042742; P:defense response to bacterium; IEP:TAIR.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0046686; P:response to cadmium ion; IEP:TAIR.::GO:0009409; P:response to cold; IEP:TAIR.::GO:0009651; P:response to salt stress; IEP:TAIR.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
30P17783    347   MDHM_CITLA Malate dehydrogenase, mitochondria...3567e-57     195     40     54GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
31Q87SU7    311   MDH_VIBPA Malate dehydrogenase OS=Vibrio para...3641e-56     193     39     54
GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.::GO:0006108; P:malate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
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