Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOL021C
Length:
1001
Number of sequences:
5887
Description:
YOL021C DIS3 SGDID:S000005381, Chr XV from 285426-282421, Genome Release 64-1-1, reverse complement, Verified ORF, "Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q08162    1001   RRP44_YEAST Exosome complex exonuclease DIS3 ...10010     2070     100     100GO:0000177; C:cytoplasmic exosome (RNase complex); IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0000176; C:nuclear exosome (RNase complex); IDA:SGD.::GO:0005730; C:nucleolus; IDA:SGD.
GO:0000175; F:3'-5'-exoribonuclease activity; IDA:SGD.::GO:0004521; F:endoribonuclease activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0000049; F:tRNA binding; IDA:SGD.
GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0070651; P:nonfunctional rRNA decay; IMP:SGD.::GO:0071028; P:nuclear mRNA surveillance; IMP:SGD.::GO:0071039; P:nuclear polyadenylation-dependent CUT catabolic process; IMP:SGD.::GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; IC:SGD.::GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IMP:SGD.::GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IDA:SGD.::GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IC:SGD.::GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IC:SGD.::GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IC:SGD.
2P37202    970   DIS3_SCHPO Exosome complex exonuclease dis3 O...9850     1014     52     70GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:PomBase.::GO:0005739; C:mitochondrion; ISS:PomBase.::GO:0000176; C:nuclear exosome (RNase complex); ISS:PomBase.
GO:0000175; F:3'-5'-exoribonuclease activity; ISS:PomBase.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0008536; F:Ran GTPase binding; IPI:PomBase.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:PomBase.::GO:0000465; P:exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:PomBase.::GO:0000070; P:mitotic sister chromatid segregation; IMP:PomBase.::GO:0070651; P:nonfunctional rRNA decay; ISS:PomBase.::GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; ISS:PomBase.::GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; ISS:PomBase.::GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; ISS:PomBase.::GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; ISS:PomBase.::GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; ISS:PomBase.::GO:0032853; P:positive regulation of Ran GTPase activity; IMP:PomBase.::GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.::GO:0007346; P:regulation of mitotic cell cycle; IMP:PomBase.::GO:0007051; P:spindle organization; IMP:PomBase.
3Q9CSH3    958   RRP44_MOUSE Exosome complex exonuclease RRP44...9710     763     43     62GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000176; C:nuclear exosome (RNase complex); ISS:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO:0000175; F:3'-5'-exoribonuclease activity; ISS:UniProtKB.::GO:0004519; F:endonuclease activity; ISS:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
4Q9Y2L1    958   RRP44_HUMAN Exosome complex exonuclease RRP44...9730     751     43     62GO:0005829; C:cytosol; TAS:Reactome.::GO:0000176; C:nuclear exosome (RNase complex); IDA:UniProtKB.::GO:0005654; C:nucleoplasm; IDA:UniProtKB.
GO:0000175; F:3'-5'-exoribonuclease activity; IMP:UniProtKB.::GO:0004519; F:endonuclease activity; IMP:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0071034; P:CUT catabolic process; IMP:UniProtKB.::GO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; TAS:Reactome.::GO:0016075; P:rRNA catabolic process; IMP:UniProtKB.::GO:0006364; P:rRNA processing; TAS:UniProtKB.
5Q17632    961   RRP44_CAEEL Probable exosome complex exonucle...9410     647     39     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0004540; F:ribonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
6Q0P4R5    1039   DI3L1_XENTR DIS3-like exonuclease 1 OS=Xenopu...9662e-152     486     34     52GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:UniProtKB.
GO:0000175; F:3'-5'-exoribonuclease activity; ISS:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
7Q6GN11    1040   DI3L1_XENLA DIS3-like exonuclease 1 OS=Xenopu...10211e-149     478     33     49GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:UniProtKB.
GO:0000175; F:3'-5'-exoribonuclease activity; ISS:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
8Q5U2P0    1054   DI3L1_RAT DIS3-like exonuclease 1 OS=Rattus n...9701e-149     478     35     51GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:UniProtKB.
GO:0000175; F:3'-5'-exoribonuclease activity; ISS:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
9Q8C0S1    1053   DI3L1_MOUSE DIS3-like exonuclease 1 OS=Mus mu...9742e-148     475     35     50GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:UniProtKB.
GO:0000175; F:3'-5'-exoribonuclease activity; ISS:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
10A0JN80    1053   DI3L1_BOVIN DIS3-like exonuclease 1 OS=Bos ta...9717e-147     471     34     51GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:UniProtKB.
GO:0000175; F:3'-5'-exoribonuclease activity; ISS:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
11Q5R5N8    1054   DI3L1_PONAB DIS3-like exonuclease 1 OS=Pongo ...10165e-143     461     33     50GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:UniProtKB.
GO:0000175; F:3'-5'-exoribonuclease activity; ISS:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
12Q8TF46    1054   DI3L1_HUMAN DIS3-like exonuclease 1 OS=Homo s...10155e-143     461     33     49GO:0005813; C:centrosome; IDA:HPA.::GO:0000177; C:cytoplasmic exosome (RNase complex); IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0000175; F:3'-5'-exoribonuclease activity; IDA:UniProtKB.::GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016075; P:rRNA catabolic process; IDA:UniProtKB.
13A2RV18    1057   DI3L1_DANRE DIS3-like exonuclease 1 OS=Danio ...10183e-142     459     33     51GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:UniProtKB.
GO:0000175; F:3'-5'-exoribonuclease activity; ISS:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
14Q8IYB7    885   DI3L2_HUMAN DIS3-like exonuclease 2 OS=Homo s...8205e-100     340     33     47GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0004540; F:ribonuclease activity; IDA:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0051306; P:mitotic sister chromatid separation; IMP:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IMP:UniProtKB.
15Q8CI75    870   DI3L2_MOUSE DIS3-like exonuclease 2 OS=Mus mu...7766e-99     337     33     48GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0004540; F:ribonuclease activity; ISS:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0051306; P:mitotic sister chromatid separation; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
16Q0V9R3    834   DI3L2_XENTR DIS3-like exonuclease 2 OS=Xenopu...7556e-99     336     34     49
GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0004540; F:ribonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
17O14040    927   DIS3L_SCHPO Dis3-like exonuclease C2C4.07c OS...7801e-89     313     32     49GO:0005829; C:cytosol; IDA:PomBase.
GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0004540; F:ribonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0033554; P:cellular response to stress; IEP:PomBase.
18Q09568    848   YR86_CAEEL Uncharacterized ribonuclease F48E8...7423e-87     304     31     49
GO:0004540; F:ribonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
19Q9WZI1    710   RNR_THEMA Ribonuclease R OS=Thermotoga mariti...5175e-55     207     32     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
20O67834    705   RNR_AQUAE Ribonuclease R OS=Aquifex aeolicus ...4503e-49     190     31     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
21Q9Z848    676   RNR_CHLPN Ribonuclease R OS=Chlamydia pneumon...5206e-49     189     30     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
22O84402    694   RNR_CHLTR Ribonuclease R OS=Chlamydia trachom...4243e-47     184     32     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
23O32231    779   RNR_BACSU Ribonuclease R OS=Bacillus subtilis...4455e-47     184     31     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
24Q9PK00    692   RNR_CHLMU Ribonuclease R OS=Chlamydia muridar...4241e-45     179     32     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
25Q9CH00    817   RNR1_LACLA Ribonuclease R 1 OS=lactis). GN=rn...5942e-44     177     27     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
26Q98QL0    725   RNR_MYCPU Ribonuclease R OS=Mycoplasma pulmon...4822e-41     166     30     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
27Q02146    665   RNR2_LACLA Ribonuclease R 2 OS=lactis). GN=rn...5054e-40     162     29     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
28Q9PR88    721   RNR_UREPA Ribonuclease R OS=Ureaplasma parvum...4808e-40     161     29     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
29P21499    813   RNR_ECOLI Ribonuclease R OS=Escherichia coli ...5645e-39     160     27     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0000175; F:3'-5'-exoribonuclease activity; IDA:EcoCyc.::GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016556; P:mRNA modification; IDA:EcoCyc.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0000154; P:rRNA modification; IDA:EcoCyc.
30P30851    813   RNR_SHIFL Ribonuclease R OS=Shigella flexneri...5648e-39     159     27     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0016070; P:RNA metabolic process; IEA:InterPro.
31Q9KNY1    821   RNR_VIBCH Ribonuclease R OS=Vibrio cholerae s...5261e-37     155     27     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008859; F:exoribonuclease II activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
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