Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOL013C
Length:
551
Number of sequences:
5887
Description:
YOL013C HRD1 SGDID:S000005373, Chr XV from 303035-301380, Genome Release 64-1-1, reverse complement, Verified ORF, "Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
331Q71FD5    238   ZNRF2_MOUSE E3 ubiquitin-protein ligase ZNRF2...551.5     34.7     31     45GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
332P29129    410   ICP0_SUHVF E3 ubiquitin-protein ligase ICP0 O...791.5     35     28     41
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
333Q9LM69    197   ATL80_ARATH RING-H2 finger protein ATL80 OS=A...531.5     34.7     30     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006952; P:defense response; IEA:UniProtKB-KW.::GO:0010200; P:response to chitin; IEP:TAIR.
334Q5R4I2    486   RNF8_PONAB E3 ubiquitin-protein ligase RNF8 O...901.5     35     29     40GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0030496; C:midbody; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006302; P:double-strand break repair; ISS:UniProtKB.::GO:0033522; P:histone H2A ubiquitination; ISS:UniProtKB.::GO:0033523; P:histone H2B ubiquitination; ISS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
335Q8NHG8    242   ZNRF2_HUMAN E3 ubiquitin-protein ligase ZNRF2...551.6     34.7     31     45GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
336Q6NKR1    254   ATL28_ARATH RING-H2 finger protein ATL28 OS=A...591.6     34.7     31     42GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
337Q9SKK8    377   ATL22_ARATH RING-H2 finger protein ATL22 OS=A...601.6     35     27     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
338Q8AWW4    404   RN128_XENLA E3 ubiquitin-protein ligase RNF12...641.7     35     23     45GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
339Q5M929    415   RN135_RAT E3 ubiquitin-protein ligase RNF135 ...661.7     35     35     42GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0032728; P:positive regulation of interferon-beta production; ISS:UniProtKB.::GO:0045088; P:regulation of innate immune response; ISS:UniProtKB.
340P87139    372   YDM9_SCHPO Uncharacterized RING finger protei...521.7     35     29     40GO:0000324; C:fungal-type vacuole; IDA:PomBase.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016567; P:protein ubiquitination; NAS:PomBase.
341Q6NML0    225   ATL76_ARATH E3 ubiquitin-protein ligase ATL76...531.8     34.3     28     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
342Q9C7E9    299   ATL20_ARATH RING-H2 finger protein ATL20 OS=A...531.8     34.7     28     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
343O70263    728   LNX1_MOUSE E3 ubiquitin-protein ligase LNX OS...601.8     35     33     43GO:0005737; C:cytoplasm; IDA:MGI.
GO:0030165; F:PDZ domain binding; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051260; P:protein homooligomerization; IDA:MGI.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:MGI.
344Q9CWS1    417   RN135_MOUSE E3 ubiquitin-protein ligase RNF13...661.8     35     33     41GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005515; F:protein binding; IPI:MGI.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0032728; P:positive regulation of interferon-beta production; ISS:UniProtKB.::GO:0045088; P:regulation of innate immune response; ISS:UniProtKB.
345Q99942    180   RNF5_HUMAN E3 ubiquitin-protein ligase RNF5 O...341.8     34.3     38     53GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0071712; P:ER-associated misfolded protein catabolic process; IMP:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
346Q9LQM2    332   ATL81_ARATH RING-H2 finger protein ATL81 OS=A...242     34.7     46     58GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
347Q54L48    87   APC11_DICDI Anaphase-promoting complex subuni...262     32.3     38     58GO:0005680; C:anaphase-promoting complex; ISS:dictyBase.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:dictyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:dictyBase.
348O76064    485   RNF8_HUMAN E3 ubiquitin-protein ligase RNF8 O...522.1     34.7     33     40GO:0030496; C:midbody; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003682; F:chromatin binding; IDA:UniProtKB.::GO:0042393; F:histone binding; IDA:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006302; P:double-strand break repair; IDA:UniProtKB.::GO:0033522; P:histone H2A ubiquitination; IDA:UniProtKB.::GO:0033523; P:histone H2B ubiquitination; ISS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045739; P:positive regulation of DNA repair; IDA:UniProtKB.::GO:0010212; P:response to ionizing radiation; IDA:UniProtKB.
349Q68DV7    783   RNF43_HUMAN RING finger protein 43 OS=Homo sa...592.1     35     24     53GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
350Q06834    288   ASR1_YEAST Alcohol-sensitive RING finger prot...272.1     34.7     48     67GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045471; P:response to ethanol; IMP:SGD.
351Q2HJ46    487   RNF8_BOVIN E3 ubiquitin-protein ligase RNF8 O...522.3     34.7     31     40GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0030496; C:midbody; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006302; P:double-strand break repair; ISS:UniProtKB.::GO:0033522; P:histone H2A ubiquitination; ISS:UniProtKB.::GO:0033523; P:histone H2B ubiquitination; ISS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
352Q5NCP0    784   RNF43_MOUSE RING finger protein 43 OS=Mus mus...592.3     34.7     24     53GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
353Q5R8A2    84   APC11_PONAB Anaphase-promoting complex subuni...272.4     32.3     37     52GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
354Q9NYG5    84   APC11_HUMAN Anaphase-promoting complex subuni...272.4     32.3     37     52GO:0005680; C:anaphase-promoting complex; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; TAS:UniProtKB.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; TAS:Reactome.::GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
355O22755    185   ATL44_ARATH RING-H2 finger protein ATL44 OS=A...242.4     33.9     42     58GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
356Q63HN8    5207   RN213_HUMAN E3 ubiquitin-protein ligase RNF21...382.5     35     42     50GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016887; F:ATPase activity; IDA:UniProtKB.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
357Q9ZT49    200   ATL45_ARATH RING-H2 finger protein ATL45 OS=A...772.5     33.9     29     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006952; P:defense response; IEA:UniProtKB-KW.::GO:0010200; P:response to chitin; IEP:TAIR.
358Q9CPX9    84   APC11_MOUSE Anaphase-promoting complex subuni...272.5     32     37     52GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
359Q3ZCF6    84   APC11_BOVIN Anaphase-promoting complex subuni...272.5     32     37     52GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
360Q5M807    180   RNF5_RAT E3 ubiquitin-protein ligase RNF5 OS=...342.5     33.5     38     53GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
361O35445    180   RNF5_MOUSE E3 ubiquitin-protein ligase RNF5 O...342.5     33.5     38     53GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0071712; P:ER-associated misfolded protein catabolic process; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.
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