Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOL081W
Length:
3079
Number of sequences:
5887
Description:
YOL081W IRA2 SGDID:S000005441, Chr XV from 171070-180309, Genome Release 64-1-1, Verified ORF, "GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31F6SEU4    1340   SYGP1_MOUSE Ras GTPase-activating protein Syn...2480.000003     57     26     48GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0043198; C:dendritic shaft; IDA:MGI.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005097; F:Rab GTPase activator activity; IDA:MGI.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0016358; P:dendrite development; IMP:MGI.::GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.::GO:0050771; P:negative regulation of axonogenesis; IDA:MGI.::GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0007389; P:pattern specification process; IMP:MGI.::GO:0007265; P:Ras protein signal transduction; IDA:MGI.::GO:0043113; P:receptor clustering; IMP:MGI.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.::GO:0043408; P:regulation of MAPK cascade; IMP:MGI.::GO:0050803; P:regulation of synapse structure and activity; IMP:MGI.::GO:0008542; P:visual learning; IMP:MGI.
32Q9QUH6    1308   SYGP1_RAT Ras GTPase-activating protein SynGA...2480.000003     57     26     48GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:UniProtKB.
33Q96PV0    1343   SYGP1_HUMAN Ras GTPase-activating protein Syn...2480.000003     57     26     48GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:UniProtKB.
34O00899    860   GAPA_DICDI Ras GTPase-activating-like protein...1830.000007     55.8     24     49GO:0005622; C:intracellular; IEA:InterPro.
GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006972; P:hyperosmotic response; IEP:dictyBase.::GO:0006979; P:response to oxidative stress; IEP:dictyBase.::GO:0019953; P:sexual reproduction; IEP:dictyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
35Q9UJF2    1139   NGAP_HUMAN Ras GTPase-activating protein nGAP...2310.00002     54.3     27     47GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007165; P:signal transduction; TAS:ProtInc.
36P46940    1657   IQGA1_HUMAN Ras GTPase-activating-like protei...1280.0002     51.6     26     48GO:0005884; C:actin filament; TAS:ProtInc.::GO:0005737; C:cytoplasm; IDA:HPA.::GO:0030496; C:midbody; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0036057; C:slit diaphragm; ISS:UniProtKB.
GO:0005516; F:calmodulin binding; TAS:ProtInc.::GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.::GO:0019903; F:protein phosphatase binding; IPI:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.::GO:0050796; P:regulation of insulin secretion; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.
37Q8C2K5    1041   RASL3_MOUSE RAS protein activator like-3 OS=M...1890.0003     50.4     23     44GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007165; P:signal transduction; IEA:InterPro.
38Q6P730    996   DAB2P_RAT Disabled homolog 2-interacting prot...2780.0003     50.4     25     44GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0047485; F:protein N-terminus binding; IPI:RGD.::GO:0005099; F:Ras GTPase activator activity; IDA:RGD.
GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:BHF-UCL.::GO:0030308; P:negative regulation of cell growth; IDA:RGD.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IDA:BHF-UCL.::GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:RGD.
39Q9JKF1    1657   IQGA1_MOUSE Ras GTPase-activating-like protei...1280.0003     50.4     26     48GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0036057; C:slit diaphragm; ISS:UniProtKB.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
40Q3UHC7    1189   DAB2P_MOUSE Disabled homolog 2-interacting pr...2300.0004     50.1     26     46GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0070059; P:apoptosis in response to endoplasmic reticulum stress; IMP:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; IMP:BHF-UCL.::GO:0035414; P:negative regulation of catenin import into nucleus; IMP:BHF-UCL.::GO:0048147; P:negative regulation of fibroblast proliferation; IMP:BHF-UCL.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0043065; P:positive regulation of apoptotic process; IMP:BHF-UCL.
41Q5VWQ8    1189   DAB2P_HUMAN Disabled homolog 2-interacting pr...2780.0004     50.1     25     44GO:0005737; C:cytoplasm; IDA:BHF-UCL.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0071889; F:14-3-3 protein binding; IDA:BHF-UCL.::GO:0005123; F:death receptor binding; IPI:BHF-UCL.::GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:BHF-UCL.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL.::GO:0051721; F:protein phosphatase 2A binding; IDA:BHF-UCL.::GO:0005099; F:Ras GTPase activator activity; ISS:BHF-UCL.::GO:0035591; F:signaling adaptor activity; IDA:BHF-UCL.
GO:0007257; P:activation of JUN kinase activity; IDA:BHF-UCL.::GO:0070059; P:apoptosis in response to endoplasmic reticulum stress; ISS:BHF-UCL.::GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; IDA:BHF-UCL.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.::GO:0035414; P:negative regulation of catenin import into nucleus; ISS:BHF-UCL.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; ISS:BHF-UCL.::GO:0010633; P:negative regulation of epithelial cell migration; TAS:BHF-UCL.::GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:BHF-UCL.::GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IMP:BHF-UCL.::GO:0048147; P:negative regulation of fibroblast proliferation; ISS:BHF-UCL.::GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IDA:BHF-UCL.::GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0034261; P:negative regulation of Ras GTPase activity; IMP:BHF-UCL.::GO:0046580; P:negative regulation of Ras protein signal transduction; IC:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0043065; P:positive regulation of apoptotic process; IDA:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
42Q14C86    1478   GAPD1_HUMAN GTPase-activating protein and VPS...2090.0004     50.1     26     50GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0032794; F:GTPase activating protein binding; IMP:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IMP:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; IMP:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
43Q54K32    822   RGAA_DICDI Ras GTPase-activating-like protein...1000.0006     49.3     25     56GO:0005938; C:cell cortex; TAS:dictyBase.::GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; ISS:dictyBase.::GO:0048365; F:Rac GTPase binding; IPI:dictyBase.::GO:0005099; F:Ras GTPase activator activity; IDA:dictyBase.
GO:0000910; P:cytokinesis; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0031149; P:sorocarp stalk cell differentiation; IMP:dictyBase.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:dictyBase.
44Q86VI3    1631   IQGA3_HUMAN Ras GTPase-activating-like protei...1300.0008     48.9     23     49
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
45P33314    1104   BUD2_YEAST Inhibitory regulator protein BUD2/...2050.001     48.5     21     49GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0007120; P:axial cellular bud site selection; TAS:SGD.::GO:0007121; P:bipolar cellular bud site selection; TAS:SGD.::GO:0030447; P:filamentous growth; IMP:SGD.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD.
46A5D794    1413   GAPD1_BOVIN GTPase-activating protein and VPS...2090.001     48.5     25     50GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0032794; F:GTPase activating protein binding; ISS:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; ISS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
47Q6PAR5    1458   GAPD1_MOUSE GTPase-activating protein and VPS...2090.003     47.4     25     50GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0032794; F:GTPase activating protein binding; IMP:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IMP:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; IMP:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
48Q22720    629   GAP1_CAEEL Ras GTPase-activating protein gap-...1840.003     47     23     42GO:0005737; C:cytoplasm; NAS:UniProtKB.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; NAS:UniProtKB.
GO:0046580; P:negative regulation of Ras protein signal transduction; IEP:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
49Q60528    676   MUC1_MESAU Mucin-1 OS=Mesocricetus auratus (G...1497     35.8     23     40GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
50Q9GYH7    1093   RME6_CAEEL Receptor-mediated endocytosis prot...1240.26     40.8     25     44GO:0045334; C:clathrin-coated endocytic vesicle; IDA:WormBase.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005769; C:early endosome; IDA:WormBase.::GO:0005886; C:plasma membrane; IDA:WormBase.
GO:0032794; F:GTPase activating protein binding; ISS:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.::GO:0017137; F:Rab GTPase binding; IPI:WormBase.
GO:0006897; P:endocytosis; IMP:WormBase.::GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IGI:WormBase.::GO:0032851; P:positive regulation of Rab GTPase activity; IGI:WormBase.::GO:2000369; P:regulation of clathrin-mediated endocytosis; IMP:WormBase.::GO:0051223; P:regulation of protein transport; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
51A0JP43    1406   EFCB5_MOUSE EF-hand calcium-binding domain-co...1350.27     40.8     24     43
GO:0005509; F:calcium ion binding; IEA:InterPro.
52A8WVM4    1104   RME6_CAEBR Receptor-mediated endocytosis prot...730.28     40.8     29     51GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0032794; F:GTPase activating protein binding; ISS:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; ISS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
53Q5R405    1083   SPT5H_PONAB Transcription elongation factor S...2320.29     40.4     22     37GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
54O00267    1087   SPT5H_HUMAN Transcription elongation factor S...2320.32     40.4     22     36GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.
GO:0007049; P:cell cycle; NAS:UniProtKB.::GO:0006338; P:chromatin remodeling; NAS:UniProtKB.::GO:0006370; P:mRNA capping; TAS:Reactome.::GO:0032785; P:negative regulation of transcription elongation, DNA-dependent; IDA:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:InterPro.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0050434; P:positive regulation of viral transcription; TAS:Reactome.::GO:0010033; P:response to organic substance; TAS:UniProtKB.::GO:0045090; P:retroviral genome replication; NAS:UniProtKB.::GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:UniProtKB.
55A2RV61    1452   GAPD1_XENLA GTPase-activating protein and VPS...2040.51     40     23     49GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0032794; F:GTPase activating protein binding; ISS:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; ISS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
56O55201    1082   SPT5H_MOUSE Transcription elongation factor S...2320.6     39.7     22     36GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003682; F:chromatin binding; IDA:MGI.
GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:InterPro.
57Q923D3    296   PARM1_MOUSE Prostate androgen-regulated mucin...1302.8     36.6     25     43GO:0005769; C:early endosome; ISS:UniProtKB.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0051973; P:positive regulation of telomerase activity; ISS:UniProtKB.
58Q7SB65    856   IRS4_NEUCR Increased rDNA silencing protein 4...1652.9     37.4     24     42
GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
59P08161    803   VE94_NPVAC Early 94 kDa protein OS=Autographa...1183.5     37     30     45
60Q59979    822   DEXT_STRSL Dextranase OS=Streptococcus saliva...2224.6     36.6     20     43
GO:0043169; F:cation binding; IEA:InterPro.::GO:0033904; F:dextranase activity; IEA:EC.
GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
61C1G966    744   ACUK_PARBD Transcription activator of glucone...1125.3     36.2     28     45GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
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