UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YOL038W

Length:

254

Number of sequences:

5887

Description:

YOL038W PRE6 SGDID:S000005398, Chr XV from 255337-256101, Genome Release 64-1-1, Verified ORF, "Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
121	Q4R932	261	PSA4_MACFA Proteasome subunit alpha type-4 OS...	236	3e-39	142	33	56	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
122	P32379	260	PSA5_YEAST Proteasome component PUP2 OS=Sacch...	209	1e-38	141	38	59	GO:0005739; C:mitochondrion; IC:SGD.::GO:0042175; C:nuclear outer membrane-endoplasmic reticulum membrane network; IC:SGD.::GO:0005634; C:nucleus; IC:SGD.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:SGD.::GO:0034515; C:proteasome storage granule; IDA:SGD.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IDA:SGD.::GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD.
123	Q9XG77	246	PSA6_TOBAC Proteasome subunit alpha type-6 OS...	240	3e-38	139	35	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
124	Q94561	247	PSA5_ENTHI Proteasome subunit alpha type-5 OS...	220	3e-38	139	35	60	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
125	Q9LSU3	246	PSA6_ORYSJ Proteasome subunit alpha type-6 OS...	241	1e-37	138	34	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
126	O48551	246	PSA6_SOYBN Proteasome subunit alpha type-6 OS...	243	1e-37	137	35	58	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
127	O81146	246	PSA6A_ARATH Proteasome subunit alpha type-6-A...	241	1e-37	137	34	59	GO:0005829; C:cytosol; IDA:TAIR.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.::GO:0005774; C:vacuolar membrane; IDA:TAIR.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0010043; P:response to zinc ion; IEP:TAIR.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
128	Q9N599	250	PSA4_CAEEL Proteasome subunit alpha type-4 OS...	214	2e-37	137	35	57	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
129	P18053	264	PSA4_DROME Proteasome subunit alpha type-4 OS...	232	5e-37	137	33	54	GO:0005737; C:cytoplasm; IDA:FlyBase.::GO:0005875; C:microtubule associated complex; IDA:FlyBase.::GO:0005634; C:nucleus; IDA:FlyBase.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0005515; F:protein binding; IPI:IntAct.::GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0008283; P:cell proliferation; IMP:FlyBase.::GO:0000022; P:mitotic spindle elongation; IMP:FlyBase.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
130	O96788	266	PSA1_TRYBR Proteasome subunit alpha type-1 OS...	234	1e-36	136	36	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
131	O81147	246	PSA6B_ARATH Proteasome subunit alpha type-6-B...	241	2e-36	135	34	58	GO:0022626; C:cytosolic ribosome; IDA:TAIR.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
132	Q9VA12	251	PSA4L_DROME Proteasome subunit alpha type-4-l...	198	4e-36	134	38	58	GO:0001673; C:male germ cell nucleus; IDA:FlyBase.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
133	Q4R3H2	263	PSA1_MACFA Proteasome subunit alpha type-1 OS...	246	4e-36	134	33	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
134	P23639	250	PSA2_YEAST Proteasome component Y7 OS=Sacchar...	216	6e-36	134	38	58	GO:0005739; C:mitochondrion; IC:SGD.::GO:0042175; C:nuclear outer membrane-endoplasmic reticulum membrane network; IC:SGD.::GO:0005634; C:nucleus; IC:SGD.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:SGD.::GO:0034515; C:proteasome storage granule; IDA:SGD.
									GO:0005515; F:protein binding; IPI:IntAct.::GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IDA:SGD.::GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD.
135	Q9R1P4	263	PSA1_MOUSE Proteasome subunit alpha type-1 OS...	246	1e-35	133	32	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0001530; F:lipopolysaccharide binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; IMP:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
136	P18420	263	PSA1_RAT Proteasome subunit alpha type-1 OS=R...	246	2e-35	132	32	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
137	Q3T0X5	263	PSA1_BOVIN Proteasome subunit alpha type-1 OS...	246	2e-35	132	32	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
138	P25786	263	PSA1_HUMAN Proteasome subunit alpha type-1 OS...	246	2e-35	132	32	53	GO:0005813; C:centrosome; IDA:HPA.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005844; C:polysome; TAS:ProtInc.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003723; F:RNA binding; TAS:ProtInc.::GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.::GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome.::GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.::GO:0010467; P:gene expression; TAS:Reactome.::GO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome.::GO:0016071; P:mRNA metabolic process; TAS:Reactome.::GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0000209; P:protein polyubiquitination; TAS:Reactome.::GO:0042981; P:regulation of apoptotic process; TAS:Reactome.::GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome.::GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.::GO:0016032; P:viral reproduction; TAS:Reactome.
139	Q27562	248	PSA1_DICDI Proteasome subunit alpha type-1 OS...	242	3e-35	132	33	54	GO:0005634; C:nucleus; IPI:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.::GO:0019773; C:proteasome core complex, alpha-subunit complex; ISS:dictyBase.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:dictyBase.
140	Q5REN2	263	PSA1_PONAB Proteasome subunit alpha type-1 OS...	246	3e-35	132	32	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
141	P92188	265	PSA1_TRYCR Proteasome subunit alpha type-1 OS...	243	7e-35	131	33	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
142	Q9V2V5	249	PSA2_HALVD Proteasome subunit alpha 2 OS=1474...	176	3e-34	129	41	58	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:UniProtKB.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0010498; P:proteasomal protein catabolic process; IDA:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
143	O42265	260	PSA1_CHICK Proteasome subunit alpha type-1 OS...	240	1e-33	127	32	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
144	P12881	279	PSA1_DROME Proteasome subunit alpha type-1 OS...	237	2e-33	128	33	55	GO:0005737; C:cytoplasm; IDA:FlyBase.::GO:0005875; C:microtubule associated complex; IDA:FlyBase.::GO:0005634; C:nucleus; IDA:FlyBase.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
145	Q9XZJ4	244	PSA6_DROME Proteasome subunit alpha type-6 OS...	245	2e-32	124	32	55	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
146	O23712	277	PSA1B_ARATH Proteasome subunit alpha type-1-B...	238	3e-32	124	31	54	GO:0005829; C:cytosol; IDA:TAIR.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:TAIR.::GO:0009506; C:plasmodesma; IDA:TAIR.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
147	P34066	278	PSA1A_ARATH Proteasome subunit alpha type-1-A...	238	1e-31	122	32	53	GO:0005829; C:cytosol; IDA:TAIR.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:TAIR.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0046685; P:response to arsenic-containing substance; IMP:TAIR.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
148	P60901	246	PSA6_RAT Proteasome subunit alpha type-6 OS=R...	214	1e-30	119	32	56	GO:0016363; C:nuclear matrix; ISS:BHF-UCL.::GO:0005844; C:polysome; ISS:BHF-UCL.::GO:0019773; C:proteasome core complex, alpha-subunit complex; ISS:BHF-UCL.::GO:0030017; C:sarcomere; IDA:BHF-UCL.
									GO:0003723; F:RNA binding; ISS:BHF-UCL.::GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
149	P60900	246	PSA6_HUMAN Proteasome subunit alpha type-6 OS...	214	1e-30	119	32	56	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005739; C:mitochondrion; IDA:HPA.::GO:0016363; C:nuclear matrix; ISS:BHF-UCL.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005844; C:polysome; IDA:BHF-UCL.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:BHF-UCL.::GO:0030017; C:sarcomere; ISS:BHF-UCL.
									GO:0051059; F:NF-kappaB binding; IPI:BHF-UCL.::GO:0035639; F:purine ribonucleoside triphosphate binding; NAS:BHF-UCL.::GO:0003723; F:RNA binding; NAS:UniProtKB.::GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.::GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome.::GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.::GO:0010467; P:gene expression; TAS:Reactome.::GO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome.::GO:0016071; P:mRNA metabolic process; TAS:Reactome.::GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0000209; P:protein polyubiquitination; TAS:Reactome.::GO:0042981; P:regulation of apoptotic process; TAS:Reactome.::GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome.::GO:0050727; P:regulation of inflammatory response; IC:BHF-UCL.::GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0016032; P:viral reproduction; TAS:Reactome.
150	Q2YDE4	246	PSA6_BOVIN Proteasome subunit alpha type-6 OS...	214	1e-30	119	32	56
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
151	Q27563	248	PSA3_DICDI Proteasome subunit alpha type-3 OS...	176	3e-30	118	37	59	GO:0005737; C:cytoplasm; IPI:dictyBase.::GO:0005634; C:nucleus; IPI:dictyBase.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.

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