Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOL113W
Length:
655
Number of sequences:
5887
Description:
YOL113W SKM1 SGDID:S000005473, Chr XV from 104326-106293, Genome Release 64-1-1, Verified ORF, "Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
541Q63572    628   TESK1_RAT Dual specificity testis-specific pr...2341e-21     103     29     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IMP:RGD.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
GO:0007283; P:spermatogenesis; IEP:RGD.
542Q6C7U8    294   PHO85_YARLI Negative regulator of the PHO sys...2521e-21     100     26     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
543Q10GB1    599   NEK1_ORYSJ Serine/threonine-protein kinase Ne...2961e-21     103     27     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
544Q9LT35    416   NEK6_ARATH Serine/threonine-protein kinase Ne...2771e-21     101     26     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
545Q8SRL5    272   IPL1_ENCCU Probable spindle assembly checkpoi...2811e-21     99.8     26     49GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
546Q9WVL4    564   RK_MOUSE Rhodopsin kinase OS=Mus musculus (Mo...1861e-21     102     32     54GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004703; F:G-protein coupled receptor kinase activity; IEA:InterPro.::GO:0050254; F:rhodopsin kinase activity; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0022400; P:regulation of rhodopsin mediated signaling pathway; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.::GO:0007601; P:visual perception; IEA:UniProtKB-KW.
547P49071    359   MAPK2_DROME MAP kinase-activated protein kina...2531e-21     100     28     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; NAS:FlyBase.
GO:0007155; P:cell adhesion; IMP:FlyBase.::GO:0045793; P:positive regulation of cell size; IGI:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.
548Q9Z1M4    485   KS6B2_MOUSE Ribosomal protein S6 kinase beta-...2271e-21     102     28     48GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
549Q7TSE6    464   ST38L_MOUSE Serine/threonine-protein kinase 3...2681e-21     102     28     48GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.::GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0007243; P:intracellular protein kinase cascade; ISS:UniProtKB.::GO:0051128; P:regulation of cellular component organization; IDA:UniProtKB.
550P17157    305   PHO85_YEAST Cyclin-dependent protein kinase P...2591e-21     100     28     48GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IPI:SGD.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0050849; P:negative regulation of calcium-mediated signaling; IGI:SGD.::GO:0045719; P:negative regulation of glycogen biosynthetic process; IMP:SGD.::GO:0016242; P:negative regulation of macroautophagy; IMP:SGD.::GO:0045936; P:negative regulation of phosphate metabolic process; IGI:SGD.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:SGD.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:SGD.::GO:0016239; P:positive regulation of macroautophagy; IMP:SGD.::GO:0032878; P:regulation of establishment or maintenance of cell polarity; IGI:SGD.::GO:0032880; P:regulation of protein localization; IDA:SGD.::GO:0031647; P:regulation of protein stability; IMP:SGD.::GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; IMP:SGD.::GO:0006974; P:response to DNA damage stimulus; IMP:SGD.
551Q9TTK0    566   CDKL2_RABIT Cyclin-dependent kinase-like 2 OS...2861e-21     102     28     47GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
552Q91YA2    424   KPSH1_MOUSE Serine/threonine-protein kinase H...2591e-21     101     29     47GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
553Q9VKN7    329   AURKB_DROME Aurora kinase B OS=Drosophila mel...3121e-21     100     24     46GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0000776; C:kinetochore; TAS:FlyBase.::GO:0030496; C:midbody; IDA:FlyBase.::GO:0051233; C:spindle midzone; IDA:FlyBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0008608; P:attachment of spindle microtubules to kinetochore; TAS:FlyBase.::GO:0000910; P:cytokinesis; IMP:FlyBase.::GO:0016572; P:histone phosphorylation; IMP:FlyBase.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0007076; P:mitotic chromosome condensation; IMP:FlyBase.::GO:0007052; P:mitotic spindle organization; IMP:FlyBase.
554Q8W1D5    488   CIPKP_ARATH CBL-interacting serine/threonine-...2751e-21     102     28     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0050832; P:defense response to fungus; IEP:TAIR.::GO:0007165; P:signal transduction; IEA:InterPro.
555Q98TY9    481   AKT1_XENLA RAC-alpha serine/threonine-protein...2691e-21     102     26     49GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0015758; P:glucose transport; ISS:UniProtKB.::GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.::GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:UniProtKB.::GO:0010975; P:regulation of neuron projection development; ISS:UniProtKB.
556P38991    367   IPL1_YEAST Spindle assembly checkpoint kinase...1462e-21     100     31     57GO:0032133; C:chromosome passenger complex; IDA:SGD.::GO:0000778; C:condensed nuclear chromosome kinetochore; IDA:SGD.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005828; C:kinetochore microtubule; IDA:SGD.::GO:0051233; C:spindle midzone; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0008608; P:attachment of spindle microtubules to kinetochore; IMP:SGD.::GO:0045143; P:homologous chromosome segregation; IMP:SGD.::GO:0045144; P:meiotic sister chromatid segregation; IMP:SGD.::GO:0070683; P:mitotic cell cycle G2/M transition decatenation checkpoint; IGI:SGD.::GO:0051228; P:mitotic spindle disassembly; IMP:SGD.::GO:0032465; P:regulation of cytokinesis; IMP:SGD.::GO:0031577; P:spindle checkpoint; IMP:SGD.
557P28867    674   KPCD_MOUSE Protein kinase C delta type OS=Mus...1852e-21     102     31     52GO:0005911; C:cell-cell junction; IDA:MGI.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043560; F:insulin receptor substrate binding; IPI:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004697; F:protein kinase C activity; IEA:EC.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042100; P:B cell proliferation; IMP:MGI.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0016064; P:immunoglobulin mediated immune response; IMP:MGI.::GO:0032613; P:interleukin-10 production; IMP:MGI.::GO:0032615; P:interleukin-12 production; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030837; P:negative regulation of actin filament polymerization; IMP:UniProtKB.::GO:0051490; P:negative regulation of filopodium assembly; IMP:UniProtKB.::GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:BHF-UCL.::GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IMP:BHF-UCL.::GO:0090331; P:negative regulation of platelet aggregation; IMP:UniProtKB.::GO:0032930; P:positive regulation of superoxide anion generation; ISS:UniProtKB.
558Q9NBK5    463   TRC_DROME Serine/threonine-protein kinase tri...3112e-21     101     25     47GO:0005938; C:cell cortex; IDA:FlyBase.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0048800; P:antennal morphogenesis; IMP:FlyBase.::GO:0022416; P:chaeta development; IMP:FlyBase.::GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.::GO:0070593; P:dendrite self-avoidance; IGI:FlyBase.::GO:0035317; P:imaginal disc-derived wing hair organization; IMP:FlyBase.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0048814; P:regulation of dendrite morphogenesis; IMP:FlyBase.
559Q8VDU5    748   SNRK_MOUSE SNF-related serine/threonine-prote...2502e-21     103     30     50GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
560P36506    400   MP2K2_RAT Dual specificity mitogen-activated ...2502e-21     100     31     50GO:0005938; C:cell cortex; IDA:RGD.::GO:0005829; C:cytosol; TAS:UniProtKB.::GO:0005769; C:early endosome; TAS:UniProtKB.::GO:0005925; C:focal adhesion; TAS:UniProtKB.::GO:0005794; C:Golgi apparatus; TAS:UniProtKB.::GO:0005770; C:late endosome; TAS:UniProtKB.::GO:0005739; C:mitochondrion; TAS:UniProtKB.::GO:0005634; C:nucleus; TAS:UniProtKB.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0005524; F:ATP binding; IDA:RGD.::GO:0004708; F:MAP kinase kinase activity; IDA:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
GO:2000641; P:regulation of early endosome to late endosome transport; TAS:UniProtKB.::GO:0090170; P:regulation of Golgi inheritance; TAS:UniProtKB.::GO:0032872; P:regulation of stress-activated MAPK cascade; TAS:UniProtKB.
561Q9LWM4    461   CIPK5_ORYSJ CBL-interacting protein kinase 5 ...2302e-21     101     28     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
562D3ZHP7    472   ULK3_RAT Serine/threonine-protein kinase ULK3...2282e-21     101     29     52GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0045879; P:negative regulation of smoothened signaling pathway; ISS:UniProtKB.::GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
563Q15569    626   TESK1_HUMAN Dual specificity testis-specific ...2342e-21     102     29     47GO:0005829; C:cytosol; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
GO:0034329; P:cell junction assembly; TAS:Reactome.::GO:0007283; P:spermatogenesis; TAS:ProtInc.
564B4KYX8    778   PLK4_DROMO Serine/threonine-protein kinase PL...2572e-21     102     28     47GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
565Q63553    746   SNRK_RAT SNF-related serine/threonine-protein...2502e-21     102     30     50GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0043523; P:regulation of neuron apoptotic process; TAS:UniProtKB.
566Q54TA1    749   DRKC_DICDI Probable serine/threonine-protein ...2612e-21     102     30     48GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030670; C:phagocytic vesicle membrane; IDA:dictyBase.::GO:0032010; C:phagolysosome; IDA:dictyBase.
GO:0005524; F:ATP binding; IC:dictyBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IDA:dictyBase.
GO:0001845; P:phagolysosome assembly; IMP:dictyBase.
567Q9XTG7    528   AKT2_CAEEL Serine/threonine-protein kinase ak...3102e-21     102     24     45GO:0005622; C:intracellular; IDA:WormBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:WormBase.
GO:0043053; P:dauer entry; IMP:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0008286; P:insulin receptor signaling pathway; IMP:WormBase.
568Q3U214    1321   MAST3_MOUSE Microtubule-associated serine/thr...2552e-21     103     29     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
569Q9Y884    363   SKH1_SCHPO MAP kinase kinase skh1/pek1 OS=Sch...2292e-21     100     35     47GO:0030428; C:cell septum; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; TAS:PomBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
GO:0051519; P:activation of bipolar cell growth; IMP:PomBase.::GO:0033205; P:cell cycle cytokinesis; NAS:PomBase.::GO:0006883; P:cellular sodium ion homeostasis; NAS:PomBase.::GO:0031505; P:fungal-type cell wall organization; NAS:PomBase.::GO:0050850; P:positive regulation of calcium-mediated signaling; IMP:PomBase.::GO:0008360; P:regulation of cell shape; NAS:PomBase.
570A4IFM7    623   MYLK2_BOVIN Myosin light chain kinase 2, skel...2482e-21     102     30     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004687; F:myosin light chain kinase activity; IEA:EC.
571Q55A09    1331   Y9963_DICDI Probable serine/threonine-protein...2592e-21     103     27     51GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
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