Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOL013C
Length:
551
Number of sequences:
5887
Description:
YOL013C HRD1 SGDID:S000005373, Chr XV from 303035-301380, Genome Release 64-1-1, reverse complement, Verified ORF, "Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
361O35445    180   RNF5_MOUSE E3 ubiquitin-protein ligase RNF5 O...342.5     33.5     38     53GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0071712; P:ER-associated misfolded protein catabolic process; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.
362Q54K33    104   RBX1_DICDI RING-box protein 1 OS=Dictyosteliu...223.3     32     36     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
363Q9M2B0    115   RBX1B_ARATH RING-box protein 1b OS=Arabidopsi...523.5     32.3     25     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
364Q8QG64    108   RBX1_SALSA RING-box protein 1 OS=Salmo salar ...223.5     32     36     55GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.::GO:0031464; C:Cul4A-RING ubiquitin ligase complex; ISS:UniProtKB.::GO:0031465; C:Cul4B-RING ubiquitin ligase complex; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
GO:0019788; F:NEDD8 ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006513; P:protein monoubiquitination; ISS:UniProtKB.::GO:0045116; P:protein neddylation; ISS:UniProtKB.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
365P62878    108   RBX1_MOUSE E3 ubiquitin-protein ligase RBX1 O...223.5     32     36     55GO:0005680; C:anaphase-promoting complex; TAS:UniProtKB.::GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.::GO:0031464; C:Cul4A-RING ubiquitin ligase complex; ISS:UniProtKB.::GO:0031465; C:Cul4B-RING ubiquitin ligase complex; ISS:UniProtKB.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
GO:0008190; F:eukaryotic initiation factor 4E binding; TAS:UniProtKB.::GO:0019788; F:NEDD8 ligase activity; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; TAS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006513; P:protein monoubiquitination; ISS:UniProtKB.::GO:0045116; P:protein neddylation; ISS:UniProtKB.::GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
366P62877    108   RBX1_HUMAN E3 ubiquitin-protein ligase RBX1 O...223.5     32     36     55GO:0031462; C:Cul2-RING ubiquitin ligase complex; IDA:UniProtKB.::GO:0031463; C:Cul3-RING ubiquitin ligase complex; IDA:UniProtKB.::GO:0031464; C:Cul4A-RING ubiquitin ligase complex; IDA:UniProtKB.::GO:0031465; C:Cul4B-RING ubiquitin ligase complex; IDA:UniProtKB.::GO:0031466; C:Cul5-RING ubiquitin ligase complex; IDA:UniProtKB.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
GO:0019788; F:NEDD8 ligase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.::GO:0045116; P:protein neddylation; IDA:UniProtKB.::GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB.::GO:0016032; P:viral reproduction; TAS:Reactome.
367Q9W5E1    108   RBX1A_DROME RING-box protein 1A OS=Drosophila...223.5     32     36     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
GO:0004842; F:ubiquitin-protein ligase activity; IDA:FlyBase.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0008283; P:cell proliferation; IMP:FlyBase.::GO:0019915; P:lipid storage; IDA:FlyBase.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IMP:FlyBase.::GO:0007224; P:smoothened signaling pathway; NAS:UniProtKB.
368Q9QZS2    194   RNF4_MOUSE E3 ubiquitin-protein ligase RNF4 O...243.7     33.1     42     67GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; ISS:UniProtKB.::GO:0031491; F:nucleosome binding; ISS:UniProtKB.::GO:0032184; F:SUMO polymer binding; ISS:UniProtKB.::GO:0008134; F:transcription factor binding; IPI:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0090234; P:regulation of kinetochore assembly; ISS:UniProtKB.::GO:0090169; P:regulation of spindle assembly; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
369Q23457    110   RBX1_CAEEL RING-box protein 1 OS=Caenorhabdit...223.9     32     36     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0008595; P:anterior/posterior axis specification, embryo; IMP:WormBase.::GO:0006915; P:apoptotic process; IMP:WormBase.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0007138; P:meiotic anaphase II; IMP:WormBase.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0040015; P:negative regulation of multicellular organism growth; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0035046; P:pronuclear migration; IMP:WormBase.::GO:0051759; P:sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation; IMP:WormBase.
370O88846    194   RNF4_RAT E3 ubiquitin-protein ligase RNF4 OS=...243.9     33.1     42     67GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; IPI:RGD.::GO:0003677; F:DNA binding; IDA:UniProtKB.::GO:0030331; F:estrogen receptor binding; IDA:RGD.::GO:0031491; F:nucleosome binding; IDA:UniProtKB.::GO:0033142; F:progesterone receptor binding; IPI:RGD.::GO:0032184; F:SUMO polymer binding; IPI:UniProtKB.::GO:0017025; F:TBP-class protein binding; TAS:RGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; IMP:UniProtKB.::GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0090234; P:regulation of kinetochore assembly; ISS:UniProtKB.::GO:0090169; P:regulation of spindle assembly; ISS:UniProtKB.::GO:0046685; P:response to arsenic-containing substance; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
371P78317    190   RNF4_HUMAN E3 ubiquitin-protein ligase RNF4 O...244.1     33.1     42     67GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; NAS:UniProtKB.::GO:0003677; F:DNA binding; ISS:UniProtKB.::GO:0031491; F:nucleosome binding; ISS:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.::GO:0032184; F:SUMO polymer binding; ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; NAS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0030521; P:androgen receptor signaling pathway; NAS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0090234; P:regulation of kinetochore assembly; IMP:UniProtKB.::GO:0090169; P:regulation of spindle assembly; IMP:UniProtKB.::GO:0046685; P:response to arsenic-containing substance; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
372O60291    552   MGRN1_HUMAN E3 ubiquitin-protein ligase MGRN1...644.3     33.9     34     48GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005769; C:early endosome; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0008333; P:endosome to lysosome transport; IMP:UniProtKB.::GO:0043951; P:negative regulation of cAMP-mediated signaling; IDA:UniProtKB.::GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; IDA:UniProtKB.::GO:0006513; P:protein monoubiquitination; IMP:UniProtKB.
373P87119    309   MU145_SCHPO RING finger protein mug145 OS=Sch...264.4     33.5     42     62GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007126; P:meiosis; IEA:UniProtKB-KW.
374Q8BFW4    522   TRI65_MOUSE Tripartite motif-containing prote...454.5     33.9     33     53
GO:0008270; F:zinc ion binding; IEA:InterPro.
375Q940X7    118   RBX1A_ARATH RING-box protein 1a OS=Arabidopsi...224.6     32     36     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019005; C:SCF ubiquitin ligase complex; IPI:TAIR.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016567; P:protein ubiquitination; TAS:TAIR.::GO:0009733; P:response to auxin stimulus; IMP:TAIR.
376Q9D4H7    753   LONF3_MOUSE LON peptidase N-terminal domain a...304.8     33.9     37     60
GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:InterPro.
377Q1L5Z9    754   LONF2_HUMAN LON peptidase N-terminal domain a...304.9     33.9     37     60
GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:InterPro.
378C0HBT3    349   RN146_SALSA E3 ubiquitin-protein ligase rnf14...585     33.5     28     45GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0072572; F:poly-ADP-D-ribose binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
379Q8L9W3    163   ATL23_ARATH E3 ubiquitin-protein ligase ATL23...535.3     32.7     23     42GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
380Q91YT2    192   RN185_MOUSE E3 ubiquitin-protein ligase RNF18...345.3     32.7     35     53GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
381Q4KLN8    487   RNF8_RAT E3 ubiquitin-protein ligase RNF8 OS=...905.6     33.5     29     40GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0030496; C:midbody; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006302; P:double-strand break repair; ISS:UniProtKB.::GO:0033522; P:histone H2A ubiquitination; ISS:UniProtKB.::GO:0033523; P:histone H2B ubiquitination; ISS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
382Q6ZMN7    1036   PZRN4_HUMAN PDZ domain-containing RING finger...235.7     33.5     48     61
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
383O42393    412   RAPSN_CHICK 43 kDa receptor-associated protei...466.1     33.1     37     48GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO:0033130; F:acetylcholine receptor binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007268; P:synaptic transmission; IEA:InterPro.
384Q568Y3    192   RN185_RAT E3 ubiquitin-protein ligase RNF185 ...346.2     32.7     35     53GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
385Q5ZIR9    194   RN185_CHICK E3 ubiquitin-protein ligase RNF18...346.5     32.3     35     53GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
386P0CH03    366   AT21C_ARATH Putative RING-H2 finger protein A...646.6     33.1     25     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
387A2AWP0    285   BIRC7_MOUSE Baculoviral IAP repeat-containing...296.9     32.7     45     59GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042127; P:regulation of cell proliferation; ISS:UniProtKB.::GO:0070247; P:regulation of natural killer cell apoptotic process; ISS:UniProtKB.
388Q496Y0    759   LONF3_HUMAN LON peptidase N-terminal domain a...306.9     33.1     37     60
GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:InterPro.
389Q96GF1    192   RN185_HUMAN E3 ubiquitin-protein ligase RNF18...346.9     32.3     35     53GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
390Q5RFK9    192   RN185_PONAB E3 ubiquitin-protein ligase RNF18...347     32.3     35     53GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
391Q8HXH0    718   LONF3_MACFA LON peptidase N-terminal domain a...307.2     33.1     37     60
GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:InterPro.
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